Systemic spread is an early step in breast cancer.

[1]  K. Chin,et al.  In situ analyses of genome instability in breast cancer , 2004, Nature Genetics.

[2]  Piero Musiani,et al.  Nonredundant roles of antibody, cytokines, and perforin in the eradication of established Her-2/neu carcinomas. , 2003, The Journal of clinical investigation.

[3]  Piero Musiani,et al.  Interleukin 12–mediated Prevention of Spontaneous Mammary Adenocarcinomas in Two Lines of Her-2/neu Transgenic Mice , 1998, The Journal of experimental medicine.

[4]  J. Coebergh,et al.  Epidemiology of unknown primary tumours; incidence and population-based survival of 1285 patients in Southeast Netherlands, 1984-1992. , 2002, European journal of cancer.

[5]  R. Cardiff,et al.  Mammary Disease Mice Model Premalignant Polyoma Middle-T Transgenic Updated Version , 2001 .

[6]  C. Klein.  The systemic progression of human cancer: a focus on the individual disseminated cancer cell--the unit of selection. , 2003, Advances in cancer research.

[7]  P. Musiani,et al.  Analysis of mammary carcinoma onset and progression in HER-2/neu oncogene transgenic mice reveals a lobular origin. , 1999, Laboratory investigation; a journal of technical methods and pathology.

[8]  T. Dimpfl,et al.  Cytokeratin-positive cells in the bone marrow and survival of patients with stage I, II, or III breast cancer. , 2000, The New England journal of medicine.

[9]  B. Fingleton,et al.  Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations , 2002, Science.

[10]  L. R. Howe,et al.  Twist is up-regulated in response to Wnt1 and inhibits mouse mammary cell differentiation. , 2003, Cancer research.

[11]  D Hölzel,et al.  The process of metastasisation for breast cancer. , 2003, European journal of cancer.

[12]  Yudong D. He,et al.  Gene expression profiling predicts clinical outcome of breast cancer , 2002, Nature.

[13]  R. Eils,et al.  Genomic analysis of single cytokeratin-positive cells from bone marrow reveals early mutational events in breast cancer. , 2005, Cancer cell.

[14]  S. Ramaswamy,et al.  Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis , 2004, Cell.

[15]  R. Tibshirani,et al.  Significance analysis of microarrays applied to the ionizing radiation response , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[16]  Andy J. Minn,et al.  Genes that mediate breast cancer metastasis to lung , 2005, Nature.

[17]  I. Fidler,et al.  Metastasis results from preexisting variant cells within a malignant tumor. , 1977, Science.

[18]  F. Neumann,et al.  Transcriptome Analysis Reveals a Role of Interferon-γ in Human Neointima Formation , 2001 .

[19]  J. Kos,et al.  Lysosomal cathepsins: structure, role in antigen processing and presentation, and cancer. , 2002, Advances in enzyme regulation.

[20]  T. Fehm,et al.  A concept for the standardized detection of disseminated tumor cells in bone marrow from patients with primary breast cancer and its clinical implementation , 2006, Cancer.

[21]  J. T. Young,et al.  The in vivo life span of normal and preneoplastic mouse mammary glands: a serial transplantation study. , 1968, Proceedings of the National Academy of Sciences of the United States of America.

[22]  C. Klein,et al.  Early cancer cell dissemination and late metastatic relapse: clinical reflections and biological approaches to the dormancy problem in patients. , 2001, Seminars in cancer biology.

[23]  C. Cordon-Cardo,et al.  A multigenic program mediating breast cancer metastasis to bone. , 2003, Cancer cell.

[24]  P. Kronqvist,et al.  Predicting aggressive outcome in T1N0M0 breast cancer , 2004, British Journal of Cancer.

[25]  T. Fehm,et al.  A pooled analysis of bone marrow micrometastasis in breast cancer. , 2005, The New England journal of medicine.

[26]  B. Vogelstein,et al.  A genetic model for colorectal tumorigenesis , 1990, Cell.

[27]  Richard M. Simon,et al.  Methods for assessing reproducibility of clustering patterns observed in analyses of microarray data , 2002, Bioinform..

[28]  M. Wilke,et al.  The Hematopoietic System–specific Minor Histocompatibility Antigen HA-1 Shows Aberrant Expression in Epithelial Cancer Cells , 2002, The Journal of experimental medicine.

[29]  Rudolf M. Huber,et al.  Combined transcriptome and genome analysis of single micrometastatic cells , 2002, Nature Biotechnology.

[30]  Piero Musiani,et al.  Gene expression analysis of immune-mediated arrest of tumorigenesis in a transgenic mouse model of HER-2/neu-positive basal-like mammary carcinoma. , 2005, The American journal of pathology.

[31]  H. Bern,et al.  Development of mammary tumors from hyperplastic alveolar nodules transplanted into gland-free mammary fat pads of female C3H mice. , 1959, Cancer research.

[32]  G. Schlimok,et al.  Micrometastatic cancer cells in bone marrow: in vitro detection with anti-cytokeratin and in vivo labeling with anti-17-1A monoclonal antibodies. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[33]  M. Speicher,et al.  Comparative genomic hybridization, loss of heterozygosity, and DNA sequence analysis of single cells. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[34]  F. Penault-Llorca,et al.  Ductal carcinoma in situ of the breast results of conservative and radical treatments in 716 patients. , 2001, European journal of cancer.

[35]  Z. Werb,et al.  New functions for the matrix metalloproteinases in cancer progression , 2002, Nature Reviews Cancer.

[36]  R. Eils,et al.  From latent disseminated cells to overt metastasis: Genetic analysis of systemic breast cancer progression , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[37]  C. la Vecchia,et al.  Epidemiology of unknown primary tumours. , 2002, European journal of cancer.

[38]  S. Rafii,et al.  VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche , 2005, Nature.

[39]  P. Leder,et al.  Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene , 1988, Cell.

[40]  V. Raman,et al.  HOXA5-Twist Interaction Alters p53 Homeostasis in Breast Cancer Cells* , 2005, Journal of Biological Chemistry.

[41]  Peter Schraml,et al.  Prognostic Relevance of Gene Amplifications and Coamplifications in Breast Cancer , 2004, Cancer Research.