Testing of dose-rate models with Chlamydomonas reinhardi.

Survival of Chlamydomonas reinhardi exposed to 1.5-MeV electrons was measured for six dose rates, from 45 to 2700 rad/min; exposure times ranged from 1 to 300 min. When the data were plotted as the quotient of the negative logarithm of the surviving fraction by the square of the dose versus the irradiation time, they fell essentially on a single curve regardless of the dose rate. Study of six dose-rate models found in the literature showed that only one of them, the Accumulation Model, predicts such a single curve; the others predict families of curves, one for each dose rate. The latter five can be rejected as not applying to C. reinhardi. The fit of the Accumulation Model to the data gave a mean recovery time of 24 min.

[1]  W. R. Garrett,et al.  Some relations between cell survival models having different inactivation mechanisms. , 1975, Radiation research.

[2]  J. Bedford,et al.  Dose-rate effects in synchronous mammalian cells in culture. , 1973, Radiation research.

[3]  J. S. Orr,et al.  Repair processes and cell survival. , 1972, The British journal of radiology.

[4]  G. Dienes.  A kinetic model of biological radiation response. , 1966, Radiation research.

[5]  E. Hall,et al.  DOSE RATE: ITS EFFECT ON THE SURVIVAL OF HELA CELLS IRRADIATED WITH GAMMA RAYS. , 1964, Radiation research.

[6]  L. Lajtha,et al.  Some radiobiological considerations in radiotherapy. , 1961, The British journal of radiology.

[7]  B. Rajewsky,et al.  ber einige Wirkungen von Strahlen. VII: Eine Erweiterung der statistischen Theorie der biologischen Strahlenwirkung. 2. Teil , 1934 .

[8]  W. Swann,et al.  The effect of radioactive radiations upon euglena , 1931 .

[9]  W. Roesch.  Lajtha-Oliver theory of dose-rate and fractionation effects , 1973 .

[10]  A. Kappos,et al.  A cybernetic model for radiation reactions in living cells. I. Sparsely-ionizing radiations; stationary cells. , 1972, International journal of radiation biology and related studies in physics, chemistry, and medicine.

[11]  W. Roesch.  Hit theory for low-LET radiation , 1972 .

[12]  Albrecht M. Kellerer,et al.  THEORY OF DUAL RADIATION ACTION. , 1972 .

[13]  R. Oliver.  A COMPARISON OF THE EFFECTS OF ACUTE AND PROTRACTED GAMMA-RADIATION ON THE GROWTH OF SEEDLINGS OF VICIA FABA. II. THEORETICAL CALCULATIONS. , 1964, International journal of radiation biology and related studies in physics, chemistry, and medicine.

[14]  O. Hug,et al.  Zur Kinetik der Strahlenwirkung , 1963 .