Cell-Mediated Immunity in Experimental Allergic Encephalomyelitis: Cross Reactivity Between Myelin Basic Protein and Mycobacteria Antigens 1

Summary Guinea pigs injected with Freund's incomplete adjuvant emulsified with guinea pig spinal cord, purified guinea pig myelin basic protein, or human myelin basic protein showed dermal reactivity to both of the basic proteins as well as to myco-bacteria antigens. Animals receiving only mycobacteria antigens expressed dermal reactivity to the sensitizing antigen in addition to basic protein. This cross reactivity may help explain the role of mycobacteria in inducing and protecting against EAE, and may have important implications concerning human demyelinating diseases. We are grateful for the assistance of Hatsumi Park and Patricia Finke.