论文信息 - Dead-time effects in TCSPC data analysis

Dead-time effects in TCSPC data analysis

In Time Correlated Single Photon Counting (TCSPC) the maximum signal throughput is limited by the occurrence of classical pile-up and dead-time effects: At a given photon rate characteristic distortions become visible in the TCSPC histogram. How to describe these distortions in mathematical terms is well known1,2. While the approach of correcting these distortions directly by operations on the raw data has drawbacks, e.g. with respect to calculation effort as well as numerical stability, it is comparably straightforward to include corrections in the models describing the data. We demonstrate the applicability of a model based approach on decay data which are heavily distorted by dead-time and pile-up effects.

[1] J A Fessler,et al. Mean and variance of single photon counting with deadtime. , 2000, Physics in medicine and biology.

[2] Peter Hall,et al. Better estimates of exponential decay parameters , 1981 .

[3] S J B Reed,et al. DEAD TIME CORRECTIONS FOR X RAY INTENSITY MEASUREMENTS WITH A Si(Li) DETECTOR. , 1972 .

[4] John G. Walker,et al. Iterative correction for 'pile-up' in single-photon lifetime measurement , 2002 .

[5] Michael Wahl,et al. Time-Correlated Single Photon Counting , 2009 .

[6] Enrico Gratton,et al. The Global Analysis of Fluorescence Intensity and Anisotropy Decay Data: Second-Generation Theory and Programs , 2002 .

[7] M. Bordessoule,et al. High-rate counters versus integrating devices in synchrotron experiments , 2002 .

[8] P. B. Coates. Pile-up corrections in the measurement of lifetimes , 1972 .

[9] J. Lakowicz. Principles of fluorescence spectroscopy , 1983 .

[10] B. Efron. The jackknife, the bootstrap, and other resampling plans , 1987 .

[11] Rainer Erdmann,et al. Dead-time optimized time-correlated photon counting instrument with synchronized, independent timing channels. , 2007, The Review of scientific instruments.

[12] B. Sharp,et al. Characterisation and correction of instrumental bias in inductively coupled plasma quadrupole mass spectrometry for accurate measurement of lead isotope ratios , 1997 .