Transdifferentiation-dependent expression of α-SMA in hepatic stellate cells does not involve TGF-β pathways leading to coinduction of collagen type I and thrombospondin-2

[1]  S. Dooley,et al.  Glucocorticoids decrease the bioavailability of TGF-β which leads to a reduced TGF-β signaling in hepatic stellate cells , 2004 .

[2]  Robert Jaster,et al.  Molecular regulation of pancreatic stellate cell function , 2004, Molecular Cancer.

[3]  X. Yang,et al.  Role of connective tissue growth factor in renal tubular epithelial-myofibroblast transdifferentiation and extracellular matrix accumulation in vitro. , 2004, Life sciences.

[4]  T. Krieg,et al.  Myofibroblast differentiation is induced in keratinocyte-fibroblast co-cultures and is antagonistically regulated by endogenous transforming growth factor-beta and interleukin-1. , 2004, The American journal of pathology.

[5]  H. Ueno,et al.  Inhibitory effect of a soluble transforming growth factor beta type II receptor on the activation of rat hepatic stellate cells in primary culture. , 2003, Journal of hepatology.

[6]  S. Dooley,et al.  Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats. , 2003, Gastroenterology.

[7]  S. Yamashita,et al.  Insulin-like growth factor-I enhances transforming growth factor-beta-induced extracellular matrix protein production through the P38/activating transcription factor-2 signaling pathway in keloid fibroblasts. , 2003, The Journal of investigative dermatology.

[8]  A. Yang,et al.  Myofibroblastic conversion of mesothelial cells. , 2003, Kidney international.

[9]  H. Kalthoff,et al.  Regulation of Biglycan Gene Expression by Transforming Growth Factor-β Requires MKK6-p38 Mitogen-activated Protein Kinase Signaling Downstream of Smad Signaling* , 2003, The Journal of Biological Chemistry.

[10]  David A. Brenner,et al.  The Role of Focal Adhesion Kinase-Phosphatidylinositol 3-Kinase-Akt Signaling in Hepatic Stellate Cell Proliferation and Type I Collagen Expression* , 2003, The Journal of Biological Chemistry.

[11]  M. Wong,et al.  Inhibition of tendon cell migration by dexamethasone is correlated with reduced alpha‐smooth muscle actin gene expression: A potential mechanism of delayed tendon healing , 2003, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[12]  K. Miyazono,et al.  Two major Smad pathways in TGF‐β superfamily signalling , 2002, Genes to cells : devoted to molecular & cellular mechanisms.

[13]  Jiahuai Han,et al.  Smad3 mediates transforming growth factor-beta-induced collagenase-3 (matrix metalloproteinase-13) expression in human gingival fibroblasts. Evidence for cross-talk between Smad3 and p38 signaling pathways. , 2002, The Journal of biological chemistry.

[14]  K. Mak,et al.  DLPC decreases TGF-beta1-induced collagen mRNA by inhibiting p38 MAPK in hepatic stellate cells. , 2002, American journal of physiology. Gastrointestinal and liver physiology.

[15]  J. Jaffrezou,et al.  p38 MAPK mediates the regulation of α1(I) procollagen mRNA levels by TNF‐α and TGF‐β in a cell line of rat hepatic stellate cells 1 , 2002 .

[16]  Ping Liu,et al.  Effects of salvianolic acid-B on TGF-beta 1 stimulated hepatic stellate cell activation and its intracellular signaling. , 2002, Zhonghua yi xue za zhi.

[17]  Ying E. Zhang,et al.  TGF‐β receptor‐activated p38 MAP kinase mediates Smad‐independent TGF‐β responses , 2002 .

[18]  A. Ghosh,et al.  Factors Involved in the Regulation of Type I Collagen Gene Expression: Implication in Fibrosis , 2002, Experimental biology and medicine.

[19]  D. Shegogue,et al.  Role of p38 MAPK in transforming growth factor beta stimulation of collagen production by scleroderma and healthy dermal fibroblasts. , 2002, The Journal of investigative dermatology.

[20]  D. Brenner,et al.  TAK1/JNK and p38 have opposite effects on rat hepatic stellate cells , 2001, Hepatology.

[21]  P. Bornstein,et al.  Altered extracellular matrix remodeling and angiogenesis in sponge granulomas of thrombospondin 2-null mice. , 2001, The American journal of pathology.

[22]  D. Brenner,et al.  The role of Smad3 in mediating mouse hepatic stellate cell activation , 2001, Hepatology.

[23]  S. Dooley,et al.  Transforming growth factor β signal transduction in hepatic stellate cells via Smad2/3 phosphorylation, a pathway that is abrogated during in vitro progression to myofibroblasts , 2001 .

[24]  P. Bornstein,et al.  Extracellular Matrix Metalloproteinase 2 Levels Are Regulated by the Low Density Lipoprotein-related Scavenger Receptor and Thrombospondin 2* , 2001, The Journal of Biological Chemistry.

[25]  A. Gressner,et al.  Expression and matrix deposition of latent transforming growth factor β binding proteins in normal and fibrotic rat liver and transdifferentiating hepatic stellate cells in culture , 2001, Hepatology.

[26]  J. Uitto,et al.  Downregulation of human type VII collagen (COL7A1) promoter activity by dexamethasone , 2001, Experimental dermatology.

[27]  S. Dooley,et al.  Modulation of transforming growth factor β response and signaling during transdifferentiation of rat hepatic stellate cells to myofibroblasts , 2000, Hepatology.

[28]  H. Reeves,et al.  Stress-activated protein kinases in the activation of rat hepatic stellate cells in culture. , 2000, Journal of hepatology.

[29]  Denis Vivien,et al.  Direct binding of Smad3 and Smad4 to critical TGFβ‐inducible elements in the promoter of human plasminogen activator inhibitor‐type 1 gene , 1998, The EMBO journal.

[30]  E. Ginns,et al.  Mice That Lack Thrombospondin 2 Display Connective Tissue Abnormalities That Are Associated with Disordered Collagen Fibrillogenesis, an Increased Vascular Density, and a Bleeding Diathesis , 1998, The Journal of cell biology.

[31]  Gressner Am Transdifferentiation of hepatic stellate cells (Ito cells) to myofibroblasts: a key event in hepatic fibrogenesis. , 1996 .

[32]  K. Cutroneo,et al.  Glucocorticoids coordinately regulate type I collagen proα1 promoter activity through both the glucocorticoid and transforming growth factor β response elements: A novel mechanism of glucocorticoid regulation of eukaryotic genes , 1995, Journal of cellular biochemistry.

[33]  W. Border,et al.  Transforming Growth Factor β in Tissue Fibrosis , 1994 .

[34]  I. K. Cohen,et al.  Morphological and immunochemical differences between keloid and hypertrophic scar. , 1994, The American journal of pathology.

[35]  M. Eghbali,et al.  Ito‐cell gene expression and collagen regulation , 1990, Hepatology.

[36]  D. Cockayne,et al.  Glucocorticoids decrease the synthesis of type I procollagen mRNAs. , 1986, Biochemistry.

[37]  J. Kountouras,et al.  Prolonged bile duct obstruction: a new experimental model for cirrhosis in the rat. , 1984, British journal of experimental pathology.

[38]  J. Myers,et al.  Cloning and characterization of five overlapping cDNAs specific for the human pro alpha 1(I) collagen chain. , 1982, Nucleic acids research.

[39]  D. Brenner,et al.  The role of TGFbeta1 in initiating hepatic stellate cell activation in vivo. , 1999, Journal of hepatology.

[40]  V. Paradis,et al.  Transforming growth factor-beta (TGF-beta): a key-role in liver fibrogenesis. , 1995, Journal of hepatology.

[41]  P. Seglen Isolation of Hepatocytes by Collagenase Perfusion , 1993 .

[42]  G. E. Paget Methods in toxicology , 1970 .