Partially Unified Multiple Property Recursive Partitioning (PUMP-RP) Analyses of Cyclooxygenase (COX) Inhibitors
暂无分享,去创建一个
[1] D. Riendeau,et al. In vitro metabolism considerations, including activity testing of metabolites, in the discovery and selection of the COX-2 inhibitor etoricoxib (MK-0663). , 2001, Bioorganic & medicinal chemistry letters.
[2] C. Koboldt,et al. SELECTIVE CYCLOOXYGENASE INHIBITORS : NOVEL 4-SPIRO 1,2-DIARYLCYCLOPENTENES ARE POTENT AND ORALLY ACTIVE COX-2 INHIBITORS , 1995 .
[3] E A Kowaluk,et al. Emerging molecular approaches to pain therapy. , 1999, Journal of medicinal chemistry.
[4] R. S. Rogers,et al. 3,4-diarylthiophenes are selective COX-2 inhibitors , 1995 .
[5] M. Percival,et al. Effect of inhibitor time-dependency on selectivity towards cyclooxygenase isoforms. , 1995, The Biochemical journal.
[6] C. Koboldt,et al. 1,2-Diarylpyrroles as potent and selective inhibitors of cyclooxygenase-2. , 1997, Journal of medicinal chemistry.
[7] C. Koboldt,et al. Selective cyclooxygenase inhibitors: novel 1,2-diarylcyclopentenes are potent and orally active COX-2 inhibitors. , 1994, Journal of medicinal chemistry.
[8] R Gordon,et al. 2,3-Diarylcyclopentenones as orally active, highly selective cyclooxygenase-2 inhibitors. , 1999, Journal of medicinal chemistry.
[9] C. Koboldt,et al. Novel terphenyls as selective cyclooxygenase-2 inhibitors and orally active anti-inflammatory agents. , 1996, Journal of medicinal chemistry.
[10] E. Knaus,et al. Design and synthesis of celecoxib and rofecoxib analogues as selective cyclooxygenase-2 (COX-2) inhibitors: replacement of sulfonamide and methylsulfonyl pharmacophores by an azido bioisostere. , 2001, Journal of medicinal chemistry.
[11] C. Koboldt,et al. 1,2-Diarylimidazoles as potent, cyclooxygenase-2 selective, and orally active antiinflammatory agents. , 1997, Journal of medicinal chemistry.
[12] Thomas P. Stockfisch,et al. Partially Unified Multiple Property Recursive Partitioning (PUMP-RP): A New Method for Predicting and Understanding Drug Selectivity , 2003, J. Chem. Inf. Comput. Sci..
[13] C. Koboldt,et al. Synthesis and activity of sulfonamide-substituted 4,5-diaryl thiazoles as selective cyclooxygenase-2 inhibitors. , 1999, Bioorganic & medicinal chemistry letters.
[14] C. Koboldt,et al. Diarylspiro[2.4]heptenes as orally active, highly selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationships. , 1996, Journal of medicinal chemistry.
[15] Jacob Cohen. A Coefficient of Agreement for Nominal Scales , 1960 .
[16] Hong Li,et al. Novel algorithms for the optimization of molecular diversity of combinatorial libraries11Color Plates for this article are on pages 533–536. , 2000 .
[17] J. Vane,et al. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. , 1971, Nature: New biology.
[18] K. Seibert,et al. Endogenous glucocorticoids regulate an inducible cyclooxygenase enzyme. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[19] G. FitzGerald,et al. The coxibs, selective inhibitors of cyclooxygenase-2. , 2001, The New England journal of medicine.
[20] R Gordon,et al. Etoricoxib (MK-0663): preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2. , 2001, The Journal of pharmacology and experimental therapeutics.
[21] C. Koboldt,et al. Selective cyclooxygenase-2 inhibitors: heteroaryl modified 1,2-diarylimidazoles are potent, orally active antiinflammatory agents. , 2000, Journal of medicinal chemistry.
[22] C. Bayly,et al. Structure-based design of COX-2 selectivity into flurbiprofen. , 1999, Bioorganic & medicinal chemistry letters.
[23] J. Talley,et al. Selective inhibitors of cyclooxygenase-2 (COX-2). , 1999, Progress in medicinal chemistry.
[24] Robert D. Brown,et al. Combinatorial library design for diversity, cost efficiency, and drug-like character. , 2000, Journal of molecular graphics & modelling.
[25] Marvin Waldman,et al. Optimization and visualization of molecular diversity of combinatorial libraries , 1996, Molecular Diversity.
[26] C. Koboldt,et al. 1,2-Diarylcyclopentenes as selective cyclooxygenase-2 inhibitors and orally active anti-inflammatory agents. , 1995, Journal of medicinal chemistry.
[27] J. Smith,et al. Aspirin selectively inhibits prostaglandin production in human platelets. , 1971, Nature: New biology.
[28] 4,5‐Diaryloxazole inhibitors of cyclooxygenase‐2 (COX‐2) , 1999, Medicinal research reviews.
[29] C. Koboldt,et al. Diaryl indenes and benzofurans: Novel classes of potent and selective cyclooxygenase-2 inhibitors , 1995 .
[30] R. S. Rogers,et al. Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib). , 1997, Journal of medicinal chemistry.