Engineering a change in cancer diagnosis and therapy through nanotechnology

The Office of Cancer Nanotechnology Research is the centerpiece of nanotechnology funding leadership at the National Cancer Institute of the National Institutes of Health. Its funding portfolio consists of premier academic institutions that engineer state of the art particles and devices to transform cancer diagnosis and treatment. Beyond its research centers, this Alliance for Nanotechnology in Cancer also funds transdisciplinary training programs for students and early career scientists and engineers. Another essential component of the Alliance is the Nanotechnology Characterization Laboratory where the standard protocols of preclinical analysis for newly derived nanoparticles are developed and performed. The guiding mission of the Alliance is to reach beyond basic research and development toward clinical testing as well as product commercialization. At the conclusion of the first Phase of the Alliance that spanned 2005–2010, several hundred patent disclosures had been filed and dozens of industrial partnerships and spin off companies had been formed. Now as the second Phase begins the OCNR and the Alliance look forward to improve on their successful record of technological innovation and developing commercial entities. Beyond the Alliance, the NIH provides funding opportunities for a vast array of research topics that can be applied to health nanotechnologies, many of which can be applied to an electrical engineering audience.

[1]  Marc D Porter,et al.  Detection of the potential pancreatic cancer marker MUC4 in serum using surface-enhanced Raman scattering. , 2011, Analytical chemistry.

[2]  Robert Sinclair,et al.  The Fate and Toxicity of Raman-Active Silica-Gold Nanoparticles in Mice , 2011, Science Translational Medicine.

[3]  Dai Fukumura,et al.  Multistage nanoparticle delivery system for deep penetration into tumor tissue , 2011, Proceedings of the National Academy of Sciences.

[4]  Mark B. Carter,et al.  Erratum: The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers (Nature Materials (2011) 10 (389-397)) , 2011 .

[5]  Mark E. Davis,et al.  Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles , 2010, Nature.

[6]  Robert Sinclair,et al.  Preclinical evaluation of Raman nanoparticle biodistribution for their potential use in clinical endoscopy imaging. , 2011, Small.

[7]  Anita W. P. Pak,et al.  Multidisciplinarity, interdisciplinarity, and transdisciplinarity in health research, services, education and policy: 3. Discipline, inter-discipline distance, and selection of discipline. , 2008, Clinical and investigative medicine. Medecine clinique et experimentale.

[8]  P. Grodzinski,et al.  Cancer Therapy Through Nanomedicine , 2011, IEEE Nanotechnology Magazine.

[9]  Dorothy Farrell,et al.  The NCI Alliance for Nanotechnology in Cancer: achievement and path forward. , 2010, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.

[10]  Hakho Lee,et al.  Micro-NMR for Rapid Molecular Analysis of Human Tumor Samples , 2011, Science Translational Medicine.

[11]  J. Richie,et al.  Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo. , 2006, Proceedings of the National Academy of Sciences of the United States of America.