Autophagy Suppresses Tumorigenesis through Elimination of p62

Robin Mathew,1,5,8 Cristina M. Karp,3,5,8 Brian Beaudoin,2,3 Nhan Vuong,3 Guanghua Chen,2 Hsin-Yi Chen,3 Kevin Bray,3 Anupama Reddy,6 Gyan Bhanot,3,5,7 Celine Gelinas,1,2 Robert S. DiPaola,4,5 Vassiliki Karantza-Wadsworth,4,5 and Eileen White1,2,3,5,* 1University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA 2Center for Advanced Biotechnology and Medicine, Rutgers University, 679 Hoes Lane, Piscataway, NJ 08854, USA 3Department of Molecular Biology and Biochemistry, Rutgers University, 604 Allison Road, Piscataway, NJ 08854, USA 4Division of Medical Oncology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA 5The Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903, USA 6RUTCOR, Rutgers University, Piscataway, NJ 08854, USA 7Department of Physics, Rutgers University, Piscataway, NJ 08854, USA 8These authors contributed equally to this work *Correspondence: whiteei@umdnj.edu DOI 10.1016/j.cell.2009.03.048

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