Low-level laser therapy, at 830 nm, for pain reduction in experimental model of rats with sciatica.

Chronic pain, resulting from nerve compression, is a common clinical presentation. One means of conservative treatment is low-level laser therapy, although controversial. The aim of this study was to evaluate the effects of two doses of low-level laser, at 830 nm, on pain reduction in animals subjected to sciatica. Eighteen rats were used, divided into three groups: GS (n=6), sciatica and simulated treatment; G4J (n=6), sciatica and treatment with 4 J/cm²; and G8J (n=6), sciatica and irradiation with 8 J/cm². The right sciatic nerve was exposed and compressed using catgut thread. Five days of treatment were started on the third postoperative day. Pain was assessed by means of the paw elevation time during gait: before sciatica, before and after the first and second therapies, and the end of the fifth therapy. Low-level laser was effective in reducing the painful condition.

[1]  M. Wright,et al.  A Practical Approach for the Differential Diagnosis of Chronic Leg Pain in the Athlete , 2005, The American journal of sports medicine.

[2]  Ihsan F R Mohammed,et al.  Promotion of regenerative processes in injured peripheral nerve induced by low-level laser therapy. , 2007, Photomedicine and laser surgery.

[3]  Juliana Moesch,et al.  Uso do laser, 670 nm, no quadro álgico de ratos submetidos à modelo experimental de ciatalgia , 2008 .

[4]  U. Oron,et al.  Ga-As (808 nm) laser irradiation enhances ATP production in human neuronal cells in culture. , 2007, Photomedicine and laser surgery.

[5]  V. Drory,et al.  Laser phototherapy (780 nm), a new modality in treatment of long-term incomplete peripheral nerve injury: a randomized double-blind placebo-controlled study. , 2007, Photomedicine and laser surgery.

[6]  O. Kharenko,et al.  Efficacy of 780-nm laser phototherapy on peripheral nerve regeneration after neurotube reconstruction procedure (double-blind randomized study). , 2007, Photomedicine and laser surgery.

[7]  A. Villaverde,et al.  COX-2 mRNA expression decreases in the subplantar muscle of rat paw subjected to carrageenan-induced inflammation after low level laser therapy , 2007, Inflammation Research.

[8]  A. Stergioulas.  Low-power laser treatment in patients with frozen shoulder: preliminary results. , 2008, Photomedicine and laser surgery.

[9]  A. Brugnera,et al.  Cytokine mRNA expression is decreased in the subplantar muscle of rat paw subjected to carrageenan-induced inflammation after low-level laser therapy. , 2007, Photomedicine and laser surgery.

[10]  G. Bennett,et al.  An animal model of neuropathic pain: A review , 1993, Muscle & nerve.

[11]  J. Deleo.  Basic science of pain. , 2006, The Journal of bone and joint surgery. American volume.

[12]  Onur Armagan,et al.  Effect of low level laser therapy in rheumatoid arthritis patients with carpal tunnel syndrome. , 2007, Swiss medical weekly.

[13]  Gary J. Bennett,et al.  A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man , 1988, Pain.

[14]  N. Mazzer,et al.  Lesão por esmagamento do nervo isquiático de ratos: estudo da vascularização , 2006 .

[15]  D. Hill,et al.  Sciatica: a review of history, epidemiology, pathogenesis, and the role of epidural steroid injection in management. , 2007, British journal of anaesthesia.

[16]  S. Ferreira,et al.  Rat knee-joint carrageenin incapacitation test: an objective screen for central and peripheral analgesics , 1992, Pain.

[17]  D. Evcik,et al.  Laser therapy in the treatment of carpal tunnel syndrome: a randomized controlled trial. , 2007, Photomedicine and laser surgery.

[18]  Kazuhiro Mizutani,et al.  A clinical study on serum prostaglandin E2 with low-level laser therapy. , 2004, Photomedicine and laser surgery.

[19]  R. Zângaro,et al.  Analgesic effect of He-Ne (632.8 nm) low-level laser therapy on acute inflammatory pain. , 2005, Photomedicine and laser surgery.

[20]  P. McCrory,et al.  Nerve Entrapment Syndromes as a Cause of Pain in the Hip, Groin and Buttock , 1999, Sports medicine.

[21]  H. Iwasaka,et al.  Pre-Irradiation of Blood by Gallium Aluminum Arsenide (830 nm) Low-Level Laser Enhances Peripheral Endogenous Opioid Analgesia in Rats , 2008, Anesthesia and analgesia.

[22]  F. Cunha,et al.  Contribution of TNFα, IL-1β and CINC-1 for articular incapacitation, edema and cell migration in a model of LPS-induced reactive arthritis , 2006 .