A novel deep learning based framework for the detection and classification of breast cancer using transfer learning

Abstract Breast cancer is among the leading cause of mortality among women in developing as well as under-developing countries. The detection and classification of breast cancer in the early stages of its development may allow patients to have proper treatment. In this article, we proposed a novel deep learning framework for the detection and classification of breast cancer in breast cytology images using the concept of transfer learning. In general, deep learning architectures are modeled to be problem specific and is performed in isolation. Contrary to classical learning paradigms, which develop and yield in isolation, transfer learning is aimed to utilize the gained knowledge during the solution of one problem into another related problem. In the proposed framework, features from images are extracted using pre-trained CNN architectures, namely, GoogLeNet, Visual Geometry Group Network (VGGNet) and Residual Networks (ResNet), which are fed into a fully connected layer for classification of malignant and benign cells using average pooling classification. To evaluate the performance of the proposed framework, experiments are performed on standard benchmark data sets. It has been observed that the proposed framework outclass all the other deep learning architectures in terms of accuracy in detection and classification of breast tumor in cytology images.

[1]  Fabio A. González,et al.  Automatic detection of invasive ductal carcinoma in whole slide images with convolutional neural networks , 2014, Medical Imaging.

[2]  H. Irshad,et al.  Methods for Nuclei Detection, Segmentation, and Classification in Digital Histopathology: A Review—Current Status and Future Potential , 2014, IEEE Reviews in Biomedical Engineering.

[3]  Bahram Parvin,et al.  Automated Histology Analysis: Opportunities for signal processing , 2015, IEEE Signal Processing Magazine.

[4]  Zhiping Lin,et al.  Deep CNNs for microscopic image classification by exploiting transfer learning and feature concatenation , 2018, 2018 IEEE International Symposium on Circuits and Systems (ISCAS).

[5]  Luca Maria Gambardella,et al.  Mitosis Detection in Breast Cancer Histology Images with Deep Neural Networks , 2013, MICCAI.

[6]  Luiz Eduardo Soares de Oliveira,et al.  A Dataset for Breast Cancer Histopathological Image Classification , 2016, IEEE Transactions on Biomedical Engineering.

[7]  Yoshua Bengio,et al.  How transferable are features in deep neural networks? , 2014, NIPS.

[8]  A. Chetlen,et al.  Breast cancer screening controversies: who, when, why, and how? , 2016, Clinical imaging.

[9]  Keijo Haataja,et al.  Computer-aided breast cancer histopathological diagnosis: Comparative analysis of three DTOCS-based features: SW-DTOCS, SW-WDTOCS and SW-3-4-DTOCS , 2014, 2014 4th International Conference on Image Processing Theory, Tools and Applications (IPTA).

[10]  Geoffrey E. Hinton,et al.  ImageNet classification with deep convolutional neural networks , 2012, Commun. ACM.

[11]  Dumitru Erhan,et al.  Going deeper with convolutions , 2014, 2015 IEEE Conference on Computer Vision and Pattern Recognition (CVPR).

[12]  Ting Chen,et al.  Deep Learning Based Automatic Immune Cell Detection for Immunohistochemistry Images , 2014, MLMI.

[13]  Gustavo Carneiro,et al.  Deep Learning and Structured Prediction for the Segmentation of Mass in Mammograms , 2015, MICCAI.

[14]  A. Jemal,et al.  Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries , 2018, CA: a cancer journal for clinicians.

[15]  Ola Spjuth,et al.  Transfer learning with deep convolutional neural networks for classifying cellular morphological changes , 2018 .

[16]  Jian Sun,et al.  Deep Residual Learning for Image Recognition , 2015, 2016 IEEE Conference on Computer Vision and Pattern Recognition (CVPR).

[17]  Roman Monczak,et al.  Computer-Aided Breast Cancer Diagnosis Based on the Analysis of Cytological Images of Fine Needle Biopsies , 2013, IEEE Transactions on Medical Imaging.

[18]  Hala H. Zayed,et al.  Remote Computer-Aided Breast Cancer Detection and Diagnosis System Based on Cytological Images , 2014, IEEE Systems Journal.

[19]  Marcial García-Rojo,et al.  Digital image analysis in breast cancer: an example of an automated methodology and the effects of image compression. , 2012, Studies in health technology and informatics.

[20]  J. S. Marron,et al.  A method for normalizing histology slides for quantitative analysis , 2009, 2009 IEEE International Symposium on Biomedical Imaging: From Nano to Macro.

[21]  Nasir M. Rajpoot,et al.  Context-Aware Learning using Transferable Features for Classification of Breast Cancer Histology Images , 2018, ICIAR.

[22]  Marek Kowal,et al.  Computer-aided diagnosis of breast cancer based on fine needle biopsy microscopic images , 2013, Comput. Biol. Medicine.

[23]  Fabio A. González,et al.  A Deep Learning Architecture for Image Representation, Visual Interpretability and Automated Basal-Cell Carcinoma Cancer Detection , 2013, MICCAI.

[24]  Stefan Carlsson,et al.  CNN Features Off-the-Shelf: An Astounding Baseline for Recognition , 2014, 2014 IEEE Conference on Computer Vision and Pattern Recognition Workshops.

[25]  Eric Cosatto,et al.  Classification of mitotic figures with convolutional neural networks and seeded blob features , 2013, Journal of pathology informatics.

[26]  Jaime G. Carbonell,et al.  A theory of transfer learning with applications to active learning , 2013, Machine Learning.

[27]  Pascal Vincent,et al.  Representation Learning: A Review and New Perspectives , 2012, IEEE Transactions on Pattern Analysis and Machine Intelligence.

[28]  Hongfei Lin,et al.  Modality Classification for Medical Images Using Multiple Deep Convolutional Neural Networks , 2015 .

[29]  Andreas K. Maier,et al.  Classification of breast cancer histology images using transfer learning , 2018, ICIAR.

[30]  Geoffrey E. Hinton,et al.  Deep Learning , 2015, Nature.

[31]  Luca Maria Gambardella,et al.  Deep Neural Networks Segment Neuronal Membranes in Electron Microscopy Images , 2012, NIPS.

[32]  Max A. Viergever,et al.  Breast Cancer Histopathology Image Analysis: A Review , 2014, IEEE Transactions on Biomedical Engineering.

[33]  U. Wojciechowska,et al.  WHO position paper on mammography screening , 2015 .

[34]  Zahoor Jan,et al.  Automated Detection of Malignant Cells Based on Structural Analysis and Naive Bayes Classifier , 2016 .