Hyperinsulinemia is associated with menstrual irregularity and altered serum androgens in Pima Indian women.

[1]  J. Clore,et al.  Insulin inhibits adrenal 17,20-lyase activity in man. , 1992, The Journal of clinical endocrinology and metabolism.

[2]  S. Haffner,et al.  Relationship of sex hormone binding globulin to overall adiposity and body fat distribution in a biethnic population. , 1989, International journal of obesity.

[3]  R. Barbieri,et al.  Androgen and insulin response to an oral glucose challenge in hyperandrogenic women. , 1987, Fertility and sterility.

[4]  C. Stuart,et al.  Insulin infusion acutely augments ovarian androgen production in normal women. , 1990, Fertility and sterility.

[5]  U. Stenman,et al.  Plasma androgens and oestradiol during oral glucose tolerance test in patients with polycystic ovaries. , 1990, Human reproduction.

[6]  L. Poretsky,et al.  The gonadotropic function of insulin. , 1987, Endocrine reviews.

[7]  V. Herbert,et al.  Coated charcoal immunoassay of insulin. , 1965, The Journal of clinical endocrinology and metabolism.

[8]  G. Schneider,et al.  Elevated production and metabolic clearance rates of androgens in morbidly obese women. , 1984, The Journal of clinical endocrinology and metabolism.

[9]  E. Ravussin,et al.  Distribution of In Vivo Insulin Action in Pima Indians as Mixture of Three Normal Distributions , 1989, Diabetes.

[10]  M. Lebwohl,et al.  Acanthosis Nigricans, insulin action, and hyperandrogenism: clinical, histological, and biochemical findings. , 1991, The Journal of clinical endocrinology and metabolism.

[11]  R. Barbieri,et al.  Insulin stimulates androgen accumulation in incubations of ovarian stroma obtained from women with hyperandrogenism. , 1986, The Journal of clinical endocrinology and metabolism.

[12]  J. Clore,et al.  Suppression of serum insulin by diazoxide reduces serum testosterone levels in obese women with polycystic ovary syndrome. , 1989, The Journal of clinical endocrinology and metabolism.

[13]  P. Bennett,et al.  Diabetes incidence and prevalence in Pima Indians: a 19-fold greater incidence than in Rochester, Minnesota. , 1978, American journal of epidemiology.

[14]  L. Poretsky On the paradox of insulin-induced hyperandrogenism in insulin-resistant states. , 1991, Endocrine reviews.

[15]  I. G. Fantus,et al.  Androgen response to endogenous insulin secretion during the frequently sampled intravenous glucose tolerance test in normal and hyperandrogenic women. , 1990, The Journal of clinical endocrinology and metabolism.

[16]  A. Dunaif Do androgens directly regulate gonadotropin secretion in the polycystic ovary syndrome? , 1986, The Journal of clinical endocrinology and metabolism.

[17]  S. Lillioja,et al.  Exaggerated early insulin release and insulin resistance in a diabetes-prone population: a metabolic comparison of Pima Indians and Caucasians. , 1991, The Journal of clinical endocrinology and metabolism.

[18]  S. Lillioja,et al.  In Vivo Insulin Action Is Familial Characteristic in Nondiabetic Pima Indians , 1987, Diabetes.

[19]  S. Reeders,et al.  FAMILIAL POLYCYSTIC OVARIES: A GENETIC DISEASE? , 1988, Clinical endocrinology.

[20]  A. Dunaif,et al.  Insulin administration alters gonadal steroid metabolism independent of changes in gonadotropin secretion in insulin-resistant women with the polycystic ovary syndrome. , 1989, The Journal of clinical investigation.

[21]  O. H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.

[22]  R. DeFronzo,et al.  Effect of acute physiological elevations of insulin on circulating androgen levels in nonobese women. , 1991, The Journal of clinical endocrinology and metabolism.

[23]  E. Adashi,et al.  Insulin-like growth factors as intraovarian regulators of granulosa cell growth and function. , 1985, Endocrine reviews.

[24]  A. Dunaif,et al.  Suppression of hyperandrogenism does not improve peripheral or hepatic insulin resistance in the polycystic ovary syndrome. , 1990, The Journal of clinical endocrinology and metabolism.

[25]  R. Rosenfield,et al.  The polycystic ovary syndrome: pathogenesis and treatment. , 1989, Annals of internal medicine.

[26]  R. Lobo,et al.  The influence of androgens on insulin resistance. , 1984, Fertility and sterility.

[27]  A. Lanzone,et al.  Insulin secretion in polycystic ovarian disease: effect of ovarian suppression by GnRH agonist. , 1990, Human reproduction.

[28]  M. Nagamani,et al.  Hyperinsulinemia in hyperthecosis of the ovaries. , 1986, American journal of obstetrics and gynecology.

[29]  J. Clore,et al.  The effects of hyperinsulinemia on serum testosterone, progesterone, dehydroepiandrosterone sulfate, and cortisol levels in normal women and in a woman with hyperandrogenism, insulin resistance, and acanthosis nigricans. , 1987, The Journal of clinical endocrinology and metabolism.

[30]  M. Prince,et al.  Hyperinsulinemia and Hyperandrogenemia: In Vivo Androgen Response to Insulin Infusion , 1987, Obstetrics and gynecology.