Mechanisms of RND multidrug efflux pumps.
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[1] Ireena Bagai,et al. Direct metal transfer between periplasmic proteins identifies a bacterial copper chaperone. , 2008, Biochemistry.
[2] C. van Delden,et al. Resistance and Virulence of Pseudomonas aeruginosa Clinical Strains Overproducing the MexCD-OprJ Efflux Pump , 2008, Antimicrobial Agents and Chemotherapy.
[3] H. Mori,et al. Crystal structure of AcrB in complex with a single transmembrane subunit reveals another twist. , 2007, Structure.
[4] Ireena Bagai,et al. Substrate-linked Conformational Change in the Periplasmic Component of a Cu(I)/Ag(I) Efflux System* , 2007, Journal of Biological Chemistry.
[5] H. Zgurskaya,et al. Fitting Periplasmic Membrane Fusion Proteins to Inner Membrane Transporters: Mutations That Enable Escherichia coli AcrA To Function with Pseudomonas aeruginosa MexB , 2007, Journal of bacteriology.
[6] H. Nikaido,et al. Ligand‐transporter interaction in the AcrB multidrug efflux pump determined by fluorescence polarization assay , 2007, FEBS letters.
[7] H. Nikaido,et al. Site-Directed Disulfide Cross-Linking Shows that Cleft Flexibility in the Periplasmic Domain Is Needed for the Multidrug Efflux Pump AcrB of Escherichia coli , 2007, Journal of bacteriology.
[8] W. Kern,et al. Altered spectrum of multidrug resistance associated with a single point mutation in the Escherichia coli RND-type MDR efflux pump YhiV (MdtF). , 2007, The Journal of antimicrobial chemotherapy.
[9] H. Zgurskaya,et al. Drug-Induced Conformational Changes in Multidrug Efflux Transporter AcrB from Haemophilus influenzae , 2007, Journal of bacteriology.
[10] E. Bokma,et al. A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug efflux pumps , 2007, Proceedings of the National Academy of Sciences.
[11] S. Lau,et al. Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB , 2007, Molecular microbiology.
[12] C. Briand,et al. Drug Export Pathway of Multidrug Exporter AcrB Revealed by DARPin Inhibitors , 2006, PLoS biology.
[13] Y. Yamauchi,et al. Cholesterol sensing, trafficking, and esterification. , 2006, Annual review of cell and developmental biology.
[14] G. McDermott,et al. Conformation of the AcrB Multidrug Efflux Pump in Mutants of the Putative Proton Relay Pathway , 2006, Journal of bacteriology.
[15] H. Nikaido,et al. Threonine-978 in the Transmembrane Segment of the Multidrug Efflux Pump AcrB of Escherichia coli Is Crucial for Drug Transport as a Probable Component of the Proton Relay Network , 2006, Journal of bacteriology.
[16] Satoshi Murakami,et al. Crystal structures of a multidrug transporter reveal a functionally rotating mechanism , 2006, Nature.
[17] K. Diederichs,et al. Structural Asymmetry of AcrB Trimer Suggests a Peristaltic Pump Mechanism , 2006, Science.
[18] C. Hotz,et al. Importance of the adaptor (membrane fusion) protein hairpin domain for the functionality of multidrug efflux pumps. , 2006, Biochemistry.
[19] H. Zgurskaya,et al. Conformational flexibility in the multidrug efflux system protein AcrA. , 2006, Structure.
[20] M. Gray,et al. Mutations in the Central Cavity and Periplasmic Domain Affect Efflux Activity of the Resistance-Nodulation-Division Pump EmhB from Pseudomonas fluorescens cLP6a , 2006, Journal of bacteriology.
[21] G. McDermott,et al. A Periplasmic Drug-Binding Site of the AcrB Multidrug Efflux Pump: a Crystallographic and Site-Directed Mutagenesis Study , 2005, Journal of bacteriology.
[22] H. Nikaido,et al. Aminoglycosides Are Captured from both Periplasm and Cytoplasm by the AcrD Multidrug Efflux Transporter of Escherichia coli , 2005, Journal of bacteriology.
[23] M. Totrov,et al. Vacuuming the Periplasm , 2005, Journal of bacteriology.
[24] Masato Yoshimura,et al. Crystal Structure of the Drug Discharge Outer Membrane Protein, OprM, of Pseudomonas aeruginosa , 2004, Journal of Biological Chemistry.
[25] J. Eswaran,et al. Three's company: component structures bring a closer view of tripartite drug efflux pumps. , 2004, Current opinion in structural biology.
[26] Conrad C. Huang,et al. UCSF Chimera—A visualization system for exploratory research and analysis , 2004, J. Comput. Chem..
[27] E. Bokma,et al. Structure of the periplasmic component of a bacterial drug efflux pump. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[28] T. Tsukihara,et al. Crystal Structure of the Membrane Fusion Protein, MexA, of the Multidrug Transporter in Pseudomonas aeruginosa* , 2004, Journal of Biological Chemistry.
[29] K. Poole,et al. Differential Impact of MexB Mutations on Substrate Selectivity of the MexAB-OprM Multidrug Efflux Pump of Pseudomonas aeruginosa , 2004, Journal of bacteriology.
[30] A. Yamaguchi,et al. Extramembrane Central Pore of Multidrug Exporter AcrB in Escherichia coli Plays an Important Role in Drug Transport* , 2004, Journal of Biological Chemistry.
[31] A. Yamaguchi,et al. Mechanisms of drug/H+ antiport: complete cysteine-scanning mutagenesis and the protein engineering approach. , 2003, Current opinion in chemical biology.
[32] H. Nikaido,et al. AcrB Multidrug Efflux Pump of Escherichia coli: Composite Substrate-Binding Cavity of Exceptional Flexibility Generates Its Extremely Wide Substrate Specificity , 2003, Journal of bacteriology.
[33] C. Elkins,et al. Chimeric Analysis of AcrA Function Reveals the Importance of Its C-Terminal Domain in Its Interaction with the AcrB Multidrug Efflux Pump , 2003, Journal of bacteriology.
[34] C. Rensing,et al. Molecular Analysis of the Copper-Transporting Efflux System CusCFBA of Escherichia coli , 2003, Journal of bacteriology.
[35] Gerry McDermott,et al. Structural Basis of Multiple Drug-Binding Capacity of the AcrB Multidrug Efflux Pump , 2003, Science.
[36] T. Nakae,et al. An Elegant Means of Self-protection in Gram-negative Bacteria by Recognizing and Extruding Xenobiotics from the Periplasmic Space* 210 , 2003, The Journal of Biological Chemistry.
[37] H. Zgurskaya,et al. Chimeric Analysis of the Multicomponent Multidrug Efflux Transporters from Gram-Negative Bacteria , 2002, Journal of bacteriology.
[38] C. Elkins,et al. Substrate Specificity of the RND-Type Multidrug Efflux Pumps AcrB and AcrD of Escherichia coli Is Determined Predominately by Two Large Periplasmic Loops , 2002, Journal of bacteriology.
[39] T. Murata,et al. On the mechanism of substrate specificity by resistance nodulation division (RND)‐type multidrug resistance pumps: the large periplasmic loops of MexD from Pseudomonas aeruginosa are involved in substrate recognition , 2002, Molecular microbiology.
[40] Satoshi Murakami,et al. Crystal structure of bacterial multidrug efflux transporter AcrB , 2002, Nature.
[41] A. Yamaguchi,et al. The Putative Response Regulator BaeR Stimulates Multidrug Resistance of Escherichia coli via a Novel Multidrug Exporter System, MdtABC , 2002, Journal of bacteriology.
[42] H. Nikaido,et al. The BaeSR Two-Component Regulatory System Activates Transcription of the yegMNOB (mdtABCD) Transporter Gene Cluster in Escherichia coli and Increases Its Resistance to Novobiocin and Deoxycholate , 2002, Journal of bacteriology.
[43] K. Poole,et al. Differential Effects of Mutations in tonB1 on Intrinsic Multidrug Resistance and Iron Acquisition in Pseudomonas aeruginosa , 2002, Journal of bacteriology.
[44] Angela Lee,et al. MexXY-OprM Efflux Pump Is Required for Antagonism of Aminoglycosides by Divalent Cations inPseudomonas aeruginosa , 2001, Antimicrobial Agents and Chemotherapy.
[45] T. Nakae,et al. Identification of Essential Charged Residues in Transmembrane Segments of the Multidrug Transporter MexB ofPseudomonas aeruginosa , 2001, Journal of bacteriology.
[46] Angela Lee,et al. Identification and Characterization of Inhibitors of Multidrug Resistance Efflux Pumps in Pseudomonas aeruginosa: Novel Agents for Combination Therapy , 2001, Antimicrobial Agents and Chemotherapy.
[47] Colin Hughes,et al. Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export , 2000, Nature.
[48] Angela Lee,et al. Interplay between Efflux Pumps May Provide Either Additive or Multiplicative Effects on Drug Resistance , 2000, Journal of bacteriology.
[49] D. Nies,et al. Energetics and Topology of CzcA, a Cation/Proton Antiporter of the Resistance-Nodulation-Cell Division Protein Family* , 1999, Journal of Biological Chemistry.
[50] H. Nikaido,et al. Bypassing the periplasm: reconstitution of the AcrAB multidrug efflux pump of Escherichia coli. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[51] H. Nikaido,et al. AcrA is a highly asymmetric protein capable of spanning the periplasm. , 1999, Journal of molecular biology.
[52] Hiroshi Nikaido,et al. Multidrug Efflux Pump AcrAB of Salmonella typhimuriumExcretes Only Those β-Lactam Antibiotics Containing Lipophilic Side Chains , 1998, Journal of bacteriology.
[53] K. Poole,et al. Influence of the TonB Energy-Coupling Protein on Efflux-Mediated Multidrug Resistance in Pseudomonas aeruginosa , 1998, Antimicrobial Agents and Chemotherapy.
[54] M H Saier,et al. A family of gram-negative bacterial outer membrane factors that function in the export of proteins, carbohydrates, drugs and heavy metals from gram-negative bacteria. , 1997, FEMS microbiology letters.
[55] H. Yoneyama,et al. Use of Fluorescence Probes to Monitor Function of the Subunit Proteins of the MexA-MexB-OprM Drug Extrusion Machinery inPseudomonas aeruginosa * , 1997, The Journal of Biological Chemistry.
[56] H. Nikaido. Multidrug efflux pumps of gram-negative bacteria , 1996, Journal of bacteriology.
[57] I. Paulsen,et al. Multidrug resistance proteins QacA and QacB from Staphylococcus aureus: membrane topology and identification of residues involved in substrate specificity. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[58] H. Nikaido,et al. Role of mexA-mexB-oprM in antibiotic efflux in Pseudomonas aeruginosa , 1995, Antimicrobial agents and chemotherapy.
[59] J. Hearst,et al. Genes acrA and acrB encode a stress‐induced efflux system of Escherichia coli , 1995, Molecular microbiology.
[60] D. Livermore,et al. Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: active efflux as a contributing factor to beta-lactam resistance , 1994, Antimicrobial Agents and Chemotherapy.
[61] P. Gros,et al. Phosphatidylcholine translocase: A physiological role for the mdr2 gene , 1994, Cell.
[62] M H Saier,et al. A family of extracytoplasmic proteins that allow transport of large molecules across the outer membranes of gram-negative bacteria , 1994, Journal of bacteriology.
[63] M. Vaara. Antibiotic-supersusceptible mutants of Escherichia coli and Salmonella typhimurium , 1993, Antimicrobial Agents and Chemotherapy.
[64] J. Hearst,et al. Molecular cloning and characterization of acrA and acrE genes of Escherichia coli , 1993, Journal of bacteriology.
[65] Y. Anraku,et al. Purification and reconstitution of Escherichia coli proline carrier using a site specifically cleavable fusion protein. , 1988, The Journal of biological chemistry.
[66] K. Diederichs,et al. Supplementary materials for : Engineered disulfide bonds support the functional rotation mechanism of multidrug efflux pump AcrB , 2007 .
[67] Arne Skerra,et al. The Strep-tag system for one-step purification and high-affinity detection or capturing of proteins , 2007, Nature Protocols.