Determination of pyrrolizidine alkaloid metabolites from mouse liver microsomes using tandem mass spectrometry and gas chromatography/mass spectrometry.

[1]  H. Ramsdell,et al.  Microsomal metabolism of pyrrolizidine alkaloids from Senecio jacobaea. Isolation and quantification of 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine and N-oxides by high performance liquid chromatography. , 1987, Drug metabolism and disposition: the biological fate of chemicals.

[2]  K. Straub,et al.  Rapid structure elucidation of catecholamine conjugates with tandem mass spectrometry. , 1986, Analytical chemistry.

[3]  H. Segall,et al.  Genotoxicity and cytotoxicity of selected pyrrolizidine alkaloids, a possible alkenal metabolite of the alkaloids, and related alkenals. , 1986, Toxicology and applied pharmacology.

[4]  K. Tomer,et al.  Fast atom bombardment and tandem mass spectrometry of covalently modified nucleosides and nucleotides: adducts of pyrrolizidine alkaloid metabolites. , 1986, Analytical chemistry.

[5]  K. Tomer,et al.  Fast atom bombardment combined with tandem mass spectrometry for determination of bile salts and their conjugates. , 1986, Biomedical & environmental mass spectrometry.

[6]  D. Buhler,et al.  Method for determination of pyrrolizidine alkaloids and their metabolites by high-performance liquid chromatography. , 1986, Analytical biochemistry.

[7]  R. Barbour,et al.  Metabolism and toxicity of synthetic analogues of macrocyclic diester pyrrolizidine alkaloids. , 1986, Chemico-biological interactions.

[8]  W. Haddon,et al.  trans-4-Hydroxy-2-hexenal: a reactive metabolite from the macrocyclic pyrrolizidine alkaloid senecionine. , 1985, Science.

[9]  W. Haddon,et al.  Two dihydropyrrolizine alkaloid metabolites isolated from mouse hepatic microsomes in vitro. , 1984, Drug metabolism and disposition: the biological fate of chemicals.

[10]  A. Mattocks.  Hydrolysis and hepatotoxicity of retronecine diesters. , 1982, Toxicology letters.

[11]  H. Segall,et al.  A new pyrrolizidine alkaloid metabolite, 19-hydroxysenecionine isolated from mouse hepatic microsomes in vitro. , 1982, Drug metabolism and disposition: the biological fate of chemicals.

[12]  Richard A. Yost,et al.  Structural elucidation of drug metabolites by triple-quadrupole mass spectrometry , 1982 .

[13]  C. Green,et al.  Metabolism, cytotoxicity, and genotoxicity of the pyrrolizidine alkaloid senecionine in primary cultures of rat hepatocytes. , 1981, Toxicology and applied pharmacology.

[14]  G. Williams,et al.  Genotoxicity of pyrrolizidine alkaloids in the hepatocyte primary culture/DNA-repair test. , 1980, Mutation research.

[15]  R. Cooks,et al.  Chemotaxonomy of columnar Mexican cacti by mass spectrometry/mass spectrometry. , 1980 .

[16]  H. Segall.  Preparative Isolation of Pyrrolizidine Alkaloids Derived from Senecio Vulgaris , 1979 .

[17]  R G Cooks,et al.  Alkaloids in Whole Plant Material: Direct Analysis by Kinetic Energy Spectrometry , 1978, Science.

[18]  P. Cheeke,et al.  Pyrrolizidine alkaloid poisoning in rats: protective effects of dietary cysteine. , 1976, Journal of animal science.

[19]  J. Allen,et al.  Resistance of the guinea pig to pyrrolizidine alkaloid intoxication. , 1973, Toxicology and Applied Pharmacology.

[20]  W. H. Butler,et al.  The conversion of the pyrrolizidine alkaloid retrorsine to pyrrolic derivatives in vivo and in vitro and its acute toxicity to various animal species. , 1973, Chemico-biological interactions.

[21]  I. White,et al.  Estimation of metabolites of pyrrolizidine alkaloids in animal tissues. , 1970, Analytical biochemistry.

[22]  E. McLean.  The toxic actions of pyrrolizidine (senecio) alkaloids. , 1970, Pharmacological reviews.

[23]  J. Edgar,et al.  Dihydropyrrolizines. III. Preparation and reactions of derivatives related to pyrrolizidine alkaloids , 1970 .

[24]  R. Schoental.  Toxicology and carcinogenic action of pyrrolizidine alkaloids. , 1968, Cancer research.

[25]  A. Mattocks.  Toxicity of Pyrrolizidine Alkaloids , 1968, Nature.

[26]  A. Mattocks.  Spectrophotometric determination of unsaturated pyrrolizidine alkaloids. , 1967, Analytical chemistry.

[27]  C. Culvenor,et al.  The alkaloids of Crotalaria retusa L , 1957 .

[28]  O. H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.

[29]  R. Adams,et al.  The Structure of Monocrotaline, the Alkaloid in Crotalaria Spectabilis and Crotalaria Retusa. I , 1939 .