论文信息 - Target compound analysis by two-dimensional gas chromatography—mass spectrometry

Target compound analysis by two-dimensional gas chromatography—mass spectrometry

Abstract The use of two-dimensional gas chromatography 1 for the analysis of specific target compounds in complex matrices in combination with mass spectrometry has been investigated. The combination of a high capacity, high polarity packed first gas chromatography column followed with a low capacity, low polarity, high resolution second column has been found useful. A component of interest is switched from the first column into a cold trap and then flash-evaporated into the second column. This combination allows part per billion analyses in complex mixtures such as soil extracts, crude oils, and biological extracts without any prior sample cleanup whatever. Two important advantages arise naturally therefore from this approach: a significant reduction in analysis time and a major improvement in the specificity of the analysis. The method offers a relatively inexpensive yet powerful alternative to mass spectrometry—mass spectrometry.

Ralph J. May | R. J. May | W. V. Ligon | Woodfin V. Ligon

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