Data standards for minimum information collection for antibody therapy experiments.

Research groups developing antibody therapies generate diverse data sets; the value of these sets would be compounded when shared or amalgamated. A complete amalgamation of diverse data sets requires data standards for information collection during experiments. We propose to define elements of the data standards in the form of common data elements (CDEs) in order to clarify each experiment's targets and data values. We have created a set of core information elements which we suggest should be collected from antibody therapy experiments. We propose these as a basis for community consultation with a view to defining a set of data standards which can be developed under the auspices of the Antibody Society.

[1]  M. Lefranc IMGT®, the International ImMunoGeneTics Information System® for Immunoinformatics , 2008, Molecular biotechnology.

[2]  J. Contreras Legal issues for biological research standards , 2008, Nature Biotechnology.

[3]  Chris F. Taylor,et al.  The minimum information about a genome sequence (MIGS) specification , 2008, Nature Biotechnology.

[4]  Rajiv Dhir,et al.  The development and deployment of Common Data Elements for tissue banks for translational research in cancer – An emerging standard based approach for the Mesothelioma Virtual Tissue Bank , 2008, BMC Cancer.

[5]  M. Eisenacher,et al.  Maintaining standardization: an update of the HUPO Brain Proteome Project , 2008, Expert review of proteomics.

[6]  Russ B. Altman,et al.  PharmGKB and the International Warfarin Pharmacogenetics Consortium: the changing role for pharmacogenomic databases and single‐drug pharmacogenetics , 2008, Human mutation.

[7]  Dongsheng Tu,et al.  Cetuximab for the treatment of colorectal cancer. , 2007, The New England journal of medicine.

[8]  Peter Woollard,et al.  The minimum information required for reporting a molecular interaction experiment (MIMIx) , 2007, Nature Biotechnology.

[9]  Marc Peeters,et al.  Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[10]  R. Begent,et al.  Incentivizing standards development and adoption , 2007, Nature Biotechnology.

[11]  Axel Kowald,et al.  Systems biology standards—the community speaks , 2007, Nature Biotechnology.

[12]  Alvis Brazma,et al.  MGED standards: work in progress. , 2006, Omics : a journal of integrative biology.

[13]  Rajiv Dhir,et al.  An informatics model for tissue banks – Lessons learned from the Cooperative Prostate Cancer Tissue Resource , 2006, BMC Cancer.

[14]  Zhilei Chen,et al.  A highly sensitive selection method for directed evolution of homing endonucleases , 2005, Nucleic acids research.

[15]  Nigel W. Hardy,et al.  Summary recommendations for standardization and reporting of metabolic analyses , 2005, Nature Biotechnology.

[16]  B. Segelke Macromolecular crystallization with microfluidic free-interface diffusion , 2005, Expert review of proteomics.

[17]  Cathy H. Wu,et al.  The Universal Protein Resource (UniProt) , 2004, Nucleic Acids Res..

[18]  Larry Wright,et al.  Overview and Utilization of the NCI Thesaurus , 2004, Comparative and functional genomics.

[19]  Gavin Sherlock,et al.  Funding high-throughput data sharing , 2004, Nature Biotechnology.

[20]  P E Bourne,et al.  The Protein Data Bank. , 2002, Nucleic acids research.

[21]  Leila Mohammadi,et al.  BMC Cancer , 2001 .