Clinical use of a waveguide hyperthermia system for superficial tumors with deep infiltration

We have developed a new double waveguide system (AMC-2 system) for hyperthermia treatment (i.e heating tumor tissue to 40–43°C) of superficial tumors with deep infiltration. The system consists of two opposing rectangular 70 MHz rotatable waveguides. The aperture size of the bottom antenna is 20×34cm. The top antenna is interchangeable and antennas with an aperture size of 20×34cm, 15×34cm and 8.5×34cm can be selected. Clinical use of this system was demonstrated for a patient with a recurrent breast tumor. Four weekly hyperthermia sessions were applied in combination with a standard radiotherapy scheme. In order to gradually increase treatment complexity, in the first two sessions only one antenna was used and the last two sessions were performed with two antennas. Results show that appropriate phase steering can substantially improve tumor heating and thereby treatment quality. Clinical hyperthermia with this system was shown feasible.

[1]  A. Hart,et al.  Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumours: a prospective, randomised, multicentre trial , 2000, The Lancet.

[2]  C. Song.  Effect of local hyperthermia on blood flow and microenvironment: a review. , 1984, Cancer research.

[3]  J. Crezee,et al.  Improving locoregional hyperthermia delivery using the 3-D controlled AMC-8 phased array hyperthermia system: A preclinical study , 2009, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[4]  Edward A. Gelvich,et al.  Contact flexible microstrip applicators (CFMA) in a range from microwaves up to short waves , 2002, IEEE Transactions on Biomedical Engineering.

[5]  P. Wust,et al.  Hyperthermia-related clinical trials on cancer treatment within the ClinicalTrials.gov registry , 2015, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[6]  F. Bardati,et al.  Radio hyperthermia for re-treatment of superficial tumours , 2009, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[7]  H P Kok,et al.  A 70 MHz double waveguide set-up for hyperthermia of deep superficial tumors , 2016, 2016 46th European Microwave Conference (EuMC).

[8]  Johannes Crezee,et al.  Effects of hyperthermia on DNA repair pathways: one treatment to inhibit them all , 2015, Radiation oncology.

[9]  J. Overgaard,et al.  Randomised trial of hyperthermia as adjuvant to radiotherapy for recurrent or metastatic malignant melanoma , 1995, The Lancet.

[10]  Peter Wust,et al.  Neo-adjuvant chemotherapy alone or with regional hyperthermia for localised high-risk soft-tissue sarcoma: a randomised phase 3 multicentre study. , 2010, The Lancet. Oncology.

[11]  D Machin,et al.  Radiotherapy with or without hyperthermia in the treatment of superficial localized breast cancer: results from five randomized controlled trials. International Collaborative Hyperthermia Group. , 1996, International journal of radiation oncology, biology, physics.

[12]  J Crezee,et al.  Temperature and SAR measurements in deep-body hyperthermia with thermocouple thermometry. , 1993, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[13]  R. Issels.  Hyperthermia adds to chemotherapy. , 2008, European journal of cancer.

[14]  L. Blank,et al.  Results of deep body hyperthermia with large waveguide radiators. , 1990, Advances in experimental medicine and biology.

[15]  P Wust,et al.  Simulation studies promote technological development of radiofrequency phased array hyperthermia. , 1996, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[16]  A. Bel,et al.  3D versus 2D steering in patient anatomies: A comparison using hyperthermia treatment planning , 2011, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[17]  A. Hart,et al.  Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumours: a prospective, randomised, multicentre trial , 2000, The Lancet.