Cyclic and dimeric fibroblast growth factor 2 variants with high biomedical potential.

[1]  J. Otlewski,et al.  Intrinsically Fluorescent Oligomeric Cytotoxic Conjugates Toxic for FGFR1-Overproducing Cancers. , 2021, Biomacromolecules.

[2]  G. Rajan,et al.  Stabilisation of Recombinant Human Basic Fibroblast Growth Factor (FGF-2) against Stressors Encountered in Medicinal Product Processing and Evaluation , 2021, Pharmaceutics.

[3]  J. Otlewski,et al.  Modular self-assembly system for development of oligomeric, highly internalizing and potent cytotoxic conjugates targeting fibroblast growth factor receptors , 2021, Journal of biomedical science.

[4]  J. Otlewski,et al.  Fibroblast Growth Factor 2 Conjugated with Monomethyl Auristatin E Inhibits Tumor Growth in a Mouse Model , 2021, Biomacromolecules.

[5]  J. Otlewski,et al.  FGF1 Fusions with the Fc Fragment of IgG1 for the Assembly of GFPpolygons-Mediated Multivalent Complexes Recognizing FGFRs , 2021, Biomolecules.

[6]  J. Wesche,et al.  Negative Regulation of FGFR (Fibroblast Growth Factor Receptor) Signaling , 2021, Cells.

[7]  Jun Ren,et al.  FGF1ΔHBS prevents diabetic cardiomyopathy by maintaining mitochondrial homeostasis and reducing oxidative stress via AMPK/Nur77 suppression , 2021, Signal Transduction and Targeted Therapy.

[8]  J. Otlewski,et al.  Dissecting biological activities of fibroblast growth factor receptors by the coiled-coil-mediated oligomerization of FGF1. , 2021, International journal of biological macromolecules.

[9]  J. Otlewski,et al.  Preparation of Site-Specific Cytotoxic Protein Conjugates via Maleimide-thiol Chemistry and Sortase A-Mediated Ligation. , 2021, Journal of visualized experiments : JoVE.

[10]  Hongwei Wang,et al.  Promoting the neural differentiation of embryonic stem cells by using thermosensitive nanocomposites , 2021, Materials Advances.

[11]  Ziming Liu,et al.  FGF2: a key regulator augmenting tendon-to-bone healing and cartilage repair. , 2020, Regenerative medicine.

[12]  Jian Q. Feng,et al.  FGF/FGFR signaling in health and disease , 2020, Signal Transduction and Targeted Therapy.

[13]  J. Otlewski,et al.  FGFR1 clustering with engineered tetravalent antibody improves the efficiency and modifies the mechanism of receptor internalization , 2020, Molecular oncology.

[14]  J. Otlewski,et al.  Site-Specific, Stoichiometric-Controlled, PEGylated Conjugates of Fibroblast Growth Factor 2 (FGF2) with Hydrophilic Auristatin Y for Highly Selective Killing of Cancer Cells Overproducing Fibroblast Growth Factor Receptor 1 (FGFR1) , 2020, Molecular pharmaceutics.

[15]  J. Otlewski,et al.  Stable Fibroblast Growth Factor 2 Dimers with High Pro-Survival and Mitogenic Potential , 2020, International journal of molecular sciences.

[16]  Leah Benington,et al.  Fibroblast Growth Factor 2—A Review of Stabilisation Approaches for Clinical Applications , 2020, Pharmaceutics.

[17]  Xiaokun Li,et al.  Exogenous fibroblast growth factor 1 ameliorates diabetes-induced cognitive decline via coordinately regulating PI3K/AKT signaling and PERK signaling , 2020, Cell Communication and Signaling.

[18]  Hongwei Wang,et al.  Heparin mimics and fibroblast growth factor-2 fabricated nanogold composite in promoting neural differentiation of mouse embryonic stem cells , 2020, Journal of biomaterials science. Polymer edition.

[19]  Hunter J. Johnson,et al.  Sustained release and protein stabilization reduce the growth factor dosage required for human pluripotent stem cell expansion. , 2020, Biomaterials.

[20]  Xiaofeng Li,et al.  Fibroblast Growth Factor 1 Ameliorates Diabetes-Induced Liver Injury by Reducing Cellular Stress and Restoring Autophagy , 2020, Frontiers in Pharmacology.

[21]  J. Damborský,et al.  Fibroblast Growth Factor 2 Protein Stability Provides Decreased Dependence on Heparin for Induction of FGFR Signaling and Alters ERK Signaling Dynamics , 2019, Front. Cell Dev. Biol..

[22]  Xiaokun Li.  The FGF metabolic axis , 2019, Frontiers of Medicine.

[23]  J. Otlewski,et al.  Differential regulation of fibroblast growth factor receptor 1 trafficking and function by extracellular galectins , 2019, Cell Communication and Signaling.

[24]  J. Otlewski,et al.  Novel Method for Preparation of Site-Specific, Stoichiometric-Controlled Dual Warhead Conjugate of FGF2 via Dimerization Employing Sortase A-Mediated Ligation. , 2019, Molecular pharmaceutics.

[25]  T. Doetschman,et al.  Ablation of low‐molecular‐weight FGF2 isoform accelerates murine osteoarthritis while loss of high‐molecular‐weight FGF2 isoforms offers protection , 2018, Journal of cellular physiology.

[26]  J. Otlewski,et al.  Targeting Cellular Trafficking of Fibroblast Growth Factor Receptors as a Strategy for Selective Cancer Treatment , 2018, Journal of clinical medicine.

[27]  Isobel Leake.  Exploring the antidiabetic effects of FGF1 , 2018, Nature Reviews Endocrinology.

[28]  R. Bergman,et al.  Peripheral Mechanisms Mediating the Sustained Antidiabetic Action of FGF1 in the Brain , 2018, Diabetes.

[29]  C. Lebrilla,et al.  FGF2 Induces Migration of Human Bone Marrow Stromal Cells by Increasing Core Fucosylations on N-Glycans of Integrins , 2018, Stem cell reports.

[30]  J. Otlewski,et al.  FGF2 Dual Warhead Conjugate with Monomethyl Auristatin E and α-Amanitin Displays a Cytotoxic Effect towards Cancer Cells Overproducing FGF Receptor 1 , 2018, International journal of molecular sciences.

[31]  P. Claus,et al.  Nanodiamonds as "artificial proteins": Regulation of a cell signalling system using low nanomolar solutions of inorganic nanocrystals. , 2018, Biomaterials.

[32]  J. Damborský,et al.  Computer-Assisted Engineering of Hyperstable Fibroblast Growth Factor 2 , 2017, bioRxiv.

[33]  Hong Chen,et al.  Deciphering the Role of Sulfonated Unit in Heparin-Mimicking Polymer to Promote Neural Differentiation of Embryonic Stem Cells. , 2017, ACS applied materials & interfaces.

[34]  J. Otlewski,et al.  Antibody-induced dimerization of FGFR1 promotes receptor endocytosis independently of its kinase activity , 2017, Scientific Reports.

[35]  J. Otlewski,et al.  Cytotoxic Conjugates of Fibroblast Growth Factor 2 (FGF2) with Monomethyl Auristatin E for Effective Killing of Cells Expressing FGF Receptors , 2017, ACS omega.

[36]  J. Otlewski,et al.  Site-specific conjugation of fibroblast growth factor 2 (FGF2) based on incorporation of alkyne-reactive unnatural amino acid. , 2017, Bioorganic & medicinal chemistry.

[37]  R. Evans,et al.  FGF1 — a new weapon to control type 2 diabetes mellitus , 2017, Nature Reviews Endocrinology.

[38]  Y. Ozsoy,et al.  Inhaled Heparin: Therapeutic Efficacy and Recent Formulations. , 2017, Journal of aerosol medicine and pulmonary drug delivery.

[39]  H. Kim,et al.  Ultrahigh protein adsorption capacity and sustained release of nanocomposite scaffolds: implication for growth factor delivery systems , 2017 .

[40]  S. Xiong,et al.  Intein-mediated backbone cyclization of VP1 protein enhanced protection of CVB3-induced viral myocarditis , 2017, Scientific Reports.

[41]  Y. Zhu,et al.  Distribution of fibroblast growth factors and their roles in skin fibroblast cell migration. , 2016, Molecular medicine reports.

[42]  H. Maynard,et al.  A Heparin-Mimicking Block Copolymer Both Stabilizes and Increases the Activity of Fibroblast Growth Factor 2 (FGF2) , 2016, Biomacromolecules.

[43]  M. Steinmetz,et al.  Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics , 2016, PloS one.

[44]  Matthew J. Potthoff,et al.  Metabolic fibroblast growth factors (FGFs): Mediators of energy homeostasis. , 2016, Seminars in cell & developmental biology.

[45]  K. O'Byrne,et al.  Targeting the fibroblast growth factor receptor family in cancer. , 2016, Cancer treatment reviews.

[46]  R. Bergman,et al.  Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents , 2016, Nature Medicine.

[47]  A. Goy,et al.  Molecular and clinical significance of fibroblast growth factor 2 (FGF2 /bFGF) in malignancies of solid and hematological cancers for personalized therapies , 2016, Oncotarget.

[48]  A. Levine,et al.  Fibroblast growth factor 2 dimer with superagonist in vitro activity improves granulation tissue formation during wound healing. , 2016, Biomaterials.

[49]  R. Evans,et al.  Fibroblast Growth Factor Signaling in Metabolic Regulation , 2016, Front. Endocrinol..

[50]  K. Hristova,et al.  Mechanism of FGF receptor dimerization and activation , 2016, Nature Communications.

[51]  Hong Chen,et al.  A new avenue to the synthesis of GAG-mimicking polymers highly promoting neural differentiation of embryonic stem cells. , 2015, Chemical communications.

[52]  T. Dobosz,et al.  The role of FGF2 in migration and tubulogenesis of endothelial progenitor cells in relation to pro-angiogenic growth factor production , 2015, Molecular and Cellular Biochemistry.

[53]  S. Choe,et al.  Biphasic Effects of FGF2 on Adipogenesis , 2015, PloS one.

[54]  N. Itoh,et al.  The Fibroblast Growth Factor signaling pathway , 2015, Wiley interdisciplinary reviews. Developmental biology.

[55]  J. Otlewski,et al.  Instability restricts signaling of multiple fibroblast growth factors , 2015, Cellular and Molecular Life Sciences.

[56]  Hong Chen,et al.  6-O-sulfated chitosan promoting the neural differentiation of mouse embryonic stem cells. , 2014, ACS applied materials & interfaces.

[57]  Evan M. Farina,et al.  Fibroblast growth factor (FGF) signaling in development and skeletal diseases , 2014, Genes & diseases.

[58]  D. Holmes.  Therapy: FGF1 restores blood glucose levels and insulin sensitivity in diabetic mice , 2014, Nature Reviews Endocrinology.

[59]  J. M. Suh,et al.  Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer , 2014, Nature.

[60]  J. Castelnuovo,et al.  Applications of basic fibroblastic growth factor (FGF-2, bFGF) in dentistry. , 2014, Dental traumatology : official publication of International Association for Dental Traumatology.

[61]  R. Grose,et al.  FGFR signalling in women's cancers. , 2013, The international journal of biochemistry & cell biology.

[62]  M. Mohammadi,et al.  Molecular mechanisms of fibroblast growth factor signaling in physiology and pathology. , 2013, Cold Spring Harbor perspectives in biology.

[63]  R. Kane,et al.  Sustained Levels of FGF2 Maintain Undifferentiated Stem Cell Cultures with Biweekly Feeding , 2013, PloS one.

[64]  Yan Chen,et al.  Drug-to-antibody ratio (DAR) by UV/Vis spectroscopy. , 2013, Methods in molecular biology.

[65]  David R. Liu,et al.  A general strategy for the evolution of bond-forming enzymes using yeast display , 2011, Proceedings of the National Academy of Sciences.

[66]  J. Wesche,et al.  Roles of Fibroblast Growth Factor Receptors in Carcinogenesis , 2010, Molecular Cancer Research.

[67]  Wei Zhang,et al.  Protein cyclization enhanced thermostability and exopeptidase-resistance of green fluorescent protein. , 2010, Journal of microbiology and biotechnology.

[68]  N. Turner,et al.  Fibroblast growth factor signalling: from development to cancer , 2010, Nature Reviews Cancer.

[69]  H. Kim,et al.  Fibroblast Growth Factors: Biology, Function, and Application for Tissue Regeneration , 2010, Journal of tissue engineering.

[70]  M. Mohammadi,et al.  The FGF family: biology, pathophysiology and therapy , 2009, Nature Reviews Drug Discovery.

[71]  J. Wesche,et al.  Ubiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosis. , 2008, Molecular biology of the cell.

[72]  P. Senter,et al.  Novel peptide linkers for highly potent antibody-auristatin conjugate. , 2008, Bioconjugate chemistry.

[73]  K. Schey,et al.  Fragmentation of multiply-charged intact protein ions using MALDI TOF-TOF mass spectrometry , 2008, Journal of the American Society for Mass Spectrometry.

[74]  Shaun K Olsen,et al.  Receptor Specificity of the Fibroblast Growth Factor Family , 2006, Journal of Biological Chemistry.

[75]  A. Brech,et al.  Different intracellular trafficking of FGF1 endocytosed by the four homologous FGF receptors , 2005, Journal of Cell Science.

[76]  Shaun K Olsen,et al.  Structural basis for fibroblast growth factor receptor activation. , 2005, Cytokine & growth factor reviews.

[77]  Robert J Linhardt,et al.  Kinetic model for FGF, FGFR, and proteoglycan signal transduction complex assembly. , 2004, Biochemistry.

[78]  V. Fuster,et al.  Guide to Anticoagulant Therapy: Heparin: A Statement for Healthcare Professionals From the American Heart Association , 2001, Circulation.

[79]  A. Vercoutter-Edouart,et al.  FGF signals for cell proliferation and migration through different pathways. , 2000, Cytokine & growth factor reviews.

[80]  D. Ornitz,et al.  FGFs, heparan sulfate and FGFRs: complex interactions essential for development. , 2000, BioEssays : news and reviews in molecular, cellular and developmental biology.

[81]  Andreas Plückthun,et al.  Circular β‐lactamase: stability enhancement by cyclizing the backbone , 1999 .

[82]  T. Maciag,et al.  Activation of the MAP Kinase Pathway by FGF-1 Correlates with Cell Proliferation Induction While Activation of the Src Pathway Correlates with Migration , 1998, The Journal of cell biology.

[83]  J. Harenberg,et al.  Pharmacology and special clinical applications of low‐molecular‐weight heparins , 1988, American journal of hematology.