Enhancer-driven transcriptional regulation is a potential key determinant for human visceral and subcutaneous adipocytes.

[1]  K. Maedler,et al.  Hippo Signaling: Key Emerging Pathway in Cellular and Whole-Body Metabolism , 2018, Trends in Endocrinology & Metabolism.

[2]  Jonathan M. Cairns,et al.  Dynamic Rewiring of Promoter-Anchored Chromatin Loops during Adipocyte Differentiation. , 2017, Molecular cell.

[3]  Michael C. Ostrowski,et al.  The ETS family of oncogenic transcription factors in solid tumours , 2017, Nature Reviews Cancer.

[4]  Weiqun Peng,et al.  MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis , 2017, Nucleic acids research.

[5]  L. Opitz,et al.  SRF and MKL1 Independently Inhibit Brown Adipogenesis , 2017, PloS one.

[6]  C. Lindgren,et al.  Sexual dimorphisms in genetic loci linked to body fat distribution , 2017, Bioscience reports.

[7]  Wei Xie,et al.  Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis , 2016, PLoS genetics.

[8]  P. Gunaratne,et al.  PPARγ agonists promote differentiation of cancer stem cells by restraining YAP transcriptional activity , 2016, Oncotarget.

[9]  S. Cinti,et al.  Convertible visceral fat as a therapeutic target to curb obesity , 2016, Nature Reviews Drug Discovery.

[10]  M. van Engeland,et al.  The emerging role of GATA transcription factors in development and disease , 2016, Expert Reviews in Molecular Medicine.

[11]  D. Clegg,et al.  The sexual dimorphism of obesity , 2015, Molecular and Cellular Endocrinology.

[12]  E. Hoffman,et al.  An analysis of DNA methylation in human adipose tissue reveals differential modification of obesity genes before and after gastric bypass and weight loss , 2015, Genome Biology.

[13]  Kun-Liang Guan,et al.  The emerging roles of YAP and TAZ in cancer , 2015, Nature Reviews Cancer.

[14]  S. Mandrup,et al.  Browning of human adipocytes requires KLF11 and reprogramming of PPARγ superenhancers , 2015, Genes & development.

[15]  W. Huber,et al.  Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 , 2014, Genome Biology.

[16]  D. Clegg,et al.  Obesity and cancer—mechanisms underlying tumour progression and recurrence , 2014, Nature Reviews Endocrinology.

[17]  Fidel Ramírez,et al.  deepTools: a flexible platform for exploring deep-sequencing data , 2014, Nucleic Acids Res..

[18]  Kazuto Nakamura,et al.  Adipokines: a link between obesity and cardiovascular disease. , 2014, Journal of cardiology.

[19]  S. Fried,et al.  Deconstructing the roles of glucocorticoids in adipose tissue biology and the development of central obesity. , 2014, Biochimica et biophysica acta.

[20]  L. Ivashkiv,et al.  Regulation of type I interferon responses , 2013, Nature Reviews Immunology.

[21]  A. James,et al.  Review of Signaling Pathways Governing MSC Osteogenic and Adipogenic Differentiation , 2013, Scientifica.

[22]  D. Carey,et al.  Gene expression profiling in subcutaneous, visceral, and epigastric adipose tissues of patients with extreme obesity , 2013, International Journal of Obesity.

[23]  Xiaoxiang Hu,et al.  Lats2 Modulates Adipocyte Proliferation and Differentiation via Hippo Signaling , 2013, PloS one.

[24]  J. Schmid,et al.  The complexity of NF-κB signaling in inflammation and cancer , 2013, Molecular Cancer.

[25]  Kinyui A. Lo,et al.  Turning WAT into BAT: a review on regulators controlling the browning of white adipocytes , 2013, Bioscience reports.

[26]  J. Ringe,et al.  Reverse Differentiation as a Gene Filtering Tool in Genome Expression Profiling of Adipogenesis for Fat Marker Gene Selection and Their Analysis , 2013, PloS one.

[27]  Kun-Liang Guan,et al.  Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation. , 2013, Genes & development.

[28]  M. Pan,et al.  NFAT gene family in inflammation and cancer. , 2013, Current molecular medicine.

[29]  A. Pobbati,et al.  Emerging roles of TEAD transcription factors and its coactivators in cancers , 2013, Cancer biology & therapy.

[30]  Data production leads,et al.  An integrated encyclopedia of DNA elements in the human genome , 2012 .

[31]  S. Aerts,et al.  i-cisTarget: an integrative genomics method for the prediction of regulatory features and cis-regulatory modules , 2012, Nucleic acids research.

[32]  Saeed Tavazoie,et al.  Analysis of gene networks in white adipose tissue development reveals a role for ETS2 in adipogenesis , 2011, Development.

[33]  H. Aburatani,et al.  Global Mapping of Cell Type–Specific Open Chromatin by FAIRE-seq Reveals the Regulatory Role of the NFI Family in Adipocyte Differentiation , 2011, PLoS genetics.

[34]  Clifford A. Meyer,et al.  Cistrome: an integrative platform for transcriptional regulation studies , 2011, Genome Biology.

[35]  Bin Zhao,et al.  The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal , 2011, Nature Cell Biology.

[36]  K. Clément,et al.  An early inflammatory gene profile in visceral adipose tissue in children. , 2011, International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity.

[37]  S. Ghosh,et al.  NF-κB, inflammation, and metabolic disease. , 2011, Cell metabolism.

[38]  Z. Kováčová,et al.  Worsening of obesity and metabolic status yields similar molecular adaptations in human subcutaneous and visceral adipose tissue: decreased metabolism and increased immune response. , 2010, Journal of Clinical Endocrinology and Metabolism.

[39]  R. Young,et al.  Histone H3K27ac separates active from poised enhancers and predicts developmental state , 2010, Proceedings of the National Academy of Sciences.

[40]  Gary D Bader,et al.  Enrichment Map: A Network-Based Method for Gene-Set Enrichment Visualization and Interpretation , 2010, PloS one.

[41]  Eric S. Lander,et al.  Comparative Epigenomic Analysis of Murine and Human Adipogenesis , 2010, Cell.

[42]  T. Mikkelsen,et al.  The NIH Roadmap Epigenomics Mapping Consortium , 2010, Nature Biotechnology.

[43]  S. Mandrup,et al.  PPARγ in adipocyte differentiation and metabolism – Novel insights from genome‐wide studies , 2010, FEBS letters.

[44]  Kevin Y. Lee,et al.  Adipose Depots Possess Unique Developmental Gene Signatures , 2010, Obesity.

[45]  Cory Y. McLean,et al.  GREAT improves functional interpretation of cis-regulatory regions , 2010, Nature Biotechnology.

[46]  M. Ibrahim Subcutaneous and visceral adipose tissue: structural and functional differences , 2010, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[47]  Jan Nedergaard,et al.  Chronic Peroxisome Proliferator-activated Receptor γ (PPARγ) Activation of Epididymally Derived White Adipocyte Cultures Reveals a Population of Thermogenically Competent, UCP1-containing Adipocytes Molecularly Distinct from Classic Brown Adipocytes* , 2009, The Journal of Biological Chemistry.

[48]  Cole Trapnell,et al.  Ultrafast and memory-efficient alignment of short DNA sequences to the human genome , 2009, Genome Biology.

[49]  Nathaniel D. Heintzman,et al.  Histone modifications at human enhancers reflect global cell-type-specific gene expression , 2009, Nature.

[50]  Clifford A. Meyer,et al.  Model-based Analysis of ChIP-Seq (MACS) , 2008, Genome Biology.

[51]  B. Staels,et al.  PPAR agonists: multimodal drugs for the treatment of type-2 diabetes. , 2007, Best practice & research. Clinical endocrinology & metabolism.

[52]  I. Graef,et al.  Role of Transcription Factor NFAT in Glucose and Insulin Homeostasis , 2006, Molecular and Cellular Biology.

[53]  A. Shuldiner,et al.  Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action. , 2006, American journal of physiology. Endocrinology and metabolism.

[54]  Daniel J. Blankenberg,et al.  Galaxy: a platform for interactive large-scale genome analysis. , 2005, Genome research.

[55]  Pablo Tamayo,et al.  Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[56]  Thomas Benjamin,et al.  TAZ, a Transcriptional Modulator of Mesenchymal Stem Cell Differentiation , 2005, Science.

[57]  P. Scherer,et al.  Adipose tissue, inflammation, and cardiovascular disease. , 2005, Circulation research.

[58]  Jean YH Yang,et al.  Bioconductor: open software development for computational biology and bioinformatics , 2004, Genome Biology.

[59]  E. Cameron,et al.  The Runx genes: lineage-specific oncogenes and tumor suppressors , 2004, Oncogene.

[60]  G. Barish,et al.  PPARs and the complex journey to obesity , 2004, Nature Medicine.

[61]  Gordon K Smyth,et al.  Statistical Applications in Genetics and Molecular Biology Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments , 2011 .

[62]  P. Shannon,et al.  Cytoscape: a software environment for integrated models of biomolecular interaction networks. , 2003, Genome research.

[63]  Rafael A Irizarry,et al.  Exploration, normalization, and summaries of high density oligonucleotide array probe level data. , 2003, Biostatistics.

[64]  Tom H. Pringle,et al.  The human genome browser at UCSC. , 2002, Genome research.

[65]  A. Sharrocks The ETS-domain transcription factor family , 2001, Nature Reviews Molecular Cell Biology.

[66]  G. Bray,et al.  Contributions of total body fat, abdominal subcutaneous adipose tissue compartments, and visceral adipose tissue to the metabolic complications of obesity. , 2001, Metabolism: clinical and experimental.

[67]  Q. Tong,et al.  Function of GATA transcription factors in preadipocyte-adipocyte transition. , 2000, Science.

[68]  Roy Garcia,et al.  STATs in oncogenesis , 2000, Oncogene.

[69]  B. Spiegelman,et al.  Identification of a potent adipocyte-specific enhancer: involvement of an NF-1-like factor. , 1991, Genes & development.

[70]  Liqiong Wu,et al.  Effect of TEAD4 on multilineage differentiation of muscle-derived stem cells. , 2018, American journal of translational research.

[71]  W. Willett,et al.  Global obesity: trends, risk factors and policy implications , 2013, Nature Reviews Endocrinology.

[72]  Thomas R. Gingeras,et al.  STAR: ultrafast universal RNA-seq aligner , 2013, Bioinform..

[73]  Steven R Smith,et al.  Distinct developmental signatures of human abdominal and gluteal subcutaneous adipose tissue depots. , 2013, The Journal of clinical endocrinology and metabolism.

[74]  Karen Gallagher-Dorval,et al.  Body mass index-independent inflammation in omental adipose tissue associated with insulin resistance in morbid obesity. , 2011, Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery.

[75]  Xiying Wu,et al.  Adipogenic differentiation of adipose-derived stem cells. , 2011, Methods in molecular biology.

[76]  K. Fujiwara,et al.  Serum response factor: master regulator of the actin cytoskeleton and contractile apparatus. , 2007, American journal of physiology. Cell physiology.