Dilute suspension flow with nanoparticle deposition in a representative nasal airway model

The human nasal cavities with an effective length of only 10cm feature a wide array of basic flow phenomena because of their complex geometrics. Employing a realistic nasal airway model and demonstrating that laminar, quasisteady airflow can be assumed, dilute nanoparticle suspension flow and nanoparticle deposition are simulated and analyzed for 7.5⩽Q⩽20L∕min and 1⩽dp⩽150nm. The understanding and quantitative assessment of mixture flow fields and local nanoparticle wall concentrations in nasal airways with a thin mucus layer are very important for estimating the health risks of inhaled toxic aerosols, determining proper drug-aerosol delivery to target sites such as the olfactory regions and developing algebraic transfer functions for overall nasal dose-response analyses. Employing a commercial software package with user-supplied programs, the validated computer modeling results can be summarized as follows: (i) Most of the air flows through the middle-to-low main passageways. Higher airflow rates result ...

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