Growth arrested live-attenuated Leishmania infantum KHARON1 null mutants display cytokinesis defect and protective immunity in mice
暂无分享,去创建一个
A. T. de Carvalho | F. Frézard | A. Orfanó | S. Murta/ | A. M. M. Santi | J. A. Fiúza | Luiza G. Tunes | R. D. do Monte-Neto | G. Roy | J. S. Lanza | André Luis Branco de Barros
[1] F. Gay,et al. Leishmaniasis , 2019, The Lancet.
[2] P. Dagur,et al. Live Attenuated Leishmania donovani Centrin Gene–Deleted Parasites Induce IL-23–Dependent IL-17–Protective Immune Response against Visceral Leishmaniasis in a Murine Model , 2018, The Journal of Immunology.
[3] V. Simonyan,et al. Whole genome sequencing of live attenuated Leishmania donovani parasites reveals novel biomarkers of attenuation and enables product characterization , 2017, Scientific Reports.
[4] D. C. Miguel,et al. The iron-dependent mitochondrial superoxide dismutase SODA promotes Leishmania virulence , 2017, The Journal of Biological Chemistry.
[5] J. M. Requena,et al. Vaccination with a Leishmania infantum HSP70-II null mutant confers long-term protective immunity against Leishmania major infection in two mice models , 2017, PLoS neglected tropical diseases.
[6] R. Madhubala,et al. The mitochondrial SIR2 related protein 2 (SIR2RP2) impacts Leishmania donovani growth and infectivity , 2017, PLoS neglected tropical diseases.
[7] Uma S. Dubey,et al. Gene deleted live attenuated Leishmania vaccine candidates against visceral leishmaniasis elicit pro-inflammatory cytokines response in human PBMCs , 2016, Scientific Reports.
[8] E. Gluenz,et al. KHARON Is an Essential Cytoskeletal Protein Involved in the Trafficking of Flagellar Membrane Proteins and Cell Division in African Trypanosomes* , 2016, The Journal of Biological Chemistry.
[9] P. Dagur,et al. Live Attenuated Leishmania donovani Centrin Knock Out Parasites Generate Non-inferior Protective Immune Response in Aged Mice against Visceral Leishmaniasis , 2016, PLoS neglected tropical diseases.
[10] Sarman Singh,et al. Possibilities and challenges for developing a successful vaccine for leishmaniasis , 2016, Parasites & Vectors.
[11] S. Teixeira,et al. Amastin Knockdown in Leishmania braziliensis Affects Parasite-Macrophage Interaction and Results in Impaired Viability of Intracellular Amastigotes , 2015, PLoS pathogens.
[12] J. Alvar,et al. Cytokine Release Assays as Tests for Exposure to Leishmania, and for Confirming Cure from Leishmaniasis, in Solid Organ Transplant Recipients , 2015, PLoS neglected tropical diseases.
[13] E. Gluenz,et al. Kharon1 Null Mutants of Leishmania mexicana Are Avirulent in Mice and Exhibit a Cytokinesis Defect within Macrophages , 2015, PloS one.
[14] P. Dagur,et al. Genetically Modified Live Attenuated Leishmania donovani Parasites Induce Innate Immunity through Classical Activation of Macrophages That Direct the Th1 Response in Mice , 2015, Infection and Immunity.
[15] Ines Kevric,et al. New World and Old World Leishmania Infections: A Practical Review. , 2015, Dermatologic clinics.
[16] R. Madhubala,et al. Genetically Engineered Ascorbic acid-deficient Live Mutants of Leishmania donovani induce long lasting Protective Immunity against Visceral Leishmaniasis , 2015, Scientific Reports.
[17] P. Leprohon,et al. Intrachromosomal Amplification, Locus Deletion and Point Mutation in the Aquaglyceroporin AQP1 Gene in Antimony Resistant Leishmania (Viannia) guyanensis , 2015, PLoS neglected tropical diseases.
[18] S. Gannavaram,et al. Vaccination using live attenuated Leishmania donovani centrin deleted parasites induces protection in dogs against Leishmania infantum. , 2015, Vaccine.
[19] M. A. Reis,et al. Nutritional Recovery Promotes Hypothalamic Inflammation in Rats during Adulthood , 2014, Mediators of inflammation.
[20] N. M. Silva,et al. IL-17-Expressing CD4+ and CD8+ T Lymphocytes in Human Toxoplasmosis , 2014, Mediators of inflammation.
[21] S. Gannavaram,et al. Generation of growth arrested Leishmania amastigotes: a tool to develop live attenuated vaccine candidates against visceral leishmaniasis. , 2014, Vaccine.
[22] R. Gazzinelli,et al. Clinical and Parasitological Protection in a Leishmania infantum-Macaque Model Vaccinated with Adenovirus and the Recombinant A2 Antigen , 2014, PLoS neglected tropical diseases.
[23] N. Ali,et al. Genetically Modified Organisms and Visceral Leishmaniasis , 2014, Front. Immunol..
[24] S. Rafati,et al. Live Vaccination Tactics: Possible Approaches for Controlling Visceral Leishmaniasis , 2014, Front. Immunol..
[25] S. Landfear,et al. KHARON1 Mediates Flagellar Targeting of a Glucose Transporter in Leishmania mexicana and Is Critical for Viability of Infectious Intracellular Amastigotes* , 2013, The Journal of Biological Chemistry.
[26] D. Liggitt,et al. Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells , 2013, Nature Immunology.
[27] D. Liggitt,et al. Trypanosoma cruzi trans-sialidase initiates an ROR-γt–AHR-independent program leading to IL-17 production by activated B cells , 2013, Nature immunology.
[28] P. Dagur,et al. Live Attenuated Leishmania donovani p27 Gene Knockout Parasites Are Nonpathogenic and Elicit Long-Term Protective Immunity in BALB/c Mice , 2013, The Journal of Immunology.
[29] S. Sundar,et al. Leishmaniasis: vaccine candidates and perspectives. , 2012, Vaccine.
[30] J. Cano,et al. Leishmaniasis Worldwide and Global Estimates of Its Incidence , 2012, PloS one.
[31] Jane E. Dalton,et al. B Cell: T Cell Interactions Occur within Hepatic Granulomas during Experimental Visceral Leishmaniasis , 2012, PloS one.
[32] S. Roberts. The genetic toolbox for Leishmania parasites , 2011, Bioengineered bugs.
[33] P. Kaye,et al. Visceral leishmaniasis: immunology and prospects for a vaccine. , 2011, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
[34] S. Gannavaram,et al. Immunity to Visceral Leishmaniasis Using Genetically Defined Live-Attenuated Parasites , 2011, Journal of tropical medicine.
[35] P. Kaye,et al. Leishmaniasis: complexity at the host–pathogen interface , 2011, Nature Reviews Microbiology.
[36] F. Raymond,et al. Gene Expression Profiling and Molecular Characterization of Antimony Resistance in Leishmania amazonensis , 2011, PLoS neglected tropical diseases.
[37] Y. Iwakura,et al. IL-17 Is Necessary for Host Protection against Acute-Phase Trypanosoma cruzi Infection , 2010, The Journal of Immunology.
[38] S. Nylén,et al. Immunological Perspectives of Leishmaniasis , 2010, Journal of global infectious diseases.
[39] Y. Goto,et al. Optimized subunit vaccine protects against experimental leishmaniasis. , 2009, Vaccine.
[40] Thomas Korn,et al. IL-17 and Th17 Cells. , 2009, Annual review of immunology.
[41] Naomi L. Dunning. Leishmania vaccines: from leishmanization to the era of DNA technology , 2009 .
[42] A. Ouaissi,et al. Live attenuated Leishmania vaccines: a potential strategic alternative , 2008, Archivum Immunologiae et Therapiae Experimentalis.
[43] Y. Goto,et al. Protective immunization against visceral leishmaniasis using Leishmania sterol 24-c-methyltransferase formulated in adjuvant. , 2007, Vaccine.
[44] Y. Goto,et al. Leish-111f, a Recombinant Polyprotein Vaccine That Protects against Visceral Leishmaniasis by Elicitation of CD4+ T Cells , 2007, Infection and Immunity.
[45] Ashutosh,et al. Molecular mechanisms of antimony resistance in Leishmania. , 2007, Journal of medical microbiology.
[46] A. Ponte-Sucre,et al. Leishmania amazonensis: metabolic adaptations induced by resistance to an ABC transporter blocker. , 2006, Experimental parasitology.
[47] K. Foulds,et al. Th1 memory: implications for vaccine development , 2006, Immunological reviews.
[48] M. Ouellette,et al. Live Nonpathogenic Parasitic Vector as a Candidate Vaccine against Visceral Leishmaniasis , 2005, Infection and Immunity.
[49] C. McKnight,et al. High-resolution crystal structures of villin headpiece and mutants with reduced F-actin binding activity. , 2005, Biochemistry.
[50] K. Figarella,et al. Substrate preferences and glucose uptake in glibenclamide-resistant Leishmania parasites. , 2005, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
[51] C. Sousa,et al. Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4+ T cell populations lacking helper function , 2005, Nature Immunology.
[52] H. Nakhasi,et al. Centrin Gene Disruption Impairs Stage-specific Basal Body Duplication and Cell Cycle Progression in Leishmania* , 2004, Journal of Biological Chemistry.
[53] G. H. Coombs,et al. Cysteine Protease B of Leishmania mexicana Inhibits Host Th1 Responses and Protective Immunity 1 , 2003, The Journal of Immunology.
[54] G. H. Coombs,et al. Leishmania mexicana and Leishmania major: attenuation of wild-type parasites and vaccination with the attenuated lines. , 2003, The Journal of infectious diseases.
[55] S. Beverley,et al. Improvements in transfection efficiency and tests of RNA interference (RNAi) approaches in the protozoan parasite Leishmania. , 2003, Molecular and biochemical parasitology.
[56] Michael P. Barrett,et al. Genetic characterization of glucose transporter function in Leishmania mexicana , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[57] G. Milon,et al. Real-Time PCR for Detection and Quantitation of Leishmania in Mouse Tissues , 2002, Journal of Clinical Microbiology.
[58] M. Ouellette,et al. Reduced Infectivity of a Leishmania donovani Biopterin Transporter Genetic Mutant and Its Use as an Attenuated Strain for Vaccination , 2002, Infection and Immunity.
[59] G. Matlashewski,et al. Immunization with A2 protein results in a mixed Th1/Th2 and a humoral response which protects mice against Leishmania donovani infections. , 2001, Vaccine.
[60] D. Das,et al. Fine Needle Aspiration Cytology Diagnosis of Cutaneous Leishmaniasis in a 6-Month-Old Child , 2001, Acta Cytologica.
[61] J. Streit,et al. Protective Immunity Against the Protozoan Leishmania chagasi Is Induced by Subclinical Cutaneous Infection with Virulent But Not Avirulent Organisms1 , 2001, The Journal of Immunology.
[62] J. Sambrook,et al. Molecular Cloning: A Laboratory Manual , 2001 .
[63] A. Hill,et al. Vaccines against intracellular infections requiring cellular immunity , 2000, Nature.
[64] J. Vandekerckhove,et al. Villin Function in the Organization of the Actin Cytoskeleton , 1999, The Journal of Biological Chemistry.
[65] S. Landfear,et al. Differential Regulation of Multiple Glucose Transporter Genes in Leishmania mexicana * , 1998, The Journal of Biological Chemistry.
[66] G. Matlashewski,et al. Loss of virulence in Leishmania donovani deficient in an amastigote-specific protein, A2. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[67] K. Mawhinney,et al. Standardization of Enzyme-Linked Immunosorbent Assays (ELISAs) for Quantitative Estimation of Antibodies Specific for Infectious Bovine Rhinotracheitis Virus, Respiratory Syncytial Virus, Parainfluenza-3 Virus, and Bovine Viral Diarrhea Virus , 1997, Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc.
[68] S. Landfear,et al. Biochemistry and molecular genetics of Leishmania glucose transporters , 1994, Parasitology.
[69] R. Titus,et al. An avirulent lipophosphoglycan-deficient Leishmania major clone induces CD4+ T cells which protect susceptible BALB/c mice against infection with virulent L. major , 1993, Infection and immunity.
[70] D. Rivier,et al. Vaccine development against cutaneous leishmaniasis. Subcutaneous administration of radioattenuated parasites protects CBA mice against virulent Leishmania major challenge , 1993, Parasite immunology.
[71] J. Cazzulo. Aerobic fermentation of glucose by trypanosomatids , 1992, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[72] S. Beverley,et al. Gene replacement in parasitic protozoa , 1990, Nature.
[73] S. Moncada,et al. Macrophage killing of Leishmania parasite in vivo is mediated by nitric oxide from L-arginine. , 1990, Journal of immunology.
[74] R. Coffman,et al. Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens , 1988, The Journal of experimental medicine.
[75] H. Amini,et al. CONTROL OF ZOONOTIC CUTANEOUS LEISHMANIASIS BY MASS LEISHMANIZATION IN HYPERENDEMIC AREA OF ISFAHAN , 1988 .
[76] W. Paul,et al. Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production. , 1987, Science.
[77] J. Berman,et al. Sodium stibogluconate (Pentostam) inhibition of glucose catabolism via the glycolytic pathway, and fatty acid beta-oxidation in Leishmania mexicana amastigotes. , 1987, Biochemical pharmacology.
[78] T. Boon,et al. A limiting dilution assay for quantifying Leishmania major in tissues of infected mice , 1985, Parasite immunology.
[79] R. Gorczynski. Immunization of susceptible BALB/c mice against Leishmania braziliensis. II. Use of temperature-sensitive avirulent clones of parasite for vaccination purposes. , 1985, Cellular immunology.
[80] E. Handman,et al. Vaccination against cutaneous leishmaniasis in mice using nonpathogenic cloned promastigotes of Leishmania major and importance of route of injection. , 1984, The Australian journal of experimental biology and medical science.
[81] T. Mosmann. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. , 1983, Journal of immunological methods.
[82] S. Maeda,et al. IVbteA Modified Colorimetric MTT Assay Adapted fbr Application to Proliferation and Cytotoxicity Assays , 2018 .
[83] D. Das,et al. Fine needle aspiration cytology diagnosis of cutaneous leishmaniasis in a 6-month-old child: a case report. , 2001, Acta cytologica.
[84] E. Javadian,et al. The experience of leishmanization in the Islamic Republic of Iran. , 1997 .
[85] D. C. Henckel,et al. Case report. , 1995, Journal.
[86] Curley,et al. A Practical Review , 2022 .