Mapping quantitative trait loci

Different alleles at quantitative trait loci (QTL) cause genetic differences between individuals and families for quantitative traits (Bulmer 1980; Falconer 1981). QTL genotypes cannot be determined by inspecting the distributions of trait phenotypes alone. This is one of the fundamental problems of quantitative genetics. Historically important quantitative genetic parameters, e.g., additive genetic variance and heritability, summarize differences between alleles at QTL, but do not shed light on the genetics of QTL. Methods for mapping QTL are needed to achieve this. QTL are mapped by using genetic markers linked to QTL to draw inferences about differences between alleles at QTL.

[1]  J. Dudley,et al.  Comparison of Different Methods of Identifying Inbreds Useful for Improving Elite Maize Hybrids , 1989 .

[2]  R. J. Baker.  TESTS FOR CROSSOVER GENOTYPE-ENVIRONMENTAL INTERACTIONS , 1988 .

[3]  J. Doebley,et al.  Genetic and morphological analysis of a maize-teosinte F2 population: implications for the origin of maize. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[4]  R. Jansen,et al.  Interval mapping of multiple quantitative trait loci. , 1993, Genetics.

[5]  A. Rosielle,et al.  Theoretical Aspects of Selection for Yield in Stress and Non-Stress Environment 1 , 1981 .

[6]  G. H. Freeman,et al.  Statistical methods for the analysis of genotype-environment interactions2 , 1973, Heredity.

[7]  J. Léon,et al.  Stability Analysis in Plant Breeding , 1988 .

[8]  C. Haley,et al.  A simple regression method for mapping quantitative trait loci in line crosses using flanking markers , 1992, Heredity.

[9]  J. Doebley,et al.  Genetic analysis of the morphological differences between maize and teosinte. , 1991, Genetics.

[10]  G. K. Shukla,et al.  Some statistical aspects of partitioning genotype-environmental components of variability , 1972, Heredity.

[11]  E. Lander,et al.  Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. , 1989, Genetics.

[12]  K. Mather,et al.  Genotype X environment interactions. II. Some genetical considerations. , 1975, Heredity.

[13]  Ritsert C. Jansen,et al.  Maximum Likelihood in a Generalized Linear Finite Mixture Model by Using the EM Algorithm , 1993 .

[14]  Chris Haley,et al.  Aspects of maximum likelihood methods for the mapping of quantitative trait loci in line crosses , 1992 .

[15]  Geoffrey J. McLachlan,et al.  Mixture models : inference and applications to clustering , 1989 .

[16]  J. Wendel,et al.  Molecular-marker-facilitated investigations of quantitative-trait loci in maize. I. Numbers, genomic distribution and types of gene action. , 1987, Genetics.

[17]  D. Cox,et al.  Two New Tests Associated with Analysis of Variance , 1984 .

[18]  Weller Ji.  Maximum likelihood techniques for the mapping and analysis of quantitative trait loci with the aid of genetic markers. , 1986 .

[19]  E. Lander,et al.  Mendelian factors underlying quantitative traits in tomato: comparison across species, generations, and environments. , 1991, Genetics.

[20]  Satterthwaite Fe.  An approximate distribution of estimates of variance components. , 1946 .

[21]  Mervyn G. Marasinghe,et al.  SAS System for Linear Models , 1991 .

[22]  D. Falconer,et al.  Introduction to Quantitative Genetics. , 1962 .

[23]  M. Bulmer.  The Mathematical Theory of Quantitative Genetics , 1981 .

[24]  B. Westcott.  Some methods of analysing genotype—environment interaction , 1986, Heredity.

[25]  T. Gerig,et al.  Interval mapping in the analysis of nonadditive quantitative trait loci , 1992 .

[26]  L. Lefkovitch,et al.  Stability Analysis : Where Do We Stand ? , 2003 .

[27]  Charles Smith.  Improvement of metric traits through specific genetic loci , 1967 .

[28]  Hugh G. Gauch,et al.  Statistical Analysis of a Yield Trial , 1988 .

[29]  S. Knapp,et al.  Using molecular markers to estimate quantitative trait locus parameters: power and genetic variances for unreplicated and replicated progeny. , 1990, Genetics.

[30]  S. Knapp,et al.  Mapping quantitative trait loci using nonsimultaneous and simultaneous estimators and hypothesis tests , 1992 .

[31]  J. Wendel,et al.  Molecular marker-facilitated investigations of quantitative trait loci in maize. II. Factors influencing yield and its component traits , 1987 .

[32]  F. Rodolphe,et al.  A multi-marker model for detecting chromosomal segments displaying QTL activity. , 1993, Genetics.

[33]  R. Michelmore,et al.  A Genetic Map of Lettuce (Lactuca sativa L.) with Restriction Fragment Length Polymorphism, Isozyme, Disease Resistance and Morphological Markers. , 1987, Genetics.

[34]  S. R. Searle.  Linear Models , 1971 .

[35]  A. F. Troyer.  A Retrospective View of Corn Genetic Resources , 1990 .

[36]  M. Kearsey,et al.  Maximum likelihood estimation of linkage between a marker gene and a quantitative trait locus. II. Application to backcross and doubled haploid populations , 1991, Heredity.

[37]  R. Lande,et al.  Efficiency of marker-assisted selection in the improvement of quantitative traits. , 1990, Genetics.

[38]  J. Dudley.  Modification of Methods for Identifying Inbred Lines Useful for Improving Parents of Elite Single Crosses 1 , 1987 .

[39]  A. F. Smith,et al.  Statistical analysis of finite mixture distributions , 1986 .

[40]  Eric S. Lander,et al.  Resolution of quantitative traits into Mendelian factors by using a complete linkage map of restriction fragment length polymorphisms , 1988, Nature.

[41]  E. Lander,et al.  Identification of genetic factors contributing to heterosis in a hybrid from two elite maize inbred lines using molecular markers. , 1992, Genetics.

[42]  M. Gail,et al.  Testing for qualitative interactions between treatment effects and patient subsets. , 1985, Biometrics.

[43]  J. Dudley.  A Method of Identifying Lines for Use in Improving Parents of a Single Cross1 , 1984 .

[44]  A. F. Troyer,et al.  Measurement of genetic diversity among popular commercial corn hybrids , 1988 .

[45]  J. Dudley.  Molecular Markers in Plant Improvement: Manipulation of Genes Affecting Quantitative Traits , 1993 .

[46]  T. Helentjaris,et al.  Restriction Fragment Length Polymorphism Analysis of Loci Associated with Insect Resistance in Tomato 1 , 1987 .