Functional analysis of a novel positive allosteric modulator of AMPA receptors derived from a structure-based drug design strategy

[1]  G. Carlson Glutamate receptor dysfunction and drug targets across models of autism spectrum disorders , 2012, Pharmacology Biochemistry and Behavior.

[2]  Rudolf Mueller and Benzotriazinone and Benzopyrimidinone Derivatives as Potent Positive Allosteric AMPA Receptor Modulators. , 2012 .

[3]  P. Naur,et al.  Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2. , 2012, The Biochemical journal.

[4]  K. Hashimoto The role of glutamate on the action of antidepressants , 2011, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[5]  E. Nisenbaum,et al.  Structural and Functional Analysis of Two New Positive Allosteric Modulators of GluA2 Desensitization and Deactivation , 2011, Molecular Pharmacology.

[6]  G. Lynch,et al.  The likelihood of cognitive enhancement , 2011, Pharmacology Biochemistry and Behavior.

[7]  F. López-Muñoz,et al.  Neurobiological Background for the Development of New Drugs in Schizophrenia , 2011, Clinical neuropharmacology.

[8]  M. Mayer Structure and mechanism of glutamate receptor ion channel assembly, activation and modulation , 2011, Current Opinion in Neurobiology.

[9]  Z. Rankovic,et al.  Structure based evolution of a novel series of positive modulators of the AMPA receptor. , 2011, Bioorganic & medicinal chemistry letters.

[10]  Z. Rankovic,et al.  A novel series of positive modulators of the AMPA receptor: structure-based lead optimization. , 2010, Bioorganic & medicinal chemistry letters.

[11]  Z. Rankovic,et al.  A novel series of positive modulators of the AMPA receptor: discovery and structure based hit-to-lead studies. , 2010, Bioorganic & medicinal chemistry letters.

[12]  S. Ward,et al.  Recent advances in the discovery of selective AMPA receptor positive allosteric modulators. , 2010, Current medicinal chemistry.

[13]  R. Dingledine,et al.  Glutamate Receptor Ion Channels: Structure, Regulation, and Function , 2010, Pharmacological Reviews.

[14]  S. Ward,et al.  Challenges for and current status of research into positive modulators of AMPA receptors , 2010, British journal of pharmacology.

[15]  C. Ptak,et al.  Molecular mechanism of flop selectivity and subsite recognition for an AMPA receptor allosteric modulator: structures of GluA2 and GluA3 in complexes with PEPA. , 2010, Biochemistry.

[16]  E. Gouaux,et al.  X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor , 2009, Nature.

[17]  C. Ptak,et al.  Probing the allosteric modulator binding site of GluR2 with thiazide derivatives. , 2009, Biochemistry.

[18]  T. Liljefors,et al.  Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2. , 2009, Journal of molecular biology.

[19]  Roberto Malinow,et al.  Synaptic AMPA Receptor Plasticity and Behavior , 2009, Neuron.

[20]  G. Swanson Targeting AMPA and kainate receptors in neurological disease: therapies on the horizon? , 2009, Neuropsychopharmacology.

[21]  T. Balkin,et al.  Ampakine (CX717) effects on performance and alertness during simulated night shift work. , 2007, Aviation, space, and environmental medicine.

[22]  M. Fleck,et al.  Targeting AMPA receptor gating processes with allosteric modulators and mutations. , 2007, Biophysical journal.

[23]  E. Nisenbaum,et al.  A novel class of AMPA receptor allosteric modulators. Part 1: design, synthesis, and SAR of 3-aryl-4-cyano-5-substituted-heteroaryl-2-carboxylic acid derivatives. , 2006, Bioorganic & medicinal chemistry letters.

[24]  C. Jamieson,et al.  Recent advances in positive allosteric modulators of the AMPA receptor. , 2006, Current opinion in drug discovery & development.

[25]  A. Arai,et al.  Use of [3H]fluorowillardiine to study properties of AMPA receptor allosteric modulators , 2006, Brain Research.

[26]  A. Arai,et al.  AMPA receptor modulators have different impact on hippocampal pyramidal cells and interneurons , 2005, Neuroscience.

[27]  Joshua T Dudman,et al.  Mechanism of Positive Allosteric Modulators Acting on AMPA Receptors , 2005, The Journal of Neuroscience.

[28]  M. Black Therapeutic potential of positive AMPA modulators and their relationship to AMPA receptor subunits. A review of preclinical data , 2005, Psychopharmacology.

[29]  M. Mayer,et al.  Mechanism of glutamate receptor desensitization , 2002, Nature.

[30]  E. Gouaux,et al.  Mechanisms for Activation and Antagonism of an AMPA-Sensitive Glutamate Receptor Crystal Structures of the GluR2 Ligand Binding Core , 2000, Neuron.

[31]  G. Rogers,et al.  The norbornenyl moiety of cyclothiazide determines the preference for flip-flop variants of AMPA receptor subunits , 2000, Neuroscience Letters.

[32]  E. Gouaux,et al.  Structure of a glutamate-receptor ligand-binding core in complex with kainate , 1998, Nature.

[33]  Richard Granger,et al.  Evidence That a Positive Modulator of AMPA-Type Glutamate Receptors Improves Delayed Recall in Aged Humans , 1997, Experimental Neurology.

[34]  M. Mayer,et al.  AMPA Receptor Flip/Flop Mutants Affecting Deactivation, Desensitization, and Modulation by Cyclothiazide, Aniracetam, and Thiocyanate , 1996, The Journal of Neuroscience.

[35]  G. Lynch,et al.  Effects of a centrally active benzoylpiperidine drug on α-amino-3-hydroxy-5-methyl-4-isoxalepropionic acid receptor kinetics , 1996, Neuroscience.

[36]  G. Lynch,et al.  Effects of a centrally active benzoylpyrrolidine drug on AMPA receptor kinetics. , 1996, Neuroscience.

[37]  B. Sakmann,et al.  Relative abundance of subunit mRNAs determines gating and Ca2+ permeability of AMPA receptors in principal neurons and interneurons in rat CNS , 1995, Neuron.

[38]  R. Dingledine,et al.  Identification of a site in glutamate receptor subunits that controls calcium permeability , 1991, Science.

[39]  B. Sakmann,et al.  Structural determinants of ion flow through recombinant glutamate receptor channels , 1991, Science.

[40]  M. Mayer,et al.  A kinetic analysis of the modulation of N‐methyl‐D‐aspartic acid receptors by glycine in mouse cultured hippocampal neurones. , 1990, The Journal of physiology.