Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor.
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M. Levings | P. Orban | D. Luciani | R. Broady | J. Gillies | Qing Huang | R. Hoeppli | K. G. MacDonald | Jana K. Gillies | Romy E Hoeppli
[1] M. Levings,et al. Discarded Human Thymus Is a Novel Source of Stable and Long‐Lived Therapeutic Regulatory T Cells , 2016, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
[2] Jeffrey A. Bluestone,et al. Type 1 diabetes immunotherapy using polyclonal regulatory T cells , 2015, Science Translational Medicine.
[3] J. Todd,et al. Epigenetic analysis of regulatory T cells using multiplex bisulfite sequencing , 2015, European journal of immunology.
[4] M. Riese,et al. Regulatory T Cells Require TCR Signaling for Their Suppressive Function , 2015, The Journal of Immunology.
[5] Ton N. Schumacher,et al. Adoptive cellular therapy: A race to the finish line , 2015, Science Translational Medicine.
[6] R. Kaplan,et al. 4-1BB Costimulation Ameliorates T Cell Exhaustion Induced by Tonic Signaling of Chimeric Antigen Receptors , 2015, Nature Medicine.
[7] Matthew J. Frigault,et al. Identification of Chimeric Antigen Receptors That Mediate Constitutive or Inducible Proliferation of T Cells , 2015, Cancer Immunology Research.
[8] C. June,et al. Going viral: chimeric antigen receptor T‐cell therapy for hematological malignancies , 2015, Immunological reviews.
[9] Marco Y. Hein,et al. Continuous T cell receptor signals maintain a functional regulatory T cell pool. , 2014, Immunity.
[10] Pamela A Shaw,et al. Chimeric antigen receptor T cells for sustained remissions in leukemia. , 2014, The New England journal of medicine.
[11] A. Rudensky,et al. Continuous requirement for the T cell receptor for regulatory T cell function , 2014, Nature Immunology.
[12] Z. Eshhar,et al. Suppression of murine colitis and its associated cancer by carcinoembryonic antigen-specific regulatory T cells. , 2014, Molecular Therapy.
[13] L. Turka,et al. Signals and pathways controlling regulatory T cells , 2014, Immunological reviews.
[14] J. Bluestone,et al. Clinical Grade Manufacturing of Human Alloantigen‐Reactive Regulatory T Cells for Use in Transplantation , 2013, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
[15] J. Wagner,et al. Adoptive transfer of umbilical cord blood-derived regulatory T cells and early viral reactivation. , 2013, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.
[16] Michel Sadelain,et al. The basic principles of chimeric antigen receptor design. , 2013, Cancer discovery.
[17] M. Levings,et al. Helios+ and Helios− Cells Coexist within the Natural FOXP3+ T Regulatory Cell Subset in Humans , 2013, The Journal of Immunology.
[18] L. Turka,et al. An obligate cell-intrinsic function for CD28 in Tregs. , 2013, The Journal of clinical investigation.
[19] J. Seo,et al. Role of HLA in Hematopoietic Stem Cell Transplantation , 2012, Bone marrow research.
[20] M. Levings,et al. The Role of the PI3K Signaling Pathway in CD4+ T Cell Differentiation and Function , 2012, Front. Immun..
[21] W. Młynarski,et al. Administration of CD4+CD25highCD127− Regulatory T Cells Preserves β-Cell Function in Type 1 Diabetes in Children , 2012, Diabetes Care.
[22] M. Essand,et al. CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery , 2012, Journal of Neuroinflammation.
[23] F. Regateiro,et al. Sustained suppression by Foxp3+ regulatory T cells is vital for infectious transplantation tolerance , 2011, The Journal of experimental medicine.
[24] R. Lechler,et al. Human Regulatory T Cells with Alloantigen Specificity Are More Potent Inhibitors of Alloimmune Skin Graft Damage than Polyclonal Regulatory T Cells , 2011, Science Translational Medicine.
[25] Bruce R. Blazar,et al. Massive ex Vivo Expansion of Human Natural Regulatory T Cells (Tregs) with Minimal Loss of in Vivo Functional Activity , 2011, Science Translational Medicine.
[26] B. Falini,et al. Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation. , 2011, Blood.
[27] J. Wagner,et al. Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics. , 2011, Blood.
[28] Yan Li,et al. Molecular Modeling and Affinity Determination of scFv Antibody: Proper Linker Peptide Enhances Its Activity , 2010, Annals of Biomedical Engineering.
[29] J. Myśliwska,et al. First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127- T regulatory cells. , 2009, Clinical immunology.
[30] D. Kofler,et al. Redirecting human CD4+CD25+ regulatory T cells from the peripheral blood with pre-defined target specificity , 2009, Gene Therapy.
[31] J. Bluestone,et al. Regulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells , 2009, Immunological reviews.
[32] E. Elinav,et al. Amelioration of colitis by genetically engineered murine regulatory T cells redirected by antigen-specific chimeric receptor. , 2009, Gastroenterology.
[33] M. Sadelain,et al. The promise and potential pitfalls of chimeric antigen receptors. , 2009, Current Opinion in Immunology.
[34] L. A. Stephens,et al. Curing CNS autoimmune disease with myelin‐reactive Foxp3+ Treg , 2009, European journal of immunology.
[35] S. Rosenberg,et al. Adoptive cell therapy for the treatment of patients with metastatic melanoma. , 2009, Current opinion in immunology.
[36] R. Andreesen,et al. Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation , 2009, European journal of immunology.
[37] R. Lechler,et al. Conferring indirect allospecificity on CD4+CD25+ Tregs by TCR gene transfer favors transplantation tolerance in mice. , 2008, The Journal of clinical investigation.
[38] E. Elinav,et al. Redirection of regulatory T cells with predetermined specificity for the treatment of experimental colitis in mice. , 2008, Gastroenterology.
[39] K. Wucherpfennig,et al. Induction of antigen-specific regulatory T cells in wild-type mice: Visualization and targets of suppression , 2008, Proceedings of the National Academy of Sciences.
[40] R. Steinman,et al. Dendritic cell–expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice , 2007, The Journal of experimental medicine.
[41] R. Lechler,et al. In vitro-expanded donor alloantigen-specific CD4+CD25+ regulatory T cells promote experimental transplantation tolerance. , 2007, Blood.
[42] R. Andreesen,et al. Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion. , 2006, Blood.
[43] G. Denardo,et al. Monospecific bivalent scFv-SH: effects of linker length and location of an engineered cysteine on production, antigen binding activity and free SH accessibility. , 2006, Journal of immunological methods.
[44] D. Klatzmann,et al. Ex Vivo-Expanded CD4+CD25+ Immunoregulatory T Cells Prevent Graft-versus-Host-Disease by Inhibiting Activation/Differentiation of Pathogenic T Cells1 , 2006, The Journal of Immunology.
[45] T. Strom,et al. Specificity of CD4+CD25+ Regulatory T Cell Function in Alloimmunity1 , 2006, The Journal of Immunology.
[46] H. Mcdevitt,et al. Expansion of Functional Endogenous Antigen-Specific CD4+CD25+ Regulatory T Cells from Nonobese Diabetic Mice1 , 2005, The Journal of Immunology.
[47] T. Ley,et al. Human T regulatory cells can use the perforin pathway to cause autologous target cell death. , 2004, Immunity.
[48] S. Sakaguchi,et al. Induction of antigen-specific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising Foxp3+CD25+CD4+ regulatory T cells. , 2004, International immunology.
[49] R. Steinman,et al. CD25+ CD4+ T Cells, Expanded with Dendritic Cells Presenting a Single Autoantigenic Peptide, Suppress Autoimmune Diabetes , 2004, The Journal of experimental medicine.
[50] Jeffrey A. Bluestone,et al. In Vitro–expanded Antigen-specific Regulatory T Cells Suppress Autoimmune Diabetes , 2004, The Journal of experimental medicine.
[51] M. Roncarolo,et al. Growth and expansion of human T regulatory type 1 cells are independent from TCR activation but require exogenous cytokines , 2002, European journal of immunology.
[52] R. Flavell,et al. Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals. , 2002, Immunity.
[53] M. Roncarolo,et al. Human Cd25+Cd4+ T Regulatory Cells Suppress Naive and Memory T Cell Proliferation and Can Be Expanded in Vitro without Loss of Function , 2001, The Journal of experimental medicine.
[54] E. Shevach,et al. CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production , 1998, The Journal of experimental medicine.
[55] J. Crawford,et al. Total body irradiation and acute graft-versus-host disease: the role of gastrointestinal damage and inflammatory cytokines. , 1997, Blood.
[56] J. Crawford,et al. An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin. , 1996, Blood.
[57] J. Schrader,et al. A novel strategy for generating monoclonal antibodies from single, isolated lymphocytes producing antibodies of defined specificities. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[58] Ruth Etzioni,et al. Role of the mixed lymphocyte culture (MLC) reaction in marrow donor selection: matching for transplants from related haploidentical donors. , 1994, Tissue Antigens.
[59] L. Naldini,et al. Generation of potent and stable human CD4+ T regulatory cells by activation-independent expression of FOXP3. , 2008, Molecular therapy : the journal of the American Society of Gene Therapy.
[60] O. Joffre,et al. Prevention of acute and chronic allograft rejection with CD4+CD25+Foxp3+ regulatory T lymphocytes , 2008, Nature Medicine.
[61] K. Jerome,et al. Measuring T-cell–mediated cytotoxicity using antibody to activated caspase 3 , 2003, Nature Medicine.
[62] C. Hurley,et al. The relative frequencies of HLA-DRB1*01 alleles in the major US populations. , 2000, Tissue antigens.