Black Cohosh (Cimicifuga Racemosa) as Treatment of Menopause-Related Symptoms: A Mini Review

in-Abstract Black cohosh belongs to the family Cimicifuga racemosa . Root and rhizome are the medicinal parts of the herb. Black cohosh is used against the treatment of Menopause symptoms (including vasomotor); Premenstrual Syndrome (PMS); depression (mild); arthritis and migraine. It is often used as an alternative to estrogen-based replacement therapies to treat hot flushes that frequently accompany the transition to menopause.

[1]  S. Smith‐Roe,et al.  Black cohosh extracts and powders induce micronuclei, a biomarker of genetic damage, in human cells , 2018, Environmental and molecular mutagenesis.

[2]  M. Leach,et al.  Black cohosh (Cimicifuga spp.) for menopausal symptoms. , 2012, The Cochrane database of systematic reviews.

[3]  M. Hardy,et al.  Black cohosh increases metastatic mammary cancer in transgenic mice expressing c-erbB2. , 2008, Cancer research.

[4]  Y. Ju,et al.  A dietary supplement for female sexual dysfunction, Avlimil, stimulates the growth of estrogen-dependent breast tumors (MCF-7) implanted in ovariectomized athymic nude mice. , 2008, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[5]  H. Boon,et al.  Black cohosh (Cimicifuga racemosa [L.] Nutt.): safety and efficacy for cancer patients , 2007, Supportive Care in Cancer.

[6]  Joo Hyun Park,et al.  Black Cohosh and St. John's Wort (GYNO-Plus®) for Climacteric Symptoms , 2007, Yonsei medical journal.

[7]  N. Taskintuna,et al.  Black cohosh and fluoxetine in the treatment of postmenopausal symptoms: A prospective, randomized trial , 2007, Advances in therapy.

[8]  P. Novotny,et al.  Phase III double-blind, randomized, placebo-controlled crossover trial of black cohosh in the management of hot flashes: NCCTG Trial N01CC1. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[9]  C. R. Lynch,et al.  Fulminant hepatic failure associated with the use of black cohosh: A case report , 2006, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[10]  W. Wuttke,et al.  Effects of black cohosh (Cimicifuga racemosa) on bone turnover, vaginal mucosa, and various blood parameters in postmenopausal women: a double-blind, placebo-controlled, and conjugated estrogens-controlled study , 2006, Menopause.

[11]  H. Te,et al.  Autoimmune hepatitis associated with the use of black cohosh: a case study , 2004, Menopause.

[12]  P. Angus,et al.  Acute liver failure associated with the use of herbal preparations containing black cohosh , 2003, The Medical journal of Australia.

[13]  B. Kligler Black cohosh. , 2003, American family physician.

[14]  R. Olson,et al.  Randomized, controlled trial of phytoestrogen in the prophylactic treatment of menstrual migraine. , 2002, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[15]  S. Mori,et al.  Analysis of thirteen populations of black cohosh for formononetin. , 2002, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[16]  D. Mckenna,et al.  Black cohosh: efficacy, safety, and use in clinical and preclinical applications. , 2001, Alternative therapies in health and medicine.

[17]  E. Umland,et al.  Phytoestrogens as Therapeutic Alternatives to Traditional Hormone Replacement in Postmenopausal Women , 2000, Pharmacotherapy.

[18]  J. Shuster HEPARIN AND THROMBOCYTOPENIA ; BLACK COHOSH ROOT? CHASTEBERRY TREE? SEIZURES! , 1996 .

[19]  H. Jarry,et al.  Effects of Extracts from Cimicifuga racemosa on Gonadotropin Release in Menopausal Women and Ovariectomized Rats , 1991, Planta medica.