Architecture and regulation of HtrA-family proteins involved in protein quality control and stress response

[1]  R. Sauer,et al.  Cage assembly of DegP protease is not required for substrate-dependent regulation of proteolytic activity or high-temperature cell survival , 2012, Proceedings of the National Academy of Sciences.

[2]  H. Saibil,et al.  Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ , 2011, Nature Structural &Molecular Biology.

[3]  Peer Bork,et al.  SMART 7: recent updates to the protein domain annotation resource , 2011, Nucleic Acids Res..

[4]  Nitu Singh,et al.  The structural basis of mode of activation and functional diversity: a case study with HtrA family of serine proteases. , 2011, Archives of biochemistry and biophysics.

[5]  V. Grantcharova,et al.  A systematic family-wide investigation reveals that ~30% of mammalian PDZ domains engage in PDZ-PDZ interactions. , 2011, Chemistry & biology.

[6]  Xiao-jing Wang,et al.  Characterization of the structure and function of Escherichia coli DegQ as a representative of the DegQ-like proteases of bacterial HtrA family proteins. , 2011, Structure.

[7]  A. Shafferman,et al.  HtrA is a major virulence determinant of Bacillus anthracis , 2011, Molecular microbiology.

[8]  Tim Clausen,et al.  Molecular Adaptation of the DegQ Protease to Exert Protein Quality Control in the Bacterial Cell Envelope* , 2011, The Journal of Biological Chemistry.

[9]  R. Hilgenfeld,et al.  The Legionella HtrA homologue DegQ is a self-compartmentizing protease that forms large 12-meric assemblies , 2011, Proceedings of the National Academy of Sciences.

[10]  M. Ehrmann,et al.  Structural adaptation of the plant protease Deg1 to repair photosystem II during light exposure , 2011, Nature Structural &Molecular Biology.

[11]  M. Ehrmann,et al.  Substrate-induced remodeling of the active site regulates human HTRA1 activity , 2011, Nature Structural &Molecular Biology.

[12]  R. Sauer,et al.  Covalent Linkage of Distinct Substrate Degrons Controls Assembly and Disassembly of DegP Proteolytic Cages , 2011, Cell.

[13]  R. Huber,et al.  HTRA proteases: regulated proteolysis in protein quality control , 2011, Nature Reviews Molecular Cell Biology.

[14]  R. Sauer,et al.  Signal integration by DegS and RseB governs the σE-mediated envelope stress response in Escherichia coli , 2011, Proceedings of the National Academy of Sciences.

[15]  G. Schneider,et al.  Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E‐cadherin to disrupt intercellular adhesion , 2010, EMBO reports.

[16]  Mingjie Zhang,et al.  Extensions of PDZ domains as important structural and functional elements , 2010, Protein & Cell.

[17]  R. Sauer,et al.  Allostery Is an Intrinsic Property of the Protease Domain of DegS , 2010, The Journal of Biological Chemistry.

[18]  M. Caraglia,et al.  The Serine Protease HtrA1 Specifically Interacts and Degrades the Tuberous Sclerosis Complex 2 Protein , 2010, Molecular Cancer Research.

[19]  Y. Hathout,et al.  Identification of novel substrates for the serine protease HTRA1 in the human RPE secretome. , 2010, Investigative ophthalmology & visual science.

[20]  R. Huber,et al.  HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues , 2010, Nature Structural &Molecular Biology.

[21]  R. Huber,et al.  Conversion of a regulatory into a degradative protease. , 2010, Journal of molecular biology.

[22]  M. Ehrmann,et al.  Molecular transformers in the cell: lessons learned from the DegP protease-chaperone. , 2010, Current opinion in structural biology.

[23]  Neil D. Rawlings,et al.  MEROPS: the peptidase database , 2009, Nucleic Acids Res..

[24]  Jie J. Zheng,et al.  PDZ domains and their binding partners: structure, specificity, and modification , 2010, Cell Communication and Signaling.

[25]  Pitter F. Huesgen,et al.  Deg/HtrA proteases as components of a network for photosystem II quality control in chloroplasts and cyanobacteria. , 2009, Research in microbiology.

[26]  H. Ingmer,et al.  Proteases in bacterial pathogenesis. , 2009, Research in microbiology.

[27]  H. Hodak,et al.  Role of DegP for two‐partner secretion in Bordetella , 2009, Molecular microbiology.

[28]  R. Sauer,et al.  OMP peptides activate the DegS stress-sensor protease by a relief of inhibition mechanism. , 2009, Structure.

[29]  J. Chien,et al.  HtrA serine proteases as potential therapeutic targets in cancer. , 2009, Current cancer drug targets.

[30]  X. Bai,et al.  Bowl-shaped oligomeric structures on membranes as DegP's new functional forms in protein quality control , 2009, Proceedings of the National Academy of Sciences.

[31]  S. Tsuji,et al.  Association of HTRA1 mutations and familial ischemic cerebral small-vessel disease. , 2009, The New England journal of medicine.

[32]  A. Rowan,et al.  Emerging roles of serine proteinases in tissue turnover in arthritis. , 2008, Arthritis and rheumatism.

[33]  E. Di Cera,et al.  Evolution of Peptidase Diversity* , 2008, Journal of Biological Chemistry.

[34]  Chris Sander,et al.  A Specificity Map for the PDZ Domain Family , 2008, PLoS biology.

[35]  Z. Zhou,et al.  Activation of DegP chaperone-protease via formation of large cage-like oligomers upon binding to substrate proteins , 2008, Proceedings of the National Academy of Sciences.

[36]  M. Edelman,et al.  D1-protein dynamics in photosystem II: the lingering enigma , 2008, Photosynthesis Research.

[37]  L. Dauphinot,et al.  HtrA1-dependent proteolysis of TGF-β controls both neuronal maturation and developmental survival , 2008, Cell Death and Differentiation.

[38]  H. Saibil,et al.  Structural basis for the regulated protease and chaperone function of DegP , 2008, Nature.

[39]  R. Huber,et al.  Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins , 2008, Proceedings of the National Academy of Sciences.

[40]  J. Sacchettini,et al.  Structure and function of the virulence-associated high-temperature requirement A of Mycobacterium tuberculosis. , 2008, Biochemistry.

[41]  F. Daldal,et al.  Overproduction or Absence of the Periplasmic Protease DegP Severely Compromises Bacterial Growth in the Absence of the Dithiol: Disulfide Oxidoreductase DsbA*S , 2008, Molecular & Cellular Proteomics.

[42]  K. Kim,et al.  The mechanism of temperature-induced bacterial HtrA activation. , 2008, Journal of molecular biology.

[43]  P. Vandenabeele,et al.  The mitochondrial serine protease HtrA2/Omi: an overview , 2008, Cell Death and Differentiation.

[44]  A. Lavie,et al.  Domain Swapping within PDZ2 Is Responsible for Dimerization of ZO Proteins* , 2007, Journal of Biological Chemistry.

[45]  R. Sauer,et al.  Allosteric Activation of DegS, a Stress Sensor PDZ Protease , 2007, Cell.

[46]  R. Kurzbauer,et al.  Regulation of the sigmaE stress response by DegS: how the PDZ domain keeps the protease inactive in the resting state and allows integration of different OMP-derived stress signals upon folding stress. , 2007, Genes & development.

[47]  R. Tanzi,et al.  HtrA2 Regulates β-Amyloid Precursor Protein (APP) Metabolism through Endoplasmic Reticulum-associated Degradation* , 2007, Journal of Biological Chemistry.

[48]  S. Nakanishi,et al.  Crystal structures of autoinhibitory PDZ domain of Tamalin: implications for metabotropic glutamate receptor trafficking regulation , 2007, The EMBO journal.

[49]  M. Valvano,et al.  Burkholderia cenocepacia Requires a Periplasmic HtrA Protease for Growth under Thermal and Osmotic Stress and for Survival In Vivo , 2007, Infection and Immunity.

[50]  R. Ghirlando,et al.  The Inner Cavity of Escherichia coli DegP Protein Is Not Essentialfor Molecular Chaperone and Proteolytic Activity , 2006, Journal of bacteriology.

[51]  Jeong-Sun Seo,et al.  Selection of Neural Differentiation‐Specific Genes by Comparing Profiles of Random Differentiation , 2006, Stem cells.

[52]  Tim Clausen,et al.  The Role of Human HtrA1 in Arthritic Disease* , 2006, Journal of Biological Chemistry.

[53]  Kevin F. Jones,et al.  Listeria monocytogenes 10403S HtrA Is Necessary for Resistance to Cellular Stress and Virulence , 2006, Infection and Immunity.

[54]  I. Biswas,et al.  Role of HtrA in Surface Protein Expression and Biofilm Formation by Streptococcus mutans , 2005, Infection and Immunity.

[55]  M. Kawaichi,et al.  Expression of mouse HtrA1 serine protease in normal bone and cartilage and its upregulation in joint cartilage damaged by experimental arthritis. , 2005, Bone.

[56]  J. Schulz,et al.  Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease. , 2005, Human molecular genetics.

[57]  R. Sleator,et al.  Role for HtrA in Stress Induction and Virulence Potential in Listeria monocytogenes , 2005, Applied and Environmental Microbiology.

[58]  K. Kim,et al.  Structure and function of HtrA family proteins, the key players in protein quality control. , 2005, Journal of biochemistry and molecular biology.

[59]  Alfonso Baldi,et al.  Implications of the serine protease HtrA1 in amyloid precursor protein processing , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[60]  T. Raivio MicroReview: Envelope stress responses and Gram‐negative bacterial pathogenesis , 2005, Molecular microbiology.

[61]  D. Clemmons,et al.  Expression and characterization of a serine protease that preferentially cleaves insulin‐like growth factor binding protein‐5 , 2005, Journal of cellular biochemistry.

[62]  J. Kormanec,et al.  Effect of Inactivation of degS on Salmonella enterica Serovar Typhimurium In Vitro and In Vivo , 2005, Infection and Immunity.

[63]  M. Roberts,et al.  Effect of Inactivation of the HtrA-Like Serine Protease DegQ on the Virulence of Salmonella enterica Serovar Typhimurium in Mice , 2004, Infection and Immunity.

[64]  K. Zeth Structural analysis of DegS, a stress sensor of the bacterial periplasm , 2004, FEBS letters.

[65]  Tim Clausen,et al.  Crystal Structure of the DegS Stress Sensor How a PDZ Domain Recognizes Misfolded Protein and Activates a Protease , 2004, Cell.

[66]  C. Gross,et al.  Regulation of the Escherichia coliσE‐dependent envelope stress response , 2004, Molecular microbiology.

[67]  M. Kawaichi,et al.  HtrA1 serine protease inhibits signaling mediated by Tgfβ family proteins , 2004, Development.

[68]  L. Cantley,et al.  Binding Specificity and Regulation of the Serine Protease and PDZ Domains of HtrA2/Omi* , 2003, Journal of Biological Chemistry.

[69]  S. Eom,et al.  Crystal Structure of the Shank PDZ-Ligand Complex Reveals a Class I PDZ Interaction and a Novel PDZ-PDZ Dimerization* , 2003, Journal of Biological Chemistry.

[70]  R. Sauer,et al.  OMP Peptide Signals Initiate the Envelope-Stress Response by Activating DegS Protease via Relief of Inhibition Mediated by Its PDZ Domain , 2003, Cell.

[71]  Seong-Hwan Rho,et al.  Crystal Structure of GRIP1 PDZ6-Peptide Complex Reveals the Structural Basis for Class II PDZ Target Recognition and PDZ Domain-mediated Multimerization* , 2003, The Journal of Biological Chemistry.

[72]  S. Ha,et al.  Crystal Structure of the Protease Domain of a Heat-shock Protein HtrA from Thermotoga maritima * , 2003, The Journal of Biological Chemistry.

[73]  B. Chait,et al.  CIAP1 and the serine protease HTRA2 are involved in a novel p53-dependent apoptosis pathway in mammals. , 2003, Genes & development.

[74]  Jacek Otlewski,et al.  PDZ domains - common players in the cell signaling. , 2003, Acta biochimica Polonica.

[75]  C. Gross,et al.  DegS and YaeL participate sequentially in the cleavage of RseA to activate the sigma(E)-dependent extracytoplasmic stress response. , 2002, Genes & development.

[76]  Emad S. Alnemri,et al.  Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi , 2002, Nature Structural Biology.

[77]  L. Fu,et al.  Is Mycobacterium tuberculosis a closer relative to Gram-positive or Gram-negative bacterial pathogens? , 2002, Tuberculosis.

[78]  Robert Huber,et al.  Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine , 2002, Nature.

[79]  C. Southan,et al.  Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response. , 2000, European journal of biochemistry.

[80]  C. Chung,et al.  Selective degradation of unfolded proteins by the self-compartmentalizing HtrA protease, a periplasmic heat shock protein in Escherichia coli. , 1999, Journal of molecular biology.

[81]  M. Wozniak,et al.  The Escherichia coli heat shock protease HtrA participates in defense against oxidative stress , 1999, Molecular and General Genetics MGG.

[82]  M. Ehrmann,et al.  A Temperature-Dependent Switch from Chaperone to Protease in a Widely Conserved Heat Shock Protein , 1999, Cell.

[83]  S. Reed,et al.  Cloning, expression, and immunological evaluation of two putative secreted serine protease antigens of Mycobacterium tuberculosis. , 1999, Infection and immunity.

[84]  R. Sauer,et al.  The DegP and DegQ periplasmic endoproteases of Escherichia coli: specificity for cleavage sites and substrate conformation , 1996, Journal of bacteriology.

[85]  R. Sauer,et al.  Characterization of degQ and degS, Escherichia coli genes encoding homologs of the DegP protease , 1996, Journal of bacteriology.

[86]  A. Wawrzynów,et al.  Site-directed mutagenesis of the HtrA (DegP) serine protease, whose proteolytic activity is indispensable for Escherichia coli survival at elevated temperatures. , 1995, Gene.

[87]  C. Georgopoulos,et al.  Sequence analysis and regulation of the htrA gene of Escherichia coli: a sigma 32-independent mechanism of heat-inducible transcription. , 1988, Nucleic acids research.