Fam49/CYRI interacts with Rac1 and locally suppresses protrusions

[1]  R. Insall,et al.  Control of actin dynamics during cell motility , 2019, F1000Research.

[2]  P. Iglesias,et al.  Wave patterns organize cellular protrusions and control cortical dynamics , 2019, Molecular systems biology.

[3]  S. Lilla,et al.  CYRI/ Fam49 Proteins Represent a New Class of Rac1 Interactors , 2019, Communicative & integrative biology.

[4]  R. Grosse,et al.  A Rac1-FMNL2 signaling module affects cell-cell contact formation independent of Cdc42 and membrane protrusions , 2018, PloS one.

[5]  M. Drysdale,et al.  Accepting from the best donor; analysis of long-lifetime donor fluorescent protein pairings to optimise dynamic FLIM-based FRET experiments , 2018, PloS one.

[6]  Hening Lin,et al.  Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies. , 2018, Chemical reviews.

[7]  P. Iglesias,et al.  Excitable Signal Transduction Networks in Directed Cell Migration. , 2017, Annual review of cell and developmental biology.

[8]  T. Walz,et al.  Rac1 GTPase activates the WAVE regulatory complex through two distinct binding sites , 2017 .

[9]  Edward W. Tate,et al.  Dynamic Protein Acylation: New Substrates, Mechanisms, and Drug Targets. , 2017, Trends in biochemical sciences.

[10]  Terry K. Smith,et al.  Molecular basis of fatty acid selectivity in the zDHHC family of S-acyltransferases revealed by click chemistry , 2017, Proceedings of the National Academy of Sciences.

[11]  M. Olson,et al.  A Cell-Permeable Biscyclooctyne As a Novel Probe for the Identification of Protein Sulfenic Acids. , 2016, ACS chemical biology.

[12]  G. Meacci,et al.  α-Actinin links extracellular matrix rigidity-sensing contractile units with periodic cell-edge retractions , 2016, Molecular Biology of the Cell.

[13]  C. Bramham,et al.  Tuning Specific Translation in Cancer Metastasis and Synaptic Memory: Control at the MNK-eIF4E Axis. , 2016, Trends in biochemical sciences.

[14]  R. Insall,et al.  Self-generated chemotactic gradients-cells steering themselves. , 2016, Current opinion in cell biology.

[15]  Jeffrey K. Moore,et al.  Cingulin and actin mediate midbody-dependent apical lumen formation during polarization of epithelial cells , 2016, Nature Communications.

[16]  Luke Tweedy,et al.  Self-Generated Chemoattractant Gradients: Attractant Depletion Extends the Range and Robustness of Chemotaxis , 2016, PLoS biology.

[17]  Jared E. Toettcher,et al.  Gβ Regulates Coupling between Actin Oscillators for Cell Polarity and Directional Migration , 2016, PLoS biology.

[18]  L. Eichinger,et al.  Coronin7 regulates WASP and SCAR through CRIB mediated interaction with Rac proteins , 2015, Scientific Reports.

[19]  S. V. van IJzendoorn,et al.  Mechanisms of apical-basal axis orientation and epithelial lumen positioning. , 2015, Trends in cell biology.

[20]  T. Svitkina,et al.  PICK1 is implicated in organelle motility in an Arp2/3 complex–independent manner , 2015, Molecular biology of the cell.

[21]  M. Dallman,et al.  Multifunctional Reagents for Quantitative Proteome-Wide Analysis of Protein Modification in Human Cells and Dynamic Profiling of Protein Lipidation During Vertebrate Development** , 2015, Angewandte Chemie.

[22]  O. Weiner,et al.  Self-organization of protrusions and polarity during eukaryotic chemotaxis. , 2014, Current opinion in cell biology.

[23]  Gabriela Kalna,et al.  Melanoma Cells Break Down LPA to Establish Local Gradients That Drive Chemotactic Dispersal , 2014, PLoS biology.

[24]  Marco Y. Hein,et al.  A “Proteomic Ruler” for Protein Copy Number and Concentration Estimation without Spike-in Standards* , 2014, Molecular & Cellular Proteomics.

[25]  Alexis Gautreau,et al.  Steering cell migration: lamellipodium dynamics and the regulation of directional persistence , 2014, Nature Reviews Molecular Cell Biology.

[26]  C. Weijer,et al.  SILAC-based proteomic quantification of chemoattractant-induced cytoskeleton dynamics on a second to minute timescale , 2014, Nature Communications.

[27]  Robert D. Finn,et al.  Skylign: a tool for creating informative, interactive logos representing sequence alignments and profile hidden Markov models , 2014, BMC Bioinformatics.

[28]  A. Noegel,et al.  A Cdc42- and Rac-interactive binding (CRIB) domain mediates functions of coronin , 2013, Proceedings of the National Academy of Sciences.

[29]  David A. Scott,et al.  Genome engineering using the CRISPR-Cas9 system , 2013, Nature Protocols.

[30]  Nadine Peyriéras,et al.  Inhibitory signalling to the Arp2/3 complex steers cell migration , 2013, Nature.

[31]  Klemens Rottner,et al.  Rac function is crucial for cell migration but is not required for spreading and focal adhesion formation , 2013, Journal of Cell Science.

[32]  R. Insall The interaction between pseudopods and extracellular signalling during chemotaxis and directed migration. , 2013, Current opinion in cell biology.

[33]  K. Anderson,et al.  β2-syntrophin and Par-3 promote an apicobasal Rac activity gradient at cell-cell junctions by differentially regulating Tiam1 activity , 2012, Nature Cell Biology.

[34]  R. Insall,et al.  SCAR knockouts in Dictyostelium: WASP assumes SCAR’s position and upstream regulators in pseudopods , 2012, The Journal of cell biology.

[35]  Kevin W Eliceiri,et al.  NIH Image to ImageJ: 25 years of image analysis , 2012, Nature Methods.

[36]  O. Sansom,et al.  Activated Mutant NRasQ61K Drives Aberrant Melanocyte Signaling, Survival, and Invasiveness via a Rac1-Dependent Mechanism , 2012, The Journal of investigative dermatology.

[37]  Michael R. Schmidt,et al.  Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex , 2012, Proceedings of the National Academy of Sciences.

[38]  M. Matsuda,et al.  Suppression of Rac1 activity at the apical membrane of MDCK cells is essential for cyst structure maintenance , 2012, EMBO reports.

[39]  M. Kollmar,et al.  Evolution of the eukaryotic ARP2/3 activators of the WASP family: WASP, WAVE, WASH, and WHAMM, and the proposed new family members WAWH and WAML , 2012, BMC Research Notes.

[40]  Thierry Meinnel,et al.  Comparative Large Scale Characterization of Plant versus Mammal Proteins Reveals Similar and Idiosyncratic N-α-Acetylation Features* , 2012, Molecular & Cellular Proteomics.

[41]  I. Jackson,et al.  Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression. , 2011, Developmental cell.

[42]  R. Insall,et al.  Actin-Based Motility: WAVE Regulatory Complex Structure Reopens Old SCARs , 2011, Current Biology.

[43]  Zbyszek Otwinowski,et al.  Structure and Control of the Actin Regulatory WAVE Complex , 2010, Nature.

[44]  Matthew P. Neilson,et al.  Use of the parameterised finite element method to robustly and efficiently evolve the edge of a moving cell. , 2010, Integrative biology : quantitative biosciences from nano to macro.

[45]  R. Insall,et al.  WASP Family Proteins: Their Evolution and Its Physiological Implications , 2010, Molecular biology of the cell.

[46]  D. Sahlender,et al.  Rapid Inactivation of Proteins by Rapamycin-Induced Rerouting to Mitochondria , 2010, Developmental cell.

[47]  Hanno Steen,et al.  Proteome Scale Characterization of Human S-Acylated Proteins in Lipid Raft-enriched and Non-raft Membranes* , 2009, Molecular & Cellular Proteomics.

[48]  Julie A. Theriot,et al.  Intracellular fluid flow in rapidly moving cells , 2009, Nature Cell Biology.

[49]  B. Kuhlman,et al.  A genetically-encoded photoactivatable Rac controls the motility of living cells , 2009, Nature.

[50]  P. V. van Haastert,et al.  A new set of small, extrachromosomal expression vectors for Dictyostelium discoideum. , 2009, Plasmid.

[51]  M. Mann,et al.  MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification , 2008, Nature Biotechnology.

[52]  U. Landegren,et al.  Characterizing proteins and their interactions in cells and tissues using the in situ proximity ligation assay. , 2008, Methods.

[53]  R. Insall,et al.  Chemotaxis in Dictyostelium: how to walk straight using parallel pathways. , 2007, Current opinion in microbiology.

[54]  Natalie Andrew,et al.  Chemotaxis in shallow gradients is mediated independently of PtdIns 3-kinase by biased choices between random protrusions , 2007, Nature Cell Biology.

[55]  F. Vazquez,et al.  Nap1 Regulates Dictyostelium Cell Motility and Adhesion through SCAR-Dependent and -Independent Pathways , 2006, Current Biology.

[56]  S. Gygi,et al.  Hem-1 Complexes Are Essential for Rac Activation, Actin Polymerization, and Myosin Regulation during Neutrophil Chemotaxis , 2006, PLoS biology.

[57]  B Franz Lang,et al.  The tree of eukaryotes. , 2005, Trends in ecology & evolution.

[58]  Yukinori Endo,et al.  A Rac switch regulates random versus directionally persistent cell migration , 2005, The Journal of cell biology.

[59]  Till Bretschneider,et al.  Mobile actin clusters and traveling waves in cells recovering from actin depolymerization. , 2004, Biophysical journal.

[60]  David A. Williams,et al.  Critical Roles for Rac1 and Rac2 GTPases in B Cell Development and Signaling , 2003, Science.

[61]  Alexey I Nesvizhskii,et al.  Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search. , 2002, Analytical chemistry.

[62]  H. Meinhardt Orientation of chemotactic cells and growth cones: models and mechanisms. , 1999, Journal of cell science.

[63]  P. Legrain,et al.  Toward a functional analysis of the yeast genome through exhaustive two-hybrid screens , 1997, Nature Genetics.

[64]  M. G. Vicker,et al.  The locomotion, shape and pseudopodial dynamics of unstimulated Dictyostelium cells are not random. , 1993, Journal of cell science.

[65]  S. Fields,et al.  Elimination of false positives that arise in using the two-hybrid system. , 1993, BioTechniques.

[66]  A. Kuspa,et al.  Tagging developmental genes in Dictyostelium by restriction enzyme-mediated integration of plasmid DNA. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[67]  Anne J. Ridley,et al.  The small GTP-binding protein rac regulates growth factor-induced membrane ruffling , 1992, Cell.

[68]  Zheying Zhang,et al.  SSH3 facilitates colorectal cancer cell invasion and metastasis by affecting signaling cascades involving LIMK1/Rac1. , 2019, American journal of cancer research.

[69]  P. Fey,et al.  One stop shop for everything Dictyostelium: dictyBase and the Dicty Stock Center in 2012. , 2013, Methods in molecular biology.

[70]  M. Sternberg,et al.  Protein structure prediction on the Web: a case study using the Phyre server , 2009, Nature Protocols.

[71]  D. Knecht,et al.  Under-agarose chemotaxis of Dictyostelium discoideum. , 2006, Methods in molecular biology.

[72]  M. Matsuda,et al.  Analysis of the spatiotemporal activation of rho GTPases using Raichu probes. , 2006, Methods in enzymology.

[73]  A. Vojtek,et al.  Ras-Raf interaction: two-hybrid analysis. , 1995, Methods in enzymology.