Autophagy in stromal fibroblasts promotes tumor desmoplasia and mammary tumorigenesis

In this study, Rudnick et al. use mouse mammary cancer models and syngeneic transplantation assays to demonstrate that genetic ablation of stromal fibroblast autophagy significantly impedes fundamental elements of the stromal desmoplastic response, including collagen and proinflammatory cytokine secretion, extracellular matrix stiffening, and neoangiogenesis. Their findings suggest the efficacy of autophagy inhibition is shaped by the ability of host stromal fibroblast autophagy to support tumor desmoplasia.

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