Hyperpolarized 13C,15N2‐Urea MRI for assessment of the urea gradient in the porcine kidney

A decline in cortico‐medullary osmolality gradient of the kidney may serve as an early indicator of pathological disruption of the tubular reabsorption process. The purpose of this study was to investigate the feasibility of hyperpolarized 13C,15N2‐urea MRI as a biomarker of renal function in healthy porcine kidneys resembling the human physiology.

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