The PABA story
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The qualities of para‐aminobenzoic acid (PABA) are discussed and an account is given of how it came to be the favourite sunscreen of the post World War II era. Slowly, however, dermatologists became aware that it was a fairly common sensitizer and that it tended to cross‐sensitize with compounds of similar chemical structure both in contact with the skin and given as systemic drugs. Furthermore, continued exposure to chemicals of this type could lead to autoimmune responses especially systemic lupus erythematosus and dermatomyositis. Discussion of these complications from the use of PABA took place at two meetings of the Dermatological Association of Australia in 1964 and 1965, and played a part in the slow withdrawal of PABA from sunscreens.
[1] C. N. Paul. The Influence of Sunlight in the Production of Cancer of the Skin , 1919, The Indian Medical Gazette.
[2] B. Mackie,et al. SYSTEMIC LUPUS ERYTHEMATOSUS–DERMATOMYOSITIS INDUCED BY SULPHACETAMIDE EYE DROPS * , 1979, The Australasian journal of dermatology.
[3] R. L. Mayer,et al. Experimental sensitization with food dyes and cross-sensitization to paraphenylenediamine. , 1949, The Journal of allergy.
[4] B. Mackie,et al. CROSS‐SENSITIZATION IK DERMATITIS DUE TO HAIR DYES. * , 1964, Australian journal of dermatology.