Distinct enhancers at the Pax3 locus can function redundantly to regulate neural tube and neural crest expressions.

[1]  A. McMahon,et al.  Fate of the mammalian cardiac neural crest. , 2000, Development.

[2]  T. Burstyn-Cohen,et al.  Canonical Wnt activity regulates trunk neural crest delamination linking BMP/noggin signaling with G1/S transition , 2004, Development.

[3]  S. Pruitt Discrete endogenous signals mediate neural competence and induction in P19 embryonal carcinoma stem cells. , 1994, Development.

[4]  B. Wlodarczyk,et al.  Spontaneous neural tube defects in splotch mice supplemented with selected micronutrients. , 2006, Toxicology and applied pharmacology.

[5]  J. T. Kadonaga,et al.  Going the distance: a current view of enhancer action. , 1998, Science.

[6]  Katie A. Burren,et al.  Gene-environment interactions in the causation of neural tube defects: folate deficiency increases susceptibility conferred by loss of Pax3 function. , 2008, Human molecular genetics.

[7]  Ivan Ovcharenko,et al.  rVISTA 2.0: evolutionary analysis of transcription factor binding sites , 2004, Nucleic Acids Res..

[8]  J. Epstein,et al.  Identification of minimal enhancer elements sufficient for Pax3 expression in neural crest and implication of Tead2 as a regulator of Pax3 , 2004, Development.

[9]  Ahmed Mansouri,et al.  Divergent functions of murine Pax3 and Pax7 in limb muscle development. , 2004, Genes & development.

[10]  J A Epstein,et al.  Transgenic rescue of congenital heart disease and spina bifida in Splotch mice. , 1999, Development.

[11]  M. Bronner‐Fraser,et al.  Dynamic alterations in gene expression after Wnt-mediated induction of avian neural crest. , 2005, Molecular biology of the cell.

[12]  Ivan Ovcharenko,et al.  Identifying synonymous regulatory elements in vertebrate genomes , 2005, Nucleic Acids Res..

[13]  K. Stankunas,et al.  Pbx1 functions in distinct regulatory networks to pattern the great arteries and cardiac outflow tract , 2008, Development.

[14]  S. Fisher,et al.  Evaluating the biological relevance of putative enhancers using Tol2 transposon-mediated transgenesis in zebrafish , 2006, Nature Protocols.

[15]  J. Epstein,et al.  Neural crest expression of Cre recombinase directed by the proximal Pax3 promoter in transgenic mice , 2000, Genesis.

[16]  M A Nowak,et al.  Evolutionary preservation of redundant duplicated genes. , 1999, Seminars in cell & developmental biology.

[17]  Chengyu Liu,et al.  Transcription factor TEAD2 is involved in neural tube closure , 2007, Genesis.

[18]  R. Auerbach Analysis of the developmental effects of a lethal mutation in the house mouse , 1954 .

[19]  A. Copp,et al.  Embryonic folate metabolism and mouse neural tube defects. , 1998, Science.

[20]  Rageshree Ramachandran,et al.  Essential and redundant functions of the MyoD distal regulatory region revealed by targeted mutagenesis. , 2002, Developmental biology.

[21]  M. Goulding,et al.  Expression of Pax-3 is initiated in the early neural plate by posteriorizing signals produced by the organizer and by posterior non-axial mesoderm. , 1997, Development.

[22]  A. McMahon,et al.  Analysis of neural crest cell migration in Splotch mice using a neural crest-specific LacZ reporter. , 1997, Developmental biology.

[23]  T. Wolfsberg,et al.  Identification of Neural Crest and Glial Enhancers at the Mouse Sox10 Locus through Transgenesis in Zebrafish , 2008, PLoS genetics.

[24]  D. Goldhamer,et al.  The core enhancer is essential for proper timing of MyoD activation in limb buds and branchial arches. , 2004, Developmental biology.

[25]  T. Natoli,et al.  Positive and negative DNA sequence elements are required to establish the pattern of Pax3 expression. , 1997, Development.

[26]  M. Tassabehji,et al.  Mutations in the PAX3 gene causing Waardenburg syndrome type 1 and type 2 , 1993, Nature Genetics.

[27]  K. Chien,et al.  Normal fate and altered function of the cardiac neural crest cell lineage in retinoic acid receptor mutant embryos , 2002, Mechanisms of Development.

[28]  J. Epstein,et al.  Insertion of Cre into the Pax3 locus creates a new allele of Splotch and identifies unexpected Pax3 derivatives. , 2005, Developmental biology.

[29]  M. Goulding,et al.  Expression of Pax-3 in the lateral neural plate is dependent on a Wnt-mediated signal from posterior nonaxial mesoderm. , 1999, Developmental biology.

[30]  A. Kispert,et al.  Tbx20 is essential for cardiac chamber differentiation and repression of Tbx2 , 2005, Development.

[31]  J. Raes,et al.  Gene duplication, the evolution of novel gene functions, and detecting functional divergence of duplicates in silico. , 2003, Applied bioinformatics.

[32]  D. Raulet,et al.  Redundant and Unique Roles of Two Enhancer Elements in the TCRγ Locus in Gene Regulation and γδ T Cell Development , 2002 .

[33]  J. Epstein,et al.  Identification of a hypaxial somite enhancer element regulating Pax3 expression in migrating myoblasts and characterization of hypaxial muscle Cre transgenic mice , 2005, Genesis.

[34]  T. Natoli,et al.  Hox/Pbx and Brn binding sites mediate Pax3 expression in vitro and in vivo. , 2004, Gene expression patterns : GEP.

[35]  J. Epstein,et al.  PlexinA2 and semaphorin signaling during cardiac neural crest development. , 2001, Development.