Inhibition of the glycogen synthase kinase 3β–hypoxia‐inducible factor 1α pathway alleviates NLRP3‐mediated pyroptosis induced by high glucose in renal tubular epithelial cells

What is the central question of this study? Activation of the glycogen synthase kinase 3 β (GSK‐3β)–hypoxia‐inducible factor 1 α (HIF‐1α) pathway results in stimulation of pyroptosis under high glucose, and exerts actions in a number renal diseases: does this pathway have a role in renal tubular epithelial cells? What is the main finding and its importance? Down‐regulation of GSK‐3β can inhibit pyroptosis of renal tubular epithelial cells induced by high glucose and this may be related to down‐regulation of HIF‐1α. This role of the GSK‐3β–HIF‐1α pathway has not previously been reported and identifies a potential new therapeutic target in diabetic nephropathy.

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