Mood disturbances and regional cerebral metabolic abnormalities in recently abstinent methamphetamine abusers.

BACKGROUND Mood disturbances in methamphetamine (MA) abusers likely influence drug use, but the neurobiological bases for these problems are poorly understood. OBJECTIVE To assess regional brain function and its possible relationships with negative affect in newly abstinent MA abusers. DESIGN Two groups were compared by measures of mood and cerebral glucose metabolism ([18F]fluorodeoxyglucose positron emission tomography) during performance of a vigilance task. SETTING Participants were recruited from the general community to a research center. PARTICIPANTS Seventeen abstaining (4-7 days) MA abusers (6 women) were compared with 18 control subjects (8 women). MAIN OUTCOME MEASURES Self-reports of depressive symptoms and anxiety were measured, as were global and relative glucose metabolism in the orbitofrontal, cingulate, lateral prefrontal, and insular cortices and the amygdala, striatum, and cerebellum. RESULTS Abusers of MA provided higher self-ratings of depression and anxiety than control subjects and differed significantly in relative regional glucose metabolism: lower in the anterior cingulate and insula and higher in the lateral orbitofrontal area, middle and posterior cingulate, amygdala, ventral striatum, and cerebellum. In MA abusers, self-reports of depressive symptoms covaried positively with relative glucose metabolism in limbic regions (eg, perigenual anterior cingulate gyrus and amygdala) and ratings of state and trait anxiety covaried negatively with relative activity in the anterior cingulate cortex and left insula. Trait anxiety also covaried negatively with relative activity in the orbitofrontal cortex and positively with amygdala activity. CONCLUSIONS Abusers of MA have abnormalities in brain regions implicated in mood disorders. Relationships between relative glucose metabolism in limbic and paralimbic regions and self-reports of depression and anxiety in MA abusers suggest that these regions are involved in affective dysregulation and may be an important target of intervention for MA dependence.

[1]  D. Wong,et al.  Brain Dopamine Neurotoxicity in Baboons Treated with Doses of Methamphetamine Comparable to Those Recreationally Abused by Humans: Evidence from [11C]WIN-35,428 Positron Emission Tomography Studies and Direct In Vitro Determinations , 1998, The Journal of Neuroscience.

[2]  C. Spielberger,et al.  Manual for the State-Trait Anxiety Inventory , 1970 .

[3]  J S Fowler,et al.  Low level of brain dopamine D2 receptors in methamphetamine abusers: association with metabolism in the orbitofrontal cortex. , 2001, The American journal of psychiatry.

[4]  Mark S. George,et al.  Regional cerebral metabolism associated with anxiety symptoms in affective disorder patients , 2000, Biological Psychiatry.

[5]  E. Hoffman,et al.  Tomographic measurement of local cerebral glucose metabolic rate in humans with (F‐18)2‐fluoro‐2‐deoxy‐D‐glucose: Validation of method , 1979, Annals of neurology.

[6]  W. Drevets.  Neuroimaging studies of mood disorders , 2000, Biological Psychiatry.

[7]  T L Faber,et al.  Neural activity related to drug craving in cocaine addiction. , 2001, Archives of general psychiatry.

[8]  Karl J. Friston,et al.  Neural responses associated with cue evoked emotional states and heroin in opiate addicts. , 2000, Drug and alcohol dependence.

[9]  L. Seiden,et al.  Long-term effects of chronic methamphetamine administration in rhesus monkeys , 1989, Brain Research.

[10]  J. Grafman,et al.  Dissociating the roles of the rostral anterior cingulate and the lateral prefrontal cortices in performing two tasks simultaneously or successively. , 2003, Cerebral cortex.

[11]  Denckla Mb,et al.  Revised Neurological Examination for Subtle Signs (1985). , 1985 .

[12]  V L Villemagne,et al.  Activation of memory circuits during cue-elicited cocaine craving. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[13]  M. Denckla,et al.  Revised Neurological Examination for Subtle Signs (1985). , 1985, Psychopharmacology bulletin.

[14]  M. Raichle,et al.  Subgenual prefrontal cortex abnormalities in mood disorders , 1997, Nature.

[15]  A. Levey,et al.  Striatal dopamine nerve terminal markers in human, chronic methamphetamine users , 1996, Nature Medicine.

[16]  J. Mazziotta,et al.  Rapid Automated Algorithm for Aligning and Reslicing PET Images , 1992, Journal of computer assisted tomography.

[17]  C. Spielberger.  Manual for the State-Trait Anxiety Inventory (STAI) (Form Y , 1983 .

[18]  W. Drevets.  Functional anatomical abnormalities in limbic and prefrontal cortical structures in major depression. , 2000, Progress in brain research.

[19]  D. Wong,et al.  Reduced Striatal Dopamine Transporter Density in Abstinent Methamphetamine and Methcathinone Users: Evidence from Positron Emission Tomography Studies with [11C]WIN-35,428 , 1998, The Journal of Neuroscience.

[20]  D. Metzger,et al.  The Fifth Edition of the Addiction Severity Index. , 1992, Journal of substance abuse treatment.

[21]  Patrick R. Hof,et al.  Monoaminergic Innervation of Cingulate Cortex , 1993 .

[22]  M. First,et al.  Structured clinical interview for DSM-IV axis II personality disorders : SCID-II , 1997 .

[23]  P. Petrovic,et al.  Placebo and Opioid Analgesia-- Imaging a Shared Neuronal Network , 2002, Science.

[24]  J S Fowler,et al.  Association of methylphenidate-induced craving with changes in right striato-orbitofrontal metabolism in cocaine abusers: implications in addiction. , 1999, The American journal of psychiatry.

[25]  R. Vaughan,et al.  Nature of methamphetamine-induced rapid and reversible changes in dopamine transporters. , 1998, European journal of pharmacology.

[26]  J. Gibb,et al.  Long-term effects of multiple doses of methamphetamine on tryptophan hydroxylase and tyrosine hydroxylase activity in rat brain. , 1980, The Journal of pharmacology and experimental therapeutics.

[27]  S. Haber,et al.  Immunocytochemical localization of the dopamine transporter in human brain , 1999, The Journal of comparative neurology.

[28]  A. Alavi,et al.  The [18F]Fluorodeoxyglucose Method for the Measurement of Local Cerebral Glucose Utilization in Mane , 1979, Circulation research.

[29]  S. Rauch,et al.  Response and Habituation of the Human Amygdala during Visual Processing of Facial Expression , 1996, Neuron.

[30]  L. DeLisi,et al.  Glucose utilization in the temporal cortex of affectively ill patients: Positron emission tomography , 1987, Biological Psychiatry.

[31]  L. Seiden,et al.  α-Methyltyrosine blocks methylamphetamine-induced degeneration in the rat somatosensory cortex , 1986, Brain Research.

[32]  M. Raichle,et al.  A functional anatomical study of unipolar depression , 1992, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[33]  J S Fowler,et al.  Higher cortical and lower subcortical metabolism in detoxified methamphetamine abusers. , 2001, The American journal of psychiatry.

[34]  J S Fowler,et al.  Regional brain metabolic activation during craving elicited by recall of previous drug experiences. , 1999, Life sciences.

[35]  L. Seiden,et al.  Long-term effects of repeated methylamphetamine administration on monoamine neurons in the rhesus monkey brain , 1985, Brain Research.

[36]  P S Goldman-Rakic,et al.  Widespread origin of the primate mesofrontal dopamine system. , 1998, Cerebral cortex.

[37]  A. Alavi,et al.  The Effect of Anxiety on Cortical Cerebral Blood Flow and Metabolism , 1987, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[38]  Karl J. Friston,et al.  Spatial registration and normalization of images , 1995 .

[39]  R. Oades,et al.  Ventral tegmental (A10) system: neurobiology. 1. Anatomy and connectivity , 1987, Brain Research Reviews.

[40]  J. Lorberbaum,et al.  From the Departments Of , 2022 .

[41]  R. Maddock.  The retrosplenial cortex and emotion: new insights from functional neuroimaging of the human brain , 1999, Trends in Neurosciences.

[42]  R L Phillips,et al.  An improved method to calculate cerebral metabolic rates of glucose using PET. , 1995, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[43]  S. Paradiso.  The Emotional Brain: The Mysterious Underpinnings of Emotional Life , 1998 .

[44]  M. Reivich,et al.  Limbic activation during cue-induced cocaine craving. , 1999, The American journal of psychiatry.

[45]  Kleven Ms,et al.  Methamphetamine and related drugs: toxicity and resulting behavioral changes in response to pharmacological probes. , 1989 .

[46]  Steven C.R. Williams,et al.  Time courses of left and right amygdalar responses to fearful facial expressions , 2001, NeuroImage.

[47]  M. Frye,et al.  Effects of mood and subtype on cerebral glucose metabolism in treatment-resistant bipolar disorder , 2001, Biological Psychiatry.

[48]  E. Stein,et al.  Cue-induced cocaine craving: neuroanatomical specificity for drug users and drug stimuli. , 2000, The American journal of psychiatry.

[49]  H. Mayberg.  Depression, II: localization of pathophysiology. , 2002, The American journal of psychiatry.

[50]  J S Fowler,et al.  Association of dopamine transporter reduction with psychomotor impairment in methamphetamine abusers. , 2001, The American journal of psychiatry.

[51]  Alan C. Evans,et al.  Functional neuroanatomy of CCK4-induced anxiety in normal healthy volunteers. , 1995, The American journal of psychiatry.

[52]  S. Hyman,et al.  Acute Effects of Cocaine on Human Brain Activity and Emotion , 1997, Neuron.

[53]  J C Gore,et al.  Functional magnetic resonance imaging of cocaine craving. , 2001, The American journal of psychiatry.

[54]  M. Brecht,et al.  Predictors of Relapse After Treatment for Methamphetamine Use , 2000, Journal of psychoactive drugs.

[55]  P. Fox,et al.  Differential limbic–cortical correlates of sadness and anxiety in healthy subjects: implications for affective disorders , 2000, Biological Psychiatry.

[56]  J. Gibb,et al.  Influence of methamphetamine on nigral and striatal tyrosine hydroxylase activity and on striatal dopamine levels. , 1976, European journal of pharmacology.

[57]  L. Seiden,et al.  Long-term effects of repeated methylamphetamine administration on dopamine and serotonin neurons in the rat brain: A regional study , 1980, Brain Research.

[58]  J. Sawusch,et al.  Covert Auditory Attention Generates Activation in the Rostral/Dorsal Anterior Cingulate Cortex , 2002, Journal of Cognitive Neuroscience.

[59]  Karl J. Friston,et al.  Statistical parametric maps in functional imaging: A general linear approach , 1994 .

[60]  E. Hoffman,et al.  TOMOGRAPHIC MEASUREMENT OF LOCAL CEREBRAL GLUCOSE METABOLIC RATE IN HUMANS WITH (F‐18)2‐FLUORO-2‐DEOXY-D‐GLUCOSE: VALIDATION OF METHOD , 1980, Annals of neurology.

[61]  S. Tsai,et al.  Effects of Repeated High-Dose Methamphetamine on Local Cerebral Glucose Utilization in Rats , 1999, Neuropsychopharmacology.

[62]  A L Malizia,et al.  Changes in regional cerebral blood flow elicited by craving memories in abstinent opiate-dependent subjects. , 2001, The American journal of psychiatry.

[63]  M. Fredrikson,et al.  Cerebral blood flow during anxiety provocation. , 1997, The Journal of clinical psychiatry.

[64]  Linda Chang,et al.  Evidence for long-term neurotoxicity associated with methamphetamine abuse , 2000, Neurology.

[65]  P F Renshaw,et al.  Functional magnetic resonance imaging of human brain activation during cue-induced cocaine craving. , 1998, The American journal of psychiatry.

[66]  J. Pardo,et al.  Brain activity in ventromedial prefrontal cortex correlates with individual differences in negative affect , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[67]  E. Hoffman,et al.  Noninvasive determination of local cerebral metabolic rate of glucose in man. , 1980, The American journal of physiology.

[68]  Karl J. Friston,et al.  Regional cerebral blood flow in depression measured by positron emission tomography: the relationship with clinical dimensions , 1993, Psychological Medicine.

[69]  Matthew L. Ho,et al.  Brain metabolic changes during cigarette craving. , 2002, Archives of general psychiatry.

[70]  J. Metcalfe,et al.  Neural Systems and Cue-Induced Cocaine Craving , 2002, Neuropsychopharmacology.

[71]  Jan-Ray Liao,et al.  Neuronal Specificity of Acupuncture Response: A fMRI Study with Electroacupuncture , 2002, NeuroImage.