Plasma noradrenaline correlates to sympathetic muscle nerve activity in normotensive man.

Recordings of multiunit sympathetic activity were made in muscle branches of the peroneal nerve in 22 healthy subjects at rest in recumbent position. Nerve activity was quantitated in terms of burst incidence (number of pulse synchronous sympathetic bursts per 100 heart beats or per min). In a separate session, 4-45 months later, blood was drawn from an antecubital vein for noradrenaline analysis. Both sympathetic activity and plasma concentrations of noradrenaline varied widely between subjects and both parameters increased with age. There was a significant positive correlation between a subject's level of sympathetic activity and his plasma concentration of noradrenaline. It is suggested that overflow of transmitter from sympathetic terminals in muscles contributes significantly to plasma levels of noradrenaline at rest.

[1]  A. Vendsalu.  Studies on adrenaline and noradrenaline in human plasma. , 1960, Acta physiologica Scandinavica. Supplementum.

[2]  B. Wallin,et al.  A Quantitative Study of Muscle Nerve Sympathetic Activity in Resting Normotensive and Hypertensive Subjects , 1979, Hypertension.

[3]  I. Kopin,et al.  Age-adjusted plasma norepinephrine levels are similar in normotensive and hypertensive subjects. , 1977, The New England journal of medicine.

[4]  P. Harper,et al.  PRENATAL PREDICTION OF MYOTONIC DYSTROPHY , 1976, The Lancet.

[5]  Wallin Bg.  Recordings of impulses in unmyelinated nerve fibres in man: sympathetic activity. , 1978 .

[6]  D. Johnson,et al.  A sensitive radioenzymatic assay for norepinephrine in tissues and plasma. , 1975, Life sciences.

[7]  V. Dequattro,et al.  Raised plasma-catecholamines in some patients with primary hypertension. , 1972, Lancet.

[8]  P. Manhem,et al.  Plasma catecholamine levels in the coronary sinus, the left renal vein and peripheral vessels in healthy males at rest and during exercise. , 1978, Acta physiologica Scandinavica.

[9]  N. Christensen,et al.  Catecholamines in plasma and urine in patients with essential hypertension determined by double-isotope derivative techniques. , 2009, Acta medica Scandinavica.

[10]  P. Sever,et al.  PLASMA-NORADRENALINE IN ESSENTIAL HYPERTENSION , 1977, The Lancet.

[11]  I. Kopin,et al.  Use of plasma norepinephrine for evaluation of sympathetic neuronal function in man. , 1976, Life sciences.

[12]  J. de Champlain,et al.  Circulating Catecholamine Levels in Human and Experimental Hypertension , 1976, Circulation research.

[13]  J. Peuler,et al.  Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamine. , 1977, Life sciences.

[14]  H. Thoenen,et al.  Relation between the rate of stimulation and the quantity of noradrenaline liberated from sympathetic nerve endings in the isolated perfused spleen of the cat. , 1965, The Journal of physiology.

[15]  B. Wallin,et al.  The variability of muscle nerve sympathetic activity in resting recumbent man , 1977, The Journal of physiology.

[16]  H. Irisawa,et al.  Sympathetic nerve activity to the spleen, kidney, and heart in response to baroceptor input. , 1971, The American journal of physiology.

[17]  B. Wallin,et al.  Human muscle nerve sympathetic activity at rest. Relationship to blood pressure and age , 1978, The Journal of physiology.

[18]  I. Kopin,et al.  Plasma noradrenaline increases with age , 1976, Nature.

[19]  J. Leblanc,et al.  Plasma catecholamines and cardiovascular responses to cold and mental activity. , 1979, Journal of applied physiology: respiratory, environmental and exercise physiology.

[20]  U. S. Euler.  Sympatho-Adrenal Activity and Physical Exercise , 1974 .

[21]  R. Nadeau,et al.  Correlation between the Response of the Heart to Sympathetic Stimulation and the Release of Endogenous Catecholamines into the Coronary Sinus of the Dog , 1975, Circulation research.