Synthesis of novel 9-O-N-aryl/aryl-alkyl amino carbonyl methyl substituted berberine analogs and evaluation of DNA binding aspects.

[1]  Jin-Yuarn Lin,et al.  Protective effect of isoquinoline alkaloid berberine on spontaneous inflammation in the spleen, liver and kidney of non-obese diabetic mice through downregulating gene expression ratios of pro-/anti-inflammatory and Th1/Th2 cytokines , 2012 .

[2]  Xiao-Ling Li,et al.  Molecular spectroscopy evidence of berberine binding to DNA: comparative binding and thermodynamic profile of intercalation. , 2012, Biomacromolecules.

[3]  G. S. Kumar,et al.  Biophysical studies on the effect of the 13 position substitution of the anticancer alkaloid berberine on its DNA binding. , 2012, The journal of physical chemistry. B.

[4]  M. Ferraroni,et al.  X-Ray diffraction analyses of the natural isoquinoline alkaloids Berberine and Sanguinarine complexed with double helix DNA d(CGTACG). , 2011, Chemical communications.

[5]  G. S. Kumar,et al.  Interaction of berberine, palmatine, coralyne, and sanguinarine to quadruplex DNA: a comparative spectroscopic and calorimetric study. , 2011, Biochimica et biophysica acta.

[6]  G. S. Kumar,et al.  Enhanced DNA binding of 9-ω-amino alkyl ether analogs from the plant alkaloid berberine. , 2011, DNA and cell biology.

[7]  G. S. Kumar,et al.  Thermodynamic profiles of the DNA binding of benzophenanthridines sanguinarine and ethidium: A comparative study with sequence specific polynucleotides , 2010 .

[8]  G. S. Kumar,et al.  Binding of the anticancer alkaloid sanguinarine to double stranded RNAs: insights into the structural and energetics aspects. , 2010, Molecular bioSystems.

[9]  S. Tsao,et al.  Berberine and Coptidis rhizoma as novel antineoplastic agents: a review of traditional use and biomedical investigations. , 2009, Journal of ethnopharmacology.

[10]  Maidul Hossain,et al.  DNA intercalation of methylene blue and quinacrine: new insights into base and sequence specificity from structural and thermodynamic studies with polynucleotides. , 2009, Molecular bioSystems.

[11]  Xiuping Chen,et al.  A systematic review of the anticancer properties of berberine, a natural product from Chinese herbs , 2009, Anti-cancer drugs.

[12]  G. S. Kumar,et al.  Interaction of isoquinoline alkaloids with an RNA triplex: structural and thermodynamic studies of berberine, palmatine, and coralyne binding to poly(U).poly(A)(*)poly(U). , 2009, The journal of physical chemistry. B.

[13]  K. Bhadra,et al.  Interaction of Isoquinoline Alkaloids with Polymorphic DNA Structures , 2009, Chemistry & biodiversity.

[14]  G. S. Kumar,et al.  DNA binding of benzophenanthridine compounds sanguinarine versus ethidium: Comparative binding and thermodynamic profile of intercalation , 2009 .

[15]  J. Hong,et al.  Berberine inhibits p53-dependent cell growth through induction of apoptosis of prostate cancer cells. , 2009, International journal of oncology.

[16]  Su Min Park,et al.  Induction of apoptosis in human leukemia U937 cells by anthocyanins through down-regulation of Bcl-2 and activation of caspases. , 2009, International journal of oncology.

[17]  J. Reymond,et al.  On-bead cyclization in a combinatorial library of 15,625 octapeptides. , 2009, Bioorganic & medicinal chemistry.

[18]  G. S. Kumar,et al.  Spectroscopic and calorimetric studies on the binding of alkaloids berberine, palmatine and coralyne to double stranded RNA polynucleotides. , 2009, The journal of physical chemistry. B.

[19]  G. S. Kumar,et al.  DNA-binding cytotoxic alkaloids: comparative study of the energetics of binding of berberine, palmatine, and coralyne. , 2008, DNA and cell biology.

[20]  K. Bhadra,et al.  Berberine-DNA complexation: new insights into the cooperative binding and energetic aspects. , 2008, Biochimica et biophysica acta.

[21]  Jin-Qiang Hou,et al.  9-N-Substituted berberine derivatives: stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc. , 2008, Bioorganic & medicinal chemistry.

[22]  S. Maiti,et al.  Binding of berberine to human telomeric quadruplex – spectroscopic, calorimetric and molecular modeling studies , 2008, The FEBS journal.

[23]  H. Hosseinzadeh,et al.  Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine , 2008, Phytotherapy research : PTR.

[24]  S. Kulkarni,et al.  On the mechanism of antidepressant-like action of berberine chloride. , 2008, European journal of pharmacology.

[25]  G. S. Kumar,et al.  Self-structure induction in single stranded poly(A) by small molecules: Studies on DNA intercalators, partial intercalators and groove binding molecules. , 2008, Archives of biochemistry and biophysics.

[26]  C. Jin,et al.  Antimicrobial properties of berberines alkaloids in Coptis chinensis Franch by microcalorimetry. , 2008, Journal of biochemical and biophysical methods.

[27]  G. S. Kumar,et al.  Binding of protoberberine alkaloid coralyne with double stranded poly(A): a biophysical study. , 2008, Molecular bioSystems.

[28]  G. S. Kumar,et al.  Thermodynamics of the binding of cytotoxic protoberberine molecule coralyne to deoxyribonucleic acids. , 2008, Biochimica et biophysica acta.

[29]  G. S. Kumar,et al.  Molecular aspects on the interaction of protoberberine, benzophenanthridine, and aristolochia group of alkaloids with nucleic acid structures and biological perspectives , 2007, Medicinal research reviews.

[30]  Ying-Chih Lin,et al.  Berberine produces antidepressant-like effects in the forced swim test and in the tail suspension test in mice. , 2007, Life sciences.

[31]  G. S. Kumar,et al.  Molecular recognition of DNA by small molecules: AT base pair specific intercalative binding of cytotoxic plant alkaloid palmatine. , 2007, Biochimica et biophysica acta.

[32]  L. Cronin,et al.  Microcalorimetry of interaction of dihydro-imidazo-phenanthridinium (DIP)-based compounds with duplex DNA. , 2007, Biophysical chemistry.

[33]  Zhi-Hong Jiang,et al.  Amplification of DNA-binding affinities of protoberberine alkaloids by appended polyamines. , 2007, Bioorganic & medicinal chemistry letters.

[34]  A. Shirwaikar,et al.  In vitro antioxidant studies on the benzyl tetra isoquinoline alkaloid berberine. , 2006, Biological & pharmaceutical bulletin.

[35]  J. Chaires,et al.  A thermodynamic signature for drug-DNA binding mode. , 2006, Archives of biochemistry and biophysics.

[36]  L. Cipak,et al.  Berberine-antiproliferative activity in vitro and induction of apoptosis/necrosis of the U937 and B16 cells. , 2006, Cancer letters.

[37]  S. Neidle,et al.  Natural and synthetic G-quadruplex interactive berberine derivatives. , 2006, Bioorganic & medicinal chemistry letters.

[38]  G. S. Kumar,et al.  The binding of DNA intercalating and non-intercalating compounds to A-form and protonated form of poly(rC).poly(rG): spectroscopic and viscometric study. , 2006, Bioorganic & medicinal chemistry.

[39]  Wen-Hua Chen,et al.  Synthesis and DNA-binding affinities of monomodified berberines. , 2005, Bioorganic & medicinal chemistry.

[40]  Z. Cai,et al.  Synthesis of linked berberine dimers and their remarkably enhanced DNA-binding affinities. , 2005, Bioorganic & medicinal chemistry letters.

[41]  L. A. Jacobson,et al.  Structural and thermodynamic strategies for site-specific DNA binding proteins. , 2000, Structure.

[42]  K. Bastow,et al.  The 9-position in berberine analogs is an important determinant of DNA topoisomerase II inhibition. , 2000, Anti-cancer drug design.

[43]  J. Chaires,et al.  Energetics of DNA intercalation reactions. , 2000, Biochemistry.

[44]  A. R. Srinivasan,et al.  Human topoisomerase I poisoning by protoberberines: potential roles for both drug-DNA and drug-enzyme interactions. , 2000, Biochemistry.

[45]  F. Murphy,et al.  Nonsequence-specific DNA recognition: a structural perspective. , 2000, Structure.

[46]  A. Gilani,et al.  Studies on preventive and curative effects of berberine on chemical-induced hepatotoxicity in rodents. , 2000, Fitoterapia.

[47]  B. Tomlinson,et al.  The Antihypertensive Effect of the Berberine Derivative 6-Protoberberine in Spontaneously Hypertensive Rats , 1999, Pharmacology.

[48]  A. R. Srinivasan,et al.  Minor groove-directed and intercalative ligand-DNA interactions in the poisoning of human DNA topoisomerase I by protoberberine analogs. , 1997, Biochemistry.

[49]  G. Kelly,et al.  Berberine: Therapeutic Potential of an Alkaloid Found in Several Medicinal Plants , 1997 .

[50]  David J Brayden,et al.  Non-antibiotic anti-diarrhoeal drugs: factors affecting oral bioavailability of berberine and loperamide in intestinal tissue , 1997 .

[51]  Rosenblum Ml,et al.  Laboratory studies of berberine used alone and in combination with 1,3-bis(2-chloroethyl)-1-nitrosourea to treat malignant brain tumors. , 1990 .

[52]  D. Crothers,et al.  Studies on interaction of anthracycline antibiotics and deoxyribonucleic acid: equilibrium binding studies on interaction of daunomycin with deoxyribonucleic acid. , 1982, Biochemistry.

[53]  K. Chaudhuri,et al.  Sanguinarine: a monofunctional intercalating alkaloid , 1982, FEBS letters.

[54]  T. Lohman,et al.  Thermodynamic analysis of ion effects on the binding and conformational equilibria of proteins and nucleic acids: the roles of ion association or release, screening, and ion effects on water activity , 1978, Quarterly Reviews of Biophysics.

[55]  P. V. von Hippel,et al.  Theoretical aspects of DNA-protein interactions: co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice. , 1974, Journal of molecular biology.

[56]  L. Lerman,et al.  Structural considerations in the interaction of DNA and acridines. , 1961, Journal of molecular biology.

[57]  G. S. Kumar,et al.  Protoberberine Alkaloids: Physicochemical and Nucleic Acid Binding Properties , 2007 .

[58]  Lenka Gryčová,et al.  Quaternary protoberberine alkaloids. , 2007, Phytochemistry.

[59]  Hye-Sook Kim,et al.  Antimalarial activity and structure-activity relationships of protoberberine alkaloids , 1998 .

[60]  C. Y. Huang Determination of binding stoichiometry by the continuous variation method: the Job plot. , 1982, Methods in enzymology.