Skeletal muscle wasting in cachexia and sarcopenia: molecular pathophysiology and impact of exercise training

[1]  S. Anker,et al.  Inhibition of xanthine oxidase reduces wasting and improves outcome in a rat model of cancer cachexia , 2012, International journal of cancer.

[2]  R. Belardinelli,et al.  10-year exercise training in chronic heart failure: a randomized controlled trial. , 2012, Journal of the American College of Cardiology.

[3]  H. Inui,et al.  The preventive effect of β-carotene on denervation-induced soleus muscle atrophy in mice , 2012, British Journal of Nutrition.

[4]  U. Wisløff,et al.  Exercise Training Prevents Oxidative Stress and Ubiquitin-Proteasome System Overactivity and Reverse Skeletal Muscle Atrophy in Heart Failure , 2012, PloS one.

[5]  StephanGielen,et al.  Exercise Training Attenuates MuRF-1 Expression in the Skeletal Muscle of Patients With Chronic Heart Failure Independent of Age , 2012 .

[6]  Louise Dyson,et al.  Age‐Related Changes in Speed and Mechanism of Adult Skeletal Muscle Stem Cell Migration , 2012, Stem cells.

[7]  G. Schuler,et al.  Exercise training leads to a reduction of elevated myostatin levels in patients with chronic heart failure , 2012, European journal of preventive cardiology.

[8]  R. Auchus,et al.  Low testosterone levels and increased inflammatory markers in patients with cancer and relationship with cachexia. , 2012, The Journal of clinical endocrinology and metabolism.

[9]  K. Smith,et al.  Muscle protein synthesis in response to nutrition and exercise , 2012, The Journal of physiology.

[10]  M. LeWinter,et al.  Resistance training alters skeletal muscle structure and function in human heart failure: effects at the tissue, cellular and molecular levels , 2012, The Journal of physiology.

[11]  R. Cencic,et al.  Targeting protein synthesis in a Myc/mTOR-driven model of anorexia-cachexia syndrome delays its onset and prolongs survival. , 2012, Cancer research.

[12]  R. Bernabei,et al.  Effects of treadmill exercise and training frequency on anabolic signaling pathways in the skeletal muscle of aged rats , 2012, Experimental Gerontology.

[13]  J. Baynes,et al.  The effect of exercise on IL-6-induced cachexia in the ApcMin/+ mouse , 2011, Journal of cachexia, sarcopenia and muscle.

[14]  Melissa M. Thomas,et al.  Alterations in intrinsic mitochondrial function with aging are fiber type‐specific and do not explain differential atrophy between muscles , 2011, Aging cell.

[15]  S. Powers,et al.  Exercise protects against doxorubicin-induced markers of autophagy signaling in skeletal muscle. , 2011, Journal of applied physiology.

[16]  M. LeWinter,et al.  Chronic heart failure reduces Akt phosphorylation in human skeletal muscle: relationship to muscle size and function. , 2011, Journal of applied physiology.

[17]  M. Tarnopolsky,et al.  Resistance exercise enhances mTOR and MAPK signalling in human muscle over that seen at rest after bolus protein ingestion , 2011, Acta physiologica.

[18]  J. Shrager,et al.  Increased proteolysis, myosin depletion, and atrophic AKT-FOXO signaling in human diaphragm disuse. , 2011, American journal of respiratory and critical care medicine.

[19]  A. Musarò,et al.  Impact of ageing on muscle cell regeneration , 2011, Ageing Research Reviews.

[20]  T. Ikizler Exercise as an anabolic intervention in patients with end-stage renal disease. , 2011, Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation.

[21]  N. Perrimon,et al.  FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging , 2010, Cell.

[22]  L. Kaminsky,et al.  Molecular adaptations to aerobic exercise training in skeletal muscle of older women. , 2010, The journals of gerontology. Series A, Biological sciences and medical sciences.

[23]  A. Goldberg,et al.  Muscle Wasting in Aged, Sarcopenic Rats Is Associated with Enhanced Activity of the Ubiquitin Proteasome Pathway* , 2010, The Journal of Biological Chemistry.

[24]  Volker Adams,et al.  Cardiovascular Effects of Exercise Training: Molecular Mechanisms , 2010, Circulation.

[25]  A. Kavazis,et al.  Nitric oxide and AMPK cooperatively regulate PGC‐1α in skeletal muscle cells , 2010, The Journal of physiology.

[26]  S. Anker,et al.  Ethical guidelines for authorship and publishing in the Journal of Cachexia, Sarcopenia and Muscle , 2010, Journal of cachexia, sarcopenia and muscle.

[27]  D. Lacey,et al.  Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival , 2010, Cell.

[28]  M. Sheffield-Moore,et al.  Pharmacological Vasodilation Improves Insulin-Stimulated Muscle Protein Anabolism but Not Glucose Utilization in Older Adults , 2010, Diabetes.

[29]  S. Zakynthinos,et al.  Effect of pulmonary rehabilitation on muscle remodelling in cachectic patients with COPD , 2010, European Respiratory Journal.

[30]  Lisa Staunton,et al.  DIGE analysis of rat skeletal muscle proteins using nonionic detergent phase extraction of young adult versus aged gastrocnemius tissue. , 2010, Journal of proteomics.

[31]  I. Papet,et al.  Presence of low-grade inflammation impaired postprandial stimulation of muscle protein synthesis in old rats. , 2010, The Journal of nutritional biochemistry.

[32]  W. Evans,et al.  Skeletal muscle loss: cachexia, sarcopenia, and inactivity. , 2010, The American journal of clinical nutrition.

[33]  J. Feehally,et al.  Physical Exercise in Patients with Severe Kidney Disease , 2010, Nephron Clinical Practice.

[34]  J. Franconi,et al.  Alteration of mitochondrial oxidative phosphorylation in aged skeletal muscle involves modification of adenine nucleotide translocator. , 2010, Biochimica et biophysica acta.

[35]  C. Leeuwenburgh,et al.  Skeletal muscle autophagy and apoptosis during aging: Effects of calorie restriction and life-long exercise , 2010, Experimental Gerontology.

[36]  S. Welle,et al.  Genetic Deletion of Myostatin From the Heart Prevents Skeletal Muscle Atrophy in Heart Failure , 2010, Circulation.

[37]  T. Zimmers,et al.  Acute inhibition of myostatin-family proteins preserves skeletal muscle in mouse models of cancer cachexia. , 2010, Biochemical and biophysical research communications.

[38]  G. Cossu,et al.  Repairing skeletal muscle: regenerative potential of skeletal muscle stem cells. , 2010, The Journal of clinical investigation.

[39]  S. M. Senf,et al.  Ros‐mediated activation of NF‐κB and Foxo during muscle disuse , 2010, Muscle & nerve.

[40]  M. Sampaolesi,et al.  Cellular mechanisms and local progenitor activation to regulate skeletal muscle mass , 2009, Journal of Muscle Research and Cell Motility.

[41]  Judy E. Anderson,et al.  Satellite cells are increasingly refractory to activation by nitric oxide and stretch in aged mouse-muscle cultures. , 2010, The international journal of biochemistry & cell biology.

[42]  D. Metzger,et al.  Autophagy is required to maintain muscle mass. , 2009, Cell metabolism.

[43]  B. Spiegelman,et al.  Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during aging , 2009, Proceedings of the National Academy of Sciences.

[44]  S. Rubin,et al.  Higher inflammatory marker levels in older persons: associations with 5-year change in muscle mass and muscle strength. , 2009, The journals of gerontology. Series A, Biological sciences and medical sciences.

[45]  I. Rieu,et al.  Reduction of low grade inflammation restores blunting of postprandial muscle anabolism and limits sarcopenia in old rats , 2009, The Journal of physiology.

[46]  W. Mitch,et al.  Exercise ameliorates chronic kidney disease-induced defects in muscle protein metabolism and progenitor cell function. , 2009, Kidney international.

[47]  R. S. Hikida,et al.  No change in skeletal muscle satellite cells in young and aging rat soleus muscle , 2009, The Journal of Physiological Sciences.

[48]  P. Costelli,et al.  Deacetylase inhibitors modulate the myostatin/follistatin axis without improving cachexia in tumor-bearing mice. , 2009, Current cancer drug targets.

[49]  C. Däpp,et al.  Different response to eccentric and concentric training in older men and women , 2009, European Journal of Applied Physiology.

[50]  E. Dupont-Versteegden,et al.  Age-related changes of cell death pathways in rat extraocular muscle , 2009, Experimental Gerontology.

[51]  A. Musarò,et al.  Localized accumulation of oxidative stress causes muscle atrophy through activation of an autophagic pathway , 2009, Autophagy.

[52]  D. Slivka,et al.  Improvements in whole muscle and myocellular function are limited with high-intensity resistance training in octogenarian women. , 2009, Journal of applied physiology.

[53]  G. Schuler,et al.  Impact of exercise training on myostatin expression in the myocardium and skeletal muscle in a chronic heart failure model , 2009, European journal of heart failure.

[54]  M. Tisdale Mechanisms of cancer cachexia. , 2009, Physiological reviews.

[55]  Yan Wang,et al.  Apoptotic signaling induced by H2O2-mediated oxidative stress in differentiated C2C12 myotubes. , 2009, Life sciences.

[56]  F. Westwood,et al.  Blunted Akt/FOXO signalling and activation of genes controlling atrophy and fuel use in statin myopathy , 2009, The Journal of physiology.

[57]  D. Taillandier,et al.  Skeletal muscle proteolysis in aging , 2009, Current opinion in clinical nutrition and metabolic care.

[58]  W. Scott,et al.  Sarcopenia ‐ Mechanisms and Treatments , 2009, Journal of geriatric physical therapy.

[59]  G. Schuler,et al.  Induction of MuRF1 is essential for TNF-alpha-induced loss of muscle function in mice. , 2008, Journal of molecular biology.

[60]  P. Ponikowski,et al.  Cachexia: a new definition. , 2008, Clinical nutrition.

[61]  T. Griffin,et al.  Quantitative proteomic profiling of muscle type-dependent and age-dependent protein carbonylation in rat skeletal muscle mitochondria. , 2008, The journals of gerontology. Series A, Biological sciences and medical sciences.

[62]  H. Chung,et al.  Age-related activation of mitochondrial caspase-independent apoptotic signaling in rat gastrocnemius muscle , 2008, Mechanisms of Ageing and Development.

[63]  A. Garnier,et al.  Transcriptional control of mitochondrial biogenesis: the central role of PGC-1alpha. , 2008, Cardiovascular research.

[64]  D. Slivka,et al.  Single muscle fiber adaptations to resistance training in old (>80 yr) men: evidence for limited skeletal muscle plasticity. , 2008, American journal of physiology. Regulatory, integrative and comparative physiology.

[65]  R. Newton,et al.  Endocrine and immune responses to resistance training in prostate cancer patients , 2008, Prostate Cancer and Prostatic Diseases.

[66]  P. Costelli,et al.  Proteasome activities in the rectus abdominis muscle of young and older individuals , 2008, Biogerontology.

[67]  A. Russell,et al.  Human sarcopenia reveals an increase in SOCS-3 and myostatin and a reduced efficiency of Akt phosphorylation. , 2008, Rejuvenation research.

[68]  Keir J. Menzies,et al.  Mitochondrial function and apoptotic susceptibility in aging skeletal muscle , 2008, Aging cell.

[69]  C. Peterson,et al.  Aging alters gene expression of growth and remodeling factors in human skeletal muscle both at rest and in response to acute resistance exercise. , 2008, Physiological genomics.

[70]  Nicholas Ling,et al.  Myostatin signals through Pax7 to regulate satellite cell self-renewal. , 2008, Experimental cell research.

[71]  F. López‐Soriano,et al.  Apoptosis signalling is essential and precedes protein degradation in wasting skeletal muscle during catabolic conditions. , 2008, The international journal of biochemistry & cell biology.

[72]  A. Goldberg,et al.  FoxO3 controls autophagy in skeletal muscle in vivo. , 2007, Cell metabolism.

[73]  D. Slivka,et al.  Proteolytic gene expression differs at rest and after resistance exercise between young and old women. , 2007, The journals of gerontology. Series A, Biological sciences and medical sciences.

[74]  P. Tien,et al.  Effect of RNA oligonucleotide targeting Foxo-1 on muscle growth in normal and cancer cachexia mice , 2007, Cancer Gene Therapy.

[75]  L. Combaret,et al.  Involvement of the calcium-dependent proteolytic system in skeletal muscle aging , 2007, Experimental Gerontology.

[76]  G. McConell,et al.  NOS isoform‐specific regulation of basal but not exercise‐induced mitochondrial biogenesis in mouse skeletal muscle , 2007, The Journal of physiology.

[77]  P. Pelicci,et al.  p66ShcA and Oxidative Stress Modulate Myogenic Differentiation and Skeletal Muscle Regeneration after Hind Limb Ischemia* , 2007, Journal of Biological Chemistry.

[78]  F. López‐Soriano,et al.  Apoptosis is present in skeletal muscle of cachectic gastro-intestinal cancer patients. , 2007, Clinical nutrition.

[79]  C. Friedenreich,et al.  Effects of aerobic and resistance exercise in breast cancer patients receiving adjuvant chemotherapy: a multicenter randomized controlled trial. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[80]  M. Tisdale,et al.  Effect of branched-chain amino acids on muscle atrophy in cancer cachexia. , 2007, The Biochemical journal.

[81]  T. Abe,et al.  Blood flow restriction during low-intensity resistance exercise increases S6K1 phosphorylation and muscle protein synthesis. , 2007, Journal of applied physiology.

[82]  M. Delp,et al.  Aging Reduces Skeletal Blood Flow, Endothelium‐Dependent Vasodilation, and NO Bioavailability in Rats , 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[83]  K. Ohlendieck,et al.  Proteomic profiling reveals a severely perturbed protein expression pattern in aged skeletal muscle. , 2007, International journal of molecular medicine.

[84]  A. Laviano,et al.  Oxidative stress and wasting in cancer , 2007, Current opinion in clinical nutrition and metabolic care.

[85]  L. Ferrucci,et al.  Oxidative protein damage is associated with poor grip strength among older women living in the community , 2007, Journal of applied physiology.

[86]  D. Ferrington,et al.  Myosin and actin expression and oxidation in aging muscle , 2006, Experimental Gerontology.

[87]  U. Wisløff,et al.  Myocardial expression of Murf-1 and MAFbx after induction of chronic heart failure: Effect on myocardial contractility. , 2007, Cardiovascular research.

[88]  G. McConell,et al.  Effect of nitric oxide synthase inhibition on mitochondrial biogenesis in rat skeletal muscle. , 2007, Journal of applied physiology.

[89]  Kazunori Nosaka,et al.  Resistance training and reduction of treatment side effects in prostate cancer patients. , 2006, Medicine and science in sports and exercise.

[90]  Jiandie D. Lin,et al.  PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription , 2006, Proceedings of the National Academy of Sciences.

[91]  Anne-Sophie Coldefy,et al.  Atrophy-related ubiquitin ligases, atrogin-1 and MuRF1 are up-regulated in aged rat Tibialis Anterior muscle , 2006, Mechanisms of Ageing and Development.

[92]  J. Viña,et al.  Exercise-induced systemic effects in muscle-wasted patients with COPD. , 2006, Medicine and science in sports and exercise.

[93]  S. Salamat,et al.  Mitochondrial DNA-deletion mutations accumulate intracellularly to detrimental levels in aged human skeletal muscle fibers. , 2006, American journal of human genetics.

[94]  E. Barreiro,et al.  Aging, sex differences, and oxidative stress in human respiratory and limb muscles. , 2006, Free radical biology & medicine.

[95]  E. Blough,et al.  Sarcopenia-related apoptosis is regulated differently in fast- and slow-twitch muscles of the aging F344/N×BN rat model , 2006, Mechanisms of Ageing and Development.

[96]  D. Ferrington,et al.  Protein nitration with aging in the rat semimembranosus and soleus muscles. , 2006, The journals of gerontology. Series A, Biological sciences and medical sciences.

[97]  Martin Hägglund,et al.  Atrogin-1/MAFbx and MuRF1 are downregulated in aging-related loss of skeletal muscle. , 2006, The journals of gerontology. Series A, Biological sciences and medical sciences.

[98]  M. Marcelli,et al.  Hypogonadism in male patients with cancer , 2006, Cancer.

[99]  E. Olson,et al.  Signaling pathways in skeletal muscle remodeling. , 2006, Annual review of biochemistry.

[100]  Charlotte A. Collins,et al.  Satellite cell self-renewal. , 2006, Current opinion in pharmacology.

[101]  M. Muscaritoli,et al.  IGF-1 is downregulated in experimental cancer cachexia. , 2006, American journal of physiology. Regulatory, integrative and comparative physiology.

[102]  R. Wolfe,et al.  Insulin resistance of muscle protein metabolism in aging , 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[103]  J. Morley,et al.  Cachexia: pathophysiology and clinical relevance. , 2006, The American journal of clinical nutrition.

[104]  F. Haddad,et al.  Aging-sensitive cellular and molecular mechanisms associated with skeletal muscle hypertrophy. , 2006, Journal of applied physiology.

[105]  D. Attaix,et al.  Altered responses in skeletal muscle protein turnover during aging in anabolic and catabolic periods. , 2005, The international journal of biochemistry & cell biology.

[106]  M. Tisdale Anorexia and Cachexia , 2005 .

[107]  Richard T. Lee,et al.  Transgenic Overexpression of Locally Acting Insulin-Like Growth Factor-1 Inhibits Ubiquitin-Mediated Muscle Atrophy in Chronic Left-Ventricular Dysfunction , 2005, Circulation research.

[108]  G. Schuler,et al.  Effects of exercise training on insulin-like growth factor-I expression in the skeletal muscle of non-cachectic patients with chronic heart failure , 2005, European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology.

[109]  L. Mcleay,et al.  Improved muscle healing through enhanced regeneration and reduced fibrosis in myostatin-null mice , 2005, Journal of Cell Science.

[110]  D. Yee,et al.  Safety and Efficacy of Weight Training in Recent Breast Cancer Survivors to Alter Body Composition, Insulin, and Insulin-Like Growth Factor Axis Proteins , 2005, Cancer Epidemiology Biomarkers & Prevention.

[111]  C. Schöneich,et al.  Proteomic Analysis of Protein Nitration in Aging Skeletal Muscle and Identification of Nitrotyrosine-containing Sequences in Vivo by Nanoelectrospray Ionization Tandem Mass Spectrometry* , 2005, Journal of Biological Chemistry.

[112]  M. Wacker,et al.  Contributions of the ubiquitin–proteasome pathway and apoptosis to human skeletal muscle wasting with age , 2005, Pflügers Archiv.

[113]  S. Powers,et al.  Selective downregulation of ubiquitin conjugation cascade mRNA occurs in the senescent rat soleus muscle , 2005, Experimental Gerontology.

[114]  R. Deberardinis,et al.  Autophagy in metazoans: cell survival in the land of plenty , 2005, Nature Reviews Molecular Cell Biology.

[115]  G. Schuler,et al.  Antioxidative Effects of Exercise Training in Patients With Chronic Heart Failure: Increase in Radical Scavenger Enzyme Activity in Skeletal Muscle , 2005, Circulation.

[116]  V. Baracos,et al.  USP19 is a ubiquitin-specific protease regulated in rat skeletal muscle during catabolic states. , 2005, American journal of physiology. Endocrinology and metabolism.

[117]  E. Barreiro,et al.  Both oxidative and nitrosative stress are associated with muscle wasting in tumour‐bearing rats , 2005, FEBS letters.

[118]  S. Fulle,et al.  Age-dependent imbalance of the antioxidative system in human satellite cells , 2005, Experimental Gerontology.

[119]  D. Mann,et al.  TNF-acts via p 38 MAPK to stimulate expression of the ubiquitin ligase atrogin 1 / MAFbx in skeletal muscle , 2005 .

[120]  Hsin C. Lin,et al.  Insulin-like Growth Factor-1 (IGF-1) Inversely Regulates Atrophy-induced Genes via the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR) Pathway* , 2005, Journal of Biological Chemistry.

[121]  V. Sirri,et al.  Degradation of MyoD Mediated by the SCF (MAFbx) Ubiquitin Ligase* , 2005, Journal of Biological Chemistry.

[122]  S. Borst Interventions for sarcopenia and muscle weakness in older people. , 2004, Age and ageing.

[123]  A. Goldberg,et al.  IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1. , 2004, American journal of physiology. Endocrinology and metabolism.

[124]  Jeffrey S. Damrauer,et al.  Cancer cachexia is regulated by selective targeting of skeletal muscle gene products. , 2004, The Journal of clinical investigation.

[125]  D. Guttridge Signaling pathways weigh in on decisions to make or break skeletal muscle , 2004, Current opinion in clinical nutrition and metabolic care.

[126]  Marco Sandri,et al.  Foxo Transcription Factors Induce the Atrophy-Related Ubiquitin Ligase Atrogin-1 and Cause Skeletal Muscle Atrophy , 2004, Cell.

[127]  K. Fearon,et al.  Reduced total energy expenditure and physical activity in cachectic patients with pancreatic cancer can be modulated by an energy and protein dense oral supplement enriched with n-3 fatty acids , 2004, British Journal of Cancer.

[128]  G. Bernardi,et al.  Stem cell-mediated muscle regeneration is enhanced by local isoform of insulin-like growth factor 1. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[129]  D. E. Goll,et al.  Interaction of calpastatin with calpain: a review , 2004, Biological chemistry.

[130]  C. Denis,et al.  Satellite cells and myonuclei in young and elderly women and men , 2004, Muscle & nerve.

[131]  A. Goldberg,et al.  Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[132]  M. Matsui,et al.  In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. , 2003, Molecular biology of the cell.

[133]  F. Bardag-Gorce,et al.  Changes in 20S proteasome activity during ageing of the LOU rat , 1999, Molecular Biology Reports.

[134]  M. H. Snow The effects of aging on satellite cells in skeletal muscles of mice and rats , 1977, Cell and Tissue Research.

[135]  W. Mitch,et al.  Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions. , 2004, The Journal of clinical investigation.

[136]  D. Ferrington,et al.  Altered proteasome function and subunit composition in aged muscle. , 2004, Archives of biochemistry and biophysics.

[137]  C. Tachi,et al.  Content and localization of myostatin in mouse skeletal muscles during aging, mechanical unloading and reloading , 2004, Journal of Muscle Research & Cell Motility.

[138]  Yi-Ping Li,et al.  Hydrogen peroxide stimulates ubiquitin-conjugating activity and expression of genes for specific E2 and E3 proteins in skeletal muscle myotubes. , 2003, American journal of physiology. Cell physiology.

[139]  F. Booth,et al.  Transcriptional profiling identifies extensive downregulation of extracellular matrix gene expression in sarcopenic rat soleus muscle. , 2003, Physiological genomics.

[140]  R. Radi,et al.  Peroxynitrite reactivity with amino acids and proteins , 2003, Amino Acids.

[141]  Seumas McCroskery,et al.  Myostatin negatively regulates satellite cell activation and self-renewal , 2003, The Journal of cell biology.

[142]  G. Schuler,et al.  Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure. , 2003, Journal of the American College of Cardiology.

[143]  G. Mantovani,et al.  Antioxidant agents are effective in inducing lymphocyte progression through cell cycle in advanced cancer patients: assessment of the most important laboratory indexes of cachexia and oxidative stress , 2003, Journal of Molecular Medicine.

[144]  Stephen Welle,et al.  Gene expression profile of aging in human muscle. , 2003, Physiological genomics.

[145]  D. E. Goll,et al.  The calpain system. , 2003, Physiological reviews.

[146]  Douglas L. Rothman,et al.  Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance , 2003, Science.

[147]  Bente Klarlund Pedersen,et al.  Exercise and IL‐6 infusion inhibit endotoxin‐induced TNF‐α production in humans , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[148]  K. Courneya,et al.  Resistance exercise in men receiving androgen deprivation therapy for prostate cancer. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[149]  R. Casaburi,et al.  Testosterone dose-dependently increases maximal voluntary strength and leg power, but does not affect fatigability or specific tension. , 2003, The Journal of clinical endocrinology and metabolism.

[150]  M. Muscaritoli,et al.  Increased Muscle Proteasome Activity Correlates With Disease Severity in Gastric Cancer Patients , 2003, Annals of surgery.

[151]  V. Paralkar,et al.  Myostatin expression in age and denervation-induced skeletal muscle atrophy. , 2003, Journal of musculoskeletal & neuronal interactions.

[152]  D. Glass Signalling pathways that mediate skeletal muscle hypertrophy and atrophy , 2003, Nature Cell Biology.

[153]  J. Patrie,et al.  Single and combined effects of growth hormone and testosterone administration on measures of body composition, physical performance, mood, sexual function, bone turnover, and muscle gene expression in healthy older men. , 2002, The Journal of clinical endocrinology and metabolism.

[154]  R. Casaburi,et al.  Testosterone-induced increase in muscle size in healthy young men is associated with muscle fiber hypertrophy. , 2002, American journal of physiology. Endocrinology and metabolism.

[155]  Maria Cristina C Gomes-Marcondes,et al.  Induction of protein catabolism and the ubiquitin-proteasome pathway by mild oxidative stress. , 2002, Cancer letters.

[156]  S. Welle,et al.  Insulin-like growth factor-1 and myostatin mRNA expression in muscle: comparison between 62–77 and 21–31yr old men , 2002, Experimental Gerontology.

[157]  A. Newman,et al.  Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: the Health ABC Study. , 2002, The journals of gerontology. Series A, Biological sciences and medical sciences.

[158]  G. Schuler,et al.  Induction of iNOS expression in skeletal muscle by IL-1β and NFκB activation: an in vitro and in vivo study , 2002 .

[159]  Eli Carmeli,et al.  The biochemistry of aging muscle , 2002, Experimental Gerontology.

[160]  G. Gibson,et al.  Skeletal muscle mRNA levels for cathepsin B, but not components of the ubiquitin-proteasome pathway, are increased in patients with lung cancer referred for thoracotomy. , 2002, Clinical science.

[161]  R. Wolfe,et al.  Testosterone administration to older men improves muscle function: molecular and physiological mechanisms. , 2002, American journal of physiology. Endocrinology and metabolism.

[162]  David Steven Scott,et al.  Exercise can reverse quadriceps sensorimotor dysfunction that is associated with rheumatoid arthritis without exacerbating disease activity. , 2002, Rheumatology.

[163]  A. Levey,et al.  Resistance Training To Counteract the Catabolism of a Low-Protein Diet in Patients with Chronic Renal Insufficiency , 2001, Annals of Internal Medicine.

[164]  I. Wilson,et al.  Effect of resistance training on self-reported physical functioning in HIV infection. , 2001, Medicine and science in sports and exercise.

[165]  D J Glass,et al.  Identification of Ubiquitin Ligases Required for Skeletal Muscle Atrophy , 2001, Science.

[166]  Se-Jin Lee,et al.  Regulation of myostatin activity and muscle growth , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[167]  M. Tisdale,et al.  Activation of ATP-ubiquitin-dependent proteolysis in skeletal muscle in vivo and murine myoblasts in vitro by a proteolysis-inducing factor (PIF) , 2001, British Journal of Cancer.

[168]  R. Lobo Androgens in Postmenopausal Women: Production, Possible Role, and Replacement Options , 2001, Obstetrical & gynecological survey.

[169]  A. Kenny,et al.  Effects of transdermal testosterone on bone and muscle in older men with low bioavailable testosterone levels. , 2001, The journals of gerontology. Series A, Biological sciences and medical sciences.

[170]  J. Belizário,et al.  Cleavage of caspases-1, -3, -6, -8 and -9 substrates by proteases in skeletal muscles from mice undergoing cancer cachexia , 2001, British Journal of Cancer.

[171]  Antonio Musarò,et al.  Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle , 2001, Nature Genetics.

[172]  G. Schuler,et al.  Apoptosis in skeletal muscle. , 2001, Frontiers in bioscience : a journal and virtual library.

[173]  E. Metter,et al.  Skeletal muscle satellite cell populations in healthy young and older men and women , 2000, The Anatomical record.

[174]  R. Wolfe,et al.  The response of muscle protein anabolism to combined hyperaminoacidemia and glucose-induced hyperinsulinemia is impaired in the elderly. , 2000, The Journal of clinical endocrinology and metabolism.

[175]  M. Tisdale Protein Loss in Cancer Cachexia , 2000, Science.

[176]  C. Y. Wang,et al.  NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia. , 2000, Science.

[177]  M. Rudnicki,et al.  Pax7 Is Required for the Specification of Myogenic Satellite Cells , 2000, Cell.

[178]  P. Esselman,et al.  Oxidative capacity and ageing in human muscle , 2000, The Journal of physiology.

[179]  M. Godschalk,et al.  Testosterone Improves Rehabilitation Outcomes in Ill Older Men , 2000, Journal of the American Geriatrics Society.

[180]  F. López‐Soriano,et al.  DNA fragmentation occurs in skeletal muscle during tumor growth: A link with cancer cachexia? , 2000, Biochemical and biophysical research communications.

[181]  E. Nieschlag,et al.  Hormone substitution in male hypogonadism , 2000, Molecular and Cellular Endocrinology.

[182]  M. Tisdale Biomedicine. Protein loss in cancer cachexia. , 2000, Science.

[183]  D. Chrysis,et al.  Regulation of components of the ubiquitin system by insulin-like growth factor I and growth hormone in skeletal muscle of rats made catabolic with dexamethasone. , 1999, Endocrinology.

[184]  J. Tenover Testosterone replacement therapy in older adult men. , 1999, International journal of andrology.

[185]  J. Fischer,et al.  The expression of genes in the ubiquitin-proteasome proteolytic pathway is increased in skeletal muscle from patients with cancer. , 1999, Surgery.

[186]  J. Berlin,et al.  Effect of testosterone treatment on body composition and muscle strength in men over 65 years of age. , 1999, The Journal of clinical endocrinology and metabolism.

[187]  M. Horan,et al.  Difficulties in measuring the effect of testosterone replacement therapy on muscle function in older men. , 1999, International journal of andrology.

[188]  F. Dimeo,et al.  Effects of physical activity on the fatigue and psychologic status of cancer patients during chemotherapy , 1999, Cancer.

[189]  F. López‐Soriano,et al.  The role of cytokines in cancer cachexia , 1999, Medicinal research reviews.

[190]  A. Goldberg,et al.  Muscle protein breakdown and the critical role of the ubiquitin-proteasome pathway in normal and disease states. , 1999, The Journal of nutrition.

[191]  K. Esser,et al.  Phosphorylation of p70S6kcorrelates with increased skeletal muscle mass following resistance exercise. , 1999, American journal of physiology. Cell physiology.

[192]  K. Esser,et al.  Phosphorylation of p70(S6k) correlates with increased skeletal muscle mass following resistance exercise. , 1999, The American journal of physiology.

[193]  N. Agell,et al.  Role of TNF receptor 1 in protein turnover during cancer cachexia using gene knockout mice , 1998, Molecular and Cellular Endocrinology.

[194]  R. Schwartz,et al.  Skeletal muscle myocytes undergo protein loss and reactive oxygen-mediated NF-κB activation in response to tumor necrosis factor α , 1998 .

[195]  S. Heymsfield,et al.  Epidemiology of sarcopenia among the elderly in New Mexico. , 1998, American journal of epidemiology.

[196]  B. Schwippert,et al.  Induction of apoptosis by high proinsulin and glucose in cultured human umbilical vein endothelial cells is mediated by reactive oxygen species , 1998, Diabetologia.

[197]  B. Schwippert,et al.  Introduction of apoptosis by high proinsulin and glucose in cultured human umbilical vein endothelial cells is mediated by reactive oxygen species. , 1998, Diabetologia.

[198]  G. Butler-Browne,et al.  Replicative potential and telomere length in human skeletal muscle: implications for satellite cell-mediated gene therapy. , 1997, Human gene therapy.

[199]  I. Gage,et al.  Effects of exercise on fatigue, physical functioning, and emotional distress during radiation therapy for breast cancer. , 1997, Oncology nursing forum.

[200]  H. Perry,et al.  Testosterone replacement in older hypogonadal men: a 12-month randomized controlled trial. , 1997, The Journal of clinical endocrinology and metabolism.

[201]  P. Ponikowski,et al.  Wasting as independent risk factor for mortality in chronic heart failure , 1997, The Lancet.

[202]  M. Kothari Lumbrical-interossei studies in distal ulnar neuropathy. , 1997, Muscle & nerve.

[203]  A. Goldberg,et al.  Mechanisms of muscle wasting. The role of the ubiquitin-proteasome pathway. , 1996, The New England journal of medicine.

[204]  D. Barritault,et al.  Growth factors in skeletal muscle regeneration. , 1996, Cytokine & growth factor reviews.

[205]  R. Weindruch,et al.  Oxidative Stress, Caloric Restriction, and Aging , 1996, Science.

[206]  M. Brink,et al.  Angiotensin II causes weight loss and decreases circulating insulin-like growth factor I in rats through a pressor-independent mechanism. , 1996, The Journal of clinical investigation.

[207]  P. Silver,et al.  MyoD is required for myogenic stem cell function in adult skeletal muscle. , 1996, Genes & development.

[208]  H. Oral,et al.  Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: a report from the Studies of Left Ventricular Dysfunction (SOLVD). , 1996, Journal of the American College of Cardiology.

[209]  M. Buck,et al.  Muscle wasting and dedifferentiation induced by oxidative stress in a murine model of cachexia is prevented by inhibitors of nitric oxide synthesis and antioxidants. , 1996, The EMBO journal.

[210]  M. Yano,et al.  Interleukin 6 receptor antibody inhibits muscle atrophy and modulates proteolytic systems in interleukin 6 transgenic mice. , 1996, The Journal of clinical investigation.

[211]  P. Kragsbjerg,et al.  Dynamics of blood cytokine concentrations in patients with bacteremic infections. , 1996, Scandinavian journal of infectious diseases.

[212]  M. Yano,et al.  Role of interleukin-6 in skeletal muscle protein breakdown and cathepsin activity in vivo. , 1996, European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes.

[213]  R. Wolfe,et al.  Testosterone administration to elderly men increases skeletal muscle strength and protein synthesis. , 1995, The American journal of physiology.

[214]  Brian K. Kobilka,et al.  Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice , 1995, Nature.

[215]  P. Laipis,et al.  Multiple Deletions Are Detectable in Mitochondrial DNA of Aging Mice (*) , 1995, The Journal of Biological Chemistry.

[216]  W. Rejeski,et al.  Moderate Exercise Training and Natural Killer Cell Cytotoxic Activity in Breast Cancer Patients , 1995, International journal of sports medicine.

[217]  J. Lexell,et al.  Aging of human muscle: structure, function and adaptability , 1995, Scandinavian journal of medicine & science in sports.

[218]  J. Balligand,et al.  Myocardial contractile dysfunction in the systemic inflammatory response syndrome: role of a cytokine-inducible nitric oxide synthase in cardiac myocytes. , 1995, Journal of molecular and cellular cardiology.

[219]  I. Karlberg,et al.  Insulin sensitivity, hormonal levels and skeletal muscle protein metabolism in tumour-bearing exercising rats. , 1995, European journal of cancer.

[220]  N. Forsberg,et al.  Effects of serum and insulin-like growth factor I on protein degradation and protease gene expression in rat L8 myotubes. , 1994, Journal of animal science.

[221]  E. Olson,et al.  bHLH factors in muscle development: dead lines and commitments, what to leave in and what to leave out. , 1994, Genes & development.

[222]  J. Cooper,et al.  Analyses of mitochondrial respiratory chain function and mitochondrial DNA deletion in human skeletal muscle: Effect of ageing , 1992, Journal of the Neurological Sciences.

[223]  H. Fillit,et al.  Elevated circulating levels of tumor necrosis factor in severe chronic heart failure. , 1990, The New England journal of medicine.

[224]  C. Dinarello,et al.  Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF. , 1990, Blood.

[225]  P. Sperryn,et al.  Blood. , 1989, British journal of sports medicine.

[226]  W. Rumsey,et al.  Bioenergetics in the aging fischer 344 rat: Effects of exercise and food restriction , 1987, Experimental Gerontology.

[227]  J. R. Warner,et al.  Applying genetics to the splicing problem. , 1987, Genes & development.

[228]  P. Deuster,et al.  Endurance exercise modifies cachexia of tumor growth in rats. , 1985, Medicine and science in sports and exercise.

[229]  E. Schultz,et al.  Age‐related differences in absolute numbers of skeletal muscle satellite cells , 1983, Muscle & nerve.

[230]  R. Chlebowski,et al.  Hypogonadism in male patients with metastatic cancer prior to chemotherapy. , 1982, Cancer research.

[231]  A. H. Norris,et al.  Effect of muscle mass decrease on age-related BMR changes. , 1977, Journal of applied physiology: respiratory, environmental and exercise physiology.

[232]  S. Schiaffino,et al.  Studies on the effect of denervation in developing muscle. II. The lysosomal system. , 1972, Journal of ultrastructure research.

[233]  G. Forbes,et al.  Adult lean body mass declines with age: some longitudinal observations. , 1970, Metabolism: clinical and experimental.

[234]  A. Mauro SATELLITE CELL OF SKELETAL MUSCLE FIBERS , 1961, The Journal of biophysical and biochemical cytology.

[235]  D. Harman Aging: a theory based on free radical and radiation chemistry. , 1956, Journal of gerontology.