Three-dimensional printing of nanomaterial scaffolds for complex tissue regeneration.

Three-dimensional (3D) printing has recently expanded in popularity, and become the cutting edge of tissue engineering research. A growing emphasis from clinicians on patient-specific care, coupled with an increasing knowledge of cellular and biomaterial interaction, has led researchers to explore new methods that enable the greatest possible control over the arrangement of cells and bioactive nanomaterials in defined scaffold geometries. In this light, the cutting edge technology of 3D printing also enables researchers to more effectively compose multi-material and cell-laden scaffolds with less effort. In this review, we explore the current state of 3D printing with a focus on printing of nanomaterials and their effect on various complex tissue regeneration applications.

[1]  Gabor Forgacs,et al.  Biofabrication and testing of a fully cellular nerve graft , 2013, Biofabrication.

[2]  Shaochen Chen,et al.  Projection printing of 3-dimensional tissue scaffolds. , 2012, Methods in molecular biology.

[3]  Qingbo Xu,et al.  An updated view on stem cell differentiation into smooth muscle cells. , 2012, Vascular pharmacology.

[4]  James J. Yoo,et al.  Hybrid printing of mechanically and biologically improved constructs for cartilage tissue engineering applications , 2012, Biofabrication.

[5]  Nathan J. Castro,et al.  Recent Progress in Interfacial Tissue Engineering Approaches for Osteochondral Defects , 2012, Annals of Biomedical Engineering.

[6]  J. Lewis,et al.  Omnidirectional Printing of 3D Microvascular Networks , 2011, Advanced materials.

[7]  Robert J. Kane,et al.  Mimicking the nanostructure of bone matrix to regenerate bone. , 2013, Materials today.

[8]  T. Laurent,et al.  The structure and function of hyaluronan: An overview. , 1996, Immunology and cell biology.

[9]  Colleen L Flanagan,et al.  Treatment of severe porcine tracheomalacia with a 3-dimensionally printed, bioresorbable, external airway splint. , 2014, JAMA otolaryngology-- head & neck surgery.

[10]  Gordon G Wallace,et al.  Bio-ink for on-demand printing of living cells. , 2013, Biomaterials science.

[11]  Marc E. Nelson,et al.  Bioresorbable airway splint created with a three-dimensional printer. , 2013, The New England journal of medicine.

[12]  Byung-Soo Kim,et al.  Culture of neural cells and stem cells on graphene , 2013, Tissue Engineering and Regenerative Medicine.

[13]  Nathan J. Castro,et al.  Electrospun fibrous scaffolds for bone and cartilage tissue generation: recent progress and future developments. , 2012, Tissue engineering. Part B, Reviews.

[14]  R. T. Tran,et al.  A new generation of sodium chloride porogen for tissue engineering , 2011, Biotechnology and applied biochemistry.

[15]  Jos Malda,et al.  Biofabrication of osteochondral tissue equivalents by printing topologically defined, cell-laden hydrogel scaffolds. , 2012, Tissue engineering. Part C, Methods.

[16]  E. Kapetanovic,et al.  Three-dimensional printed trileaflet valve conduits using biological hydrogels and human valve interstitial cells. , 2014, Acta biomaterialia.

[17]  Wei Zhu,et al.  Development of novel three-dimensional printed scaffolds for osteochondral regeneration. , 2015, Tissue engineering. Part A.

[18]  Tao Xu,et al.  Viability and electrophysiology of neural cell structures generated by the inkjet printing method. , 2006, Biomaterials.

[19]  Holger Weber,et al.  Spheroid-based engineering of a human vasculature in mice , 2008, Nature Methods.

[20]  F. Marga,et al.  Toward engineering functional organ modules by additive manufacturing , 2012, Biofabrication.

[21]  Wei Sun,et al.  Mechanical characterization of bioprinted in vitro soft tissue models , 2013, Biofabrication.

[22]  T. Hasan,et al.  A three-dimensional in vitro ovarian cancer coculture model using a high-throughput cell patterning platform. , 2011, Biotechnology journal.

[23]  Xiaofeng Jia,et al.  Engineering anatomically shaped vascularized bone grafts with hASCs and 3D-printed PCL scaffolds. , 2014, Journal of biomedical materials research. Part A.

[24]  G. Prestwich,et al.  Photocrosslinkable hyaluronan-gelatin hydrogels for two-step bioprinting. , 2010, Tissue engineering. Part A.

[25]  Andrew D. Jones,et al.  Cytocompatibility evaluation of microwave sintered biphasic calcium phosphate scaffolds synthesized using pH control. , 2013, Materials science & engineering. C, Materials for biological applications.

[26]  Vladimir Mironov,et al.  Organ printing: tissue spheroids as building blocks. , 2009, Biomaterials.

[27]  T. Webster,et al.  Bioactive rosette nanotube-hydroxyapatite nanocomposites improve osteoblast functions. , 2012, Tissue engineering. Part A.

[28]  Jens Ducrée,et al.  Fabricating electrodes for amperometric detection in hybrid paper/polymer lab-on-a-chip devices. , 2012, Lab on a chip.

[29]  Yury Gogotsi,et al.  Fluorescent PLLA-nanodiamond composites for bone tissue engineering. , 2011, Biomaterials.

[30]  R. Kandel,et al.  Porous calcium polyphosphate as load-bearing bone substitutes: in vivo study. , 2013, Journal of biomedical materials research. Part B, Applied biomaterials.

[31]  Robert Langer,et al.  Tissue engineering: the design and fabrication of living replacement devices for surgical reconstruction and transplantation , 1999, The Lancet.

[32]  Itamar Willner,et al.  Biomolecule/nanomaterial hybrid systems for nanobiotechnology. , 2012, Advances in experimental medicine and biology.

[33]  L. Sherman,et al.  Neural stem cell niches: roles for the hyaluronan-based extracellular matrix. , 2011, Frontiers in bioscience.

[34]  Shengmin Zhang,et al.  Evaluation of bacterial nanocellulose-based uniform wound dressing for large area skin transplantation. , 2013, Materials science & engineering. C, Materials for biological applications.

[35]  M. J. Moore,et al.  Fabrication of Micropatterned Hydrogels for Neural Culture Systems using Dynamic Mask Projection Photolithography , 2011, Journal of visualized experiments : JoVE.

[36]  Eyal Zussman,et al.  Slow-release human recombinant bone morphogenetic protein-2 embedded within electrospun scaffolds for regeneration of bone defect: in vitro and in vivo evaluation. , 2011, Tissue engineering. Part A.

[37]  Brendon M. Baker,et al.  Rapid casting of patterned vascular networks for perfusable engineered 3D tissues , 2012, Nature materials.

[38]  Wei Zhu,et al.  3D nano/microfabrication techniques and nanobiomaterials for neural tissue regeneration. , 2014, Nanomedicine.

[39]  Mei Tu,et al.  Fabrication and in vivo osteogenesis of biomimetic poly(propylene carbonate) scaffold with nanofibrous chitosan network in macropores for bone tissue engineering , 2012, Journal of Materials Science: Materials in Medicine.

[40]  François Berthiaume,et al.  Tissue Engineering and Regenerative Medicine : History , Progress , and Challenges , 2013 .

[41]  Anthony Atala,et al.  Tissue engineering of human bladder. , 2011, British medical bulletin.

[42]  James J. Yoo,et al.  Complex heterogeneous tissue constructs containing multiple cell types prepared by inkjet printing technology. , 2013, Biomaterials.

[43]  A. Khademhosseini,et al.  Layer by layer three-dimensional tissue epitaxy by cell-laden hydrogel droplets. , 2010, Tissue engineering. Part C, Methods.

[44]  Nathan J. Castro,et al.  Novel biologically-inspired rosette nanotube PLLA scaffolds for improving human mesenchymal stem cell chondrogenic differentiation , 2013, Biomedical materials.

[45]  Richard E. Groff,et al.  Design and implementation of a two-dimensional inkjet bioprinter , 2009, 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[46]  W. Schumaker,et al.  Stereolithography based method of creating custom gas density profile targets for high intensity laser-plasma experiments. , 2012, The Review of scientific instruments.

[47]  Nathan J. Castro,et al.  Enhanced human bone marrow mesenchymal stem cell functions in novel 3D cartilage scaffolds with hydrogen treated multi-walled carbon nanotubes , 2013, Nanotechnology.

[48]  Anthony Atala,et al.  Engineering functional bladder tissues , 2013, Journal of tissue engineering and regenerative medicine.

[49]  T. Webster,et al.  Nanomaterials for Improved Orthopedic and Bone Tissue Engineering Applications , 2010 .

[50]  Dietmar W Hutmacher,et al.  Assessment of bone ingrowth into porous biomaterials using MICRO-CT. , 2007, Biomaterials.

[51]  Vladimir Mironov,et al.  Organ printing: from bioprinter to organ biofabrication line. , 2011, Current opinion in biotechnology.

[52]  O. Akhavan,et al.  Differentiation of human neural stem cells into neural networks on graphene nanogrids. , 2013, Journal of materials chemistry. B.

[53]  Seung Hyun Ahn,et al.  Polycaprolactone scaffolds fabricated with an advanced electrohydrodynamic direct-printing method for bone tissue regeneration. , 2011, Biomacromolecules.

[54]  Vamsi Krishna Balla,et al.  Microwave‐sintered 3D printed tricalcium phosphate scaffolds for bone tissue engineering , 2013, Journal of tissue engineering and regenerative medicine.

[55]  U. Demirci,et al.  A droplet-based building block approach for bladder smooth muscle cell (SMC) proliferation , 2010, Biofabrication.

[56]  Xiaofeng Cui,et al.  Thermal inkjet printing in tissue engineering and regenerative medicine. , 2012, Recent patents on drug delivery & formulation.

[57]  Ralph Müller,et al.  Mechanical evaluation of bacterial nanocellulose as an implant material for ear cartilage replacement. , 2013, Journal of the mechanical behavior of biomedical materials.

[58]  M. Fainzilber,et al.  Axon–soma communication in neuronal injury , 2013, Nature Reviews Neuroscience.

[59]  Thomas J Webster,et al.  Biologically inspired rosette nanotubes and nanocrystalline hydroxyapatite hydrogel nanocomposites as improved bone substitutes , 2009, Nanotechnology.

[60]  Sailing He,et al.  Rapid Fabrication of Complex 3D Extracellular Microenvironments by Dynamic Optical Projection Stereolithography , 2012, Advanced materials.

[61]  Hod Lipson,et al.  Direct Freeform Fabrication of Seeded Hydrogels in Arbitrary Geometries , 2022 .

[62]  A. Das,et al.  Mesenchymal stem cells for cartilage repair in osteoarthritis , 2012, Stem Cell Research & Therapy.

[63]  Seunghun Hong,et al.  Improved neural differentiation of human mesenchymal stem cells interfaced with carbon nanotube scaffolds. , 2013, Nanomedicine.

[64]  Anthony Atala,et al.  A NOVEL HYBRID PRINTING SYSTEM FOR THE GENERATION OF ORGANIZED BLADDER TISSUE , 2009 .

[65]  Ashutosh Kumar Singh,et al.  Solid freeform fabrication of designer scaffolds of hyaluronic acid for nerve tissue engineering , 2011, Biomedical microdevices.

[66]  R. Gurny,et al.  Long term performance of polycaprolactone vascular grafts in a rat abdominal aorta replacement model. , 2012, Biomaterials.

[67]  Michael Keidar,et al.  Greater osteoblast and mesenchymal stem cell adhesion and proliferation on titanium with hydrothermally treated nanocrystalline hydroxyapatite/magnetically treated carbon nanotubes. , 2012, Journal of nanoscience and nanotechnology.

[68]  M. Keidar,et al.  Design of biomimetic and bioactive cold plasma-modified nanostructured scaffolds for enhanced osteogenic differentiation of bone marrow-derived mesenchymal stem cells. , 2014, Tissue engineering. Part A.

[69]  Hyeongjin Lee,et al.  Three-dimensional hierarchical composite scaffolds consisting of polycaprolactone, β-tricalcium phosphate, and collagen nanofibers: fabrication, physical properties, and in vitro cell activity for bone tissue regeneration. , 2011, Biomacromolecules.

[70]  W. Dhert,et al.  The osteoinductive potential of printable, cell-laden hydrogel-ceramic composites. , 2012, Journal of biomedical materials research. Part A.

[71]  D. D’Lima,et al.  Direct human cartilage repair using three-dimensional bioprinting technology. , 2012, Tissue engineering. Part A.

[72]  Miguel Castilho,et al.  Direct 3D powder printing of biphasic calcium phosphate scaffolds for substitution of complex bone defects , 2014, Biofabrication.

[73]  Tzu-Wei Wang,et al.  Carbon nanotube rope with electrical stimulation promotes the differentiation and maturity of neural stem cells. , 2012, Small.

[74]  Glenn D Prestwich,et al.  Bioprinting vessel-like constructs using hyaluronan hydrogels crosslinked with tetrahedral polyethylene glycol tetracrylates. , 2010, Biomaterials.

[75]  James J. Yoo,et al.  Tissue-engineered autologous bladders for patients needing cystoplasty , 2006, The Lancet.

[76]  A. Sola,et al.  A new hydroxyapatite-based biocomposite for bone replacement. , 2013, Materials science & engineering. C, Materials for biological applications.

[77]  Jerry C. Hu,et al.  The role of tissue engineering in articular cartilage repair and regeneration. , 2009, Critical reviews in biomedical engineering.

[78]  Duc Truong Pham,et al.  A comparison of rapid prototyping technologies , 1998 .

[79]  J. Vacanti,et al.  A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering. , 2003, Biomaterials.

[80]  Q. Wang,et al.  A novel small animal model for biocompatibility assessment of polymeric materials for use in prosthetic heart valves. , 2009, Journal of biomedical materials research. Part A.

[81]  T. Webster,et al.  Nanotechnology and nanomaterials: Promises for improved tissue regeneration , 2009 .

[82]  Peter Schmidt,et al.  Reverse Engineering—Rapid Prototyping of the Skull in Forensic Trauma Analysis , 2011, Journal of forensic sciences.

[83]  M. Leu,et al.  Effect of material, process parameters, and simulated body fluids on mechanical properties of 13-93 bioactive glass porous constructs made by selective laser sintering. , 2012, Journal of the mechanical behavior of biomedical materials.

[84]  Aaron Tan,et al.  Nanomaterial scaffolds for stem cell proliferation and differentiation in tissue engineering. , 2013, Biotechnology advances.

[85]  James B. Hoying,et al.  Encapsulation of Adipose Stromal Vascular Fraction Cells in Alginate Hydrogel Spheroids Using a Direct-Write Three-Dimensional Printing System , 2013, BioResearch open access.

[86]  M. Keidar,et al.  Biomimetic three-dimensional nanocrystalline hydroxyapatite and magnetically synthesized single-walled carbon nanotube chitosan nanocomposite for bone regeneration , 2012, International journal of nanomedicine.

[87]  P. Tran,et al.  Carbon nanofibers and carbon nanotubes in regenerative medicine. , 2009, Advanced drug delivery reviews.

[88]  Scott J Hollister,et al.  A paradigm for the development and evaluation of novel implant topologies for bone fixation: implant design and fabrication. , 2012, Journal of biomechanics.

[89]  D. Hutmacher,et al.  Osteogenic differentiation of mesenchymal progenitor cells in computer designed fibrin-polymer-ceramic scaffolds manufactured by fused deposition modeling , 2005, Journal of materials science. Materials in medicine.

[90]  M. Prabhakaran,et al.  Phenotypic modulation of smooth muscle cells by chemical and mechanical cues of electrospun tecophilic/gelatin nanofibers. , 2014, ACS applied materials & interfaces.

[91]  Aimin Chen,et al.  Innervation of reconstructed bladder above the level of spinal cord injury for inducing micturition by contractions of the abdomen-to-bladder reflex arc. , 2010 .