Mechanisms of organ fibrosis: Emerging concepts and implications for novel treatment strategies.

[1]  P. Subramanian,et al.  Hepatic Stellate Cells: Dictating Outcome in Nonalcoholic Fatty Liver Disease , 2023, Cellular and molecular gastroenterology and hepatology.

[2]  R. Gallo,et al.  Essential immune functions of fibroblasts in innate host defense , 2022, Frontiers in Immunology.

[3]  P. Sun,et al.  Epithelial-Mesenchymal Plasticity and Endothelial-Mesenchymal Transition in Cutaneous Wound Healing. , 2022, Cold Spring Harbor perspectives in biology.

[4]  C. von Kalle,et al.  Cenicriviroc for the treatment of COVID-19: first interim results of a randomised, placebo-controlled, investigator-initiated, double-blind phase II trial , 2022, Journal of Global Antimicrobial Resistance.

[5]  R. Schwabe,et al.  Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis , 2022, Nature.

[6]  G. Raghu,et al.  Safety, tolerability, and efficacy of pirfenidone in patients with rheumatoid arthritis-associated interstitial lung disease: a randomised, double-blind, placebo-controlled, phase 2 study. , 2022, The Lancet. Respiratory medicine.

[7]  C. Jakubzick,et al.  Biology of lung macrophages in health and disease. , 2022, Immunity.

[8]  M. Wijsenbeek,et al.  Interstitial lung diseases , 2022, The Lancet.

[9]  F. Tacke,et al.  Prognostic and Predictive Molecular Markers in Cholangiocarcinoma , 2022, Cancers.

[10]  F. Tacke,et al.  Genetic Variant of CXCR1 (rs2234671) Associates with Clinical Outcome in Perihilar Cholangiocarcinoma , 2022, Liver Cancer.

[11]  F. Ginhoux,et al.  Expanding dendritic cell nomenclature in the single-cell era , 2022, Nature Reviews Immunology.

[12]  S. Friedman,et al.  Hepatic fibrosis 2022: Unmet needs and a blueprint for the future , 2021, Hepatology.

[13]  F. Tacke,et al.  Molecular and Cellular Mediators of the Gut-Liver Axis in the Progression of Liver Diseases , 2021, Frontiers in Medicine.

[14]  M. Zhang,et al.  The anti-fibrotic drug pirfenidone inhibits liver fibrosis by targeting the small oxidoreductase glutaredoxin-1 , 2021, Science advances.

[15]  S. Carmichael,et al.  Heart and Brain Pericytes Exhibit a Pro-Fibrotic Response After Vascular Injury. , 2021, Circulation research.

[16]  T. Kanai,et al.  CD8+ tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells , 2021, Nature Communications.

[17]  P. Dell’Era,et al.  EBF1 is expressed in pericytes and contributes to pericyte cell commitment , 2021, Histochemistry and Cell Biology.

[18]  Yongfei Hu,et al.  Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases , 2021, Nature Communications.

[19]  Junhao Hu,et al.  Single‐Cell Transcriptomic Analysis Reveals a Hepatic Stellate Cell–Activation Roadmap and Myofibroblast Origin During Liver Fibrosis in Mice , 2021, Hepatology.

[20]  F. Luppi,et al.  Molecular Biomarkers in Idiopathic Pulmonary Fibrosis: State of the Art and Future Directions , 2021, International journal of molecular sciences.

[21]  J. Falcón-Pérez,et al.  Transcriptomic Profiling of the Liver Sinusoidal Endothelium during Cirrhosis Reveals Stage-Specific Secretory Signature , 2021, Cancers.

[22]  I. Amit,et al.  XCR1+ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis , 2021, Nature Medicine.

[23]  H. Shim,et al.  Club cell-specific role of programmed cell death 5 in pulmonary fibrosis , 2021, Nature Communications.

[24]  Amy S. Shah,et al.  PKM2-dependent metabolic skewing of hepatic Th17 cells regulates pathogenesis of non-alcoholic fatty liver disease. , 2021, Cell metabolism.

[25]  F. Tacke,et al.  In Situ Vaccination as a Strategy to Modulate the Immune Microenvironment of Hepatocellular Carcinoma , 2021, Frontiers in Immunology.

[26]  Lin Sun,et al.  Effects of HIF-1α on renal fibrosis in cisplatin-induced chronic kidney disease. , 2021, Clinical science.

[27]  R. Derynck,et al.  TGF‐β as a driver of fibrosis: physiological roles and therapeutic opportunities , 2021, The Journal of pathology.

[28]  H. Tilg,et al.  Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH , 2021, Nature.

[29]  Ruhong Li,et al.  Cancer-associated fibroblasts: overview, progress, challenges, and directions , 2021, Cancer Gene Therapy.

[30]  R. Francés,et al.  Role of liver sinusoidal endothelial cells in liver diseases , 2021, Nature Reviews Gastroenterology & Hepatology.

[31]  M. Bashir,et al.  A structurally optimized FXR agonist, MET409, reduced liver fat content over 12 weeks in patients with non-alcoholic steatohepatitis. , 2021, Journal of hepatology.

[32]  F. Tacke,et al.  Impact of Angiogenesis- and Hypoxia-Associated Polymorphisms on Tumor Recurrence in Patients with Hepatocellular Carcinoma Undergoing Surgical Resection , 2020, Cancers.

[33]  N. Henderson,et al.  Hepatic Stellate Cell Regulation of Liver Regeneration and Repair , 2020, Hepatology communications.

[34]  Victor G. Puelles,et al.  Decoding myofibroblast origins in human kidney fibrosis , 2020, Nature.

[35]  T. Wynn,et al.  Fibrosis: from mechanisms to medicines , 2020, Nature.

[36]  D. Klionsky,et al.  Ferroptosis is a type of autophagy-dependent cell death. , 2020, Seminars in cancer biology.

[37]  D. Brenner,et al.  Molecular and cellular mechanisms of liver fibrosis and its regression , 2020, Nature Reviews Gastroenterology & Hepatology.

[38]  V. Pardo-Jiménez,et al.  TGF-β1 decreases CHOP expression and prevents cardiac fibroblast apoptosis induced by endoplasmic reticulum stress. , 2020, Toxicology in vitro : an international journal published in association with BIBRA.

[39]  F. Tacke,et al.  Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities , 2020, Cellular & molecular immunology.

[40]  F. Tacke,et al.  Dendritic Cell and T Cell Crosstalk in Liver Fibrogenesis and Hepatocarcinogenesis: Implications for Prevention and Therapy of Liver Cancer , 2020, International journal of molecular sciences.

[41]  U. Laufs,et al.  Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis. , 2020, Journal of hepatology.

[42]  Yuan Zhang,et al.  Single cell transcriptomic architecture and intercellular crosstalk of human intrahepatic cholangiocarcinoma. , 2020, Journal of hepatology.

[43]  K. Nagata,et al.  Neoplastic fibrocytes play an essential role in bone marrow fibrosis in Jak2V617F-induced primary myelofibrosis mice , 2020, Leukemia.

[44]  Yulei N. Wang,et al.  Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma. , 2020, The New England journal of medicine.

[45]  P. An,et al.  Hepatocyte mitochondria-derived danger signals directly activate hepatic stellate cells and drive progression of liver fibrosis , 2020, Nature Communications.

[46]  F. Ginhoux,et al.  Kidney dendritic cells: fundamental biology and functional roles in health and disease , 2020, Nature Reviews Nephrology.

[47]  O. Lindvall,et al.  Pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesions , 2020, Nature Communications.

[48]  N. Kaminski,et al.  Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis , 2020, Nature Communications.

[49]  B. Lambrecht,et al.  Human Lung Conventional Dendritic Cells Orchestrate Lymphoid Neogenesis During COPD. , 2020, American journal of respiratory and critical care medicine.

[50]  M. McConnell,et al.  Single-Cell Transcriptomics Reveals Zone-Specific Alterations of Liver Sinusoidal Endothelial Cells in Cirrhosis , 2020, bioRxiv.

[51]  N. Frangogiannis,et al.  The role of Smad2 and Smad3 in regulating homeostatic functions of fibroblasts in vitro and in adult mice. , 2020, Biochimica et biophysica acta. Molecular cell research.

[52]  F. Tacke,et al.  Ischemia-Reperfusion Injury in Marginal Liver Grafts and the Role of Hypothermic Machine Perfusion: Molecular Mechanisms and Clinical Implications , 2020, Journal of clinical medicine.

[53]  M. Kreuter,et al.  Pirfenidone in patients with unclassifiable progressive fibrosing interstitial lung disease: a double-blind, randomised, placebo-controlled, phase 2 trial. , 2020, The Lancet. Respiratory medicine.

[54]  P. Bardin,et al.  Pirfenidone: Molecular Mechanisms and Potential Clinical Applications in Lung Disease. , 2020, American journal of respiratory cell and molecular biology.

[55]  V. Wong,et al.  Cenicriviroc Treatment for Adults With Nonalcoholic Steatohepatitis and Fibrosis: Final Analysis of the Phase 2b CENTAUR Study , 2020, Hepatology.

[56]  M. Lopus,et al.  Cell death mechanisms in eukaryotes , 2019, Cell Biology and Toxicology.

[57]  T. Welte,et al.  Morphomolecular motifs of pulmonary neoangiogenesis in interstitial lung diseases , 2019, European Respiratory Journal.

[58]  P. Scherer,et al.  Dermal adipose tissue has high plasticity and undergoes reversible dedifferentiation in mice. , 2019, The Journal of clinical investigation.

[59]  J. Privratsky,et al.  Classical Dendritic Cells Mediate Hypertension by Promoting Renal Oxidative Stress and Fluid Retention. , 2019, Hypertension.

[60]  N. Henderson,et al.  Unravelling fibrosis using single-cell transcriptomics. , 2019, Current opinion in pharmacology.

[61]  Xuetao Sun,et al.  Endothelium-mediated contributions to fibrosis. , 2019, Seminars in cell & developmental biology.

[62]  E. S. Chambers,et al.  Skin barrier immunity and ageing , 2019, Immunology.

[63]  Y. Inagaki,et al.  CD103hi Treg cells constrain lung fibrosis induced by CD103lo tissue-resident pathogenic CD4 T cells , 2019, Nature Immunology.

[64]  M. Whitfield,et al.  Shared and distinct mechanisms of fibrosis , 2019, Nature Reviews Rheumatology.

[65]  S. Walsh,et al.  Nintedanib in Progressive Fibrosing Interstitial Lung Diseases. , 2019, The New England journal of medicine.

[66]  H. Foda,et al.  Interferon-γ enhances the antifibrotic effects of pirfenidone by attenuating IPF lung fibroblast activation and differentiation , 2019, Respiratory Research.

[67]  F. Tacke,et al.  CX3CR1 Mediates the Development of Monocyte-Derived Dendritic Cells during Hepatic Inflammation , 2019, Cells.

[68]  Hui Zhao,et al.  Hypoxia inducible factor‐1 promotes liver fibrosis in nonalcoholic fatty liver disease by activating PTEN/p65 signaling pathway , 2019, Journal of cellular biochemistry.

[69]  J. Kawabe,et al.  Capillary‐resident EphA7+ pericytes are multipotent cells with anti‐ischemic effects through capillary formation , 2019, Stem cells translational medicine.

[70]  Chun Fan,et al.  TGF-β induces periodontal ligament stem cell senescence through increase of ROS production , 2019, Molecular medicine reports.

[71]  Juan Zhang,et al.  Differential roles of VEGF: Relevance to tissue fibrosis , 2019, Journal of cellular biochemistry.

[72]  D. Howells,et al.  Pericytes and Neurovascular Function in the Healthy and Diseased Brain , 2019, Front. Cell. Neurosci..

[73]  G. Raghu,et al.  Nintedanib for Systemic Sclerosis-Associated Interstitial Lung Disease. , 2019, The New England journal of medicine.

[74]  T. Luedde,et al.  Myeloid cells in liver and bone marrow acquire a functionally distinct inflammatory phenotype during obesity-related steatohepatitis , 2019, Gut.

[75]  D. DeLuca,et al.  The FMS-like tyrosine kinase-3 ligand/lung dendritic cell axis contributes to regulation of pulmonary fibrosis , 2019, Thorax.

[76]  J. Finkelstein,et al.  Apoptosis resistance in fibroblasts precedes progressive scarring in pulmonary fibrosis and is partially mediated by Toll-like receptor 4 activation. , 2019, Toxicological sciences : an official journal of the Society of Toxicology.

[77]  F. Tacke,et al.  Liver Macrophages: Old Dogmas and New Insights , 2019, Hepatology communications.

[78]  Eduard Batlle,et al.  Transforming Growth Factor-β Signaling in Immunity and Cancer. , 2019, Immunity.

[79]  Richard P Harvey,et al.  Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury , 2019, eLife.

[80]  U. Neumann,et al.  Treatment Strategies for Hepatocellular Carcinoma—A Multidisciplinary Approach , 2019, International journal of molecular sciences.

[81]  F. Tacke,et al.  Organ and tissue fibrosis: Molecular signals, cellular mechanisms and translational implications. , 2019, Molecular aspects of medicine.

[82]  S. Prabhu,et al.  Dysfunctional and Proinflammatory Regulatory T-Lymphocytes Are Essential for Adverse Cardiac Remodeling in Ischemic Cardiomyopathy , 2019, Circulation.

[83]  T. Luedde,et al.  The CCR2+ Macrophage Subset Promotes Pathogenic Angiogenesis for Tumor Vascularization in Fibrotic Livers , 2018, Cellular and molecular gastroenterology and hepatology.

[84]  J. H. Kim,et al.  CX3CR1 differentiates F4/80low monocytes into pro-inflammatory F4/80high macrophages in the liver , 2018, Scientific Reports.

[85]  F. Tacke,et al.  Machine perfusion for liver transplantation in the era of marginal organs—New kids on the block , 2018, Liver international : official journal of the International Association for the Study of the Liver.

[86]  Li Li,et al.  Extracellular matrix remodeling and cardiac fibrosis. , 2018, Matrix biology : journal of the International Society for Matrix Biology.

[87]  N. Heaton,et al.  A randomized trial of normothermic preservation in liver transplantation , 2018, Nature.

[88]  T. Luedde,et al.  Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis , 2018, Hepatology.

[89]  Camille Stephan-Otto Attolini,et al.  TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis , 2018, Nature.

[90]  V. Wong,et al.  A randomized, placebo‐controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis , 2018, Hepatology.

[91]  I. Rusyn,et al.  Effects of pirfenidone in acute and sub‐chronic liver fibrosis, and an initiation‐promotion cancer model in the mouse , 2018, Toxicology and applied pharmacology.

[92]  Zach Odeh,et al.  Novel Mechanism of the Pericyte-Myofibroblast Transition in Renal Interstitial Fibrosis: Core Fucosylation Regulation , 2017, Scientific Reports.

[93]  M. Aronovitz,et al.  Th1 effector T cells selectively orchestrate cardiac fibrosis in nonischemic heart failure , 2017, The Journal of experimental medicine.

[94]  A. Leask,et al.  Antioxidants and NOX1/NOX4 inhibition blocks TGFβ1-induced CCN2 and α-SMA expression in dermal and gingival fibroblasts , 2017, PloS one.

[95]  Sucha Singh,et al.  Platelet-Derived Growth Factor Receptor α Contributes to Human Hepatic Stellate Cell Proliferation and Migration. , 2017, The American journal of pathology.

[96]  E. Morrisey,et al.  Distinct Mesenchymal Lineages and Niches Promote Epithelial Self-Renewal and Myofibrogenesis in the Lung , 2017, Cell.

[97]  J. Mecsas,et al.  Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance , 2017, Front. Cell. Infect. Microbiol..

[98]  P. Henson,et al.  Monocyte differentiation and antigen-presenting functions , 2017, Nature Reviews Immunology.

[99]  Jaclyn N. Taroni,et al.  A novel multi-network approach reveals tissue-specific cellular modulators of fibrosis in systemic sclerosis , 2017, Genome Medicine.

[100]  F. Tacke,et al.  Liver macrophages in tissue homeostasis and disease , 2017, Nature Reviews Immunology.

[101]  M. Fujiwara,et al.  The stellate cell system (vitamin A-storing cell system) , 2017, Anatomical Science International.

[102]  A. Mortazavi,et al.  Regeneration of fat cells from myofibroblasts during wound healing , 2017, Science.

[103]  W. Seeger,et al.  Two-Way Conversion between Lipogenic and Myogenic Fibroblastic Phenotypes Marks the Progression and Resolution of Lung Fibrosis. , 2017, Cell stem cell.

[104]  F. Zannad,et al.  Myocardial fibrosis: biomedical research from bench to bedside , 2017, European journal of heart failure.

[105]  I. N. Crispe,et al.  Infiltrating monocytes in liver injury and repair , 2016, Clinical & translational immunology.

[106]  P. Wolters,et al.  Telomere dysfunction in alveolar epithelial cells causes lung remodeling and fibrosis. , 2016, JCI insight.

[107]  Y. B. Sun,et al.  The origin of renal fibroblasts/myofibroblasts and the signals that trigger fibrosis. , 2016, Differentiation; research in biological diversity.

[108]  M. Tomic-Canic,et al.  Epithelial-mesenchymal transition in tissue repair and fibrosis , 2016, Cell and Tissue Research.

[109]  S. Forbes,et al.  Interleukin-13 Activates Distinct Cellular Pathways Leading to Ductular Reaction, Steatosis, and Fibrosis. , 2016, Immunity.

[110]  S. Friedman,et al.  Antifibrotic Effects of the Dual CCR2/CCR5 Antagonist Cenicriviroc in Animal Models of Liver and Kidney Fibrosis , 2016, PloS one.

[111]  M. Selman,et al.  Role of matrix metalloproteinases in the pathogenesis of idiopathic pulmonary fibrosis , 2016, Respiratory Research.

[112]  Xin Liu,et al.  Persistence of cirrhosis is maintained by intrahepatic regulatory T cells that inhibit fibrosis resolution by regulating the balance of tissue inhibitors of metalloproteinases and matrix metalloproteinases. , 2016, Translational research : the journal of laboratory and clinical medicine.

[113]  C. Iacobuzio-Donahue,et al.  TGF-β Tumor Suppression through a Lethal EMT , 2016, Cell.

[114]  Frank Tacke,et al.  Immunology in the liver — from homeostasis to disease , 2016, Nature Reviews Gastroenterology &Hepatology.

[115]  R. Touyz,et al.  Progenitor Cells, Bone Marrow-Derived Fibrocytes and Endothelial-to-Mesenchymal Transition: New Players in Vascular Fibrosis. , 2016, Hypertension.

[116]  R. Weiskirchen Hepatoprotective and Anti-fibrotic Agents: It's Time to Take the Next Step , 2016, Front. Pharmacol..

[117]  K. Lindor,et al.  Recent advances in the development of farnesoid X receptor agonists. , 2015, Annals of translational medicine.

[118]  E. Albano,et al.  CX3CR1-expressing inflammatory dendritic cells contribute to the progression of steatohepatitis. , 2015, Clinical science.

[119]  L. Desai,et al.  Reciprocal regulation of TGF-β and reactive oxygen species: A perverse cycle for fibrosis , 2015, Redox biology.

[120]  T. Kisseleva,et al.  Reversibility of liver fibrosis. , 2015, Clinics and research in hepatology and gastroenterology.

[121]  L. DeLeve Liver sinusoidal endothelial cells in hepatic fibrosis , 2015, Hepatology.

[122]  Hae-June Lee,et al.  A Hypoxia-Induced Vascular Endothelial-to-Mesenchymal Transition in Development of Radiation-Induced Pulmonary Fibrosis , 2015, Clinical Cancer Research.

[123]  F. Chisari,et al.  Immunosurveillance of the Liver by Intravascular Effector CD8+ T Cells , 2015, Cell.

[124]  M. Goligorsky,et al.  Curtailing endothelial TGF-β signaling is sufficient to reduce endothelial-mesenchymal transition and fibrosis in CKD. , 2015, Journal of the American Society of Nephrology : JASN.

[125]  Tammara A. Wood,et al.  Myofibroblasts in Murine Cutaneous Fibrosis Originate From Adiponectin‐Positive Intradermal Progenitors , 2015, Arthritis & rheumatology.

[126]  N. Itoh,et al.  The Fibroblast Growth Factor signaling pathway , 2015, Wiley interdisciplinary reviews. Developmental biology.

[127]  J. Berzofsky,et al.  Cutaneous keratoacanthomas/squamous cell carcinomas associated with neutralization of transforming growth factor β by the monoclonal antibody fresolimumab (GC1008) , 2015, Cancer Immunology, Immunotherapy.

[128]  M. Loebe,et al.  Hypoxia-induced deoxycytidine kinase contributes to epithelial proliferation in pulmonary fibrosis. , 2014, American journal of respiratory and critical care medicine.

[129]  J. Madenspacher,et al.  A pneumocyte-macrophage paracrine lipid axis drives the lung toward fibrosis. , 2014, American journal of respiratory cell and molecular biology.

[130]  A. Desmoulière,et al.  Fibroblasts and myofibroblasts in wound healing , 2014, Clinical, cosmetic and investigational dermatology.

[131]  B. Kahaleh,et al.  Endothelial dysfunction in systemic sclerosis , 2014, Current opinion in rheumatology.

[132]  J. Armendáriz-Borunda,et al.  Treatment with pirfenidone for two years decreases fibrosis, cytokine levels and enhances CB2 gene expression in patients with chronic hepatitis C , 2014, BMC Gastroenterology.

[133]  R. Sussman,et al.  A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis. , 2014, The New England journal of medicine.

[134]  H. Collard,et al.  Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis. , 2014, The New England journal of medicine.

[135]  Douglas A. Simonetto,et al.  Vascular endothelial growth factor promotes fibrosis resolution and repair in mice. , 2014, Gastroenterology.

[136]  D. Phelan,et al.  Hypoxia-induced epigenetic modifications are associated with cardiac tissue fibrosis and the development of a myofibroblast-like phenotype. , 2014, Human molecular genetics.

[137]  Dean Sheppard,et al.  TGF-β activation and function in immunity. , 2014, Annual review of immunology.

[138]  R. Virmani,et al.  TGF-β Signaling Mediates Endothelial-to-Mesenchymal Transition (EndMT) During Vein Graft Remodeling , 2014, Science Translational Medicine.

[139]  T. Luedde,et al.  Pharmacological inhibition of the chemokine C‐C motif chemokine ligand 2 (monocyte chemoattractant protein 1) accelerates liver fibrosis regression by suppressing Ly‐6C+ macrophage infiltration in mice , 2014, Hepatology.

[140]  Fabian Kiessling,et al.  CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis , 2014, Gut.

[141]  M. Jakóbisiak,et al.  Interleukin 12: still a promising candidate for tumor immunotherapy? , 2014, Cancer Immunology, Immunotherapy.

[142]  S. Gharib,et al.  MMP28 promotes macrophage polarization toward M2 cells and augments pulmonary fibrosis , 2014, Journal of leukocyte biology.

[143]  P. Agostinis,et al.  Immature, Semi-Mature, and Fully Mature Dendritic Cells: Toward a DC-Cancer Cells Interface That Augments Anticancer Immunity , 2013, Front. Immunol..

[144]  L. DiPietro,et al.  Apoptosis and angiogenesis: an evolving mechanism for fibrosis , 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[145]  R. Schwabe,et al.  Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice , 2013, Hepatology.

[146]  C. Sakamoto,et al.  Inactivation of tumor-specific CD8+ CTLs by tumor-infiltrating tolerogenic dendritic cells , 2013, Immunology and cell biology.

[147]  R. Gay,et al.  Vascular endothelial growth factor aggravates fibrosis and vasculopathy in experimental models of systemic sclerosis , 2013, Annals of the rheumatic diseases.

[148]  R. Weiskirchen,et al.  BMP-7 counteracting TGF-beta1 activities in organ fibrosis. , 2013, Frontiers in bioscience.

[149]  M. Loebe,et al.  Hypoxia‐induced deoxycytidine kinase expression contributes to apoptosis in chronic lung disease , 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[150]  Yuchang Li,et al.  Mesothelial cells give rise to hepatic stellate cells and myofibroblasts via mesothelial–mesenchymal transition in liver injury , 2013, Proceedings of the National Academy of Sciences.

[151]  H. Anders,et al.  Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1β secretion. , 2013, The Journal of clinical investigation.

[152]  S. Friedman,et al.  CD11b+ Gr1+ bone marrow cells ameliorate liver fibrosis by producing interleukin‐10 in mice , 2012, Hepatology.

[153]  J. Fallowfield,et al.  Edinburgh Research Explorer Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis Differential Ly-6C expression identi fi es the recruited macrophage phenotype, which orchestrates the regression of murine liver fi brosis , 2022 .

[154]  S. Zheng,et al.  Dendritic Cell-Specific Disruption of TGF-β Receptor II Leads to Altered Regulatory T Cell Phenotype and Spontaneous Multiorgan Autoimmunity , 2012, The Journal of Immunology.

[155]  K. Iwaisako,et al.  Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice. , 2012, Gastroenterology.

[156]  T. Wynn,et al.  Mechanisms of fibrosis: therapeutic translation for fibrotic disease , 2012, Nature Medicine.

[157]  S. Qiu,et al.  Significance of the Balance between Regulatory T (Treg) and T Helper 17 (Th17) Cells during Hepatitis B Virus Related Liver Fibrosis , 2012, PloS one.

[158]  Xiao-ming Meng,et al.  Diverse roles of TGF‐β receptor II in renal fibrosis and inflammation in vivo and in vitro , 2012, The Journal of pathology.

[159]  Christopher K. Glass,et al.  Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis , 2012, Proceedings of the National Academy of Sciences.

[160]  G. Kanel,et al.  Role of differentiation of liver sinusoidal endothelial cells in progression and regression of hepatic fibrosis in rats. , 2012, Gastroenterology.

[161]  Michael J. Cronce,et al.  Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition , 2011, Proceedings of the National Academy of Sciences.

[162]  C. Heuser,et al.  Kidney dendritic cells induce innate immunity against bacterial pyelonephritis. , 2011, Journal of the American Society of Nephrology : JASN.

[163]  R. Bucala,et al.  Fibrocytes: emerging effector cells in chronic inflammation , 2011, Nature Reviews Immunology.

[164]  S. Sahn,et al.  Pirfenidone in patients with idiopathic pulmonary fibrosis (CAPACITY): two randomised trials , 2011, The Lancet.

[165]  Ivana V. Yang,et al.  A common MUC5B promoter polymorphism and pulmonary fibrosis. , 2011, The New England journal of medicine.

[166]  N. Chatauret,et al.  Analysis of machine perfusion benefits in kidney grafts: a preclinical study , 2011, Journal of Translational Medicine.

[167]  J. Olgin,et al.  Pirfenidone mitigates left ventricular fibrosis and dysfunction after myocardial infarction and reduces arrhythmias. , 2010, Heart rhythm.

[168]  Ruth R. Montgomery,et al.  Circulating monocytes from systemic sclerosis patients with interstitial lung disease show an enhanced profibrotic phenotype , 2010, Laboratory Investigation.

[169]  F. Ginhoux,et al.  Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis , 2009, Hepatology.

[170]  M. Fujimoto,et al.  Clinical Significance of Serum HMGB-1 and sRAGE Levels in Systemic Sclerosis: Association with Disease Severity , 2009, Journal of Clinical Immunology.

[171]  David S. Rogers,et al.  Endothelin-1 and transforming growth factor-beta1 independently induce fibroblast resistance to apoptosis via AKT activation. , 2009, American Journal of Respiratory Cell and Molecular Biology.

[172]  Amitava Das,et al.  Platelet-derived growth factor signaling through ephrin-b2 regulates hepatic vascular structure and function. , 2008, Gastroenterology.

[173]  R. Gomer,et al.  Pivotal Advance: Th‐1 cytokines inhibit, and Th‐2 cytokines promote fibrocyte differentiation , 2008, Journal of leukocyte biology.

[174]  D. Littman,et al.  The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt , 2008, Nature Immunology.

[175]  F. Marra,et al.  Proangiogenic cytokines as hypoxia-dependent factors stimulating migration of human hepatic stellate cells. , 2007, The American journal of pathology.

[176]  Bruce M. Spiegelman,et al.  Adipocytes as regulators of energy balance and glucose homeostasis , 2006, Nature.

[177]  G. Ramadori,et al.  Interferon-gamma acts proapoptotic on hepatic stellate cells (HSC) and abrogates the antiapoptotic effect of interferon-alpha by an HSP70-dependant pathway. , 2005, European journal of cell biology.

[178]  D. Warburton,et al.  Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice. , 2002, American journal of physiology. Lung cellular and molecular physiology.

[179]  R. Homer,et al.  Interleukin-13 Induces Tissue Fibrosis by Selectively Stimulating and Activating Transforming Growth Factor β1 , 2001, The Journal of experimental medicine.

[180]  R. Atkins,et al.  Tubular epithelial-myofibroblast transdifferentiation in progressive tubulointerstitial fibrosis in 5/6 nephrectomized rats. , 1998, Kidney international.

[181]  S. Friedman,et al.  Hepatic lipocytes: the principal collagen-producing cells of normal rat liver. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[182]  B. Hinz,et al.  Myofibroblast Markers and Microscopy Detection Methods in Cell Culture and Histology. , 2021, Methods in molecular biology.

[183]  M. Barras,et al.  ROS directly activates transforming growth factor β type 1 receptor signalling in human vascular smooth muscle cells. , 2019, Biochimica et biophysica acta. General subjects.

[184]  H. Ni,et al.  Morphology and Evaluation of Renal Fibrosis. , 2019, Advances in experimental medicine and biology.

[185]  O. Ornatsky,et al.  Opposing Roles of Dendritic Cell Subsets in Experimental GN. , 2018, Journal of the American Society of Nephrology : JASN.

[186]  M. Conforti,et al.  Differential expression of junctional adhesion molecules in different stages of systemic sclerosis. , 2013, Arthritis and rheumatism.

[187]  A. McMahon,et al.  Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. , 2010, The American journal of pathology.

[188]  A. Zaiman,et al.  PDE5A inhibition attenuates bleomycin-induced pulmonary fibrosis and pulmonary hypertension through inhibition of ROS generation and RhoA/Rho kinase activation. , 2008, American journal of physiology. Lung cellular and molecular physiology.

[189]  S. Targan,et al.  Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease. , 2002, Gastroenterology.