Bilirubin and biliverdin protect rodents against diabetic nephropathy by downregulating NAD(P)H oxidase.

[1]  J. Weuve,et al.  Serum total bilirubin level, prevalent stroke, and stroke outcomes: NHANES 1999-2004. , 2008, The American journal of medicine.

[2]  R. Takayanagi,et al.  Relationship between Gilbert syndrome and prevalence of vascular complications in patients with diabetes. , 2007, JAMA.

[3]  R. Takayanagi,et al.  Pitavastatin ameliorates albuminuria and renal mesangial expansion by downregulating NOX4 in db/db mice. , 2007, Kidney international.

[4]  Hung-Yi Chen,et al.  Melatonin decreases neurovascular oxidative/nitrosative damage and protects against early increases in the blood–brain barrier permeability after transient focal cerebral ischemia in mice , 2006, Journal of pineal research.

[5]  H. Abboud,et al.  Nox4 NAD(P)H Oxidase Mediates Hypertrophy and Fibronectin Expression in the Diabetic Kidney* , 2005, Journal of Biological Chemistry.

[6]  S. Bloc,et al.  Bilirubin decreases NOS2 expression via inhibition of NAD(P)H oxidase: implications for protection against endotoxic shock in rats , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[7]  T. Morita Heme Oxygenase and Atherosclerosis , 2005, Arteriosclerosis, thrombosis, and vascular biology.

[8]  H. Utsumi,et al.  Statin attenuates high glucose-induced and diabetes-induced oxidative stress in vitro and in vivo evaluated by electron spin resonance measurement. , 2005, Free radical biology & medicine.

[9]  N. Abraham,et al.  Heme oxygenase and the cardiovascular-renal system. , 2005, Free radical biology & medicine.

[10]  H. Nawata,et al.  NAD(P)H Oxidase Activation: A Potential Target Mechanism for Diabetic Vascular Complications, Progressive β-Cell Dysfunction and Metabolic Syndrome , 2005 .

[11]  R. Stocker Antioxidant activities of bile pigments. , 2004, Antioxidants & redox signaling.

[12]  S. Matsumoto,et al.  Evidence for contribution of vascular NAD(P)H oxidase to increased oxidative stress in animal models of diabetes and obesity. , 2004, Free radical biology & medicine.

[13]  S. Araki,et al.  Translocation of glomerular p47phox and p67phox by protein kinase C-beta activation is required for oxidative stress in diabetic nephropathy. , 2003, Diabetes.

[14]  H. Nawata,et al.  Increased expression of NAD(P)H oxidase subunits, NOX4 and p22phox, in the kidney of streptozotocin-induced diabetic rats and its reversibity by interventive insulin treatment , 2003, Diabetologia.

[15]  H. Utsumi,et al.  Protein kinase C-dependent increase in reactive oxygen species (ROS) production in vascular tissues of diabetes: role of vascular NAD(P)H oxidase. , 2003, Journal of the American Society of Nephrology : JASN.

[16]  R. Clempus,et al.  Vascular NAD(P)H oxidases: specific features, expression, and regulation. , 2003, American journal of physiology. Regulatory, integrative and comparative physiology.

[17]  C. Betsholtz,et al.  A new method for large scale isolation of kidney glomeruli from mice. , 2002, The American journal of pathology.

[18]  H. Nawata,et al.  Accumulation of 8-hydroxy-2'-deoxyguanosine and mitochondrial DNA deletion in kidney of diabetic rats. , 2002, Diabetes.

[19]  C. Kim,et al.  Vascular NADH oxidase is involved in impaired endothelium-dependent vasodilation in OLETF rats, a model of type 2 diabetes. , 2002, Diabetes.

[20]  T. Münzel,et al.  Mechanisms Underlying Endothelial Dysfunction in Diabetes Mellitus , 2001, Circulation research.

[21]  M. Hattori,et al.  A Novel Superoxide-producing NAD(P)H Oxidase in Kidney* , 2001, The Journal of Biological Chemistry.

[22]  H. Utsumi,et al.  High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells. , 2000, Diabetes.

[23]  P. Várnai,et al.  Identification of renox, an NAD(P)H oxidase in kidney. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[24]  J. Zweier,et al.  Validation of Lucigenin (Bis-N-methylacridinium) as a Chemilumigenic Probe for Detecting Superoxide Anion Radical Production by Enzymatic and Cellular Systems* , 1998, The Journal of Biological Chemistry.

[25]  S. Hunt,et al.  Higher serum bilirubin is associated with decreased risk for early familial coronary artery disease. , 1996, Arteriosclerosis, thrombosis, and vascular biology.

[26]  S. Ebrahim,et al.  Serum bilirubin and risk of ischemic heart disease in middle-aged British men. , 1995, Clinical chemistry.

[27]  F. Ziyadeh,et al.  Role of transforming growth factor beta in diabetic nephropathy. , 1994, Experimental nephrology.

[28]  K. H. Kim,et al.  DNA damage in the kidneys of diabetic rats exhibiting microalbuminuria. , 1994, Free radical biology & medicine.

[29]  J. Baynes Role of Oxidative Stress in Development of Complications in Diabetes , 1991, Diabetes.

[30]  K. Takeshige,et al.  Bilirubin inhibits the activation of superoxide-producing NADPH oxidase in a neutrophil cell-free system. , 1991, Biochimica et biophysica acta.

[31]  B. Ames,et al.  Bilirubin is an antioxidant of possible physiological importance. , 1987, Science.

[32]  G. Lippi,et al.  Relationship of serum bilirubin concentrations to kidney function and albuminuria in the United States adult population. Findings from the National Health and Nutrition Examination Survey 2001–2006 , 2009, Clinical chemistry and laboratory medicine.

[33]  K. Griendling,et al.  Smooth Muscle Cells , 2005 .

[34]  H. Nawata,et al.  NAD(P)H oxidase activation: a potential target mechanism for diabetic vascular complications, progressive beta-cell dysfunction and metabolic syndrome. , 2005, Current drug targets.

[35]  S. Wolff,et al.  Protein glycation and oxidative stress in diabetes mellitus and ageing. , 1991, Free radical biology & medicine.

[36]  R. Stocker,et al.  Induction of haem oxygenase as a defence against oxidative stress. , 1990, Free radical research communications.

[37]  L. Oberley Free radicals and diabetes. , 1988, Free radical biology & medicine.