Hereditary Gingival Fibromatosis: A Family Study

Hereditary gingival fibromatosis is considered a rare disease, which appears in the oral cavity. Its prevalence is 1:750000. A gradually progressive of the gingival characterizes the condition. Usually hereditary gingival fibromatosis appears with autosomal-dominant inheritance but it can also appear with autosomal-recessive inheritance. The most common mutation is the Son of Sevenless-1 gene. It can be either non-Syndromic or Syndromic. The onset is usually with the eruption of permanent dentition. All treatment modalities aim to the removal of the excessive gingival tissues. However, there is recurrence of the condition after miscellaneous period of time. This study is about a three generation appearance of Hereditary Gingival Fibromatosis, occurred only in female members of the family. Its biological mechanism, diagnosis and treatment are described.

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