β-1,2-Mannosylation of Candida albicans Mannoproteins and Glycolipids Differs with Growth Temperature and Serotype

ABSTRACT Increasing the growth temperature from 28 to 37°C reduced the expression of β-1,2-oligomannoside epitopes on mannoproteins of Candida albicans serotypes A and B. In contrast, β-1,2-mannosylation of phospholipomannan (PLM) remained constant despite a slight decrease in the relative molecular weight (Mr) of this compound. At all growth temperatures investigated, serotype A PLM displayed an Mr and an antigenicity different from those of serotype B PLM when they were tested with a panel of monoclonal antibodies.

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