Evaluation of the novel liver micronucleus assay using formalin-fixed tissues

[1]  S. Hamada,et al.  Optimization of specimen preparation from formalin-fixed liver tissues for liver micronucleus assays: Hepatocyte staining with fluorescent dyes. , 2016, Mutation research. Genetic toxicology and environmental mutagenesis.

[2]  A. Maeda,et al.  Evaluation of the repeated-dose liver micronucleus assay using 2,4-dinitrotoluene: a report of a collaborative study by CSGMT/JEMS.MMS. , 2015, Mutation research. Genetic toxicology and environmental mutagenesis.

[3]  S. Hamada,et al.  Evaluation of a repeated dose liver micronucleus assay in rats treated with two genotoxic hepatocarcinogens, dimethylnitrosamine and 2-acetylaminofluorene: the possibility of integrating micronucleus tests with multiple tissues into a repeated dose general toxicity study. , 2015, Mutation research. Genetic toxicology and environmental mutagenesis.

[4]  S. Souma,et al.  Detection of micronuclei in hepatocytes isolated from young adult rats repeatedly treated with N-nitrosodi-n-propylamine. , 2015, Mutation research. Genetic toxicology and environmental mutagenesis.

[5]  M. Hayashi,et al.  Repeated-dose liver and gastrointestinal tract micronucleus assays for quinoline in rats. , 2015, Mutation research. Genetic toxicology and environmental mutagenesis.

[6]  Kaori Takahashi,et al.  Repeated-dose liver micronucleus assay: an investigation with 2-nitropropane, a hepatocarcinogen. , 2015, Mutation research. Genetic toxicology and environmental mutagenesis.

[7]  M. Honma,et al.  Evaluation of the repeated-dose liver and gastrointestinal tract micronucleus assays with 22 chemicals using young adult rats: summary of the collaborative study by the Collaborative Study Group for the Micronucleus Test (CSGMT)/The Japanese Environmental Mutagen Society (JEMS) - Mammalian Mutagenic , 2015, Mutation research. Genetic toxicology and environmental mutagenesis.

[8]  S. Hamada,et al.  Micronucleus induction in rat liver and bone marrow by acute vs. repeat doses of the genotoxic hepatocarcinogen monocrotaline. , 2015, Mutation research. Genetic toxicology and environmental mutagenesis.

[9]  Kenji Inoue,et al.  The 14-day repeated dose liver micronucleus test with methapyrilene hydrochloride using young adult rats. , 2015, Mutation research. Genetic toxicology and environmental mutagenesis.

[10]  Y. Wako,et al.  Evaluation of the repeated dose liver micronucleus assay using young adult rats with cyclophosphamide monohydrate: a report of a collaborative study by CSGMT/JEMS.MMS. , 2015, Mutation research. Genetic toxicology and environmental mutagenesis.

[11]  S. Hamada,et al.  Evaluation of the repeated-dose liver micronucleus assay using N-nitrosomorpholine in young adult rats: report on collaborative study by the Collaborative Study Group for the Micronucleus Test (CSGMT)/Japanese Environmental Mutagen Society (JEMS)-Mammalian Mutagenicity Study (MMS) Group. , 2015, Mutation research. Genetic toxicology and environmental mutagenesis.

[12]  Y. Wako,et al.  Evaluation of the repeated-dose liver micronucleus assay with p-dimethylaminoazobenzene. , 2015, Mutation research. Genetic toxicology and environmental mutagenesis.

[13]  Tatsuya Kato,et al.  Assessment of methyl methanesulfonate using the repeated-dose liver micronucleus assay in young adult rats. , 2015, Mutation research. Genetic toxicology and environmental mutagenesis.

[14]  H. Hori,et al.  Repeated dose liver micronucleus assay using clofibrate in young adult rats. , 2015, Mutation research. Genetic toxicology and environmental mutagenesis.

[15]  N. Nishiyama,et al.  Repeated-dose liver and gastrointestinal tract micronucleus assays with CI Solvent Yellow 14 (Sudan I) using young adult rats. , 2015, Mutation research. Genetic toxicology and environmental mutagenesis.

[16]  H. Hori,et al.  Repeated dose liver and gastrointestinal tract micronucleus assays using N-methyl-N'-nitro-N-nitrosoguanidine in young adult rats. , 2015, Mutation research. Genetic toxicology and environmental mutagenesis.

[17]  S. Furukawa,et al.  Evaluation of repeated dose micronucleus assays of the liver using N-nitrosopyrrolidine: a report of the collaborative study by CSGMT/JEMS.MMS. , 2015, Mutation research. Genetic toxicology and environmental mutagenesis.

[18]  W. Ohyama,et al.  Evaluation of repeated dose micronucleus assays of the liver and gastrointestinal tract using potassium bromate: a report of the collaborative study by CSGMT/JEMS.MMS. , 2015, Mutation research. Genetic toxicology and environmental mutagenesis.

[19]  Y. Wako,et al.  Evaluation of in vivo genotoxicity by thioacetamide in a 28-day repeated-dose liver micronucleus assay using male young adult rats. , 2015, Mutation research. Genetic toxicology and environmental mutagenesis.

[20]  M. Hayashi,et al.  Development of a repeated-dose liver micronucleus assay using adult rats: an investigation of diethylnitrosamine and 2,4-diaminotoluene. , 2012, Mutation research.

[21]  M. Hayashi,et al.  Evaluation of a liver micronucleus assay in young rats (IV): a study using a double-dosing/single-sampling method by the Collaborative Study Group for the Micronucleus Test (CSGMT)/Japanese Environmental Mutagen Society (JEMS)-Mammalian Mutagenicity Study Group (MMS). , 2010, Mutation research.

[22]  C. Aruga,et al.  Evaluation of a liver micronucleus assay in young rats (III): a study using nine hepatotoxicants by the Collaborative Study Group for the Micronucleus Test (CSGMT)/Japanese Environmental Mutagen Society (JEMS)-Mammalian Mutagenicity Study Group (MMS). , 2010, Mutation research.

[23]  M. Hayashi,et al.  Evaluation of a liver micronucleus assay with 12 chemicals using young rats (II): a study by the Collaborative Study Group for the Micronucleus Test/Japanese Environmental Mutagen Society-Mammalian Mutagenicity Study Group. , 2008, Mutagenesis.

[24]  Lutz Müller,et al.  Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens I. Sensitivity, specificity and relative predictivity. , 2005, Mutation research.

[25]  Takayoshi Suzuki,et al.  Evaluation of liver and peripheral blood micronucleus assays with 9 chemicals using young rats. A study by the Collaborative Study Group for the Micronucleus Test (CSGMT)/Japanese Environmental Mutagen Society (JEMS)-Mammalian Mutagenicity Study Group (MMS). , 2005, Mutation research.

[26]  Makoto Hayashi,et al.  Evaluation of the rat micronucleus test with bone marrow and peripheral blood: Summary of the 9th collaborative study by CSGMT/JEMS·MMS , 1998, Environmental and molecular mutagenesis.

[27]  T Sofuni,et al.  Evaluation of the rodent micronucleus assay in the screening of IARC carcinogens (groups 1, 2A and 2B) the summary report of the 6th collaborative study by CSGMT/JEMS MMS. Collaborative Study of the Micronucleus Group Test. Mammalian Mutagenicity Study Group. , 1997, Mutation research.

[28]  M. Garriott,et al.  An evaluation of micronucleus induction in bone marrow and in hepatocytes isolated from collagenase perfused liver or from formalin‐fixed liver using four‐week‐old rats treated with known clastogens , 1997, Environmental and molecular mutagenesis.

[29]  F. Angelosanto.  Tissues other than bone marrow that can be used for cytogenetic analyses , 1995, Environmental and molecular mutagenesis.

[30]  R Kato,et al.  Sex-specific cytochrome P450 as a cause of sex- and species-related differences in drug toxicity. , 1992, Toxicology letters.

[31]  C. Westmoreland,et al.  Evaluation of the in vivo genotoxicity of the structural analogues 2,6-diaminotoluene and 2,4-diaminotoluene using the rat micronucleus test and rat liver UDS assay. , 1991, Carcinogenesis.

[32]  R. Tennant,et al.  Definitive relationships among chemical structure, carcinogenicity and mutagenicity for 301 chemicals tested by the U.S. NTP. , 1991, Mutation research.

[33]  J. Ashby,et al.  The rat-liver carcinogen N-nitrosomorpholine initiates unscheduled DNA synthesis and induces micronuclei in the rat liver in vivo. , 1989, Mutation research.

[34]  A. Tates,et al.  The role of short-lived lesions in the induction of micronuclei in rat liver by ethylnitrosourea and methyl methanesulphonate: the importance of experimental design. , 1989, Mutation research.

[35]  J. Ashby,et al.  A non-invasive micronucleus assay in the rat liver. , 1988, Mutation research.

[36]  A. Rossi,et al.  DNA synthesis, mitotic index, drug-metabolising systems and cytogenetic analysis in regenerating rat liver. Comparison with bone marrow test after 'in vivo' treatment with cyclophosphamide. , 1987, Mutation research.

[37]  A. Tates,et al.  A micronucleus technique for detecting clastogenic effects of mutagens/carcinogens (DEN, DMN) in hepatocytes of rat liver in vivo. , 1980, Mutation research.

[38]  A. Tates,et al.  Ctrogenetic effects of mutagens/carcinogens after activation in a microsomal system in vitro I. Induction of chromosome aberrations and sister chromatid exchanges by diethylnitrosamine (DEN) and dimethylnitrosamine (DMN) in CHO cells in the presence of rat-liver microsomes , 1976 .

[39]  A. Tates,et al.  Cytogenetic effects of mutagens/carcinogens after activation in a microsomal system in vitro I. Induction of chromosome aberrations and sister chromatid exchanges by diethylnitrosamine (DEN) and dimethylnitrosamine (DMN) in CHO cells in the presence of rat-liver microsomes. , 1976, Mutation research.

[40]  M A Kastenbaum,et al.  Tables for determining the statistical significance of mutation frequencies. , 1970, Mutation research.