Serum sonic hedgehog (SHH) and interleukin-(IL-6) as dual prognostic biomarkers in progressive metastatic breast cancer

[1]  Ruo-Pan Huang,et al.  Cytokines in cancer drug resistance: Cues to new therapeutic strategies. , 2016, Biochimica et biophysica acta.

[2]  A. Aboussekhra,et al.  Overexpression of sonic hedgehog in the triple negative breast cancer: clinicopathological characteristics of high burden breast cancer patients from Bangladesh , 2016, Scientific Reports.

[3]  K. Hahm,et al.  Sonic hedgehog inhibitors prevent colitis-associated cancer via orchestrated mechanisms of IL-6/gp130 inhibition, 15-PGDH induction, Bcl-2 abrogation, and tumorsphere inhibition , 2015, Oncotarget.

[4]  J. Hatina,et al.  Simultaneous Targeting of Bladder Tumor Growth, Survival, and Epithelial-to-Mesenchymal Transition with a Novel Therapeutic Combination of Acetazolamide (AZ) and Sulforaphane (SFN) , 2016, Targeted Oncology.

[5]  D. Flynn,et al.  Wound Healing and Cancer Stem Cells: Inflammation as a Driver of Treatment Resistance in Breast Cancer , 2015, Cancer growth and metastasis.

[6]  J. Cerhan,et al.  Prognostic Significance of Pretreatment Serum Cytokines in Classical Hodgkin Lymphoma , 2013, Clinical Cancer Research.

[7]  Chien-Jen Chen,et al.  Circulating interleukin‐6 level is a prognostic marker for survival in advanced nonsmall cell lung cancer patients treated with chemotherapy , 2013, International journal of cancer.

[8]  Sandra A O'Toole,et al.  The Hedgehog signalling pathway in breast development, carcinogenesis and cancer therapy , 2013, Breast Cancer Research.

[9]  P. Hojman,et al.  The role of intratumoral and systemic IL-6 in breast cancer , 2013, Breast Cancer Research and Treatment.

[10]  Michelle A. Anderson,et al.  Plasma Shh Levels Reduced in Pancreatic Cancer Patients , 2012, Pancreas.

[11]  J. Schneider,et al.  Hedgehog signaling inhibition blocks growth of resistant tumors through effects on tumor microenvironment. , 2012, Cancer research.

[12]  F. Esteva.  Molecular serum portraits in patients with primary breast cancer predict the development of distant metastases: Carlsson A, Wingren C, Kristensson M, et al (Lund Univ, Sweden; Et al) Proc Natl Acad Sci U S A 108:14252-14257, 2011 , 2012 .

[13]  Mitsuo Katano,et al.  Hedgehog signaling pathway as a therapeutic target in various types of cancer , 2011, Cancer science.

[14]  J. Scheller,et al.  Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling. , 2011, The Journal of clinical investigation.

[15]  Carsten Peterson,et al.  Molecular serum portraits in patients with primary breast cancer predict the development of distant metastases , 2011, Proceedings of the National Academy of Sciences.

[16]  M. Lisanti,et al.  The role of breast cancer stem cells in metastasis and therapeutic implications. , 2011, The American journal of pathology.

[17]  Stephen Gould,et al.  Canonical hedgehog signaling augments tumor angiogenesis by induction of VEGF-A in stromal perivascular cells , 2011, Proceedings of the National Academy of Sciences.

[18]  R. Samant,et al.  Hedgehog Signaling Induced by Breast Cancer Cells Promotes Osteoclastogenesis and Osteolysis* , 2010, The Journal of Biological Chemistry.

[19]  Mitch Dowsett,et al.  Current and emerging biomarkers in breast cancer: prognosis and prediction. , 2010, Endocrine-related cancer.

[20]  R. Mahato,et al.  Inhibition of Endogenous Hedgehog Signaling Protects Against Acute Liver Injury After Ischemia Reperfusion , 2010, Pharmaceutical Research.

[21]  E. van Marck,et al.  Is there a role for mammary stem cells in inflammatory breast carcinoma? , 2010, Cancer.

[22]  Lee F. Peng,et al.  Small-molecule modulators of the Sonic Hedgehog signaling pathway. , 2010, Molecular bioSystems.

[23]  M. Kasper,et al.  Hedgehog signalling in breast cancer. , 2009, Carcinogenesis.

[24]  H. Tian,et al.  Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis , 2009, Proceedings of the National Academy of Sciences.

[25]  Wenjun Guo,et al.  The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells , 2008, Cell.

[26]  Hua Tian,et al.  A paracrine requirement for hedgehog signalling in cancer , 2008, Nature.

[27]  Heike Knüpfer,et al.  Significance of interleukin-6 (IL-6) in breast cancer (review) , 2007, Breast Cancer Research and Treatment.

[28]  L. Pusztai,et al.  Molecular classification of breast cancer: implications for selection of adjuvant chemotherapy , 2006, Nature Clinical Practice Oncology.

[29]  G. Page,et al.  Hedgehog signaling and response to cyclopamine differs in epithelial and stromal cells in benign breast and breast cancer , 2006, Cancer biology & therapy.

[30]  L. Goldstein,et al.  Prognostic and predictive factors in early-stage breast cancer. , 2004, The oncologist.

[31]  Rosette Lidereau,et al.  Molecular Profiling of Inflammatory Breast Cancer , 2004, Clinical Cancer Research.

[32]  Masatoshi Nomura,et al.  Hedgehog Signaling Pathway is a New Therapeutic Target for Patients with Breast Cancer , 2004, Cancer Research.

[33]  M. Duffy,et al.  High preoperative CA 15-3 concentrations predict adverse outcome in node-negative and node-positive breast cancer: study of 600 patients with histologically confirmed breast cancer. , 2004, Clinical chemistry.

[34]  J. Blay,et al.  Prognostic value of serum levels of interleukin 6 and of serum and plasma levels of vascular endothelial growth factor in hormone-refractory metastatic breast cancer patients , 2003, British Journal of Cancer.

[35]  E. van Marck,et al.  Circulating interleukin‐6 predicts survival in patients with metastatic breast cancer , 2003, International journal of cancer.

[36]  N. Anderson,et al.  The Human Plasma Proteome: History, Character, and Diagnostic Prospects , 2003, Molecular & Cellular Proteomics.

[37]  J. Folkman.  Role of angiogenesis in tumor growth and metastasis. , 2002, Seminars in oncology.

[38]  N. Anderson,et al.  The Human Plasma Proteome , 2002, Molecular & Cellular Proteomics.

[39]  Yudong D. He,et al.  Gene expression profiling predicts clinical outcome of breast cancer , 2002, Nature.

[40]  P. Ingham,et al.  Hedgehog signaling in animal development: paradigms and principles. , 2001, Genes & development.

[41]  R. Weinberg,et al.  Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation. , 2001, Experimental cell research.

[42]  R. Nishimura,et al.  An Analysis of Serum Interleukin-6 Levels to Predict Benefits of Medroxyprogesterone Acetate in Advanced or Recurrent Breast Cancer , 2000, Oncology.

[43]  J. Naeyaert,et al.  Serological markers for melanoma , 2000, The British journal of dermatology.

[44]  Y. Morishita,et al.  Trends of IL-6 and IL-8 levels in patients with recurrent breast cancer: preliminary report , 2000, Breast cancer.

[45]  M. MacLean,et al.  Prognosis and prediction. , 1955 .

[46]  M. Sherman,et al.  A Preliminary Report , 1953 .