Peroxisome proliferator-activated receptor γ (PPARγ): A master gatekeeper in CNS injury and repair

[1]  A. Qureshi,et al.  Acute hypertensive response in patients with intracerebral hemorrhage pathophysiology and treatment , 2017, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[2]  H. Vries,et al.  Inflammation at the blood-brain barrier: The role of liver X receptors , 2017, Neurobiology of Disease.

[3]  Xiaobo Tang,et al.  Activation of peroxisome proliferator-activated receptor-γ by a 12/15-lipoxygenase product of arachidonic acid: a possible neuroprotective effect in the brain after experimental intracerebral hemorrhage. , 2017, Journal of neurosurgery.

[4]  F. Biering-Sørensen,et al.  Renal deterioration after spinal cord injury is associated with length of detrusor contractions during cystometry—A study with a median of 41 years follow‐up , 2017, Neurourology and urodynamics.

[5]  T. Battey,et al.  Hyperglycemia is associated with more severe cytotoxic injury after stroke , 2017, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[6]  Shao-Jun Tang,et al.  HIV-1 gp120 Upregulates Brain-Derived Neurotrophic Factor (BDNF) Expression in BV2 Cells via the Wnt/β-Catenin Signaling Pathway , 2017, Journal of Molecular Neuroscience.

[7]  Andre Obenaus,et al.  Response of the cerebral vasculature following traumatic brain injury , 2017, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[8]  R. Paulson,et al.  Activation of PPARγ by endogenous prostaglandin J2 mediates the antileukemic effect of selenium in murine leukemia. , 2017, Blood.

[9]  Feng Zhang,et al.  The impact of cerebrovascular aging on vascular cognitive impairment and dementia , 2017, Ageing Research Reviews.

[10]  Qing-Wu Yang,et al.  Regulatory T cells ameliorate intracerebral hemorrhage-induced inflammatory injury by modulating microglia/macrophage polarization through the IL-10/GSK3β/PTEN axis , 2017, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[11]  M. Simmaco,et al.  Clinical Applications of Personalized Medicine: A New Paradigm and Challenge. , 2017, Current pharmaceutical biotechnology.

[12]  H. Feng,et al.  Simvastatin Promotes Hematoma Absorption and Reduces Hydrocephalus Following Intraventricular Hemorrhage in Part by Upregulating CD36 , 2017, Translational Stroke Research.

[13]  Minshu Li,et al.  Depletion of microglia exacerbates postischemic inflammation and brain injury , 2017, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[14]  Jia Liu,et al.  Peroxisome proliferator-activated receptor gamma agonists for preventing recurrent stroke and other vascular events in people with stroke or transient ischaemic attack. , 2015, The Cochrane database of systematic reviews.

[15]  J. Lukens,et al.  Emerging Roles for the Immune System in Traumatic Brain Injury , 2016, Front. Immunol..

[16]  Michael Loran Dustin.  Complement Receptors in Myeloid Cell Adhesion and Phagocytosis. , 2016, Microbiology spectrum.

[17]  Regina C. Armstrong,et al.  Myelin and oligodendrocyte lineage cells in white matter pathology and plasticity after traumatic brain injury , 2016, Neuropharmacology.

[18]  Zhaoyang Yang,et al.  Endogenous neurogenesis in adult mammals after spinal cord injury , 2016, Science China Life Sciences.

[19]  Jun Chen,et al.  A Post-stroke Therapeutic Regimen with Omega-3 Polyunsaturated Fatty Acids that Promotes White Matter Integrity and Beneficial Microglial Responses after Cerebral Ischemia , 2016, Translational Stroke Research.

[20]  M. Woo,et al.  Cell Surface CD36 Protein in Monocyte/Macrophage Contributes to Phagocytosis during the Resolution Phase of Ischemic Stroke in Mice* , 2016, The Journal of Biological Chemistry.

[21]  K. Furie,et al.  The IRIS (Insulin Resistance Intervention after Stroke) trial: A new perspective on pioglitazone , 2016, Journal of diabetes.

[22]  M. Ribeiro,et al.  Astrocytes as a target for neuroprotection: Modulation by progesterone and dehydroepiandrosterone , 2016, Progress in Neurobiology.

[23]  P. Bath,et al.  The Insulin Resistance Intervention after Stroke trial: A perspective on future practice and research , 2016, International journal of stroke : official journal of the International Stroke Society.

[24]  Ann M. Stowe,et al.  Spreading depolarizations increase delayed brain injury in a rat model of subarachnoid hemorrhage , 2016, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[25]  Laura B. Ferguson,et al.  Localization of PPAR isotypes in the adult mouse and human brain , 2016, Scientific Reports.

[26]  X. Ji,et al.  White matter injury in ischemic stroke , 2016, Progress in Neurobiology.

[27]  ShefaliKhanna Sharma,et al.  The role of danger-associated molecular patterns (DAMPs) in trauma and infections. , 2016, Journal of thoracic disease.

[28]  C. Dixon,et al.  Rosiglitazone attenuates inflammation and CA3 neuronal loss following traumatic brain injury in rats. , 2016, Biochemical and biophysical research communications.

[29]  M. Peschanski,et al.  PPARγ Is Activated during Congenital Cytomegalovirus Infection and Inhibits Neuronogenesis from Human Neural Stem Cells , 2016, PLoS pathogens.

[30]  Simone Degan,et al.  Dysregulation of oxygen hemodynamic responses to synaptic train stimulation in a rat hippocampal model of subarachnoid hemorrhage , 2016, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[31]  E Erdmann,et al.  Ten‐year observational follow‐up of PROactive: a randomized cardiovascular outcomes trial evaluating pioglitazone in type 2 diabetes , 2016, Diabetes, obesity & metabolism.

[32]  D. Tanné,et al.  Pioglitazone after Ischemic Stroke or Transient Ischemic Attack. , 2016, The New England journal of medicine.

[33]  C. Alvira,et al.  Loss of PPARγ in endothelial cells leads to impaired angiogenesis , 2016, Journal of Cell Science.

[34]  R. Keep,et al.  Role of Erythrocyte CD47 in Intracerebral Hematoma Clearance , 2016, Stroke.

[35]  David Attwell,et al.  What is a pericyte? , 2016, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[36]  R. Keep,et al.  Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury , 2016, Nature Communications.

[37]  Mark D. Huffman,et al.  Heart Disease and Stroke Statistics—2016 Update: A Report From the American Heart Association , 2016, Circulation.

[38]  R. Keep,et al.  Translational Stroke Research on Blood-Brain Barrier Damage: Challenges, Perspectives, and Goals , 2016, Translational Stroke Research.

[39]  G. Rosenberg.  Vascular cognitive impairment: Biomarkers in diagnosis and molecular targets in therapy , 2016, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[40]  L. Wolfson,et al.  Cardiovascular risk factors and small vessel disease of the brain: Blood pressure, white matter lesions, and functional decline in older persons , 2016, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[41]  A. Orekhov,et al.  Macrophage‐mediated cholesterol handling in atherosclerosis , 2015, Journal of cellular and molecular medicine.

[42]  Tuo Yang,et al.  The Role of Nonneuronal Nrf2 Pathway in Ischemic Stroke: Damage Control and Potential Tissue Repair , 2016 .

[43]  F. Quelle,et al.  Endothelial PPAR-γ provides vascular protection from IL-1β-induced oxidative stress. , 2016, American journal of physiology. Heart and circulatory physiology.

[44]  Regina C. Armstrong,et al.  White matter involvement after TBI: Clues to axon and myelin repair capacity , 2016, Experimental Neurology.

[45]  Teng-Nan Lin,et al.  PPAR-γ Ameliorates Neuronal Apoptosis and Ischemic Brain Injury via Suppressing NF-κB-Driven p22phox Transcription , 2015, Molecular Neurobiology.

[46]  L. Schlichter,et al.  After Intracerebral Hemorrhage, Oligodendrocyte Precursors Proliferate and Differentiate Inside White-Matter Tracts in the Rat Striatum , 2016, Translational Stroke Research.

[47]  N. Hattori,et al.  Effects of Pioglitazone for Secondary Stroke Prevention in Patients with Impaired Glucose Tolerance and Newly Diagnosed Diabetes: The J-SPIRIT Study. , 2015, Journal of atherosclerosis and thrombosis.

[48]  M. Nasr-Esfahani,et al.  A ground state of PPARγ activity and expression is required for appropriate neural differentiation of hESCs , 2015, Pharmacological reports : PR.

[49]  B. Renaud,et al.  Clinical Neurochemistry of Subarachnoid Hemorrhage: Toward Predicting Individual Outcomes via Biomarkers of Brain Energy Metabolism. , 2015, ACS chemical neuroscience.

[50]  O. Lindvall,et al.  Neurogenesis following Stroke Affecting the Adult Brain. , 2015, Cold Spring Harbor perspectives in biology.

[51]  R. Leak,et al.  Demyelination as a rational therapeutic target for ischemic or traumatic brain injury , 2015, Experimental Neurology.

[52]  S. Sauer.  Ligands for the Nuclear Peroxisome Proliferator-Activated Receptor Gamma. , 2015, Trends in pharmacological sciences.

[53]  Xiang Zhang,et al.  Rosiglitazone exerts neuroprotective effects via the suppression of neuronal autophagy and apoptosis in the cortex following traumatic brain injury , 2015, Molecular medicine reports.

[54]  B. Zhai,et al.  Biochanin A inhibits lipopolysaccharide-induced inflammation in human umbilical vein endothelial cells. , 2015, Life sciences.

[55]  R. Leak,et al.  Rosiglitazone Promotes White Matter Integrity and Long-Term Functional Recovery After Focal Cerebral Ischemia , 2015, Stroke.

[56]  C. Sanderson,et al.  Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways , 2015, Biochemical Society transactions.

[57]  A. Johnson,et al.  Activation of Central PPAR-&ggr; Attenuates Angiotensin II–Induced Hypertension , 2015, Hypertension.

[58]  Michael Detmar,et al.  A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules , 2015 .

[59]  M. Castelo‐Branco,et al.  Early Disrupted Neurovascular Coupling and Changed Event Level Hemodynamic Response Function in Type 2 Diabetes: An fMRI Study , 2015, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[60]  A. Bjorksten,et al.  The peroxisome proliferator activated receptor gamma agonist pioglitazone increases functional expression of the glutamate transporter excitatory amino acid transporter 2 (EAAT2) in human glioblastoma cells , 2015, Oncotarget.

[61]  Burkhard Becher,et al.  Immune attack: the role of inflammation in Alzheimer disease , 2015, Nature Reviews Neuroscience.

[62]  Timothy J Keyes,et al.  Structural and functional features of central nervous system lymphatics , 2015, Nature.

[63]  F. Pan,et al.  The role of nuclear receptors in regulation of Th17/Treg biology and its implications for diseases , 2015, Cellular and Molecular Immunology.

[64]  Xian Yang,et al.  Peroxisome Proliferator‐activated Receptor‐γ Agonist Pioglitazone Ameliorates White Matter Lesion and Cognitive Impairment in Hypertensive Rats , 2015, CNS neuroscience & therapeutics.

[65]  Chih-Zen Chang,et al.  Glycyrrhizin Attenuates Proinflammatory Cytokines through a Peroxisome Proliferator-Activated Receptor-γ-Dependent Mechanism and Experimental Vasospasm in a Rat Model , 2015, Journal of Vascular Research.

[66]  T. England,et al.  Endocannabinoids modulate human blood–brain barrier permeability in vitro , 2015, British journal of pharmacology.

[67]  J. Aronowski,et al.  Pleiotropic Role of PPARγ in Intracerebral Hemorrhage: An Intricate System Involving Nrf2, RXR, and NF‐κB , 2015, CNS neuroscience & therapeutics.

[68]  J. Aronowski,et al.  Cleaning up after ICH: the role of Nrf2 in modulating microglia function and hematoma clearance , 2015, Journal of neurochemistry.

[69]  M. Yenari,et al.  Inflammatory responses in brain ischemia. , 2015, Current medicinal chemistry.

[70]  R. Fern,et al.  Premyelinated Central Axons Express Neurotoxic NMDA Receptors: Relevance to Early Developing White-Matter Injury , 2015, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[71]  Fan Wang,et al.  Rosiglitazone infusion therapy following minimally invasive surgery for intracerebral hemorrhage evacuation decreases matrix metalloproteinase-9 and blood–brain barrier disruption in rabbits , 2015, BMC Neurology.

[72]  P. Ho,et al.  Influence of drug transporters and stereoselectivity on the brain penetration of pioglitazone as a potential medicine against Alzheimer's disease , 2015, Scientific Reports.

[73]  L. Watkins,et al.  Pioglitazone rapidly reduces neuropathic pain through astrocyte and nongenomic PPAR&ggr; mechanisms , 2015, Pain.

[74]  Regina C. Armstrong,et al.  Components of Myelin Damage and Repair in the Progression of White Matter Pathology After Mild Traumatic Brain Injury , 2015, Journal of neuropathology and experimental neurology.

[75]  K. Pennypacker,et al.  The Role of the Spleen in Ischemic Stroke , 2015, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[76]  I. Bechmann,et al.  Blood—Brain Barrier Breakdown Involves Four Distinct Stages of Vascular Damage in Various Models of Experimental Focal Cerebral Ischemia , 2015, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[77]  D. McTigue,et al.  Chronic Oligodendrogenesis and Remyelination after Spinal Cord Injury in Mice and Rats , 2015, The Journal of Neuroscience.

[78]  K. Tracey,et al.  DAMP Signaling is a Key Pathway Inducing Immune Modulation after Brain Injury , 2015, The Journal of Neuroscience.

[79]  Y. Liu,et al.  Macrophage peroxisome proliferator-activated receptor γ deficiency delays skin wound healing through impairing apoptotic cell clearance in mice , 2015, Cell Death and Disease.

[80]  C. Janani,et al.  PPAR gamma gene--a review. , 2015, Diabetes & metabolic syndrome.

[81]  R. Leak,et al.  Microglial and macrophage polarization—new prospects for brain repair , 2015, Nature Reviews Neurology.

[82]  W. Le,et al.  Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases , 2015, Molecular Neurobiology.

[83]  Wei Zhou,et al.  Antigen Dependently Activated Cluster of Differentiation 8-Positive T Cells Cause Perforin-Mediated Neurotoxicity in Experimental Stroke , 2014, The Journal of Neuroscience.

[84]  D. Tanné,et al.  Pioglitazone for secondary prevention after ischemic stroke and transient ischemic attack: rationale and design of the Insulin Resistance Intervention after Stroke Trial. , 2014, American heart journal.

[85]  Wangxu,et al.  CD36 Upregulation Mediated by Intranasal LV-NRF2 Treatment Mitigates Hypoxia-Induced Progression of Alzheimer's-Like Pathogenesis , 2014 .

[86]  S. Thal,et al.  The blood-brain barrier as a target in traumatic brain injury treatment. , 2014, Archives of medical research.

[87]  Y. E. Chen,et al.  Non-coding RNAs in cerebral endothelial pathophysiology: Emerging roles in stroke , 2014, Neurochemistry International.

[88]  S. Grinstein,et al.  Phagocytosis: receptors, signal integration, and the cytoskeleton , 2014, Immunological reviews.

[89]  Laura B. Ferguson,et al.  PPAR agonists regulate brain gene expression: Relationship to their effects on ethanol consumption , 2014, Neuropharmacology.

[90]  S. Sidney,et al.  Timing and number of minor infections as risk factors for childhood arterial ischemic stroke , 2014, Neurology.

[91]  T. Montine,et al.  PROSTAGLANDIN E2 RECEPTOR SUBTYPE 2 REGULATION OF SCAVENGER RECEPTOR CD36 MODULATES MICROGLIAL AB42 PHAGOCYTOSIS , 2014, Alzheimer's & Dementia.

[92]  M. Dennis,et al.  Renal Dysfunction in Stroke Patients: A Hospital-Based Cohort Study and Systematic Review , 2014, International journal of stroke : official journal of the International Stroke Society.

[93]  M. Matsuhisa,et al.  Effects of pioglitazone on macrovascular events in patients with type 2 diabetes mellitus at high risk of stroke: the PROFIT-J study. , 2014, Journal of atherosclerosis and thrombosis.

[94]  J. Chen,et al.  CD36-Mediated Hematoma Absorption following Intracerebral Hemorrhage: Negative Regulation by TLR4 Signaling , 2014, The Journal of Immunology.

[95]  K. Arai,et al.  Mechanisms of neurovascular dysfunction in acute ischemic brain. , 2014, Current medicinal chemistry.

[96]  S. David,et al.  Differences in the Phagocytic Response of Microglia and Peripheral Macrophages after Spinal Cord Injury and Its Effects on Cell Death , 2014, The Journal of Neuroscience.

[97]  John H. Zhang,et al.  Controversies and evolving new mechanisms in subarachnoid hemorrhage , 2014, Progress in Neurobiology.

[98]  Á. Corbí,et al.  Rosiglitazone‐induced CD36 up‐regulation resolves inflammation by PPARγ and 5‐LO‐dependent pathways , 2014, Journal of leukocyte biology.

[99]  Y. T. Wang,et al.  Excitotoxicity and stroke: Identifying novel targets for neuroprotection , 2014, Progress in Neurobiology.

[100]  B. Grygiel-Górniak.  Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications – a review , 2014, Nutrition Journal.

[101]  F. Shi,et al.  Ischemic neurons recruit natural killer cells that accelerate brain infarction , 2014, Proceedings of the National Academy of Sciences.

[102]  E. Erdmann,et al.  Observational follow‐up of the PROactive study: a 6‐year update , 2014, Diabetes, obesity & metabolism.

[103]  J. Aronowski,et al.  The Role of PPARγ in Stroke , 2014 .

[104]  V. Dhawan.  Reactive Oxygen and Nitrogen Species: General Considerations , 2014 .

[105]  R. Giffard,et al.  Role of Astrocytes in Delayed Neuronal Death: GLT-1 and its Novel Regulation by MicroRNAs. , 2014, Advances in neurobiology.

[106]  X. Navarro,et al.  Phagocytic microglial phenotype induced by glibenclamide improves functional recovery but worsens hyperalgesia after spinal cord injury in adult rats , 2013, The European journal of neuroscience.

[107]  M. A. Moro,et al.  N2 Neutrophils, Novel Players in Brain Inflammation After Stroke: Modulation by the PPAR&ggr; Agonist Rosiglitazone , 2013, Stroke.

[108]  Sheng-Kwei Song,et al.  Oligodendrocyte Lineage and Subventricular Zone Response to Traumatic Axonal Injury in the Corpus Callosum , 2013, Journal of neuropathology and experimental neurology.

[109]  Paul D. Morton,et al.  Inhibition of NADPH Oxidase Activation in Oligodendrocytes Reduces Cytotoxicity Following Trauma , 2013, PloS one.

[110]  D. McTigue,et al.  PPAR agonists as therapeutics for CNS trauma and neurological diseases , 2013, ASN neuro.

[111]  P. Wolinski,et al.  Chemokines and Neurodegeneration in the Early Stage of Experimental Ischemic Stroke , 2013, Mediators of inflammation.

[112]  J. Sheehan,et al.  Reciprocal modulation of C/EBP‐α and C/EBP‐β by IL‐13 in activated microglia prevents neuronal death , 2013, European journal of immunology.

[113]  Chung Y. Hsu,et al.  Risk of Stroke with Thiazolidinediones: A Ten-Year Nationwide Population-Based Cohort Study , 2013, Cerebrovascular Diseases.

[114]  S. Grinstein,et al.  Scavenger receptors in homeostasis and immunity , 2013, Nature Reviews Immunology.

[115]  R. Frye,et al.  Rosiglitazone and Outcomes for Patients With Diabetes Mellitus and Coronary Artery Disease in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) Trial , 2013, Circulation.

[116]  Yanqin Gao,et al.  Microglia/Macrophage Polarization Dynamics in White Matter after Traumatic Brain Injury , 2013, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[117]  J. Larraín,et al.  Spinal cord regeneration: Lessons for mammals from non‐mammalian vertebrates , 2013, Genesis.

[118]  Robert Bigelow,et al.  Results of a reevaluation of cardiovascular outcomes in the RECORD trial. , 2013, American heart journal.

[119]  I. Pitta,et al.  PPARγ Agonists in Adaptive Immunity: What Do Immune Disorders and Their Models Have to Tell Us? , 2013, PPAR research.

[120]  Carlos Vallarino,et al.  Comparing Pioglitazone to Insulin with Respect to Cancer, Cardiovascular and Bone Fracture Endpoints, Using Propensity Score Weights , 2013, Clinical Drug Investigation.

[121]  N. Marklund,et al.  Myelin loss and oligodendrocyte pathology in white matter tracts following traumatic brain injury in the rat , 2013, The European journal of neuroscience.

[122]  J. Puyal,et al.  Multiple interacting cell death mechanisms in the mediation of excitotoxicity and ischemic brain damage: A challenge for neuroprotection , 2013, Progress in Neurobiology.

[123]  L. McCullough,et al.  Microglia and ischemic stroke: a double-edged sword. , 2013, International journal of physiology, pathophysiology and pharmacology.

[124]  L. Qiu,et al.  Spinal neuroimmune activation inhibited by repeated administration of pioglitazone in rats after L5 spinal nerve transection , 2013, Neuroscience Letters.

[125]  S. Ceccatelli,et al.  Perfluorooctane sulfonate induces neuronal and oligodendrocytic differentiation in neural stem cells and alters the expression of PPARγ in vitro and in vivo. , 2013, Toxicology and applied pharmacology.

[126]  J. M. Suh,et al.  PPARγ signaling and metabolism: the good, the bad and the future , 2013, Nature Medicine.

[127]  C. Vigouroux,et al.  Peroxisome Proliferator-Activated Receptor-&ggr; Mutations Responsible for Lipodystrophy With Severe Hypertension Activate the Cellular Renin–Angiotensin System , 2013, Arteriosclerosis, thrombosis, and vascular biology.

[128]  L. Hool,et al.  Role of the cytoskeleton in communication between L‐type Ca2+ channels and mitochondria , 2013, Clinical and experimental pharmacology & physiology.

[129]  Jiandie D. Lin,et al.  KLF11 mediates PPARγ cerebrovascular protection in ischaemic stroke. , 2013, Brain : a journal of neurology.

[130]  Y. Ahn,et al.  Modulation of the Transcriptional Activity of Peroxisome Proliferator-Activated Receptor Gamma by Protein-Protein Interactions and Post-Translational Modifications , 2013, Yonsei medical journal.

[131]  T. Palmer,et al.  PPARγ activation prevents impairments in spatial memory and neurogenesis following transient illness , 2013, Brain, Behavior, and Immunity.

[132]  R. Leak,et al.  Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection , 2013, Progress in Neurobiology.

[133]  C. Grommes,et al.  The PPARγ agonist pioglitazone crosses the blood–brain barrier and reduces tumor growth in a human xenograft model , 2013, Cancer Chemotherapy and Pharmacology.

[134]  Xiangjin Lin,et al.  Peroxisome proliferator-activated receptor-γ agonist rosiglitazone reduces secondary damage in experimental spinal cord injury , 2013, The Journal of international medical research.

[135]  S. Cuzzocrea,et al.  Molecular evidence for the involvement of PPAR-δ and PPAR-γ in anti-inflammatory and neuroprotective activities of palmitoylethanolamide after spinal cord trauma , 2013, Journal of Neuroinflammation.

[136]  B. Zielinski,et al.  Recent trauma and acute infection as risk factors for childhood arterial ischemic stroke , 2012, Annals of neurology.

[137]  Michael T. Heneka,et al.  PPARγ/RXRα-Induced and CD36-Mediated Microglial Amyloid-β Phagocytosis Results in Cognitive Improvement in Amyloid Precursor Protein/Presenilin 1 Mice , 2012, The Journal of Neuroscience.

[138]  Sushil K. Gupta,et al.  PPARγ Agonists Promote Oligodendrocyte Differentiation of Neural Stem Cells by Modulating Stemness and Differentiation Genes , 2012, PloS one.

[139]  A. Scheen.  Outcomes and lessons from the PROactive study. , 2012, Diabetes research and clinical practice.

[140]  R. Leak,et al.  Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia , 2012, Stroke.

[141]  L. Gan,et al.  Myelin debris regulates inflammatory responses in an experimental demyelination animal model and multiple sclerosis lesions , 2012, Glia.

[142]  F. Gonzalez,et al.  Gemfibrozil, a Lipid-lowering Drug, Increases Myelin Genes in Human Oligodendrocytes via Peroxisome Proliferator-activated Receptor-β* , 2012, The Journal of Biological Chemistry.

[143]  K. Jin,et al.  Conditional Depletion of Neurogenesis Inhibits Long-Term Recovery after Experimental Stroke in Mice , 2012, PloS one.

[144]  Pierre J. Magistretti,et al.  Oligodendroglia metabolically support axons and contribute to neurodegeneration , 2012, Nature.

[145]  Jens Frahm,et al.  Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity , 2012, Nature.

[146]  E. Kalkhoven,et al.  PPARγ as a therapeutic target in cystic fibrosis. , 2012, Trends in molecular medicine.

[147]  M. Mogi,et al.  Peroxisome Proliferator-Activated Receptor-&ggr; Activation With Angiotensin II Type 1 Receptor Blockade Is Pivotal for the Prevention of Blood-Brain Barrier Impairment and Cognitive Decline in Type 2 Diabetic Mice , 2012, Hypertension.

[148]  C. Benoist,et al.  PPARγ is a major driver of the accumulation and phenotype of adipose-tissue Treg cells , 2012, Nature.

[149]  Chien-Yu Huang,et al.  Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) and Neurodegenerative Disorders , 2012, Molecular Neurobiology.

[150]  W. Baumgärtner,et al.  Microglial contribution to secondary injury evaluated in a large animal model of human spinal cord trauma. , 2012, Journal of neurotrauma.

[151]  A. Galli,et al.  PPARγ and Oxidative Stress: Con(β) Catenating NRF2 and FOXO , 2012, PPAR research.

[152]  Guo-Yuan Yang,et al.  Roles of chemokine CXCL12 and its receptors in ischemic stroke. , 2012, Current drug targets.

[153]  B. Clarkson,et al.  Innate-adaptive crosstalk: how dendritic cells shape immune responses in the CNS. , 2012, Advances in experimental medicine and biology.

[154]  Li-jun Ma,et al.  Protective effects of PPARγ agonist in acute nephrotic syndrome. , 2012, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[155]  E. Henze,et al.  Activation of cerebral peroxisome proliferator‐activated receptors γ (PPARγ) reduces neuronal damage in the substantia nigra after transient focal cerebral ischaemia in the rat , 2011, Neuropathology and applied neurobiology.

[156]  M. Woodward,et al.  Isolated Low Levels of High-Density Lipoprotein Cholesterol Are Associated With an Increased Risk of Coronary Heart Disease: An Individual Participant Data Meta-Analysis of 23 Studies in the Asia-Pacific Region , 2011, Circulation.

[157]  L. Eichinger,et al.  RpkA, a Highly Conserved GPCR with a Lipid Kinase Domain, Has a Role in Phagocytosis and Anti-Bacterial Defense , 2011, PloS one.

[158]  A. Majid,et al.  Symptomatic and asymptomatic carotid artery plaque , 2011, Expert review of cardiovascular therapy.

[159]  A. Bernardo,et al.  Peroxisome Proliferator-Activated Receptor &ggr; Agonists Accelerate Oligodendrocyte Maturation and Influence Mitochondrial Functions and Oscillatory Ca2+ Waves , 2011, Journal of neuropathology and experimental neurology.

[160]  Scott A. Busby,et al.  Anti-Diabetic Actions of a Non-Agonist PPARγ Ligand Blocking Cdk5-Mediated Phosphorylation , 2011, Nature.

[161]  D. Bailey,et al.  Neuro-oxidative-nitrosative stress in sepsis , 2011, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[162]  C. Werner,et al.  Pioglitazone reduces secondary brain damage after experimental brain trauma by PPAR-γ-independent mechanisms. , 2011, Journal of neurotrauma.

[163]  J. Schmidt,et al.  Infection after Acute Ischemic Stroke: Risk Factors, Biomarkers, and Outcome , 2011, Stroke research and treatment.

[164]  C. Kane,et al.  Protection of neurons and microglia against ethanol in a mouse model of fetal alcohol spectrum disorders by peroxisome proliferator-activated receptor-γ agonists , 2011, Brain, Behavior, and Immunity.

[165]  C. Huang,et al.  Effects of a Single Dose of Methylprednisolone versus Three Doses of Rosiglitazone on Nerve Growth Factor Levels after Spinal Cord Injury , 2011, The Journal of international medical research.

[166]  J. Aronowski,et al.  Molecular pathophysiology of cerebral hemorrhage: secondary brain injury. , 2011, Stroke.

[167]  A. Tedgui,et al.  Recent Advances on the Role of Cytokines in Atherosclerosis , 2011, Arteriosclerosis, thrombosis, and vascular biology.

[168]  S. Tyagi,et al.  Role of PPARgamma, a nuclear hormone receptor in neuroprotection. , 2011, Indian journal of biochemistry & biophysics.

[169]  G. Ning,et al.  Ex Vivo Diffusion Tensor Imaging and Neuropathological Correlation in a Murine Model of Hypoxia–Ischemia-Induced Thrombotic Stroke , 2011, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[170]  C. Blaiss,et al.  Temporally Specified Genetic Ablation of Neurogenesis Impairs Cognitive Recovery after Traumatic Brain Injury , 2011, The Journal of Neuroscience.

[171]  James P Calvet,et al.  PPAR-gamma agonist ameliorates kidney and liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease. , 2011, American journal of physiology. Renal physiology.

[172]  S. Beggs,et al.  Brain-derived neurotrophic factor from microglia: a molecular substrate for neuropathic pain. , 2011, Neuron glia biology.

[173]  A. Sugawara,et al.  Peroxisome proliferator-activated receptor-{gamma} suppresses CYP11B2 expression and aldosterone production. , 2011, Journal of molecular endocrinology.

[174]  A. Fenton,et al.  Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation , 2011, Nature.

[175]  G. V. Chaitanya,et al.  Role of Cytotoxic Protease Granzyme‐b in Neuronal Degeneration During Human Stroke , 2011, Brain pathology.

[176]  C. Oyinbo.  Secondary injury mechanisms in traumatic spinal cord injury: a nugget of this multiply cascade. , 2011, Acta neurobiologiae experimentalis.

[177]  D. Tanné,et al.  Chronic Kidney Disease in Patients with Acute Intracerebral Hemorrhage: Association with Large Hematoma Volume and Poor Outcome , 2010, Cerebrovascular Diseases.

[178]  M. Migaud,et al.  Emerging new sites for adult neurogenesis in the mammalian brain: a comparative study between the hypothalamus and the classical neurogenic zones , 2010, The European journal of neuroscience.

[179]  A. Grau,et al.  Common infections and the risk of stroke , 2010, Nature Reviews Neurology.

[180]  U. Jurkunas,et al.  Evidence of oxidative stress in the pathogenesis of fuchs endothelial corneal dystrophy. , 2010, The American journal of pathology.

[181]  I. Singh,et al.  Activation of PPAR‐γ and PTEN cascade participates in lovastatin‐mediated accelerated differentiation of oligodendrocyte progenitor cells , 2010, Glia.

[182]  K. Meletis,et al.  Origin of new glial cells in intact and injured adult spinal cord. , 2010, Cell stem cell.

[183]  A. Jacob,et al.  Peroxisome proliferator activated receptor-γ and traumatic brain injury. , 2010, International journal of clinical and experimental medicine.

[184]  W. Wahli,et al.  Multifaceted roles of peroxisome proliferator-activated receptors (PPARs) at the cellular and whole organism levels. , 2010, Swiss medical weekly.

[185]  E. Molina-Holgado,et al.  Mending the broken brain: neuroimmune interactions in neurogenesis , 2010, Journal of neurochemistry.

[186]  E. Erdmann,et al.  Pioglitazone and the risk of cardiovascular events in patients with Type 2 diabetes receiving concomitant treatment with nitrates, renin–angiotensin system blockers, or insulin: results from the PROactive study (PROactive 20) , 2010, Journal of diabetes.

[187]  Michael Gold,et al.  Rosiglitazone Monotherapy in Mild-to-Moderate Alzheimer’s Disease: Results from a Randomized, Double-Blind, Placebo-Controlled Phase III Study , 2010, Dementia and Geriatric Cognitive Disorders.

[188]  Rita Ouellet-Hellstrom,et al.  Risk of acute myocardial infarction, stroke, heart failure, and death in elderly Medicare patients treated with rosiglitazone or pioglitazone. , 2010, JAMA.

[189]  S. Nissen,et al.  Rosiglitazone revisited: an updated meta-analysis of risk for myocardial infarction and cardiovascular mortality. , 2010, Archives of internal medicine.

[190]  Patrick R. Griffin,et al.  Obesity-linked phosphorylation of PPARγ by cdk5 is a direct target of the anti-diabetic PPARγ ligands , 2010, Nature.

[191]  S. Reddy,et al.  Nrf2-regulated PPAR{gamma} expression is critical to protection against acute lung injury in mice. , 2010, American journal of respiratory and critical care medicine.

[192]  H. Wilson.  Macrophages heterogeneity in atherosclerosis – implications for therapy , 2010, Journal of cellular and molecular medicine.

[193]  M. Wainwright,et al.  Journal of Neuroinflammation Open Access Research Chronic Upregulation of Activated Microglia Immunoreactive for Galectin-3/mac-2 and Nerve Growth Factor following Diffuse Axonal Injury , 2022 .

[194]  Y. E. Chen,et al.  Peroxisome Proliferator-Activated Receptor δ Regulation of miR-15a in Ischemia-Induced Cerebral Vascular Endothelial Injury , 2010, The Journal of Neuroscience.

[195]  Guohong Li,et al.  Inflammatory mechanisms in ischemic stroke: role of inflammatory cells , 2010, Journal of leukocyte biology.

[196]  P. Sarafidis,et al.  Effect of thiazolidinediones on albuminuria and proteinuria in diabetes: a meta-analysis. , 2010, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[197]  R. Kaundal,et al.  Peroxisome proliferator-activated receptor gamma agonists as neuroprotective agents. , 2010, Drug news & perspectives.

[198]  B. Staels,et al.  Fibrates, Glitazones, and Peroxisome Proliferator–Activated Receptors , 2010, Arteriosclerosis, thrombosis, and vascular biology.

[199]  K. Jin,et al.  Transgenic ablation of doublecortin-expressing cells suppresses adult neurogenesis and worsens stroke outcome in mice , 2010, Proceedings of the National Academy of Sciences.

[200]  S. Suissa,et al.  Thiazolidinediones and the risk of incident strokes in patients with type 2 diabetes: a nested case‐control study , 2010, Pharmacoepidemiology and drug safety.

[201]  Chungho Kim,et al.  The final steps of integrin activation: the end game , 2010, Nature Reviews Molecular Cell Biology.

[202]  Wenzhi Hu,et al.  PPARγ agonist rosiglitazone is neuroprotective after traumatic spinal cord injury via anti-inflammatory in adult rats , 2010, Neurological research.

[203]  Donald M Yealy,et al.  National variation in United States sepsis mortality: a descriptive study , 2010, International journal of health geographics.

[204]  S. Vannucci,et al.  The PPAR-γ Agonist, Darglitazone, Restores Acute Inflammatory Responses to Cerebral Hypoxia–Ischemia in the Diabetic ob/ob Mouse , 2010, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[205]  Andrew A. Pierce,et al.  De Novo Neurogenesis in Adult Hypothalamus as a Compensatory Mechanism to Regulate Energy Balance , 2010, The Journal of Neuroscience.

[206]  Shing-Hwa Liu,et al.  IL-13 downregulates PPAR-γ/heme oxygenase-1 via ER stress-stimulated calpain activation: aggravation of activated microglia death , 2010, Cellular and Molecular Life Sciences.

[207]  N. Suzuki,et al.  Pioglitazone enhances pyruvate and lactate oxidation in cultured neurons but not in cultured astroglia , 2009, Brain Research.

[208]  B. Staels,et al.  SUMOylation of Human Peroxisome Proliferator-activated Receptor α Inhibits Its Trans-activity through the Recruitment of the Nuclear Corepressor NCoR* , 2009, The Journal of Biological Chemistry.

[209]  Y. Tsai,et al.  Genetic variations in peroxisome proliferator-activated receptor γ expression affect blood pressure , 2009, Proceedings of the National Academy of Sciences.

[210]  Li-jun Ma,et al.  The PPARgamma agonist pioglitazone ameliorates aging-related progressive renal injury. , 2009, Journal of the American Society of Nephrology : JASN.

[211]  Michael Famulok,et al.  The nuclear receptor PPARγ selectively inhibits Th17 differentiation in a T cell–intrinsic fashion and suppresses CNS autoimmunity , 2009, The Journal of experimental medicine.

[212]  M. Weir,et al.  Thiazolidinediones and cardiovascular events in high-risk patients with type-2 diabetes mellitus: a comparison with other oral antidiabetic agents. , 2009, P & T : a peer-reviewed journal for formulary management.

[213]  Zi-lin Sun,et al.  PPARγ-mediated advanced glycation end products regulation of neural stem cells , 2009, Molecular and Cellular Endocrinology.

[214]  F. Hsiao,et al.  Thiazolidinediones and Cardiovascular Events in Patients with Type 2 Diabetes Mellitus , 2009, Drug safety.

[215]  L. Saksida,et al.  A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation , 2009, Science.

[216]  A. Bernardo,et al.  Peroxisome Proliferator-Activated Receptor-&ggr; Agonists Promote Differentiation and Antioxidant Defenses of Oligodendrocyte Progenitor Cells , 2009, Journal of neuropathology and experimental neurology.

[217]  M. Hanefeld,et al.  Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial , 2009, The Lancet.

[218]  G. Divine,et al.  Relationship between thiazolidinedione use and cardiovascular outcomes and all‐cause mortality among patients with diabetes: a time‐updated propensity analysis , 2009, Pharmacoepidemiology and drug safety.

[219]  J. Goverman.  Autoimmune T cell responses in the central nervous system , 2009, Nature Reviews Immunology.

[220]  E. Shevach.  Mechanisms of foxp3+ T regulatory cell-mediated suppression. , 2009, Immunity.

[221]  E. Benarroch.  Oligodendrocytes , 2009, Neurology.

[222]  M. Arababadi,et al.  Delayed post ischemic treatment with Rosiglitazone attenuates infarct volume, neurological deficits and neutrophilia after embolic stroke in rat , 2009, Brain Research.

[223]  J. Grotta,et al.  Neuronal PPARγ Deficiency Increases Susceptibility to Brain Damage after Cerebral Ischemia , 2009, The Journal of Neuroscience.

[224]  S. Ludwin,et al.  Statin therapy inhibits remyelination in the central nervous system. , 2009, The American journal of pathology.

[225]  Christian Gerloff,et al.  Temporal and spatial dynamics of cerebral immune cell accumulation in stroke. , 2009, Stroke.

[226]  S. Cazaubon,et al.  The blood-brain barrier in brain homeostasis and neurological diseases. , 2009, Biochimica et biophysica acta.

[227]  Y. E. Chen,et al.  PPARs and the cardiovascular system. , 2009, Antioxidants & redox signaling.

[228]  R. Ransohoff,et al.  Localizing central nervous system immune surveillance: Meningeal antigen‐presenting cells activate T cells during experimental autoimmune encephalomyelitis , 2009, Annals of neurology.

[229]  A. Carpentier,et al.  Stroke and cardiovascular morbidity and mortality associated with rosiglitazone use in elderly diabetic patients , 2009, Diabetes & vascular disease research.

[230]  S. Shyue,et al.  Ligand-Activated Peroxisome Proliferator–Activated Receptor-γ Protects Against Ischemic Cerebral Infarction and Neuronal Apoptosis by 14-3-3&egr; Upregulation , 2009, Circulation.

[231]  Gary A Rosenberg,et al.  Inflammation and white matter damage in vascular cognitive impairment. , 2009, Stroke.

[232]  J. Grotta,et al.  Hematoma resolution as a therapeutic target: the role of microglia/macrophages. , 2009, Stroke.

[233]  Á. Chamorro,et al.  Stroke induced immunodepression syndrome: from bench to bedside. , 2009, Current molecular medicine.

[234]  S. Rotshenker.  The Role of Galectin-3/MAC-2 in the Activation of the Innate-Immune Function of Phagocytosis in Microglia in Injury and Disease , 2009, Journal of Molecular Neuroscience.

[235]  B. Zinman,et al.  Medical Management of Hyperglycemia in Type 2 Diabetes: A Consensus Algorithm for the Initiation and Adjustment of Therapy , 2009, Diabetes Care.

[236]  Arne Schousboe,et al.  Role of astrocytes in glutamate homeostasis: Implications for excitotoxicity , 2005, Neurotoxicity Research.

[237]  Jichun Yang,et al.  Role of PPARgamma in renoprotection in Type 2 diabetes: molecular mechanisms and therapeutic potential. , 2009, Clinical science.

[238]  H. Althaus,et al.  Negative Impact of Statins on Oligodendrocytes and Myelin Formation In Vitro and In Vivo , 2008, The Journal of Neuroscience.

[239]  J. Yi,et al.  PPARγ agonist rosiglitazone is neuroprotective after traumatic brain injury via anti-inflammatory and anti-oxidative mechanisms , 2008, Brain Research.

[240]  L. Schlichter,et al.  White matter injury in young and aged rats after intracerebral hemorrhage , 2008, Experimental Neurology.

[241]  Jin Y. Jin,et al.  Model‐Based Development of a PPARγ Agonist, Rivoglitazone, to Aid Dose Selection and Optimize Clinical Trial Designs , 2008, Journal of clinical pharmacology.

[242]  N. Kiguchi,et al.  Pioglitazone attenuates tactile allodynia and microglial activation in mice with peripheral nerve injury. , 2008, Drug discoveries & therapeutics.

[243]  W. Winkelmayer,et al.  Comparison of cardiovascular outcomes in elderly patients with diabetes who initiated rosiglitazone vs pioglitazone therapy. , 2008, Archives of internal medicine.

[244]  R. Harrison,et al.  Membrane ruffles capture C3bi-opsonized particles in activated macrophages. , 2008, Molecular biology of the cell.

[245]  C. Urrutia,et al.  A PPARs cross‐talk concertedly commits C6 glioma cells to oligodendrocytes and induces enzymes involved in myelin synthesis , 2008, Journal of cellular physiology.

[246]  Robin J. M. Franklin,et al.  Remyelination in the CNS: from biology to therapy , 2008, Nature Reviews Neuroscience.

[247]  B. Brüne,et al.  Sumoylation of Peroxisome Proliferator-Activated Receptor γ by Apoptotic Cells Prevents Lipopolysaccharide-Induced NCoR Removal from κB Binding Sites Mediating Transrepression of Proinflammatory Cytokines1 , 2008, The Journal of Immunology.

[248]  D. Granger,et al.  Cell adhesion molecules and ischemic stroke , 2008, Neurological research.

[249]  J. Stephens,et al.  Caspase‐mediated Degradation of PPARγ Proteins in Adipocytes , 2008, Obesity.

[250]  C. Werner,et al.  Selection of endogenous control genes for normalization of gene expression analysis after experimental brain trauma in mice. , 2008, Journal of neurotrauma.

[251]  W. Cefalu,et al.  Modulation of peroxisome proliferator-activated receptor gamma stability and transcriptional activity in adipocytes by resveratrol. , 2008, Metabolism: clinical and experimental.

[252]  G. E. Vates,et al.  Statin treatment of adult human glial progenitors induces PPARγ‐mediated oligodendrocytic differentiation , 2008, Glia.

[253]  M. Carlén,et al.  Spinal Cord Injury Reveals Multilineage Differentiation of Ependymal Cells , 2008, PLoS biology.

[254]  K. Reymann,et al.  Microglia Cells Protect Neurons by Direct Engulfment of Invading Neutrophil Granulocytes: A New Mechanism of CNS Immune Privilege , 2008, The Journal of Neuroscience.

[255]  K. Irvine,et al.  Remyelination protects axons from demyelination-associated axon degeneration. , 2008, Brain : a journal of neurology.

[256]  J. Naegele,et al.  IGF‐1 receptor‐mediated ERK/MAPK signaling couples status epilepticus to progenitor cell proliferation in the subgranular layer of the dentate gyrus , 2008, Glia.

[257]  I. Singh,et al.  Inhibition of Rho Family Functions by Lovastatin Promotes Myelin Repair in Ameliorating Experimental Autoimmune Encephalomyelitis , 2008, Molecular Pharmacology.

[258]  K. Jin,et al.  Neurogenesis after Primary Intracerebral Hemorrhage in Adult Human Brain , 2008, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[259]  T. Kielian,et al.  The Synthetic Peroxisome Proliferator-Activated Receptor-γ Agonist Ciglitazone Attenuates Neuroinflammation and Accelerates Encapsulation in Bacterial Brain Abscesses1 , 2008, The Journal of Immunology.

[260]  Y. Tsai,et al.  Interference With PPARγ Signaling Causes Cerebral Vascular Dysfunction, Hypertrophy, and Remodeling , 2008, Hypertension.

[261]  D. McTigue.  Potential Therapeutic Targets for PPARγ after Spinal Cord Injury , 2008, PPAR research.

[262]  W. D. de Lange,et al.  Interference with PPAR gamma function in smooth muscle causes vascular dysfunction and hypertension. , 2008, Cell metabolism.

[263]  R. Mortensen,et al.  Peroxisome Proliferator-Activated Receptor-γ–Mediated Effects in the Vasculature , 2008, Circulation research.

[264]  R. Bellomo,et al.  A Multi-Center Evaluation of Early Acute Kidney Injury in Critically Ill Trauma Patients , 2008, Renal failure.

[265]  E. Mazzon,et al.  EFFECT OF CYCLOPENTANONE PROSTAGLANDIN 15-DEOXY-&Dgr;12,14PGJ2 ON EARLY FUNCTIONAL RECOVERY FROM EXPERIMENTAL SPINAL CORD INJURY , 2007, Shock.

[266]  J. Yi,et al.  Mechanisms of anti-inflammatory and neuroprotective actions of PPAR-gamma agonists. , 2008, Frontiers in bioscience : a journal and virtual library.

[267]  P. Klepstad,et al.  Severe head injury: control of physiological variables, organ failure and complications in the intensive care unit , 2007, Acta anaesthesiologica Scandinavica.

[268]  H. Nishino,et al.  Increase in neurogenesis and neuroblast migration after a small intracerebral hemorrhage in rats , 2007, Neuroscience Letters.

[269]  Olivier Michielin,et al.  Peroxisome proliferator-activated receptor structures: ligand specificity, molecular switch and interactions with regulators. , 2007, Biochimica et biophysica acta.

[270]  C. Carlberg,et al.  Meta-analysis of primary target genes of peroxisome proliferator-activated receptors , 2007, Genome Biology.

[271]  I. Katzan.  Can add-on pioglitazone prevent recurrent stroke in patients with type 2 diabetes? , 2007, Nature Clinical Practice Neurology.

[272]  Z. Xiang,et al.  15d-PGJ2 induces apoptosis of mouse oligodendrocyte precursor cells , 2007, Journal of Neuroinflammation.

[273]  Deepak L. Bhatt,et al.  Peroxisome proliferator-activated receptor gamma agonists for the Prevention of Adverse events following percutaneous coronary Revascularization--results of the PPAR study. , 2007, American heart journal.

[274]  A. Lash,et al.  The PPAR gamma agonist Pioglitazone improves anatomical and locomotor recovery after rodent spinal cord injury , 2007, Experimental Neurology.

[275]  J. Leza,et al.  Effects of Peroxisome Proliferator-Activated Receptor Gamma Agonists on Brain Glucose and Glutamate Transporters after Stress in Rats , 2007, Neuropsychopharmacology.

[276]  A. Pérez-Samartín,et al.  Excitotoxic damage to white matter , 2007, Journal of anatomy.

[277]  T. Herdegen,et al.  PPAR-γ: therapeutic target for ischemic stroke , 2007 .

[278]  L. Fésüs,et al.  PPARγ‐dependent regulation of human macrophages in phagocytosis of apoptotic cells , 2007, European journal of immunology.

[279]  D. McTigue,et al.  Prominent oligodendrocyte genesis along the border of spinal contusion lesions , 2007, Glia.

[280]  K. Jacobson,et al.  UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis , 2007, Nature.

[281]  G. Shulman,et al.  n-3 Fatty Acids Preserve Insulin Sensitivity In Vivo in a Peroxisome Proliferator–Activated Receptor-α–Dependent Manner , 2007, Diabetes.

[282]  Erin Nevius,et al.  Peroxisome Proliferator-Activated Receptor γ (PPARγ) and Immunoregulation: Enhancement of Regulatory T Cells through PPARγ-Dependent and -Independent Mechanisms , 2007, The Journal of Immunology.

[283]  B. Tesfamariam,et al.  Endothelial injury in the initiation and progression of vascular disorders. , 2007, Vascular pharmacology.

[284]  J. Grotta,et al.  Hematoma resolution as a target for intracerebral hemorrhage treatment: Role for peroxisome proliferator‐activated receptor γ in microglia/macrophages , 2007, Annals of neurology.

[285]  D. Betteridge,et al.  Effects of Pioglitazone in Patients With Type 2 Diabetes With or Without Previous Stroke: Results From PROactive (PROspective pioglitAzone Clinical Trial In macroVascular Events 04) , 2007, Stroke.

[286]  F. Zipp,et al.  Neuronal damage in brain inflammation. , 2007, Archives of neurology.

[287]  S. Zamvil,et al.  Simvastatin regulates oligodendroglial process dynamics and survival , 2007, Glia.

[288]  O. Hurtado,et al.  Ischemic Preconditioning Reveals that GLT1/EAAT2 Glutamate Transporter is a Novel PPARγ Target Gene Involved in Neuroprotection , 2007, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[289]  M. Reding,et al.  Effects of Thiazolidinediones on Stroke Recovery: A Case-Matched Controlled Study , 2007, Neurochemical Research.

[290]  Carol A Barnes,et al.  Integration of New Neurons into Functional Neural Networks , 2006, The Journal of Neuroscience.

[291]  A. Butt,et al.  Neurotransmitter‐mediated calcium signalling in oligodendrocyte physiology and pathology , 2006, Glia.

[292]  D. Liebetanz,et al.  Effects of commissural de- and remyelination on motor skill behaviour in the cuprizone mouse model of multiple sclerosis , 2006, Experimental Neurology.

[293]  S. O’Rahilly,et al.  Non-DNA binding, dominant-negative, human PPARγ mutations cause lipodystrophic insulin resistance , 2006, Cell metabolism.

[294]  B. Melchior,et al.  CNS immune privilege: hiding in plain sight , 2006, Immunological reviews.

[295]  J. Aronowski,et al.  Altered PPARγ expression and activation after transient focal ischemia in rats , 2006 .

[296]  E. Shevach,et al.  The lifestyle of naturally occurring CD4+CD25+Foxp3+ regulatory T cells , 2006, Immunological reviews.

[297]  Shijie Jin,et al.  Tumor Necrosis Factor-α Induces Neurotoxicity via Glutamate Release from Hemichannels of Activated Microglia in an Autocrine Manner* , 2006, Journal of Biological Chemistry.

[298]  Ping Wang,et al.  The anti-inflammatory effect of curcumin in an experimental model of sepsis is mediated by up-regulation of peroxisome proliferator-activated receptor-γ* , 2006 .

[299]  Danielle G. Lemay,et al.  Genome-wide identification of peroxisome proliferator response elements using integrated computational genomics s⃞ Published, JLR Papers in Press, April 3, 2006. , 2006, Journal of Lipid Research.

[300]  K. Kristiansen,et al.  Peroxisome proliferator-activated receptor gamma recruits the positive transcription elongation factor b complex to activate transcription and promote adipogenesis. , 2006, Molecular endocrinology.

[301]  J. Grotta,et al.  Neuronal expression of peroxisome proliferator-activated receptor-gamma (PPARγ) and 15d-prostaglandin J2—Mediated protection of brain after experimental cerebral ischemia in rat , 2006, Brain Research.

[302]  J. Roh,et al.  Peroxisome proliferator-activated receptor-γ-agonist, rosiglitazone, promotes angiogenesis after focal cerebral ischemia , 2006, Brain Research.

[303]  A. Lasaridis,et al.  Actions of peroxisome proliferator-activated receptors-gamma agonists explaining a possible blood pressure-lowering effect. , 2006, American journal of hypertension.

[304]  S. Craft,et al.  Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice , 2006, Experimental Neurology.

[305]  J. Grotta,et al.  15d-Prostaglandin J2 Activates Peroxisome Proliferator-Activated Receptor-γ, Promotes Expression of Catalase, and Reduces Inflammation, Behavioral Dysfunction, and Neuronal Loss after Intracerebral Hemorrhage in Rats , 2006, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[306]  H. Makino,et al.  Thiazolidinediones Ameliorate Diabetic Nephropathy via Cell Cycle–Dependent Mechanisms , 2006, Diabetes.

[307]  T. Mayumi,et al.  Peroxisome Proliferator-activated Receptor γ-mediated Regulation of Neural Stem Cell Proliferation and Differentiation* , 2006, Journal of Biological Chemistry.

[308]  D. Hume,et al.  Apoptotic cell removal in development and tissue homeostasis. , 2006, Trends in immunology.

[309]  Jun Chen,et al.  Neuroprotection against focal ischemic brain injury by the peroxisome proliferator‐activated receptor‐γ agonist rosiglitazone , 2006, Journal of neurochemistry.

[310]  S. O’Rahilly,et al.  PPARγ and human metabolic disease , 2006 .

[311]  W. Wahli,et al.  Involvement of PPAR nuclear receptors in tissue injury and wound repair. , 2006, The Journal of clinical investigation.

[312]  Nader Sanai,et al.  Cellular composition and cytoarchitecture of the adult human subventricular zone: A niche of neural stem cells , 2006, The Journal of comparative neurology.

[313]  C. Thiemermann,et al.  Modulation of the oxidative stress and inflammatory response by PPAR-gamma agonists in the hippocampus of rats exposed to cerebral ischemia/reperfusion. , 2006, European journal of pharmacology.

[314]  A. Fasolo,et al.  Neurogenesis in the Caudate Nucleus of the Adult Rabbit , 2006, The Journal of Neuroscience.

[315]  S. Shyue,et al.  15d-Prostaglandin J2 Protects Brain From Ischemia-Reperfusion Injury , 2005, Arteriosclerosis, thrombosis, and vascular biology.

[316]  Nayyar Iqbal,et al.  Effects of Rosiglitazone on Lipids, Adipokines, and Inflammatory Markers in Nondiabetic Patients With Low High-Density Lipoprotein Cholesterol and Metabolic Syndrome , 2005, Arteriosclerosis, thrombosis, and vascular biology.

[317]  E. Raines,et al.  Macrophage expression of active MMP-9 induces acute plaque disruption in apoE-deficient mice. , 2005, The Journal of clinical investigation.

[318]  Christopher K. Glass,et al.  Combinatorial roles of nuclear receptors in inflammation and immunity , 2006, Nature Reviews Immunology.

[319]  A. Jean,et al.  In vivo neurogenesis in the dorsal vagal complex of the adult rat brainstem , 2005, Neuroscience.

[320]  M. Salter,et al.  NMDA receptors are expressed in developing oligodendrocyte processes and mediate injury , 2005, Nature.

[321]  E. Ringelstein,et al.  Predominant phagocytic activity of resident microglia over hematogenous macrophages following transient focal cerebral ischemia: An investigation using green fluorescent protein transgenic bone marrow chimeric mice , 2005, Experimental Neurology.

[322]  B. Isaac,et al.  A WAVE2-Abi1 complex mediates CSF-1-induced F-actin-rich membrane protrusions and migration in macrophages , 2005, Journal of Cell Science.

[323]  G. Kollias,et al.  Apoptosis of Oligodendrocytes via Fas and TNF-R1 Is a Key Event in the Induction of Experimental Autoimmune Encephalomyelitis1 , 2005, The Journal of Immunology.

[324]  J. Flier,et al.  Neurogenesis in the Hypothalamus of Adult Mice: Potential Role in Energy Balance , 2005, Science.

[325]  Erland Erdmann,et al.  Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial , 2005, The Lancet.

[326]  Amir Gamliel,et al.  A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γ , 2005, Nature.

[327]  J. Koenigsknecht-Talboo,et al.  Microglial Phagocytosis Induced by Fibrillar β-Amyloid and IgGs Are Differentially Regulated by Proinflammatory Cytokines , 2005, The Journal of Neuroscience.

[328]  T. Vollmer,et al.  HMG‐CoA reductase inhibitor augments survival and differentiation of oligodendrocyte progenitors in animal model of multiple sclerosis , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[329]  P V Bayly,et al.  Deformation of the human brain induced by mild acceleration. , 2005, Journal of neurotrauma.

[330]  A. Sugawara,et al.  Rosiglitazone Protects Against Cyclosporine‐Induced Pancreatic and Renal Injury in Rats , 2005, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[331]  J. Hoeijmakers,et al.  Dysregulation of the Peroxisome Proliferator-Activated Receptor Target Genes by XPD Mutations , 2005, Molecular and Cellular Biology.

[332]  J. Losy,et al.  CXCL1 (GRO-alpha) chemokine in acute ischaemic stroke patients. , 2005, Folia neuropathologica.

[333]  Timothy H Murphy,et al.  Induction of the Nrf2-driven Antioxidant Response Confers Neuroprotection during Mitochondrial Stress in Vivo* , 2005, Journal of Biological Chemistry.

[334]  M. Alonso,et al.  Regulation of Inflammatory Response in Neural Cells in Vitro by Thiadiazolidinones Derivatives through Peroxisome Proliferator-activated Receptor γ Activation* , 2005, Journal of Biological Chemistry.

[335]  M. A. Moro,et al.  Increased Plasma Levels of 15-Deoxy &Dgr; Prostaglandin J2 Are Associated With Good Outcome in Acute Atherothrombotic Ischemic Stroke , 2005, Stroke.

[336]  D. Ron,et al.  Endoplasmic reticulum stress modulates the response of myelinating oligodendrocytes to the immune cytokine interferon-γ , 2005, The Journal of cell biology.

[337]  Y. Pang,et al.  Effect of tumor necrosis factor‐α on developing optic nerve oligodendrocytes in culture , 2005 .

[338]  N. Tamamaki,et al.  Neurogenesis in the ependymal layer of the adult rat 3rd ventricle , 2005, Experimental Neurology.

[339]  Jihong Xu,et al.  Cyclopentenone prostaglandins PGA2 and 15‐deoxy‐δ12,14 PGJ2 suppress activation of murine microglia and astrocytes: Implications for multiple sclerosis , 2005, Journal of neuroscience research.

[340]  S. Tsirka,et al.  Tuftsin Fragment 1–3 Is Beneficial When Delivered After the Induction of Intracerebral Hemorrhage , 2005, Stroke.

[341]  H. Cameron,et al.  New GABAergic interneurons in the adult neocortex and striatum are generated from different precursors , 2005, The Journal of cell biology.

[342]  D. Piomelli,et al.  The Nuclear Receptor Peroxisome Proliferator-Activated Receptor-α Mediates the Anti-Inflammatory Actions of Palmitoylethanolamide , 2005, Molecular Pharmacology.

[343]  A. Bringmann,et al.  PPAR-gamma agonists inhibit toll-like receptor-mediated activation of dendritic cells via the MAP kinase and NF-kappaB pathways. , 2004, Blood.

[344]  Timothy J. Burroughs,et al.  15-DEOXY-Δ12,14-PROSTAGLANDIN J2 (15D-PGJ2), A PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR γ LIGAND, REDUCES TISSUE LEUKOSEQUESTRATION AND MORTALITY IN ENDOTOXIC SHOCK , 2005 .

[345]  J. Wilberger,et al.  The impact of hyperglycemia on patients with severe brain injury. , 2005, The Journal of trauma.

[346]  A. Minagar,et al.  Troglitazone, a PPAR-γ activator prevents endothelial cell adhesion molecule expression and lymphocyte adhesion mediated by TNF-α , 2005, BMC Physiology.

[347]  S. Moreno,et al.  Immunolocalization of peroxisome proliferator-activated receptors and retinoid x receptors in the adult rat CNS , 2004, Neuroscience.

[348]  R. Oppenheim,et al.  Overexpression of glial cell line-derived neurotrophic factor in the CNS rescues motoneurons from programmed cell death and promotes their long-term survival following axotomy , 2004, Experimental Neurology.

[349]  C. S. Bickel,et al.  Intramuscular fat and glucose tolerance after spinal cord injury – a cross-sectional study , 2004, Spinal Cord.

[350]  Hong Wang,et al.  Peroxynitrite-Induced Neuronal Apoptosis Is Mediated by Intracellular Zinc Release and 12-Lipoxygenase Activation , 2004, The Journal of Neuroscience.

[351]  H. Young,et al.  Peroxisome proliferator-activated receptor-γ and its ligands attenuate biologic functions of human natural killer cells , 2004 .

[352]  T. Osumi,et al.  The transactivating function of peroxisome proliferator‐activated receptor γ is negatively regulated by SUMO conjugation in the amino‐terminal domain , 2004, Genes to cells : devoted to molecular & cellular mechanisms.

[353]  S. Fancy,et al.  Increased expression of Nkx2.2 and Olig2 identifies reactive oligodendrocyte progenitor cells responding to demyelination in the adult CNS , 2004, Molecular and Cellular Neuroscience.

[354]  B. Hamrén,et al.  Pharmacokinetics and metabolism of tesaglitazar, a novel dual-acting peroxisome proliferator-activated receptor alpha/gamma agonist, after a single oral and intravenous dose in humans. , 2004, Drug metabolism and disposition: the biological fate of chemicals.

[355]  Y. Yun,et al.  Neuronal differentiation of embryonic midbrain cells by upregulation of peroxisome proliferator-activated receptor-gamma via the JNK-dependent pathway. , 2004, Experimental cell research.

[356]  K. Yano,et al.  High density lipoprotein cholesterol and the risk of stroke in elderly men: the Honolulu heart program. , 2004, American journal of epidemiology.

[357]  John Dormandy,et al.  The prospective pioglitazone clinical trial in macrovascular events (PROactive): can pioglitazone reduce cardiovascular events in diabetes? Study design and baseline characteristics of 5238 patients. , 2004, Diabetes care.

[358]  Namjin Chung,et al.  Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ , 2004, Nature.

[359]  C. Glass,et al.  Repression of IFN-γ Expression by Peroxisome Proliferator-Activated Receptor γ1 , 2004, The Journal of Immunology.

[360]  J. Gamble,et al.  PPARγ Agonists Ameliorate Endothelial Cell Activation via Inhibition of Diacylglycerol–Protein Kinase C Signaling Pathway: Role of Diacylglycerol Kinase , 2004, Circulation research.

[361]  I. Cho,et al.  Transactivation of the PPAR-Responsive Enhancer Module in Chemopreventive Glutathione S-Transferase Gene by the Peroxisome Proliferator-Activated Receptor-γ and Retinoid X Receptor Heterodimer , 2004, Cancer Research.

[362]  G. Landreth,et al.  Antiinflammatory properties of PPARgamma agonists following ischemia. , 2004, Drug news & perspectives.

[363]  A. Harris,et al.  Activation of peroxisome proliferator-activated receptor delta stimulates the proliferation of human breast and prostate cancer cell lines. , 2004, Cancer research.

[364]  R. Willette,et al.  Anti-apoptotic effects of rosiglitazone in hypercholesterolemic rabbits subjected to myocardial ischemia and reperfusion. , 2004, Cardiovascular research.

[365]  K. Itoh,et al.  Downloaded from http://circres.ahajournals.org / by guest on February 23, 2013Role of Nrf2 in the Regulation of CD36 and Stress Protein Expression in Murine Macrophages Activation by Oxidatively Modified LDL and 4-Hydroxynonenal , 2004 .

[366]  Todd G. Smith,et al.  CD36 mediates the phagocytosis of Plasmodium falciparum-infected erythrocytes by rodent macrophages. , 2004, The Journal of infectious diseases.

[367]  Jo Leonardi-Bee,et al.  High Blood Pressure in Acute Stroke and Subsequent Outcome: A Systematic Review , 2004 .

[368]  L. Eng,et al.  Inflammation in Traumatic Brain Injury: Role of Cytokines and Chemokines , 1998, Neurochemical Research.

[369]  Y. Naito,et al.  Inhibitory effect of pioglitazone on expression of adhesion molecules on neutrophils and endothelial cells , 2004, BioFactors.

[370]  C. Baylis,et al.  Peroxisome Proliferator-Activated Receptor γ Agonist Provides Superior Renal Protection versus Angiotensin-Converting Enzyme Inhibition in a Rat Model of Type 2 Diabetes with Obesity , 2003, Journal of Pharmacology and Experimental Therapeutics.

[371]  S. Tsirka,et al.  Protective role of tuftsin fragment 1‐3 in an animal model of intracerebral hemorrhage , 2003, Annals of neurology.

[372]  T. Chou,et al.  Troglitazone administration limits infarct size by reduced phosphorylation of canine myocardial connexin43 proteins. , 2003, American journal of physiology. Heart and circulatory physiology.

[373]  Richard Reynolds,et al.  NG2-expressing glial progenitor cells: an abundant and widespread population of cycling cells in the adult rat CNS , 2003, Molecular and Cellular Neuroscience.

[374]  E. Fleck,et al.  Regulation of the Growth Arrest and DNA Damage-Inducible Gene 45 (GADD45) by Peroxisome Proliferator-Activated Receptor &ggr; in Vascular Smooth Muscle Cells , 2003, Circulation research.

[375]  J. Simpkins,et al.  Role of PPAR-gamma ligands in neuroprotection against glutamate-induced cytotoxicity in retinal ganglion cells. , 2003, Investigative ophthalmology & visual science.

[376]  Kieran Clarke,et al.  The PPARgamma-activator rosiglitazone does not alter remodeling but increases mortality in rats post-myocardial infarction. , 2003, Cardiovascular research.

[377]  L. Barbeito,et al.  PPAR γ activators induce growth arrest and process extension in B12 oligodendrocyte‐like cells and terminal differentiation of cultured oligodendrocytes , 2003, Journal of neuroscience research.

[378]  Jan A Staessen,et al.  Hypertension prevalence and stroke mortality across populations. , 2003, JAMA.

[379]  C. Long,et al.  Deleterious effects of acute treatment with a peroxisome proliferator-activated receptor-gamma activator in myocardial ischemia and reperfusion in pigs. , 2003, Diabetes.

[380]  Soo Young Park,et al.  15d-PGJ2 and Rosiglitazone Suppress Janus Kinase-STAT Inflammatory Signaling through Induction of Suppressor of Cytokine Signaling 1 (SOCS1) and SOCS3 in Glia* , 2003, The Journal of Biological Chemistry.

[381]  E. Fleck,et al.  A non-thiazolidinedione partial peroxisome proliferator-activated receptor gamma ligand inhibits vascular smooth muscle cell growth. , 2003, European journal of pharmacology.

[382]  R. Evans,et al.  Peroxisome-Proliferator-Activated Receptor δ Activates Fat Metabolism to Prevent Obesity , 2003, Cell.

[383]  D. Feinstein,et al.  Peroxisome Proliferator-activated Receptor γ Thiazolidinedione Agonists Increase Glucose Metabolism in Astrocytes* , 2003, The Journal of Biological Chemistry.

[384]  D. Feinstein,et al.  Inhibition of glial cell proinflammatory activities by peroxisome proliferator‐activated receptor gamma agonist confers partial protection during antimyelin oligodendrocyte glycoprotein demyelination in vitro , 2003, Journal of neuroscience research.

[385]  S. Rotshenker.  Microglia and macrophage activation and the regulation of complement-receptor-3 (CR3/MAC-1)-mediated myelin phagocytosis in injury and disease , 2003, Journal of Molecular Neuroscience.

[386]  A. Takeshita,et al.  Pioglitazone, a Peroxisome Proliferator-Activated Receptor-&ggr; Agonist, Attenuates Left Ventricular Remodeling and Failure After Experimental Myocardial Infarction , 2002, Circulation.

[387]  F. Domann,et al.  Identification of a functional peroxisome proliferator-activated receptor response element in the rat catalase promoter. , 2002, Molecular endocrinology.

[388]  Jasmine Chen,et al.  Constitutive Activation of Peroxisome Proliferator-activated Receptor-γ Suppresses Pro-inflammatory Adhesion Molecules in Human Vascular Endothelial Cells* , 2002, The Journal of Biological Chemistry.

[389]  M. Lazar,et al.  Thiazolidinedione Activation of Peroxisome Proliferator-activated Receptor γ Can Enhance Mitochondrial Potential and Promote Cell Survival* , 2002, The Journal of Biological Chemistry.

[390]  O. Lindvall,et al.  Neuronal replacement from endogenous precursors in the adult brain after stroke , 2002, Nature Medicine.

[391]  A. Parent,et al.  Newly generated neurons in the amygdala and adjoining cortex of adult primates , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[392]  T. Mariani,et al.  Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression. , 2002, Free radical biology & medicine.

[393]  S. Cuzzocrea,et al.  Ligands of the peroxisome proliferator‐activated receptors (PPAR‐γ and PPAR‐α) reduce myocardial infarct size , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[394]  C. Brosnan,et al.  Peroxisome proliferator‐activated receptor‐γ agonists prevent experimental autoimmune encephalomyelitis , 2002 .

[395]  T. Willson,et al.  Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662. , 2002, Biochemistry.

[396]  B. Staels,et al.  Rosiglitazone, a peroxisome proliferator-activated receptor-gamma, inhibits the Jun NH(2)-terminal kinase/activating protein 1 pathway and protects the heart from ischemia/reperfusion injury. , 2002, Diabetes.

[397]  D. Morabito,et al.  Serum levels of Hsp 72 measured early after trauma correlate with survival. , 2002, The Journal of trauma.

[398]  K. Clarke,et al.  Thiazolidinedione treatment normalizes insulin resistance and ischemic injury in the zucker Fatty rat heart. , 2002, Diabetes.

[399]  Chao Zhao,et al.  The Age-Related Decrease in CNS Remyelination Efficiency Is Attributable to an Impairment of Both Oligodendrocyte Progenitor Recruitment and Differentiation , 2002, The Journal of Neuroscience.

[400]  D. W. Desmond.  Cognition and White Matter Lesions , 2002, Cerebrovascular Diseases.

[401]  M. Chopp,et al.  Vascular endothelial growth factor and angiopoietins in focal cerebral ischemia. , 2002, Trends in cardiovascular medicine.

[402]  R. Weiss,et al.  Prognostic value of urodynamic testing in myelodysplastic patients. 1981. , 1981, The Journal of urology.

[403]  J. Berger,et al.  The mechanisms of action of PPARs. , 2002, Annual review of medicine.

[404]  W. Bao,et al.  In Vivo Myocardial Protection From Ischemia/Reperfusion Injury by the Peroxisome Proliferator–Activated Receptor-&ggr; Agonist Rosiglitazone , 2001, Circulation.

[405]  T. Lewander,et al.  Monitoring of reactive oxygen species production after traumatic brain injury in rats with microdialysis and the 4-hydroxybenzoic acid trapping method. , 2001, Journal of neurotrauma.

[406]  Philippe Gosset,et al.  Peroxisome proliferator‐activated receptor γ  activators affect the maturation of human monocyte‐derived dendritic cells , 2001 .

[407]  J. García-Verdugo,et al.  Astrocytes Give Rise to New Neurons in the Adult Mammalian Hippocampus , 2001, The Journal of Neuroscience.

[408]  M. Rancan,et al.  ROLE OF CEREBRAL INFLAMMATION AFTER TRAUMATIC BRAIN INJURY: A REVISITED CONCEPT , 2001, Shock.

[409]  A. Sugawara,et al.  Transcriptional Suppression of Type 1 Angiotensin II Receptor Gene Expression by Peroxisome Proliferator-Activated Receptor-γ in Vascular Smooth Muscle Cells. , 2001, Endocrinology.

[410]  M. Goldberg,et al.  AMPA/Kainate Receptor Activation Mediates Hypoxic Oligodendrocyte Death and Axonal Injury in Cerebral White Matter , 2001, The Journal of Neuroscience.

[411]  D. Hanley,et al.  Spontaneous Intracerebral Hemorrhage , 2012, Neuromethods.

[412]  M. Ato,et al.  Amelioration of experimental autoimmune encephalomyelitis in C57BL/6 mice by an agonist of peroxisome proliferator-activated receptor-γ , 2001, Journal of Neuroimmunology.

[413]  J. Stephens,et al.  Interferon-γ-induced Regulation of Peroxisome Proliferator-activated Receptor γ and STATs in Adipocytes* , 2001, The Journal of Biological Chemistry.

[414]  I. Saluja,et al.  PPAR δ agonists stimulate oligodendrocyte differentiation in tissue culture , 2001 .

[415]  S. Perrey,et al.  Troglitazone Inhibits Atherosclerosis in Apolipoprotein E–Knockout Mice: Pleiotropic Effects on CD36 Expression and HDL , 2001, Arteriosclerosis, thrombosis, and vascular biology.

[416]  B. Brüne,et al.  Delayed activation of PPARγ by LPS and IFN-γ attenuates the oxidative burst in macrophages , 2001 .

[417]  M. Jaye,et al.  PPAR-α and PPAR-γ activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway , 2001, Nature Medicine.

[418]  M. Moser,et al.  Peroxisome proliferator‐activated receptor γ activators inhibit interleukin‐12 production in murine dendritic cells , 2000 .

[419]  Terry J. Smith,et al.  Peroxisome Proliferator Activator Receptor-γ Agonists and 15-Deoxy-Δ12,1412,14-PGJ2 Induce Apoptosis in Normal and Malignant B-Lineage Cells1 , 2000, The Journal of Immunology.

[420]  N. Maurits,et al.  Comparison of serum S-100 protein levels following stroke and traumatic brain injury , 2000, Journal of the Neurological Sciences.

[421]  P. Bjerre,et al.  Cerebral microdialysis monitoring: determination of normal and ischemic cerebral metabolisms in patients with aneurysmal subarachnoid hemorrhage. , 2000, Journal of neurosurgery.

[422]  A. Sugawara,et al.  Suppression of Rat Thromboxane Synthase Gene Transcription by Peroxisome Proliferator-activated Receptor γ in Macrophages via an Interaction with NRF2* , 2000, The Journal of Biological Chemistry.

[423]  M Chopp,et al.  VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain. , 2000, The Journal of clinical investigation.

[424]  J. Ghajar.  Traumatic brain injury , 2000, The Lancet.

[425]  Andrew C. Li,et al.  Peroxisome proliferator–activated receptor γ ligands inhibit development of atherosclerosis in LDL receptor–deficient mice , 2000 .

[426]  R. Keep,et al.  Acute inflammatory reaction following experimental intracerebral hemorrhage in rat , 2000, Brain Research.

[427]  G. Levi,et al.  Role of the peroxisome proliferator‐activated receptor‐γ (PPAR‐γ) and its natural ligand 15‐deoxy‐Δ12,14‐prostaglandin J2 in the regulation of microglial functions , 2000 .

[428]  P. Libby,et al.  Peroxisome Proliferator-Activated Receptor-γ Activators Inhibit IFN-γ-Induced Expression of the T Cell-Active CXC Chemokines IP-10, Mig, and I-TAC in Human Endothelial Cells1 , 2000, The Journal of Immunology.

[429]  M. Xue,et al.  Intracerebral injection of autologous whole blood in rats: time course of inflammation and cell death , 2000, Neuroscience Letters.

[430]  B. Staels,et al.  Oxidized phospholipids activate PPARα in a phospholipase A2‐dependent manner , 2000 .

[431]  J. G. Scandalios,et al.  Cis-elements and trans-factors that regulate expression of the maize Cat1 antioxidant gene in response to ABA and osmotic stress: H2O2 is the likely intermediary signaling molecule for the response. , 2000, The Plant journal : for cell and molecular biology.

[432]  T. Hla,et al.  The Nuclear Receptor PPARγ and Immunoregulation: PPARγ Mediates Inhibition of Helper T Cell Responses1 , 2000, The Journal of Immunology.

[433]  V. Pasceri,et al.  Modulation of vascular inflammation in vitro and in vivo by peroxisome proliferator-activated receptor-gamma activators. , 2000, Circulation.

[434]  S. O’Rahilly,et al.  Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension , 1999, Nature.

[435]  A Hofman,et al.  Diabetes mellitus and the risk of dementia , 1999, Neurology.

[436]  T. Klockgether,et al.  Peroxisome proliferator-activated receptor gamma agonists protect cerebellar granule cells from cytokine-induced apoptotic cell death by inhibition of inducible nitric oxide synthase , 1999, Journal of Neuroimmunology.

[437]  Tianxin Yang,et al.  Expression of peroxisomal proliferator-activated receptors and retinoid X receptors in the kidney. , 1999, American journal of physiology. Renal physiology.

[438]  J. Grotta,et al.  Nuclear Factor-κB and Cell Death After Experimental Intracerebral Hemorrhage in Rats , 1999 .

[439]  Asano,et al.  Oxyhemoglobin as the principal cause of cerebral vasospasm: a holistic view of its actions. , 1999, Critical reviews in neurosurgery : CR.

[440]  M. Moskowitz,et al.  Pathobiology of ischaemic stroke: an integrated view , 1999, Trends in Neurosciences.

[441]  W. Hsueh,et al.  Peroxisome proliferator-activated receptor activators target human endothelial cells to inhibit leukocyte-endothelial cell interaction. , 1999, Arteriosclerosis, thrombosis, and vascular biology.

[442]  J. Vinten-johansen,et al.  The role of neutrophils in myocardial ischemia-reperfusion injury. , 1999, Cardiovascular research.

[443]  H. Rho,et al.  Induction of the rat Cu/Zn superoxide dismutase gene through the peroxisome proliferator-responsive element by arachidonic acid. , 1999, Gene.

[444]  Jonas Frisén,et al.  Identification of a Neural Stem Cell in the Adult Mammalian Central Nervous System , 1999, Cell.

[445]  R. Ross,et al.  Atherosclerosis is an inflammatory disease. , 1998, American heart journal.

[446]  M. Robinson.  Review Article The family of sodium-dependent glutamate transporters: a focus on the GLT-1/EAAT2 subtype , 1998, Neurochemistry International.

[447]  V. Fadok,et al.  CD36 is required for phagocytosis of apoptotic cells by human macrophages that use either a phosphatidylserine receptor or the vitronectin receptor (alpha v beta 3). , 1998, Journal of immunology.

[448]  M. Lazar,et al.  Interdomain communication regulating ligand binding by PPAR-γ , 1998, Nature.

[449]  F. Gage,et al.  Neurogenesis in the adult human hippocampus , 1998, Nature Medicine.

[450]  J. Trojanowski,et al.  Experimental Brain Injury Induces Regionally Distinct Apoptosis during the Acute and Delayed Post-Traumatic Period , 1998, The Journal of Neuroscience.

[451]  W. Wahli,et al.  Printed in U.S.A. Copyright © 1998 by The Endocrine Society Differential Expression of Peroxisome Proliferator- Activated Receptor-�,-�, and- � during Rat , 2022 .

[452]  R. Evans,et al.  PPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDL , 1998, Cell.

[453]  K. Bhakoo,et al.  Distribution of mRNAs Encoding the Peroxisome Proliferator‐Activated Receptor α, β, and γ and the Retinoid X Receptor α, β, and γ in Rat Central Nervous System , 1998 .

[454]  G. Savić,et al.  Long-term survival in spinal cord injury: a fifty year investigation , 1998, Spinal Cord.

[455]  W. Carroll,et al.  Identification of the adult resting progenitor cell by autoradiographic tracking of oligodendrocyte precursors in experimental CNS demyelination. , 1998, Brain : a journal of neurology.

[456]  Christopher K. Glass,et al.  The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation , 1998, Nature.

[457]  B. Juurlink.  Response of Glial Cells to Ischemia: Roles of Reactive Oxygen Species and Glutathione , 1997, Neuroscience & Biobehavioral Reviews.

[458]  M. Breyer,et al.  Expression of peroxisome proliferator-activated receptors in urinary tract of rabbits and humans. , 1997, American journal of physiology. Renal physiology.

[459]  U. Shankavaram,et al.  Role of macrophages in vascular tissue remodelling. , 1997, Transplant immunology.

[460]  J. Auwerx,et al.  The Organization, Promoter Analysis, and Expression of the Human PPARγ Gene* , 1997, The Journal of Biological Chemistry.

[461]  J. García-Verdugo,et al.  Cellular Composition and Three-Dimensional Organization of the Subventricular Germinal Zone in the Adult Mammalian Brain , 1997, The Journal of Neuroscience.

[462]  J. Goldman,et al.  Endogenous Progenitors Remyelinate Demyelinated Axons in the Adult CNS , 1997, Neuron.

[463]  Alan D. Lopez,et al.  Alternative projections of mortality and disability by cause 1990–2020: Global Burden of Disease Study , 1997, The Lancet.

[464]  T. Yanagihara,et al.  Ischemic damage and subsequent proliferation of oligodendrocytes in focal cerebral ischemia , 1997, Neuroscience.

[465]  A. Elliott,et al.  First SPET images of glutamate (NMDA) receptor activation in vivo in cerebral ischaemia , 1997, Nuclear medicine communications.

[466]  W. Blakemore,et al.  Locomotor deficits induced by experimental spinal cord demyelination are abolished by spontaneous remyelination. , 1997, Brain : a journal of neurology.

[467]  Bruce M. Spiegelman,et al.  Inhibition of Adipogenesis Through MAP Kinase-Mediated Phosphorylation of PPARγ , 1996, Science.

[468]  J. Garcìa,et al.  Cerebral white matter is highly vulnerable to ischemia. , 1996, Stroke.

[469]  M. D. Leibowitz,et al.  Molecular Cloning, Expression and Characterization of Human Peroxisome Proliferator Activated Receptors γ1 and γ2 , 1996 .

[470]  W. Hacke,et al.  'Malignant' middle cerebral artery territory infarction : Clinical course and prognostic signs , 1996 .

[471]  C. Piantadosi,et al.  Mitochondrial generation of reactive oxygen species after brain ischemia in the rat. , 1996, Stroke.

[472]  D. Smith,et al.  Inflammatory leukocytic recruitment and diffuse neuronal degeneration are separate pathological processes resulting from traumatic brain injury , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[473]  B. Spiegelman,et al.  15-Deoxy-Δ 12,14-Prostaglandin J 2 is a ligand for the adipocyte determination factor PPARγ , 1995, Cell.

[474]  J. Wayne Streilein,et al.  Unraveling Immune Privilege , 1995, Science.

[475]  B. Juurlink,et al.  Oligodendroglial precursor cell susceptibility to hypoxia is related to poor ability to cope with reactive oxygen species , 1995, Brain Research.

[476]  X. Chen,et al.  Structural organization of mouse peroxisome proliferator-activated receptor gamma (mPPAR gamma) gene: alternative promoter use and different splicing yield two mPPAR gamma isoforms. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[477]  V. Howard,et al.  Is the stroke belt disappearing? An analysis of racial, temporal, and age effects. , 1995, Stroke.

[478]  J. Lehmann,et al.  An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ) (*) , 1995, The Journal of Biological Chemistry.

[479]  B. Blumberg,et al.  Isolation of the human peroxisome proliferator activated receptor gamma cDNA: expression in hematopoietic cells and chromosomal mapping. , 1995, Gene expression.

[480]  P. Kochanek,et al.  Neutrophil accumulation after traumatic brain injury in rats: comparison of weight drop and controlled cortical impact models. , 1994, Journal of neurotrauma.

[481]  T. Olsen,et al.  Recovery of upper extremity function in stroke patients: the Copenhagen Stroke Study. , 1994, Archives of physical medicine and rehabilitation.

[482]  F. Barone,et al.  Development of tissue damage, inflammation and resolution following stroke: An immunohistochemical and quantitative planimetric study , 1993, Brain Research Bulletin.

[483]  R. Ross.  The pathogenesis of atherosclerosis: a perspective for the 1990s , 1993, Nature.

[484]  Charles Tator,et al.  Secondary Ca2+ overload indicates early neuronal injury which precedes staining with viability indicators , 1993, Brain Research.

[485]  R. Franklin,et al.  Repair of demyelinated lesions by transplantation of purified 0-2A progenitor cells , 1993, Nature.

[486]  T A Gennarelli,et al.  Mechanisms of brain injury. , 1993, The Journal of emergency medicine.

[487]  Samuel Thayer,et al.  Glutamate-induced calcium transient triggers delayed calcium overload and neurotoxicity in rat hippocampal neurons , 1992, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[488]  N. Hogg,et al.  Macrophage cytoskeleton association with CR3 and CR4 regulates receptor mobility and phagocytosis of iC3b‐opsonized erythrocytes , 1992, Journal of leukocyte biology.

[489]  T. Rushmore,et al.  The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity. , 1991, The Journal of biological chemistry.

[490]  W. Mcdonald,et al.  Patterns of blood-brain barrier breakdown in inflammatory demyelination. , 1991, Brain : a journal of neurology.

[491]  P. Bailly,et al.  Molecular characterization of the human macrophage mannose receptor: demonstration of multiple carbohydrate recognition-like domains and phagocytosis of yeasts in Cos-1 cells , 1990, The Journal of experimental medicine.

[492]  I. Issemann,et al.  Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators , 1990, Nature.

[493]  T. Rushmore,et al.  Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene. Characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants. , 1990, The Journal of biological chemistry.

[494]  C. Anderson,et al.  Phagocytosis mediated by three distinct Fc gamma receptor classes on human leukocytes , 1990, The Journal of experimental medicine.

[495]  R. Rodriguez y Baena,et al.  Arachidonic acid metabolism and pathophysiologic aspects of subarachnoid hemorrhage in rats. , 1990, Stroke.

[496]  M. Feola,et al.  Generation of free oxygen radicals and the toxicity of hemoglobin solutions. , 1990, Biomaterials, artificial cells, and artificial organs.

[497]  B. V. Van Ness,et al.  Single copy gene detection requiring minimal cell numbers. , 1989, BioTechniques.

[498]  W. Mcdonald,et al.  Central remyelination restores secure conduction , 1979, Nature.

[499]  Gledhill Rf,et al.  Remyelination after transient compression of the spinal cord. , 1975 .

[500]  W. Blakemore.  Pattern of remyelination in the CNS , 1974, Nature.

[501]  J. Rosenbluth.  REDUNDANT MYELIN SHEATHS AND OTHER ULTRASTRUCTURAL FEATURES OF THE TOAD CEREBELLUM , 1966, The Journal of cell biology.

[502]  N. Borhani.  CHANGES AND GEOGRAPHIC DISTRIBUTION OF MORTALITY FROM CEREBROVASCULAR DISEASE. , 1965, American journal of public health and the nation's health.