Novel amplification unit at chromosome 3q25–q27 in human prostate cancer

In prostate carcinoma, amplification of the genes c‐MYC, Her2/NEU, and the androgen receptor gene has been documented, with gene amplification being related to progressive tumor growth. Recently, using comparative genomic hybridization (CGH), we provided evidence for DNA copy number gains at chromosome 3q25–q26 in prostate cancer [Sattler et al.: Prostate 39:79–86, 1999].

[1]  H. Kastendieck,et al.  Cytogenetic survey of 32 cancers of the prostate. , 1993, Cancer genetics and cytogenetics.

[2]  Stefan Joos,et al.  Mapping of chromosomal gains and losses in prostate cancer by comparative genomic hybridization , 1995, Genes, chromosomes & cancer.

[3]  E. Meese,et al.  Comparative PCR: an improved method to detect gene amplification. , 1998, BioTechniques.

[4]  B. Wullich,et al.  Comparative genomic hybridization reveals DNA copy number gains to frequently occur in human prostate cancer , 1999, The Prostate.

[5]  E. Meese,et al.  Amplification of the genes BCHE and SLC2A2 in 40% of squamous cell carcinoma of the lung. , 1997, Cancer research.

[6]  C. Sheehan,et al.  HER-2/neu gene amplification status in prostate cancer by fluorescence in situ hybridization. , 1997, Human pathology.

[7]  G. Haas,et al.  Epidemiology of prostate cancer , 1997, CA: a cancer journal for clinicians.

[8]  M. Stöckle,et al.  Comparison of the malignant phenotype and genotype of the human androgen-independent cell line DU 145 and a subline derived from metastasis after orthotopic implantation in nude mice. , 2001, Cancer genetics and cytogenetics.

[9]  Jorma Isola,et al.  In vivo amplification of the androgen receptor gene and progression of human prostate cancer , 1995, Nature Genetics.

[10]  N. Tanaka,et al.  Molecular definition of a small amplification domain within 3q26 in tumors of cervix, ovary, and lung. , 2000, Cancer genetics and cytogenetics.

[11]  Y. Nakamura,et al.  Localization of a tumor suppressor gene associated with progression of human prostate cancer within a 1.2 Mb region of 8p22‐p21.3 , 1995, Genes, chromosomes & cancer.

[12]  M. Pfreundschuh,et al.  Translation initiation factor eIF-4gamma is encoded by an amplified gene and induces an immune response in squamous cell lung carcinoma. , 1997, Human molecular genetics.

[13]  T C Gasser,et al.  Survey of gene amplifications during prostate cancer progression by high-throughout fluorescence in situ hybridization on tissue microarrays. , 1999, Cancer research.

[14]  W. Lee,et al.  Promoter deletion and loss of retinoblastoma gene expression in human prostate carcinoma. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[15]  M. Becich,et al.  Allelic loss detected on chromosomes 8, 10, and 17 by fluorescence in situ hybridization using single-copy P1 probes on isolated nuclei from paraffin-embedded prostate tumors. , 1997, The American journal of pathology.

[16]  M. Schwab,et al.  Oncogene amplification in tumor cells. , 1986, Advances in cancer research.

[17]  J. Barrett,et al.  KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2. , 1995, Science.

[18]  F. Mitelman,et al.  Double minutes in two primary adenocarcinomas of the prostate. , 1989, Cancer genetics and cytogenetics.

[19]  J. Warrington,et al.  Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5. , 1992, Genomics.

[20]  M. Bittner,et al.  DNA sequence amplification in human prostate cancer identified by chromosome microdissection: potential prognostic implications. , 1995, Clinical cancer research : an official journal of the American Association for Cancer Research.

[21]  J Piper,et al.  Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[22]  G. Nucifora.  The EVI1 gene in myeloid leukemia , 1997, Leukemia.

[23]  E. Payen,et al.  The ovine SOX2 gene: sequence, chromosomal localization and gonadal expression. , 1997, Gene.

[24]  M. Poutanen,et al.  Loss of heterozygosity at 16q24.1-q24.2 is significantly associated with metastatic and aggressive behavior of prostate cancer. , 1997, Cancer research.

[25]  J. Sambrook,et al.  Molecular Cloning: A Laboratory Manual , 2001 .

[26]  P. Lichter,et al.  Primary mediastinal (thymic) B-cell lymphoma is characterized by gains of chromosomal material including 9p and amplification of the REL gene. , 1996, Blood.

[27]  A. Brothman,et al.  Chromosome 7 abnormalities in prostate cancer detected by dual-color fluorescence in situ hybridization. , 1998, Cancer genetics and cytogenetics.

[28]  F. Mitelman,et al.  Cytogenetic analysis of 57 primary prostatic adenocarcinomas , 1992, Genes, chromosomes & cancer.

[29]  P. Carroll,et al.  Genetic alterations in untreated metastases and androgen-independent prostate cancer detected by comparative genomic hybridization and allelotyping. , 1996, Cancer research.

[30]  W. W. Nichols,et al.  p53 protein accumulation and gene mutation in the progression of human prostate carcinoma. , 1993, Journal of the National Cancer Institute.

[31]  K. Franssila,et al.  DNA copy number changes in diffuse large B-cell lymphoma--comparative genomic hybridization study. , 1996, Blood.

[32]  T. Visakorpi,et al.  Androgen receptor gene and hormonal therapy failure of prostate cancer. , 1998, The American journal of pathology.

[33]  D. Paulson,et al.  Isolation of a human prostate carcinoma cell line (DU 145) , 1978, International journal of cancer.

[34]  D. Bostwick,et al.  A molecular cytogenetic analysis of 7q31 in prostate cancer. , 1997, Cancer research.

[35]  K. Offit,et al.  REL proto-oncogene is frequently amplified in extranodal diffuse large cell lymphoma , 1996 .

[36]  R. Vessella,et al.  Comparative genomic hybridization and molecular cytogenetic characterization of two prostate cancer xenografts , 1997, Genes, chromosomes & cancer.

[37]  D. Bostwick,et al.  Detection of c-myc oncogene amplification and chromosomal anomalies in metastatic prostatic carcinoma by fluorescence in situ hybridization. , 1997, Cancer research.

[38]  T. Visakorpi,et al.  Genetic alterations in prostate cancer cell lines detected by comparative genomic hybridization. , 1998, Cancer genetics and cytogenetics.

[39]  B. Wullich,et al.  Genotypic characterization of prostatic carcinomas: a combined cytogenetic, flow cytometry, and in situ DNA hybridization study. , 1993, Cancer research.