Comparison of the protective effects of desflurane and propofol anesthesia in rats hepatic ischemia-reperfusion injury model: 9AP4-2

Results: The postischemic serum IL-1β levels were significantly higher with propofol than with ketamine (P = 0.014). In the postischemic period, in the ischemia-desflurane group, TNF-α levels were significantly lower than in the ischemia-propofol (P = 0.009). The number of polymorphonuclear leukocytes was the lowest in the ketamine group in the postischemic period (P < 0.01). Conclusion: In order to reach a definitive judgment, studies with a larger number of subjects are necessary.

[1]  M. Albrecht,et al.  Effect of propofol on hypoxia re‐oxygenation induced neuronal cell damage in vitro * , 2013, Anaesthesia.

[2]  K. Boudjema,et al.  Effect of an anesthesia with propofol compared with desflurane on free radical production and liver function after partial hepatectomy , 2012, Fundamental & clinical pharmacology.

[3]  Yiming Lu,et al.  In Vitro Kinetic Evaluation of the Free Radical Scavenging Ability of Propofol , 2012, Anesthesiology.

[4]  H. Sert,et al.  Taurine is protective against oxidative stress during cold ischemia in the rat kidney , 2011, Turkish Journal of Medical Sciences.

[5]  Ke Chen,et al.  Effects of Wy14643 on hepatic ischemia reperfusion injury in rats. , 2008, World journal of gastroenterology.

[6]  S. Choi,et al.  The effects of desflurane and propofol‐remifentanil on postoperative hepatic and renal functions after right hepatectomy in liver donors , 2008, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[7]  D. Geller,et al.  Factors in the pathophysiology of the liver ischemia-reperfusion injury. , 2008, The Journal of surgical research.

[8]  Biao Zhu,et al.  Desflurane Preconditioning Inhibits Endothelial Nuclear Factor-&kgr;-B Activation by Targeting the Proximal End of Tumor Necrosis Factor-α Signaling , 2008, Anesthesia and analgesia.

[9]  J. González‐Gallego,et al.  Halothane induces oxidative stress and NF-kappaB activation in rat liver: protective effect of propofol. , 2006, Toxicology.

[10]  H. Jaeschke Mechanisms of Liver Injury. II. Mechanisms of neutrophil-induced liver cell injury during hepatic ischemia-reperfusion and other acute inflammatory conditions. , 2006, American journal of physiology. Gastrointestinal and liver physiology.

[11]  Z. Biao,et al.  The In Vitro Effect of Desflurane Preconditioning on Endothelial Adhesion Molecules and mRNA Expression , 2005, Anesthesia and analgesia.

[12]  I. Gülçin,et al.  Determination of in vitro antioxidant and radical scavenging activities of propofol. , 2005, Chemical & pharmaceutical bulletin.

[13]  K. Dou,et al.  Protective effects of tumor necrosis factor α antibody and ulinastatin on liver ischemic reperfusion in rats , 2004 .

[14]  A. Lentsch,et al.  Peroxisome proliferator-activated receptor-α regulates postischemic liver injury , 2004 .

[15]  G. Farrell,et al.  Dual role of tumor necrosis factor‐α in hepatic ischemia‐reperfusion injury: Studies in tumor necrosis factor‐α gene knockout mice , 2004 .

[16]  Y. Kanmura,et al.  Propofol Displays No Protective Effect Against Hypoxia/Reoxygenation Injury in Rat Liver Slices , 2003, Anesthesia and analgesia.

[17]  A. Bedirli,et al.  Bacterial Translocation after Partial Hepatic Resection under Ischemia and Reperfusion in Rats: Incidence and Time Course* , 2003 .

[18]  G. K. Chambers,et al.  Tissue Antioxidant Capacity During Anesthesia: Propofol Enhances In Vivo Red Cell and Tissue Antioxidant Capacity in a Rat Model , 2002, Anesthesia and analgesia.

[19]  D. Remick,et al.  Inhibition of Kupffer cells reduced CXC chemokine production and liver injury. , 2001, The Journal of surgical research.

[20]  A. Gelb,et al.  Anesthetic Concentrations of Propofol Protect against Oxidative Stress in Primary Astrocyte Cultures: Comparison with Hypothermia , 2001, Anesthesiology.

[21]  P. Pagel,et al.  Sarcolemmal and Mitochondrial Adenosine Triphosphate– dependent Potassium Channels: Mechanism of Desflurane-induced Cardioprotection , 2000, Anesthesiology.

[22]  F. S. de la Cuesta,et al.  The In Vitro Effects of Propofol on Tissular Oxidative Stress in the Rat , 1998, Anesthesia and analgesia.

[23]  S. Kawachi,et al.  Up-regulation of oxygen-derived free radicals by interleukin-1 in hepatic ischemia/reperfusion injury. , 1997, Transplantation.

[24]  M. Kitajima,et al.  Interleukin 1 receptor blockade reduces tumor necrosis factor production, tissue injury, and mortality after hepatic ischemia-reperfusion in the rat. , 1997, Transplantation.

[25]  A. Bast,et al.  The widely used anesthetic agent propofol can replace α‐tocopherol as an antioxidant , 1995 .

[26]  L. Toledo-Pereyra,et al.  Neutrophils, cytokines, and adhesion molecules in hepatic ischemia and reperfusion injury. , 1994, Journal of the American College of Surgeons.

[27]  M. Davies,et al.  The effect of propofol anaesthesia on free radical-induced lipid peroxidation in rat liver microsomes. , 1993, European journal of anaesthesiology.

[28]  H. Flad,et al.  PRODUCTION OF CYTOKINES (TNF‐ALPHA, IL‐1‐BETA) AND ENDOTHELIAL CELL ACTIVATION IN HUMAN LIVER ALLOGRAFT REJECTION1 , 1993, Transplantation.

[29]  M. Bianchi,et al.  Antioxidant action of propofol on liver microsomes, mitochondria and brain synaptosomes in the rat. , 1991, Pharmacology & toxicology.

[30]  R. Strieter,et al.  Role of tumor necrosis factor-alpha in the pathophysiologic alterations after hepatic ischemia/reperfusion injury in the rat. , 1990, The Journal of clinical investigation.

[31]  S. Kamaci,et al.  Comparison of effects of anaesthesia with desflurane and enflurane on liver function. , 2009, Singapore medical journal.