Genetics of heart development.

The genes that drive heart-cell differentiation in vertebrates and Drosophila are similar, even though the Drosophila 'heart' is a simple tube and the vertebrate heart is a multichambered physiologically complex organ. Mutational analysis in mice and, as particular focus of this review, in zebrafish, reveals the additional genes brought into play to fashion these evolutionarily 'new' organotypic components.

[1]  G. Lyons,et al.  Vertebrate homologs of tinman and bagpipe: roles of the homeobox genes in cardiovascular development. , 1998, Developmental genetics.

[2]  D. L. Weeks,et al.  Epithelial-mesenchymal transformation of embryonic cardiac endothelial cells is inhibited by a modified antisense oligodeoxynucleotide to transforming growth factor beta 3. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[3]  K. Saigo,et al.  Requirements of DFR1/Heartless, a mesoderm-specific Drosophila FGF-receptor, for the formation of heart, visceral and somatic muscles, and ensheathing of longitudinal axon tracts in CNS. , 1997, Development.

[4]  H. Keshishian,et al.  Patterning the dorsal longitudinal flight muscles (DLM) of Drosophila: insights from the ablation of larval scaffolds. , 1996, Development.

[5]  A. Lassar,et al.  A role for bone morphogenetic proteins in the induction of cardiac myogenesis. , 1997, Genes & development.

[6]  Hanh T. Nguyen,et al.  Genetic Control of Mesoderm Patterning and Differentiation During Drosophila Embryogenesis , 1999 .

[7]  Vincent Gm,et al.  The molecular genetics of the long QT syndrome: genes causing fainting and sudden death. , 1998 .

[8]  S. Camper,et al.  Dosage requirement of Pitx2 for development of multiple organs. , 1999, Development.

[9]  C. Bucana,et al.  Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C. , 1997, Science.

[10]  D. Paul,et al.  Genetic diseases and gene knockouts reveal diverse connexin functions. , 1999, Annual review of physiology.

[11]  G. Boivin,et al.  TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes. , 1997, Development.

[12]  L. Leatherbury,et al.  Role of cardiac neural crest cells in cardiovascular development. , 1998, Annual review of physiology.

[13]  L Hartley,et al.  Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants. , 1993, Development.

[14]  L. Zon,et al.  Cloche, an early acting zebrafish gene, is required by both the endothelial and hematopoietic lineages. , 1995, Development.

[15]  W. Talbot,et al.  The EGF-CFC Protein One-Eyed Pinhead Is Essential for Nodal Signaling , 1999, Cell.

[16]  J. Rossant,et al.  Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium , 1995, Nature.

[17]  F. Grosveld,et al.  The transcription factor GATA6 is essential for early extraembryonic development. , 1999, Development.

[18]  D. Stainier,et al.  A molecular pathway leading to endoderm formation in zebrafish , 1999, Current Biology.

[19]  M. Frasch,et al.  Induction of visceral and cardiac mesoderm by ectodermal Dpp in the early Drosophila embryo , 1995, Nature.

[20]  R. Bodmer.  The gene tinman is required for specification of the heart and visceral muscles in Drosophila. , 1993, Development.

[21]  R. Schwartz,et al.  Building the heart piece by piece: modularity of cis-elements regulating Nkx2-5 transcription. , 1999, Development.

[22]  Raymond B. Runyan,et al.  Epithelial-mesenchymal cell transformation in the embryonic heart can be mediated, in part, by transforming growth factor beta. , 1989, Developmental biology.

[23]  Tak W. Mak,et al.  Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum , 1998, Nature.

[24]  Y. Jan,et al.  Polarity in Cell Division What Frames Thy Fearful Asymmetry? , 2000, Cell.

[25]  J. Seidman,et al.  Erratum: Mutations in human TBX5 cause limb and cardiac malformation in Holt-Oram syndrome , 1997, Nature Genetics.

[26]  D. Wilson,et al.  Wild-type endoderm abrogates the ventral developmental defects associated with GATA-4 deficiency in the mouse. , 1997, Developmental biology.

[27]  M. Kennedy,et al.  A common precursor for hematopoietic and endothelial cells. , 1998, Development.

[28]  M. Fishman,et al.  Notochord regulates cardiac lineage in zebrafish embryos. , 1998, Developmental biology.

[29]  B. Shilo,et al.  Heartless, a Drosophila FGF receptor homolog, is essential for cell migration and establishment of several mesodermal lineages. , 1996, Genes & development.

[30]  X. Zhu,et al.  Combined BMP-2 and FGF-4, but neither factor alone, induces cardiogenesis in non-precardiac embryonic mesoderm. , 1996, Developmental biology.

[31]  B. Hogan,et al.  The mammalian Tolloid-like 1 gene, Tll1, is necessary for normal septation and positioning of the heart. , 1999, Development.

[32]  David I. Wilson,et al.  Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family , 1997, Nature Genetics.

[33]  J. Seidman,et al.  Congenital heart disease caused by mutations in the transcription factor NKX2-5. , 1998, Science.

[34]  M. Frasch,et al.  Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm. , 1998, Genes & development.

[35]  P. Krieg,et al.  Tinman function is essential for vertebrate heart development: elimination of cardiac differentiation by dominant inhibitory mutants of the tinman-related genes, XNkx2-3 and XNkx2-5. , 1998, Developmental biology.

[36]  M. Rosenfeld,et al.  Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis , 1999, Nature.

[37]  D. Wilson,et al.  Cardiomyocyte differentiation by GATA-4-deficient embryonic stem cells. , 1997, Development.

[38]  Thomas N. Sato,et al.  Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation , 1995, Nature.

[39]  R. Schulz,et al.  The zinc finger proteins Pannier and GATA4 function as cardiogenic factors in Drosophila. , 1999, Development.

[40]  M. Brand,et al.  Induction and differentiation of the zebrafish heart requires fibroblast growth factor 8 (fgf8/acerebellar). , 2000, Development.

[41]  R. Ho,et al.  The bHLH transcription factor hand2 plays parallel roles in zebrafish heart and pectoral fin development. , 2000, Development.

[42]  M. Fishman,et al.  Defective "pacemaker" current (Ih) in a zebrafish mutant with a slow heart rate. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[43]  T. Evans,et al.  Regulation of Cardiac Gene Expression by GATA-4/5/6. , 1997, Trends in cardiovascular medicine.

[44]  H. Sucov,et al.  Molecular insights into cardiac development. , 1998, Annual review of physiology.

[45]  M. Fishman,et al.  Regulation in the heart field of zebrafish. , 1998, Development.

[46]  Lieve Moons,et al.  Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele , 1996, Nature.

[47]  D. Srivastava,et al.  Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND , 1997, Nature Genetics.

[48]  D. Stainier,et al.  Gata5 is required for the development of the heart and endoderm in zebrafish. , 1999, Genes & development.

[49]  E. Olson,et al.  Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. , 1997, Genes & development.

[50]  Y. Saijoh,et al.  lefty-1 Is Required for Left-Right Determination as a Regulator of lefty-2 and nodal , 1998, Cell.

[51]  E. Morrisey,et al.  GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo. , 1998, Genes & development.

[52]  M. Frasch,et al.  ladybird, a new component of the cardiogenic pathway in Drosophila required for diversification of heart precursors. , 1997, Development.

[53]  L. Zon,et al.  The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning. , 1997, Development.

[54]  D. Stainier,et al.  casanova plays an early and essential role in endoderm formation in zebrafish. , 1999, Developmental biology.

[55]  C. Nüsslein-Volhard,et al.  Mutations affecting the cardiovascular system and other internal organs in zebrafish. , 1996, Development.

[56]  Stephen S. Gisselbrecht,et al.  heartless encodes a fibroblast growth factor receptor (DFR1/DFGF-R2) involved in the directional migration of early mesodermal cells in the Drosophila embryo. , 1996, Genes & development.

[57]  S. Miyagawa-Tomita,et al.  Mouse Pitx2 deficiency leads to anomalies of the ventral body wall, heart, extra- and periocular mesoderm and right pulmonary isomerism. , 1999, Development.

[58]  M. Fishman,et al.  Fashioning the vertebrate heart: earliest embryonic decisions. , 1997, Development.

[59]  C. Nüsslein-Volhard,et al.  Mutations affecting segment number and polarity in Drosophila , 1980, Nature.

[60]  M. Fishman,et al.  Parsing the Heart: Genetic Modules for Organ Assembly , 1997, Cell.

[61]  Michael J. Grusby,et al.  The transcription factor NF-ATc is essential for cardiac valve formation , 1998, Nature.

[62]  Kenneth J. Hillan,et al.  Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene , 1996, Nature.

[63]  K Sigrist,et al.  GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. , 1997, Genes & development.

[64]  R. Kucherlapati,et al.  Mutations in human cause limb and cardiac malformation in Holt-Oram syndrome , 1997, Nature Genetics.

[65]  David L. Paul,et al.  Mice lacking connexin40 have cardiac conduction abnormalities characteristic of atrioventricular block and bundle branch block , 1998, Current Biology.

[66]  A. Schier,et al.  Mutations affecting the formation and function of the cardiovascular system in the zebrafish embryo. , 1996, Development.

[67]  Wei Yan,et al.  Vertebrate tinman homologues XNkx2-3 and XNkx2-5 are required for heart formation in a functionally redundant manner. , 1998, Development.

[68]  Janet Rossant,et al.  Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice , 1995, Nature.