Respiratory uncoupling in skeletal muscle delays death and diminishes age-related disease.

[1]  S. Humphries,et al.  Variation in the UCP2-UCP3 Gene Cluster Predicts the Development of Type 2 Diabetes in Healthy Middle-Aged Men , 2006, Diabetes.

[2]  C. Kenyon,et al.  A C. elegans mutant that lives twice as long as wild type , 1993, Nature.

[3]  K. Wheatley,et al.  Association between premature mortality and hypopituitarism , 2001, The Lancet.

[4]  G. Sumara,et al.  Requirement of JNK2 for Scavenger Receptor A-Mediated Foam Cell Formation in Atherogenesis , 2004, Science.

[5]  L. Nolte,et al.  Respiratory Uncoupling Lowers Blood Pressure Through a Leptin-Dependent Mechanism in Genetically Obese Mice , 2002, Arteriosclerosis, thrombosis, and vascular biology.

[6]  A. Bartke,et al.  Adipocytokines and lipid levels in Ames dwarf and calorie-restricted mice. , 2006, The journals of gerontology. Series A, Biological sciences and medical sciences.

[7]  L. Muglia,et al.  Vascular respiratory uncoupling increases blood pressure and atherosclerosis , 2005, Nature.

[8]  A. Bartke,et al.  Low Body Temperature in Long-Lived Ames Dwarf Mice at Rest and During Stress , 1999, Physiology & Behavior.

[9]  H. Jasper,et al.  JNK Extends Life Span and Limits Growth by Antagonizing Cellular and Organism-Wide Responses to Insulin Signaling , 2005, Cell.

[10]  M. Tatar,et al.  A Mutant Drosophila Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function , 2001, Science.

[11]  P. Antin,et al.  Tetracycline-Inducible System for Regulation of Skeletal Muscle-Specific Gene Expression in Transgenic Mice , 2003, Transgenic Research.

[12]  Frank Hu,et al.  The Relationship between Overweight in Adolescence and Premature Death in Women , 2006, Annals of Internal Medicine.

[13]  A. Saltiel,et al.  Increased Inflammatory Properties of Adipose Tissue Macrophages Recruited During Diet-Induced Obesity , 2007, Diabetes.

[14]  J. Wands,et al.  Enhanced colon tumor induction in uncoupling protein-2 deficient mice is associated with NF-kappaB activation and oxidative stress. , 2006, Carcinogenesis.

[15]  T. Horvath,et al.  Uncoupling proteins-2 and 3 influence obesity and inflammation in transgenic mice , 2003, International Journal of Obesity.

[16]  C. Kahn,et al.  Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. , 2000, Molecular cell.

[17]  J. Holloszy,et al.  Effect of voluntary exercise on longevity of rats. , 1985, Journal of applied physiology.

[18]  Tamara B Harris,et al.  Daily activity energy expenditure and mortality among older adults. , 2006, JAMA.

[19]  G. Shulman,et al.  Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance. , 2007, The Journal of clinical investigation.

[20]  Martin Holzenberger,et al.  IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice , 2003, Nature.

[21]  I. Gram,et al.  Body mass index, waist circumference and waist–hip ratio and serum levels of IGF-I and IGFBP-3 in European women , 2006, International Journal of Obesity.

[22]  M. Päivänsalo,et al.  IGF‐I concentrations are positively associated with carotid artery atherosclerosis in women , 2005, Annals of medicine.

[23]  Matthias Blüher,et al.  Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue , 2003, Science.

[24]  A. Daugherty,et al.  Effects of heterozygous lipoprotein lipase deficiency on diet-induced atherosclerosis in mice. , 1998, Journal of lipid research.

[25]  M. Kushmerick,et al.  Mild mitochondrial uncoupling impacts cellular aging in human muscles in vivo , 2007, Proceedings of the National Academy of Sciences.

[26]  Michael Karin,et al.  A central role for JNK in obesity and insulin resistance , 2002, Nature.

[27]  P. Froguel,et al.  Globular Adiponectin Protected ob/ob Mice from Diabetes and ApoE-deficient Mice from Atherosclerosis* , 2003, The Journal of Biological Chemistry.

[28]  S. Pan,et al.  Physical activity, obesity, energy intake, and the risk of non-Hodgkin's lymphoma: a population-based case-control study. , 2005, American journal of epidemiology.

[29]  J. Holloszy.  Exercise increases average longevity of female rats despite increased food intake and no growth retardation. , 1993, Journal of gerontology.

[30]  Wilhelm Haas,et al.  Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1 , 2005, Nature.

[31]  Subramaniam Pennathur,et al.  Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDL. , 2007, The Journal of clinical investigation.

[32]  L. Guarente.  Sirtuins as potential targets for metabolic syndrome , 2006, Nature.

[33]  H Tunstall-Pedoe,et al.  Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis. , 2005, JAMA.

[34]  Andrzej Bartke,et al.  Dwarf mice and the ageing process , 1996, Nature.

[35]  J. A. Barreto-Filho,et al.  Lack of evidence of premature atherosclerosis in untreated severe isolated growth hormone (GH) deficiency due to a GH-releasing hormone receptor mutation. , 2006, The Journal of clinical endocrinology and metabolism.

[36]  Richard A. Miller,et al.  Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[37]  Martin D. Brand,et al.  Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean , 2000, Nature.

[38]  J. Ju,et al.  Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice , 2000, Nature Medicine.

[39]  R. Clayton,et al.  The effect of hypopituitarism on life expectancy. , 1996, The Journal of clinical endocrinology and metabolism.

[40]  K. Cianflone,et al.  Plasma acylation-stimulating protein, adiponectin, leptin, and ghrelin before and after weight loss induced by gastric bypass surgery in morbidly obese subjects. , 2003, The Journal of clinical endocrinology and metabolism.

[41]  Z. Laron,et al.  Do deficiencies in growth hormone and insulin-like growth factor-1 (IGF-1) shorten or prolong longevity? , 2005, Mechanisms of Ageing and Development.

[42]  A. Russell,et al.  Reduced skeletal muscle uncoupling protein-3 content in prediabetic subjects and type 2 diabetic patients: restoration by rosiglitazone treatment. , 2006, The Journal of clinical endocrinology and metabolism.

[43]  Stephen N. Jones,et al.  p53 mutant mice that display early ageing-associated phenotypes , 2002, Nature.

[44]  G. Mazzotta,et al.  The third component of the complement (C3) is a marker of the risk of atherogenesis , 2006, European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology.

[45]  Raphaelle Winsky-Sommerer,et al.  Transgenic Mice with a Reduced Core Body Temperature Have an Increased Life Span , 2006, Science.