Genome-wide identification of direct HBx genomic targets

[1]  Yanbao Yu,et al.  Hepatitis B Virus X Protein Promotes Degradation of SMC5/6 to Enhance HBV Replication. , 2016, Cell reports.

[2]  G. D. De Ferrari,et al.  The enzymes LSD1 and Set1A cooperate with the viral protein HBx to establish an active hepatitis B viral chromatin state , 2016, Scientific Reports.

[3]  S. Fletcher,et al.  Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor , 2016, Nature.

[4]  Qiang Deng,et al.  HBx relieves chromatin-mediated transcriptional repression of hepatitis B viral cccDNA involving SETDB1 histone methyltransferase. , 2015, Journal of hepatology.

[5]  M. Tao,et al.  MicroRNA-130a can inhibit hepatitis B virus replication via targeting PGC1α and PPARγ , 2015, RNA.

[6]  O. J. Semmes,et al.  The Tudor Domain Protein Spindlin1 Is Involved in Intrinsic Antiviral Defense against Incoming Hepatitis B Virus and Herpes Simplex Virus Type 1 , 2014, PLoS pathogens.

[7]  N. Hiraga,et al.  Human microRNA hsa‐miR‐1231 suppresses hepatitis B virus replication by targeting core mRNA , 2014, Journal of viral hepatitis.

[8]  S. Imbeaud,et al.  Integration of tumour and viral genomic characterisations in HBV-related hepatocellular carcinomas , 2014, Gut.

[9]  Shibo Jiang,et al.  Modulation of HBV replication by microRNA-15b through targeting hepatocyte nuclear factor 1α , 2014, Nucleic acids research.

[10]  Ira Mellman,et al.  Endocytosis and cancer. , 2013, Cold Spring Harbor perspectives in biology.

[11]  Mengji Lu,et al.  Regulation of hepatitis B virus replication by epigenetic mechanisms and microRNAs , 2013, Front. Genet..

[12]  T. Zeng,et al.  HBx-mediated miR-21 upregulation represses tumor-suppressor function of PDCD4 in hepatocellular carcinoma , 2013, Oncogene.

[13]  Anna Tramontano,et al.  FIDEA: a server for the functional interpretation of differential expression analysis , 2013, Nucleic Acids Res..

[14]  C. Shin,et al.  c‐Myc‐mediated overexpression of miR‐17‐92 suppresses replication of hepatitis B virus in human hepatoma cells , 2013, Journal of medical virology.

[15]  Xiang-Dong Fu,et al.  Hepatitis B Viral RNA Directly Mediates Down-regulation of the Tumor Suppressor MicroRNA miR-15a/miR-16-1 in Hepatocytes* , 2013, The Journal of Biological Chemistry.

[16]  M. Levrero,et al.  Molecular Mechanisms of HBV-Associated Hepatocarcinogenesis , 2013, Seminars in Liver Disease.

[17]  Alina Macovei,et al.  Regulation of Hepatitis B Virus Infection by Rab5, Rab7, and the Endolysosomal Compartment , 2013, Journal of Virology.

[18]  M. Buendia,et al.  Methyltransferase PRMT1 Is a Binding Partner of HBx and a Negative Regulator of Hepatitis B Virus Transcription , 2013, Journal of Virology.

[19]  Zhongjun Wu,et al.  miR-101 is down-regulated by the hepatitis B virus x protein and induces aberrant DNA methylation by targeting DNA methyltransferase 3A. , 2013, Cellular signalling.

[20]  D. Fan,et al.  MicroRNA-501 promotes HBV replication by targeting HBXIP. , 2013, Biochemical and biophysical research communications.

[21]  L. Stein,et al.  Annotating Cancer Variants and Anti-Cancer Therapeutics in Reactome , 2012, Cancers.

[22]  Yong Zhang,et al.  Identifying ChIP-seq enrichment using MACS , 2012, Nature Protocols.

[23]  Wen Chang,et al.  Entry of Hepatitis B Virus into Immortalized Human Primary Hepatocytes by Clathrin-Dependent Endocytosis , 2012, Journal of Virology.

[24]  Robert D. Finn,et al.  InterPro in 2011: new developments in the family and domain prediction database , 2011, Nucleic acids research.

[25]  M. Levrero,et al.  Transcriptional regulation of miR-224 upregulated in human HCCs by NFκB inflammatory pathways. , 2012, Journal of Hepatology.

[26]  Y. Li,et al.  MicroRNA-141 Represses HBV Replication by Targeting PPARA , 2012, PloS one.

[27]  Gretchen A. Stevens,et al.  Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBsAg seroprevalence and endemicity. , 2012, Vaccine.

[28]  G. Gao,et al.  Loss of microRNA 122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G1‐modulated P53 activity , 2012, Hepatology.

[29]  M. Levrero,et al.  IFN-α inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome. , 2012, The Journal of clinical investigation.

[30]  Laurence D. Hurst,et al.  Young intragenic miRNAs are less coexpressed with host genes than old ones: implications of miRNA–host gene coevolution , 2012, Nucleic acids research.

[31]  M. Buendia,et al.  Inhibition of PP1 Phosphatase Activity by HBx: A Mechanism for the Activation of Hepatitis B Virus Transcription , 2012, Science Signaling.

[32]  Fabien Zoulim,et al.  Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection. , 2011, Journal of hepatology.

[33]  M. Bouchard,et al.  The Hepatitis B Virus X Protein Elevates Cytosolic Calcium Signals by Modulating Mitochondrial Calcium Uptake , 2011, Journal of Virology.

[34]  Liang Zhang,et al.  MicroRNAs‐372/373 promote the expression of hepatitis B virus through the targeting of nuclear factor I/B , 2011, Hepatology.

[35]  A. Huang,et al.  Hepatitis B virus and hepatocellular carcinoma at the miRNA level. , 2011, World journal of gastroenterology.

[36]  Peng Gao,et al.  Deregulation of microRNA expression occurs early and accumulates in early stages of HBV-associated multistep hepatocarcinogenesis. , 2011, Journal of hepatology.

[37]  Zhiyong Ma,et al.  Modulation of hepatitis B virus replication and hepatocyte differentiation by MicroRNA‐1 , 2011, Hepatology.

[38]  Xiaohui Xie,et al.  Genome-wide localization of SREBP-2 in hepatic chromatin predicts a role in autophagy. , 2011, Cell metabolism.

[39]  Xin Li,et al.  Suppression of hepatitis B virus replication by microRNA-199a-3p and microRNA-210. , 2010, Antiviral research.

[40]  D. Ann,et al.  The early autophagic pathway is activated by hepatitis B virus and required for viral DNA replication , 2010, Proceedings of the National Academy of Sciences.

[41]  M. Levrero,et al.  Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function , 2009, Proceedings of the National Academy of Sciences.

[42]  M. Levrero,et al.  Control of cccDNA function in hepatitis B virus infection. , 2009, Journal of hepatology.

[43]  Cole Trapnell,et al.  Ultrafast and memory-efficient alignment of short DNA sequences to the human genome , 2009, Genome Biology.

[44]  Ze-Guang Han,et al.  Epigenetic modification induced by hepatitis B virus X protein via interaction with de novo DNA methyltransferase DNMT3A. , 2009, Journal of hepatology.

[45]  Mu-jun Zhao,et al.  Hepatitis B virus X protein sensitizes cells to starvation‐induced autophagy via up‐regulation of beclin 1 expression , 2009, Hepatology.

[46]  Jianren Gu,et al.  Diagnostic and prognostic implications of microRNAs in human hepatocellular carcinoma , 2008, International journal of cancer.

[47]  Clifford A. Meyer,et al.  Model-based Analysis of ChIP-Seq (MACS) , 2008, Genome Biology.

[48]  Stijn van Dongen,et al.  miRBase: tools for microRNA genomics , 2007, Nucleic Acids Res..

[49]  S. Cairo,et al.  The Hepatitis B Virus X Protein Functionally Interacts with CREB-binding Protein/p300 in the Regulation of CREB-mediated Transcription* , 2007, Journal of Biological Chemistry.

[50]  M. Levrero,et al.  Hepatitis B virus replication is regulated by the acetylation status of hepatitis B virus cccDNA-bound H3 and H4 histones. , 2006, Gastroenterology.

[51]  M. Ashburner,et al.  Gene Ontology: tool for the unification of biology , 2000, Nature Genetics.

[52]  R. Schneider,et al.  Activation of Src family kinases by hepatitis B virus HBx protein and coupled signaling to Ras , 1997, Molecular and cellular biology.

[53]  G. Práctica,et al.  European Association for the Study of the Liver , 1971 .

[54]  David Croft,et al.  Building models using Reactome pathways as templates. , 2013, Methods in molecular biology.

[55]  S. Zeuzem,et al.  EASL Clinical Practice Guidelines: management of hepatitis C virus infection. , 2011, Journal of hepatology.

[56]  E. Alexandre,et al.  Isolation and culture of primary hepatocytes from resected human liver tissue. , 2010, Methods in molecular biology.

[57]  F. Zoulim,et al.  Persistence of the hepatitis B virus covalently closed circular DNA in HepaRG human hepatocyte-like cells. , 2009, The Journal of general virology.

[58]  Brad T. Sherman,et al.  Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources , 2008, Nature Protocols.

[59]  Hiroyuki Ogata,et al.  KEGG: Kyoto Encyclopedia of Genes and Genomes , 1999, Nucleic Acids Res..