Evaluation of the adequacy of drug prescriptions in patients with chronic kidney disease: results from the CKD‐REIN cohort

Drug prescription is difficult to manage in patients with chronic kidney disease (CKD). We assessed the prevalence and determinants of inappropriate drug prescriptions (whether contraindications or inappropriately high doses) with regard to kidney function in patients with CKD under nephrology care. We also assessed the impact of the equation used to estimate GFR on the prevalence estimates.

[1]  M. Jose,et al.  Potentially Inappropriate Prescribing of Renally Cleared Drugs in Elderly Patients in Community and Aged Care Settings , 2015, Drugs & Aging.

[2]  C. Jacquelinet,et al.  Risk profile, quality of life and care of patients with moderate and advanced CKD: The French CKD-REIN Cohort Study , 2019, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[3]  Stef van Buuren,et al.  Multiple imputation of discrete and continuous data by fully conditional specification , 2007 .

[4]  Pierre Delanaye,et al.  Discrepancies between the Cockcroft–Gault and Chronic Kidney Disease Epidemiology (CKD-EPI) Equations: Implications for Refining Drug Dosage Adjustment Strategies , 2017, Clinical Pharmacokinetics.

[5]  D. D. Bois,et al.  CLINICAL CALORIMETRY: TENTH PAPER A FORMULA TO ESTIMATE THE APPROXIMATE SURFACE AREA IF HEIGHT AND WEIGHT BE KNOWN , 1916 .

[6]  M. Bédard,et al.  Assessment of Adherence to Renal Dosing Guidelines in Long‐Term Care Facilities , 2000, Journal of the American Geriatrics Society.

[7]  G. Peterson,et al.  Impact of the Pharmacist Medication Review Services on Drug-Related Problems and Potentially Inappropriate Prescribing of Renally Cleared Medications in Residents of Aged Care Facilities , 2014, Drugs & Aging.

[8]  Organización Mundial de la Salud Guidelines for ATC classification and DDD assignment , 1996 .

[9]  W J Spruill,et al.  Continuing the Use of the Cockcroft–Gault Equation for Drug Dosing in Patients With Impaired Renal Function , 2009, Clinical pharmacology and therapeutics.

[10]  R. Bilous,et al.  KDOQI Clinical Practice Guideline for Diabetes and CKD: 2012 Update. , 2012, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[11]  Josef Coresh,et al.  Chronic kidney disease , 2012, The Lancet.

[12]  C. Jacquelinet,et al.  The French Chronic Kidney Disease-Renal Epidemiology and Information Network (CKD-REIN) cohort study , 2013, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[13]  D. Bolignano,et al.  Clinical Practice Guideline on management of patients with diabetes and chronic kidney disease stage 3b or higher (eGFR <45 mL/min). , 2015, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[14]  John E. Murphy,et al.  Evaluation of Renal Drug Dosing: Prescribing Information and Clinical Pharmacist Approaches , 2010, Pharmacotherapy.

[15]  O. Moranne,et al.  Adaptation posologique des médicaments et fonction rénale : quel(s) estimateur(s) faut-il choisir ? , 2016 .

[16]  Brenda R. Hemmelgarn,et al.  Notice , 2012, Kidney International Supplements.

[17]  C. Tzourio,et al.  Inappropriate drug use and mortality in community-dwelling elderly with impaired kidney function--the Three-City population-based study. , 2011, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[18]  Y. Hassan,et al.  Drug use and dosing in chronic kidney disease. , 2009, Annals of the Academy of Medicine, Singapore.

[19]  O. Hanon,et al.  [Assessment of antihypertensive compliance using a self-administered questionnaire: development and use in a hypertension clinic]. , 2001, Presse medicale.

[20]  E. Schaeffner,et al.  Two Novel Equations to Estimate Kidney Function in Persons Aged 70 Years or Older , 2012, Annals of Internal Medicine.

[21]  S. Herget-Rosenthal,et al.  Renal Insufficiency and Medication in Nursing Home Residents , 2016 .

[22]  M. Steinman,et al.  Use of Renally Inappropriate Medications in Older Veterans: A National Study , 2015, Journal of the American Geriatrics Society.

[23]  Cockcroft Dw,et al.  Prediction of Creatinine Clearance from Serum Creatinine , 1976 .

[24]  K. Hande,et al.  Severe allopurinol toxicity. Description and guidelines for prevention in patients with renal insufficiency. , 1984, The American journal of medicine.

[25]  M. Kuo,et al.  Allopurinol‐induced Severe Hypersensitivity with Acute Renal Failure , 2005, The Kaohsiung journal of medical sciences.

[26]  K. Hande,et al.  Severe Allopurinol Toxicity. Description and Guidelines for Prevention in Patients With Renal Insufficiency , 1984 .

[27]  S. Herget-Rosenthal,et al.  Renal Insufficiency and Medication in Nursing Home Residents. A Cross-Sectional Study (IMREN). , 2016, Deutsches Arzteblatt international.

[28]  Y. Dimitrov,et al.  Oral antidiabetics use among diabetic type 2 patients with chronic kidney disease. Do nephrologists take account of recommendations? , 2016, Journal of diabetes and its complications.

[29]  T. Nolin A Synopsis of Clinical Pharmacokinetic Alterations in Advanced CKD , 2015, Seminars in dialysis.

[30]  O. Hanon,et al.  Evaluation de l'observance du traitement antihypertenseur par un questionnaire : mise au point et utilisation dans un service spécialisé , 2001 .

[31]  W. Shibeshi,et al.  Drug dosage adjustment in hospitalized patients with renal impairment at Tikur Anbessa specialized hospital, Addis Ababa, Ethiopia , 2015, BMC Nephrology.

[32]  C. Schmid,et al.  A new equation to estimate glomerular filtration rate. , 2009, Annals of internal medicine.

[33]  Myrna Y Munar,et al.  Drug dosing adjustments in patients with chronic kidney disease. , 2007, American family physician.

[34]  A. Weill,et al.  French national health insurance information system and the permanent beneficiaries sample. , 2010, Revue d'epidemiologie et de sante publique.

[35]  P. Awadalla,et al.  Prevalence, awareness, and management of CKD and cardiovascular risk factors in publicly funded health care. , 2014, Clinical journal of the American Society of Nephrology : CJASN.