Understanding and controlling the cell cycle with natural products.

[1]  J. Essigmann,et al.  The mismatch-repair protein hMSH2 binds selectively to DNA adducts of the anticancer drug cisplatin. , 1996, Chemistry & biology.

[2]  S. Schreiber,et al.  Controlling protein association and subcellular localization with a synthetic ligand that induces heterodimerization of proteins. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[3]  S. Schreiber,et al.  Didemnin binds to the protein palmitoyl thioesterase responsible for infantile neuronal ceroid lipofuscinosis. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[4]  S. Schreiber,et al.  A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p , 1996, Science.

[5]  S. Schreiber,et al.  (+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest. , 1996, Chemistry & biology.

[6]  S. Schreiber,et al.  Protein Structure-Based Combinatorial Chemistry: Discovery of Non-Peptide Binding Elements to Src SH3 Domain , 1996 .

[7]  H. Rosenkranz,et al.  Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol. , 1996, Biochemistry.

[8]  N. Sonenberg,et al.  Repression of cap‐dependent translation by 4E‐binding protein 1: competition with p220 for binding to eukaryotic initiation factor‐4E. , 1995, The EMBO journal.

[9]  S. Lippard,et al.  Crystal structure of double-stranded DNA containing the major adduct of the anticancer drug cisplatin , 1995, Nature.

[10]  S. Schreiber,et al.  PIK-Related Kinases: DNA Repair, Recombination, and Cell Cycle Checkpoints , 1995, Science.

[11]  S. Schreiber,et al.  Control of p70 S6 kinase by kinase activity of FRAP in vivo , 1995, Nature.

[12]  R. Margolis,et al.  Delay of HeLa cell cleavage into interphase using dihydrocytochalasin B: retention of a postmitotic spindle and telophase disc correlates with synchronous cleavage recovery , 1995, The Journal of cell biology.

[13]  Z. Darżynkiewicz,et al.  Discrimination of G2 and mitotic cells by flow cytometry based on different expression of cyclins A and B1. , 1995, Experimental cell research.

[14]  R. Schlegel,et al.  The human papilloma virus 16E6 gene sensitizes human mammary epithelial cells to apoptosis induced by DNA damage. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[15]  A Khodjakov,et al.  The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores , 1995, The Journal of cell biology.

[16]  S. Schreiber,et al.  Synthesis and cellular characterization of the detransformation agent, (-)-depudecin. , 1995, Chemistry & biology.

[17]  P. Toogood,et al.  Mechanism of protein synthesis inhibition by didemnin B in vitro. , 1995, Biochemistry.

[18]  Y. Miyake,et al.  Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin. , 1995, Biochemical and biophysical research communications.

[19]  E. Nogales,et al.  Structure of tubulin at 6.5 Å and location of the taxol-binding site , 1995, Nature.

[20]  E. Lazarides,et al.  Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action. , 1995, Cancer research.

[21]  R F Standaert,et al.  Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin , 1995, Science.

[22]  S. Horinouchi,et al.  Trichostatin A and trapoxin: Novel chemical probes for the role of histone acetylation in chromatin structure and function , 1995, BioEssays : news and reviews in molecular, cellular and developmental biology.

[23]  M. DePamphilis,et al.  Mimosine Arrests DNA Synthesis at Replication Forks by Inhibiting Deoxyribonucleotide Metabolism (*) , 1995, The Journal of Biological Chemistry.

[24]  P. Traub,et al.  Okadaic acid co‐induces vimentin expression and cell cycle arrest in MPC‐11 mouse plasmacytoma cells , 1995, Journal of cellular physiology.

[25]  B. Ducommun,et al.  Effects of phleomycin‐induced DNA damage on the fission yeast Schizosaccharomyces pombe cell cycle , 1995, Yeast.

[26]  B. Sinha.  Topoisomerase inhibitors. A review of their therapeutic potential in cancer. , 1995, Drugs.

[27]  J. M. de Pereda,et al.  Solution structure of Taxotere-induced microtubules to 3-nm resolution. The change in protofilament number is linked to the binding of the taxol side chain. , 1994, The Journal of biological chemistry.

[28]  D. J. Clarke,et al.  A topoisomerase II-dependent G2 cycle checkpoint in mammalian cells , 1994, Nature.

[29]  C. Rieder,et al.  Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle , 1994, The Journal of cell biology.

[30]  S. Lippard,et al.  HMG-domain proteins specifically inhibit the repair of the major DNA adduct of the anticancer drug cisplatin by human excision nuclease. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[31]  P. Kiener,et al.  Activation of p34cdc2 coincident with taxol-induced apoptosis. , 1994, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[32]  A. Fornace,et al.  The p53-dependent G1 cell cycle checkpoint pathway and ataxia-telangiectasia. , 1994, Cancer research.

[33]  J. Blow,et al.  Inhibition of cyclin-dependent kinases by purine analogues. , 1994, European journal of biochemistry.

[34]  A. Horváth,et al.  Ceramide synthesis enhances transport of GPI‐anchored proteins to the Golgi apparatus in yeast. , 1994, The EMBO journal.

[35]  Tony Hunter,et al.  p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21 , 1994, Cell.

[36]  James M. Roberts,et al.  Cloning of p27 Kip1 , a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals , 1994, Cell.

[37]  Paul Tempst,et al.  RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs , 1994, Cell.

[38]  Andrius Kazlauskas,et al.  PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase , 1994, Nature.

[39]  J. Blenis,et al.  Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation , 1994, Molecular and cellular biology.

[40]  Stuart L. Schreiber,et al.  A mammalian protein targeted by G1-arresting rapamycin–receptor complex , 1994, Nature.

[41]  Z. Darżynkiewicz,et al.  Staurosporine blocks cell progression through G1 between the cyclin D and cyclin E restriction points. , 1994, Cancer research.

[42]  S. Schreiber,et al.  GTP-dependent binding of the antiproliferative agent didemnin to elongation factor 1 alpha. , 1994, The Journal of biological chemistry.

[43]  C. Riccardi,et al.  The natural tyrosine kinase inhibitor genistein produces cell cycle arrest and apoptosis in Jurkat T-leukemia cells. , 1994, Leukemia research.

[44]  J. Barrett,et al.  Disruption of G0-G1 arrest in quiescent and senescent cells treated with phosphatase inhibitors. , 1994, Cancer research.

[45]  Y. Koiso,et al.  Interaction of ustiloxin A with bovine brain tubulin. , 1994, Biochemical pharmacology.

[46]  S. Schreiber,et al.  A beta-lactone related to lactacystin induces neurite outgrowth in a neuroblastoma cell line and inhibits cell cycle progression in an osteosarcoma cell line. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[47]  K. Kohn,et al.  The protein kinase C inhibitor ilmofosine (BM 41 440) arrests cells in G2 phase and suppresses CDC2 kinase activation through a mechanism different from that of DNA damaging agents. , 1994, Biochemical and biophysical research communications.

[48]  D. Fujiwara,et al.  Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression. , 1994, The Journal of biological chemistry.

[49]  J. Wang,et al.  Antitumor bisdioxopiperazines inhibit yeast DNA topoisomerase II by trapping the enzyme in the form of a closed protein clamp. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[50]  M. Kastan,et al.  DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways , 1994, Molecular and cellular biology.

[51]  I. Ringel,et al.  3'-(p-azidobenzamido)taxol photolabels the N-terminal 31 amino acids of beta-tubulin. , 1994, The Journal of biological chemistry.

[52]  K. Nicolaou,et al.  Chemistry and Biology of Taxol , 1994 .

[53]  G. Guénard,et al.  Rhazinilam mimics the cellular effects of taxol by different mechanisms of action. , 1994, Cell motility and the cytoskeleton.

[54]  D. J. Clarke,et al.  A topoisomerase II-dependent G2 cycle checkpoint in mammalian cells , 1994, Nature.

[55]  V. Hu.  The Cell Cycle , 1994, GWUMC Department of Biochemistry Annual Spring Symposia.

[56]  K. Nasmyth,et al.  Dams and sluices , 1993, Nature.

[57]  David Beach,et al.  p21 is a universal inhibitor of cyclin kinases , 1993, Nature.

[58]  D. Sackett,et al.  Localization of the colchicine-binding site of tubulin. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[59]  Y. Nonomura,et al.  Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells. , 1993, The Journal of biological chemistry.

[60]  T. Hunter.  Braking the cycle , 1993, Cell.

[61]  S. Elledge,et al.  The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases , 1993, Cell.

[62]  S. Schreiber,et al.  FKBP-rapamycin inhibits a cyclin-dependent kinase activity and a cyclin D1-Cdk association in early G1 of an osteosarcoma cell line. , 1993, The Journal of biological chemistry.

[63]  M. Jordan,et al.  Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[64]  Z. Cichacz,et al.  Spongistatin 1, a highly cytotoxic, sponge-derived, marine natural product that inhibits mitosis, microtubule assembly, and the binding of vinblastine to tubulin. , 1993, Molecular pharmacology.

[65]  B. Dahllöf,et al.  Estramustine depolymerizes microtubules by binding to tubulin. , 1993, Cancer research.

[66]  D. Housman,et al.  p53-dependent apoptosis modulates the cytotoxicity of anticancer agents , 1993, Cell.

[67]  Gwyn T. Williams,et al.  Molecular regulation of apoptosis: Genetic controls on cell death , 1993, Cell.

[68]  A. Levinson,et al.  Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells. , 1993, Science.

[69]  R L Smith,et al.  Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor. , 1993, Science.

[70]  Thomas E. Deerinck,et al.  Complete vesiculation of Golgi membranes and inhibition of protein transport by a novel sea sponge metabolite, ilimaquinone , 1993, Cell.

[71]  A. Hyman,et al.  Identification of essential components of the S. cerevisiae kinetochore , 1993, Cell.

[72]  J. Kunz,et al.  Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression , 1993, Cell.

[73]  E. Sausville,et al.  Cell cycle arrest and growth inhibition by the protein kinase antagonist UCN-01 in human breast carcinoma cells. , 1993, Cancer research.

[74]  P. Scheuer,et al.  Palau'amine: a cytotoxic and immunosuppressive hexacyclic bisguanidine antibiotic from the sponge Stylotella agminata , 1993 .

[75]  Y. Hannun,et al.  Programmed cell death induced by ceramide. , 1993, Science.

[76]  V. Prasad,et al.  Interaction of halichondrin B and homohalichondrin B with bovine brain tubulin. , 1993, Biochemical pharmacology.

[77]  K. Nasmyth,et al.  Cell cycle. Dams and sluices. , 1993, Nature.

[78]  L. Obeid,et al.  The novel second messenger ceramide: identification, mechanism of action, and cellular activity. , 1993, Advances in lipid research.

[79]  H. Kwon,et al.  Potent and specific inhibition of p60v-src protein kinase both in vivo and in vitro by radicicol. , 1992, Cancer research.

[80]  T. Nikaido,et al.  Quercetin arrests human leukemic T-cells in late G1 phase of the cell cycle. , 1992, Cancer research.

[81]  B. Vogelstein,et al.  A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia , 1992, Cell.

[82]  S. Nadler,et al.  Interaction of the immunosuppressant deoxyspergualin with a member of the Hsp70 family of heat shock proteins. , 1992, Science.

[83]  A. Murray,et al.  Creative blocks: cell-cycle checkpoints and feedback controls , 1992, Nature.

[84]  E. Gabrielson,et al.  Reversible G1 arrest of a human lung epithelial cell line by staurosporine , 1992, Journal of cellular physiology.

[85]  Bert Vogelstein,et al.  p53 function and dysfunction , 1992, Cell.

[86]  C. Crews,et al.  Interleukin 2 stimulation of p70 S6 kinase activity is inhibited by the immunosuppressant rapamycin. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[87]  S. Schreiber.  Immunophilin-sensitive protein phosphatase action in cell signaling pathways , 1992, Cell.

[88]  E. Nogales,et al.  Low resolution structure of microtubules in solution. Synchrotron X-ray scattering and electron microscopy of taxol-induced microtubules assembled from purified tubulin in comparison with glycerol and MAP-induced microtubules. , 1992, Journal of molecular biology.

[89]  G. Crabtree,et al.  Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase , 1992, Nature.

[90]  G. Crabtree,et al.  Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases , 1992, Cell.

[91]  A. D. Buss,et al.  The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity. , 1992, The Journal of antibiotics.

[92]  A. Shinohara,et al.  Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein , 1992, Cell.

[93]  R. A. Swank,et al.  Staurosporine is a potent inhibitor of p34cdc2 and p34cdc2-like kinases. , 1992, Biochemical and biophysical research communications.

[94]  H. Joshi,et al.  γ-Tubulin is a centrosomal protein required for cell cycle-dependent microtubule nucleation , 1992, Nature.

[95]  K. Nicolaou,et al.  Chemistry and Biology of the Enediyne Anticancer Antibiotics , 1991 .

[96]  T. Langan,et al.  Isoprenoids and astroglial cell cycling: Diminished mevalonate availability and inhibition of dolichol‐linked glycoprotein synthesis arrest cycling through distinct mechanisms , 1991, Journal of cellular physiology.

[97]  A. Hershko,et al.  Methylated ubiquitin inhibits cyclin degradation in clam embryo extracts. , 1991, The Journal of biological chemistry.

[98]  Stuart L. Schreiber,et al.  Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes , 1991, Cell.

[99]  A. Kimchi,et al.  Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6 , 1991, Nature.

[100]  William Fenical,et al.  Isolation and Structure Determination of Diazonamides A and B, Unusual Cytotoxic Metabolites from the Marine Ascidian Diazona chinensis , 1991 .

[101]  I. Goldberg.  Mechanism of Neocarzinostatin Action: Role of DNA Microstructure in Determination of Chemistry of Bistranded Oxidative Damage , 1991 .

[102]  S. Spiegel,et al.  Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation , 1991, The Journal of cell biology.

[103]  S. Henikoff,et al.  Trans-sensing effects from Drosophila to humans , 1991, Cell.

[104]  Y. Akimoto,et al.  Stimulation by Bt2cAMP of epidermal mucous metaplasia in retinol-pretreated chick embryonic cultured skin, and its inhibition by herbimycin A, an inhibitor for protein-tyrosine kinase. , 1991, Experimental cell research.

[105]  H. Koshino,et al.  Reveromycin A, a new antibiotic which inhibits the mitogenic activity of epidermal growth factor. , 1991, The Journal of antibiotics.

[106]  L. Cantley,et al.  Oncogenes and signal transduction , 1991, Cell.

[107]  A. Murray,et al.  Cyclin is degraded by the ubiquitin pathway , 1991, Nature.

[108]  N. Heintz,et al.  Transcriptional regulation in the eukaryotic cell cycle. , 1991, Trends in biochemical sciences.

[109]  G. Pettit.  The bryostatins. , 1991, Fortschritte der Chemie organischer Naturstoffe = Progress in the chemistry of organic natural products. Progres dans la chimie des substances organiques naturelles.

[110]  A. Hata,et al.  Structural and functional diversities of a family of signal transducing protein kinases, protein kinase C family; two distinct classes of PKC, conventional cPKC and novel nPKC. , 1991, Advances in enzyme regulation.

[111]  M. Yoshida,et al.  Highly synchronous culture of fibroblasts from G2 block caused by staurosporine, a potent inhibitor of protein kinases. , 1991, Experimental cell research.

[112]  Yumay Chen,et al.  Genetic mechanisms of tumor suppression by the human p53 gene , 1990, Science.

[113]  A. Zetterberg,et al.  Cytotoxic effects of cell cycle phase specific agents: result of cell cycle perturbation. , 1990, Cancer research.

[114]  D. E. Levin,et al.  A candidate protein kinase C gene, PKC1, is required for the S. cerevisiae cell cycle , 1990, Cell.

[115]  M. Dasso,et al.  Completion of DNA replication is monitored by a feedback system that controls the initiation of mitosis in vitro: Studies in Xenopus , 1990, Cell.

[116]  Joseph Schlessinger,et al.  Signal transduction by receptors with tyrosine kinase activity , 1990, Cell.

[117]  H. Osada,et al.  Epiderstatin, a new inhibitor of the mitogenic activity induced by epidermal growth factor. I. Taxonomy, fermentation, isolation and characterization. , 1989, The Journal of antibiotics.

[118]  L. Hartwell,et al.  Checkpoints: controls that ensure the order of cell cycle events. , 1989, Science.

[119]  H. Osada,et al.  Epiderstatin, a new inhibitor of the mitogenic activity induced by epidermal growth factor. II. Structure elucidation. , 1989, The Journal of antibiotics.

[120]  T. Sakai,et al.  Protection by cycloheximide against cytotoxicity induced by vincristine, colchicine, or delta 12-prostaglandin J2 on human osteosarcoma cells. , 1989, Cancer research.

[121]  J. Raff,et al.  Nuclear and cytoplasmic mitotic cycles continue in Drosophila embryos in which DNA synthesis is inhibited with aphidicolin , 1988, The Journal of cell biology.

[122]  A. Kandutsch,et al.  Requirement for mevalonate in cycling cells: Quantitative and temporal aspects , 1988, Journal of cellular physiology.

[123]  L. Hartwell,et al.  The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae. , 1988, Science.

[124]  F. Traganos,et al.  Resistance of human leukemic and normal lymphocytes to drug-induced DNA cleavage and low levels of DNA topoisomerase II. , 1988, Cancer research.

[125]  W. Earnshaw,et al.  Differential expression of DNA topoisomerases I and II during the eukaryotic cell cycle. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[126]  J. Volpe,et al.  Dolichol‐Linked Glycoprotein Synthesis in G1 Is Necessary for DNA Synthesis in Synchronized Primary Cultures of Cerebral Glia , 1987, Journal of neurochemistry.

[127]  J. Stubbe,et al.  Mechanisms of bleomycin-induced DNA degradation , 1987 .

[128]  J. Volpe,et al.  Cell Cycle‐Specific Requirement for Mevalonate, but Not for Cholesterol, for DNA Synthesis in Glial Primary Cultures , 1987, Journal of neurochemistry.

[129]  T. Sugimura,et al.  New classes of tumor promoters: teleocidin, aplysiatoxin, and palytoxin. , 1987, Advances in cancer research.

[130]  A. Zetterberg,et al.  Effects of 25‐hydroxycholesterol, cholesterol, and isoprenoid derivatives on the G1 progression in Swiss 3T3 cells , 1986, Journal of cellular physiology.

[131]  W. Stigelman,et al.  Goodman and Gilman's the Pharmacological Basis of Therapeutics , 1986 .

[132]  R. Schlegel,et al.  Caffeine-induced uncoupling of mitosis from the completion of DNA replication in mammalian cells. , 1986, Science.

[133]  W. Lennarz.  Regulation of glycoprotein synthesis during development of the sea urchin embryo. , 1986, Developmental biology.

[134]  J. Nelson,et al.  The dual role of mevalonate in the cell cycle. , 1983, The Journal of biological chemistry.

[135]  R. Margolis,et al.  Mechanism of colchicine-dimer addition to microtubule ends: implications for the microtubule polymerization mechanism. , 1980, Biochemistry.

[136]  M. Wiley,et al.  Isopentenyladenine as a mediator of mevalonate-regulated DNA replication. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[137]  E. Medrano,et al.  Prevalent deficiency in tumor cells of cycloheximide-induced cycle arrest. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[138]  P. Blumberg,et al.  Different biological targets for resiniferatoxin and phorbol 12-myristate 13-acetate. , 1980, Cancer research.

[139]  M. Wiley,et al.  Isopentenyl adenine as a mediator of mevalonate-regulated DNA replication. , 1980, Transactions of the Association of American Physicians.

[140]  A. Wyllie,et al.  Cell death: the significance of apoptosis. , 1980, International review of cytology.

[141]  M. Wiley,et al.  Essential role for mevalonate synthesis in DNA replication. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[142]  J. Gray,et al.  Effect of methylglyoxal-bis (guanylhydrazone), an inhibitor of spermidine and spermine synthesis, on cell cycle traverse. , 1977, European journal of cancer.

[143]  G C Johnston,et al.  Coordination of growth with cell division in the yeast Saccharomyces cerevisiae. , 1977, Experimental cell research.

[144]  B. Bhattacharyya,et al.  Podophyllotoxin as a probe for the colchicine binding site of tubulin. , 1977, The Journal of biological chemistry.

[145]  K. Weber,et al.  Griseofulvin interacts with microtubules both in vivo and in vitro. , 1976, Journal of molecular biology.

[146]  M. De Brabander,et al.  Interaction of oncodazole (R 17934), a new antitumoral drug, with rat brain tubulin. , 1976, Biochemical and biophysical research communications.

[147]  J. Lee,et al.  Interaction of Vinblastine with Calf Brain Microtubule protein. , 1975, The Journal of biological chemistry.

[148]  A. Pardee,et al.  Cell cycle studies of mononucleate and cytochalasin-B--nduced binucleate fibroblasts. , 1975, Proceedings of the National Academy of Sciences of the United States of America.

[149]  D. Pettijohn,et al.  Polyamines stabilise DNA folds , 1975, Nature.

[150]  K. Bensch,et al.  Antimitotic Action of Griseofulvin does not Involve Disruption of Microtubules , 1973, Nature.

[151]  J. Chiu,et al.  Effect of spermidine on the activity of DNA polymerases. , 1972, Biochimica et biophysica acta.

[152]  C. Gilmore,et al.  Maytansine, a novel antileukemic ansa macrolide from Maytenus ovatus. , 1972, Journal of the American Chemical Society.

[153]  P. Calabresi,et al.  Chemotherapy of neoplastic diseases. , 1962, Annual review of medicine.

[154]  D. Karnofsky,et al.  Chemotherapy of neoplastic diseases. , 1950, The Medical clinics of North America.